...X. Edward Zhou; Kelly Suino-Powell; Chad R. Schultz; Bilal Aleiwi; Joseph S. Brunzelle; Jared Lamp; Irving E. Vega; Edmund Ellsworth; André S. Bachmann; Karsten Melcher Ornithine decarboxylase (ODC) is the rate-limiting enzyme for the synthesis of polyamines (PAs). PAs are oncometabolites...

...Chad R. Schultz; Caleb P. Bupp; Surender Rajasekaran; André S. Bachmann We recently described a new autosomal dominant genetic disorder in a pediatric patient caused by a heterozygous de novo mutation in the ornithine decarboxylase 1 ( ODC1 ) gene. The new genetic disorder is characterized...

...Chaim Kahana Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme in the biosynthesis of polyamines, low-molecular-mass aliphatic polycations that are ubiquitously present in all living cells and are essential for fundamental cellular processes. Most cellular polyamines are bound...

..., and increased levels of polyamines and their biosynthetic enzyme ornithine decarboxylase (ODC) are associated with cancer. Triethylenetetramine (TETA) is a charge-deficient isosteric analogue of the polyamine spermidine (Spd) and a Cu(II)-chelating compound used for the treatment of Wilson's disease, and it has...

... (2-difluoromethylornithine), an inhibitor of ornithine decarboxylase, in human colorectal cancer cells. DFMO treatment depletes natural polyamines and increases the uptake of exogenous polyamines. The combination of oligoamines and DFMO results in a synergistic re-expression of aberrantly silenced...

.... In the present paper, we report that cellular polyamines regulate MEK-1 expression at the post-transcriptional level through the RNA-binding protein HuR (Hu-antigen R) in IECs (intestinal epithelial cells). Decreasing the levels of cellular polyamines by inhibiting ODC (ornithine decarboxylase) stabilized MEK-1...

...Zohar Snapir; Alona Keren-Paz; Zippi Bercovich; Chaim Kahana Azs (antizymes) are small polyamine-induced proteins that function as feedback regulators of cellular polyamine homoeostasis. They bind to transient ODC (ornithine decarboxylase) monomeric subunits, resulting in inhibition of ODC activity...

... that polyamines modulate subcellular localization of HuR through AMPK-regulated phosphorylation and acetylation of Impα1 (importin α1) in IECs. Decreased levels of cellular polyamines as a result of inhibiting ODC (ornithine decarboxylase) with DFMO ( D , L -α-difluoromethylornithine) repressed AMPK activity...

...-difluoromethylornithine growth arrest intestinal epithelium ornithine decarboxylase transcriptional regulation JunD belongs to the family of Jun proteins, which are primary components of the AP-1 (activator protein-1) transcription factors. Via their basic-leucine zipper domains, Jun proteins can form AP-1...

...Lisa M. SHANTZ ODC (ornithine decarboxylase) activity is induced following ras activation. However, the Ras effector pathways responsible are unknown. These experiments used NIH-3T3 cells expressing partial-loss-of-function Ras mutants to activate selectively pathways downstream of Ras and examined...

...Ning QU; Natalia A. IGNATENKO; Phillip YAMAUCHI; David E. STRINGER; Corey LEVENSON; Patrick SHANNON; Scott PERRIN; Eugene W. GERNER Racemic difluoromethylornithine ( d / l -DFMO) is an inhibitor of ODC (ornithine decarboxylase), the first enzyme in eukaryotic polyamine biosynthesis. d / l -DFMO...

... 2002 ornithine decarboxylase proliferating cell nuclear antigen spermidine/spermine N 1 -acetyltransferase gene transgenic rat Abbreviations used: SSAT, spermidine/spermine N 1 -acetyltransferase; ODC, ornithine decarboxylase; DENSPM, N 1 , N 11 -diethylnorspermine; PCNA...

... been found. We show here that increasing the activity of ornithine decarboxylase, or adding polyamines to the outside of cells, increases the level of gap junction communication between various epithelial cells. Conversely, reduction of ornithine decarboxylase activity decreases the level of gap...

... chromatin damage. The Biochemical Society, London © 2000 2000 free radicals ornithine decarboxylase Phex gene polyamines Biochem. J. (2000) 352, 381 387 (Printed in Great Britain) 381 Skin fibroblasts from spermine synthase-deficient hemizygous gyro male (Gy/Y) mice overproduce spermidine...

...Takatoshi SAITO; Tomasz HASCILOWICZ; Ichiro OHKIDO; Yutaka KIKUCHI; Hitoshi OKAMOTO; Shin-ichi HAYASHI; Yasuko MURAKAMI; Senya MATSUFUJI Cellular polyamines are regulated by a unique feedback mechanism involving ornithine decarboxylase (ODC) antizyme. The synthesis of mammalian antizyme requires...

...-mail Juhani.Janne@uku.fi ). 21 8 1998 12 10 1998 10 12 1998 The Biochemical Society, London © 1999 1999 mitochondrial swelling ornithine decarboxylase polyamine catabolism putrescine Biochem. J. (1999) 338, 311 316 (Printed in Great Britain) 311 Overexpression of spermidine...