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Keywords: oxidative stress
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Biochem J (2021) 478 (20): 3741–3756.
Published: 21 October 2021
... and CNC homolog 1 (BACH1). BACH1 is a ubiquitous master regulator of the cellular response to oxidative stress. Here, we show that BACH1 may have a dual effect on CFTR expression by direct occupancy of CREs at physiological oxygen (∼8%), while indirectly modulating expression under conditions of oxidative...
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Biochem J (2021) 478 (12): 2359–2370.
Published: 23 June 2021
... 2021 27 5 2021 1 6 2021 1 6 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 base excision repair DNA damage DNA glycosylase oxidative stress Activation of macrophages and neutrophils during the inflammatory...
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Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
..., in particular through alterations in electron transport chain function, reactive oxygen species (ROS) production and oxidative stress (OS), mitochondrial dynamics and mitophagy. Finally, we describe the impact of cocaine on brain energy metabolism in the developing brain following prenatal exposure...
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Biochem J (2020) 477 (21): 4281–4294.
Published: 13 November 2020
... 15 10 2020 28 10 2020 28 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 heat shock proteins myocardium oxidative stress sarcoplasmic reticulum skeletal muscle Diaphragms of Sln -null ( n  = 6...
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Biochem J (2020) 477 (19): 3709–3727.
Published: 05 October 2020
... oxidative stress to form S -mycothiolated monomer or inter-molecular disulfide-containing dimer, resulting in its dissociation from the target DNA promoter. Transcriptomics uncovered the strong up-regulation of many multidrug efflux pump genes and organic peroxide stress-involving genes in oasR mutant...
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Biochem J (2020) 477 (17): 3123–3130.
Published: 04 September 2020
... in cardiomyocytes that includes fetal reprogramming of gene expression where adult genes are repressed and fetal genes turned on, endoplasmic reticulum stress and oxidative stress. In this short review and analysis, we examine these different phenomenon from the viewpoint of the glutathione cycle and the role...
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Biochem J (2020) 477 (16): 3033–3054.
Published: 26 August 2020
... of the organelle. The protein import into mitochondria is mediated by diverse import pathways and is continuously under watch by quality control systems. However, it is often challenged by both internal and external factors, such as oxidative stress or energy shortage. The impaired protein import and biogenesis...
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Biochem J (2020) 477 (15): 2859–2871.
Published: 12 August 2020
...-oxoadenine DNA polymerase mutagenesis oxidative DNA damage oxidative stress translesion synthesis © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Correspondence: Seongmin Lee ( seongminlee@austin.utexas.edu ) 4 6 2020 15 7 2020...
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Biochem J (2020) 477 (7): 1323–1344.
Published: 17 April 2020
... cathepsins-B, D and L, and caspase-3 and -7 were not inhibited by SS-5. SS-5 blocked the development of P. falciparum in vitro (IC50 1 µM) and caused prominent morphological distortions. Incubation with SS-5 led to persistent parasite oxidative stress accompanied by depolarization of mitochondrial potential...
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Biochem J (2019) 476 (3): 581–593.
Published: 14 February 2019
... to regulate a gene network for mitigating light-induced oxidative stress [ 66 ]. However, the underlying molecular mechanisms of this retrograde signaling chain are still unknown. LHC genes form a large family in plants and algae. In C. reinhardtii , there are at least 20 different LHC isoforms...
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Biochem J (2019) 476 (3): 595–611.
Published: 14 February 2019
...Andrew G. Turner; Karrera Y. Djoko; Cheryl-lynn Y. Ong; Timothy C. Barnett; Mark J. Walker; Alastair G. McEwan Bacterial pathogens encounter a variety of adverse physiological conditions during infection, including metal starvation, metal overload and oxidative stress. Here, we demonstrate...
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Biochem J (2018) 475 (19): 3105–3121.
Published: 12 October 2018
... was up-regulated in response to salinity, drought, and oxidative stress. Full-length cDNA encoding OsCSD3 was cloned and expressed in Escherichia coli and analyzed for spectral characteristics. UV (ultraviolet)–visible spectroscopic analysis showed evidences of d–d transitions, while circular dichroism...
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Biochem J (2018) 475 (19): 3057–3071.
Published: 10 October 2018
... pathway, and revelation of superoxide dismutase activity suggest that Vic_CAPAN has an important role during oxidative stress. As salicylic acid changes the redox state of cell, it may act as a downstream signal for various pathways involved in plant biotic and abiotic stress rescue. C. annuum...
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Biochem J (2018) 475 (10): 1789–1791.
Published: 31 May 2018
... and the response to oxidative stress, whereas plasmalogens, a poorly studied class of phospholipids, are known contributors to insulin resistance and hypertension. Both classes of metabolites are intriguing candidate biomarkers that warrant further investigation. Correspondence: Alessandro Rufini ( ar230...
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Biochem J (2018) 475 (5): 923–929.
Published: 09 March 2018
... activation can lead to programmed cell death through the activation of multiple signalling pathways (e.g. [ 6 , 10 – 12 ]). © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ER stress IRE1 oxidative stress unfolded protein response...
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Biochem J (2018) 475 (1): 87–97.
Published: 02 January 2018
...Ana Perea; José Ignacio Manzano; Yasuhisa Kimura; Kazumitsu Ueda; Santiago Castanys; Francisco Gamarro The Leishmania LABCG2 transporter has a key role in the redox metabolism of these protozoan parasites. Recently, the involvement of LABCG2 in virulence, autophagy and oxidative stress has been...
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Biochem J (2017) 474 (23): 3887–3902.
Published: 10 November 2017
...). Published by Portland Press Limited on behalf of the Biochemical Society 2017 autophagy mitophagy oxidative stress stress transfection agent Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic pathway found in all eukaryotes involving delivery...
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Biochem J (2017) 474 (17): 3027–3043.
Published: 22 August 2017
.... Periplanetasin-2 induced oxidative stress by generation of reactive oxygen species (ROS) and lipid peroxidation. Periplanetasin-2 also caused apoptosis by exposure of phosphatidylserine and fragmentation of DNA, exerted in a concentration-dependent manner. Hence, we investigated the mitochondrial apoptotic...
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Biochem J (2017) 474 (15): 2563–2572.
Published: 18 July 2017
... be a previously unrecognized mechanism by which ascorbate mitigates oxidative damage to heme-dependent enzymes and redox proteins in nature. antioxidants cytochrome electron transfer oxidative stress peroxidases proton transfer Correspondence: Victor L. Davidson ( victor.davidson@ucf.edu...
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Biochem J (2017) 474 (7): 1195–1203.
Published: 20 March 2017
...Yasemin Sunucu Karafakıoğlu; Mehmet Fatih Bozkurt; Ömer Hazman; A. Fatih Fıdan The aim of the present study was to investigate the effects of safranal on cisplatin-induced nephrotoxicity and oxidative stress in rats. Adult male Sprague–Dawley rats were randomly divided into five groups. The control...
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Biochem J (2016) 473 (23): 4443–4456.
Published: 25 November 2016
... O 2 and will have great utility for islet studies involving mechanisms of H 2 O 2 -mediated signaling and oxidative stress. glucose uptake hydrogen peroxide mitochondria oxidative stress Failure of pancreatic β-cells to compensate for increased insulin resistance is a major...
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Biochem J (2016) 473 (23): 4373–4384.
Published: 25 November 2016
... polymerization. In the present study, we investigated the influence of oxidative stress of fibrinogen induced by H 2 O 2 on the polymerization state of fibrin. UV absorbance spectroscopy, circular dichroism, ζ-potential, dynamic light scattering and steady shear viscosity were all employed to study the influence...
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Biochem J (2016) 473 (22): 4205–4225.
Published: 10 November 2016
...Dong Keun Rhee; Jung Chae Lim; Steven C. Hockman; Faiyaz Ahmad; Dong Ho Woo; Youn Wook Chung; Shiwei Liu; Allison L. Hockman; Vincent C. Manganiello Oxidative stress plays a pivotal role in pathogenesis of cardiovascular diseases and diabetes; however, the roles of protein kinase A (PKA) and human...
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Biochem J (2016) 473 (6): 769–777.
Published: 10 March 2016
... necrosis oxidative stress Ras Erastin and the aspartic protease inhibitor pepstatin A-methyl ester (PepA-Me) were purchased from Calbiochem. Bafilomycin A 1 (Baf A 1 ), an inhibitor of vacuolar H + -ATPase, was purchased from Wako. The iron chelator deferoxamine (DFO) was purchased from Sigma...
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Biochem J (2016) 473 (1): 21–30.
Published: 09 December 2015
...-plaque formation in the brain by accelerating lysosomal degradation of BACE1. Therefore, we hypothesized that bisecting GlcNAc would stabilize BACE1 protein on oxidative stress. In the present study, we first show that Aβ deposition in the mouse brain induces oxidative stress, together with an increase...
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Biochem J (2015) 471 (2): 267–279.
Published: 02 October 2015
.... cancer lipid signalling melanoma oxidative stress peroxiredoxin Compared with normal healthy tissue, tumour tissue displays many features which are common to different cancer types. Among these features is elevated ROS (reactive oxygen species) metabolism, which is the result of various...
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Biochem J (2015) 470 (3): 281–291.
Published: 04 September 2015
...Ami Oguro; Shoko Oida; Susumu Imaoka sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids). Previously, we found that high-glucose-induced oxidative stress suppressed sEH levels in a hepatocarcinoma cell line...
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Biochem J (2014) 462 (1): 125–132.
Published: 24 July 2014
... of its inhibitory activity on protein kinase A. G-protein-coupled receptor 39 (GPR39) oxidative stress protein kinase A inhibitor β (PKIB) zinc GPCRs (G-protein-coupled receptors) constitute the largest family of cell-surface transmembrane proteins [ 1 ]. They are activated by a wide...
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Biochem J (2014) 460 (3): 425–435.
Published: 29 May 2014
... peroxide (H 2 O 2 ). Cellular oxidative stress also increased significantly upon PAG inhibition or CSE knockdown. Further experiments using an activity-null Y60A mutant, a hyperactive E339A mutant and a control E349A mutant demonstrated that modulation of CSE catalytic activity altered its antioxidative...
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Biochem J (2013) 455 (3): 329–337.
Published: 10 October 2013
... and triggered autophagy by a mechanism dependent on reactive oxygen species overproduction in osteoblastic MC3T3-E1 cells. MC3T3-E1 cell survival was impaired by HG and worsened by chemical or genetic inhibition of autophagy. These findings were mimicked by H 2 O 2 -induced oxidative stress in these cells...
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