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Keywords: oligomer
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Articles
Biochem J (2020) 477 (3): 645–670.
Published: 11 February 2020
... of fibrillation ( Figure 4Ci and ii). Scutellarin containing sample showed much smaller, round structures in AFM measurements ( Figure 4D i and ii) which appear to be oligomers. Further analysis of the scutellarin containing sample by denaturing SDS–PAGE revealed two discrete oligomeric bands; one at ∼44 kDa...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (1): 123–147.
Published: 22 December 2016
.... We found that each BPM induced the HuPrP to form unique oligomeric nanostructures differing in their biophysical properties, cellular toxicities and response to conformation-specific antibodies. While Leu-BPMs were found to stabilize the oligomers, Trp-BPMs effected transient oligomerization...
Includes: Supplementary data
Articles
Biochem J (2015) 471 (3): 323–333.
Published: 16 October 2015
... that the inflammatory properties rely on fibril-specific structural features. amyloid fibril cross-β structure nucleotide oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome oligomer structure-inflammatory properties relationship α-synuclein Parkinson's disease (PD...
Articles
Biochem J (2015) 468 (3): 485–493.
Published: 15 June 2015
... geometries for unknown protein complexes, and this gives valuable insights into the topology of the oligomers [ 27 , 28 ]. In the present study, oligomeric forms of α-syn [ 6 , 29 ] have been solubilized under MS-compatible conditions by the use of ammonium acetate as a buffer to enable ESI–IMS–MS analysis...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 579–590.
Published: 21 December 2011
... disease and is known to have a detrimental effect on neuronal cell function and survival when assembled into an oligomeric form. In the present study we show that administration of freshly prepared Aβ42 oligomers to a neuroblastoma (SH-SY5Y) cell line results in a reduction in survival, and that Aβ42...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (2): 323–332.
Published: 22 December 2010
... with the existence of unique Aβ42 oligomers. Met 35 oxidation to sulfoxide or sulfone eliminates the differences in early oligomerization between Aβ40 and Aβ42. Met 35 oxidation to sulfoxide has been reported to decrease Aβ assembly kinetics and neurotoxicity, whereas oxidation to sulfone has rarely been studied...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (1): 65–76.
Published: 25 October 2010
... to regulate gene expression. Although other components of the triacylglycerol synthesis pathway can form oligomeric complexes, it is unknown whether lipin proteins also exist as oligomers. In the present study, using various approaches, we revealed that lipin 1 formed stable homo-oligomers with itself...
Articles
Biochem J (2010) 430 (2): 265–274.
Published: 13 August 2010
.... Chem. 2006 281 33588 33596 17 Hou Z. Matherly L. H. Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function J. Biol. Chem. 2009 284 3285 3293 18 Zhao R. Gao F...
Includes: Supplementary data
Articles
Biochem J (2006) 396 (2): 265–275.
Published: 15 May 2006
... the formation of FPN hetero-oligomers. 1 To whom correspondence should be addressed, at INSERM U773, Centre de Recherche Biomédicale Bichat Beaujon, Université Paris 7 site Bichat, 16 rue Henri Huchard, BP416, 75018 Paris, France (email beaumont@bichat.inserm.fr ). 18 10 2005 26 1 2006 3...
Includes: Supplementary data
Articles
Biochem J (2005) 392 (2): 375–381.
Published: 22 November 2005
... allow us to examine previously hidden processes in protein folding [ 1 – 4 ]. Normal protein oligomers are essential for life, whereas unwanted oligomers are the basis of amyloid and prion diseases. Furthermore, the folding of membrane and oligomeric proteins has important implications for both...
Includes: Supplementary data
Articles
Biochem J (2005) 391 (2): 167–175.
Published: 10 October 2005
...) and chito-oligomeric–monomeric mixture. The yield of the latter was 14–16% and 14–19% respectively for papain- and Pronase-catalysed reactions, depending on the reaction time (1–5 h). HPLC revealed the presence of monomer(s) and oligomers of DP (degree of polymerization) 2–6, which was also confirmed...
Articles
Biochem J (2003) 371 (2): 515–523.
Published: 15 April 2003
... should be addressed (e-mail decker@biophysik.biologie.uni-mainz.de ). 5 7 2002 8 11 2002 4 12 2002 4 12 2002 The Biochemical Society, London ©2003 2003 catechol oxidase haemocyanin oligomer phenol oxidase structure Abbreviations used: CPC, cetylpyridinium...
Articles
Biochem J (2002) 367 (3): 801–808.
Published: 01 November 2002
... and facilitates Ia entry into the cytosol. By Western-blot analysis, Ib incubated with Vero cells at 37°C generated a cell-associated, SDS-insoluble oligomer of Ib (molecular mass>220kDa) within 15s, which was still evident 110min after washing cells. Ib oligomerization was temperature, but not pH, dependent...
Articles
Biochem J (2002) 367 (1): 107–111.
Published: 01 October 2002
... acids, had no significant difference in oligomer formation upon solubilization (Figures 1 3) and in glutamate- transport kinetics (Figures 2 and 3). This finding unequivocally indicated that the oligomerization process involved non-covalent and}or covalent interactions of GLAST polypeptides that oc...
Articles
Biochem J (2000) 351 (2): 509–516.
Published: 10 October 2000
... products do not promote oligomerization of the intact Ab peptide. Key words: Alzheimer s disease, Ab proteolysis, metalloendo- peptidase, oligomer. metallopeptidases, as well as a type-I peroxisomal targeting signal [9 14]. Consistent with this last feature, IDE has been shown to localize intracellularly...