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Keywords: necroptosis
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Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
...Bart Tummers; Douglas R. Green Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also...
Articles
Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
... to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We...
Articles
Biochem J (2022) 479 (10): 1103–1119.
Published: 24 May 2022
...Kim Newton; Alexander D. Gitlin Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification...
Articles
Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
... downstream of inflammasome activation, death receptor and mitochondrial apoptosis, and necroptosis. This new era in cell death research therefore holds significant promise in identifying how distinct, yet often networked, pyroptotic cell death pathways might be manipulated for therapeutic benefit to treat...
Articles
Biochem J (2022) 479 (9): 929–951.
Published: 06 May 2022
... 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis necroptosis phosphorylation RIP1 RIPK1 ubiquitin Proper regulation of cell death is critical for the development and maintenance of homeostasis in metazoans [ 1...
Articles
Biochem J (2022) 479 (5): 677–685.
Published: 16 March 2022
.... However, that concept has been challenged by recent advancements in understanding the regulation of cell death. Necroptosis is a form of regulated cell death, where cells show necrotic morphology. Necroptosis is triggered by death receptors, toll-like receptors, and some viral infections. The membrane...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... Apoptosis (extrinsic/p53) [ 27 , 50–52 ] NK and B-cells Apoptosis [ 53 ] pDCs Apoptosis [ 41 ] Macrophages Pyroptosis/Necroptosis [ 39 , 42 , 54 ] Monocytes Apoptosis/Pyroptosis [ 53 , 55 , 56 ] Pneumocyte Pyroptosis [ 23 ] Cardiomyocytes Apoptosis [ 57 ] Adipocytes...
Articles
Biochem J (2022) 479 (1): 75–90.
Published: 14 January 2022
... this cross-talk is disrupted, in the context of disease. 14 11 2021 21 12 2021 23 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis autophagic cell death autophagy cancer necroptosis neurodegeneration...
Articles
Biochem J (2016) 473 (6): 743–755.
Published: 10 March 2016
... in the induction of apoptosis, but a role for these lipids in necroptosis is largely unknown. Necroptosis is a programmed form of cell death that, unlike apoptosis, does not require ATP. Necroptosis can be induced under a variety of conditions, including nutrient deprivation and plays a major role in ischaemia...
Includes: Supplementary data
Articles
Articles
Biochem J (2013) 456 (3): 409–415.
Published: 22 November 2013
...Thomas McQuade; YoungSik Cho; Francis Ka-Ming Chan Programmed necrosis or necroptosis is controlled by the action of two serine/threonine kinases, RIP1 (receptor-interacting serine/threonine protein kinase 1; also known as RIPK1) and RIP3. The phosphorylation of RIP1 and RIP3 is critical...