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Keywords: necroptosis
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Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
...Bart Tummers; Douglas R. Green Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also...
Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
... to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We...
Biochem J (2022) 479 (10): 1103–1119.
Published: 24 May 2022
...Kim Newton; Alexander D. Gitlin Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification...
Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
... downstream of inflammasome activation, death receptor and mitochondrial apoptosis, and necroptosis. This new era in cell death research therefore holds significant promise in identifying how distinct, yet often networked, pyroptotic cell death pathways might be manipulated for therapeutic benefit to treat...
Biochem J (2022) 479 (9): 929–951.
Published: 06 May 2022
... in metazoans [ 1 ]. Aberrations in cell death pathways are linked to a variety of human diseases, including immune disorders, tissue damage, and neurodegeneration [ 2 , 3 ]. Cell death can be executed through a variety of pathway including apoptosis and necroptosis [ 4 ]. Receptor interacting protein 1 (RIP1...
Biochem J (2022) 479 (5): 677–685.
Published: 16 March 2022
.... However, that concept has been challenged by recent advancements in understanding the regulation of cell death. Necroptosis is a form of regulated cell death, where cells show necrotic morphology. Necroptosis is triggered by death receptors, toll-like receptors, and some viral infections. The membrane...
Includes: Supplementary data
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Covid-19 inflammation necroptosis pyroptosis therapeutics On New Years eve 2019, media reports emerged ∼27 cases of viral pneumonia in the central city of Wuhan, China [ 1 ]. Within the following two weeks...
Biochem J (2022) 479 (1): 75–90.
Published: 14 January 2022
... this cross-talk is disrupted, in the context of disease. apoptosis autophagic cell death autophagy cancer necroptosis neurodegeneration The first in vivo case of autophagy-dependent cell death was described in D. melanogaster . During the developmental stage of metamorphosis, Drosophila...
Biochem J (2016) 473 (6): 743–755.
Published: 10 March 2016
... in the induction of apoptosis, but a role for these lipids in necroptosis is largely unknown. Necroptosis is a programmed form of cell death that, unlike apoptosis, does not require ATP. Necroptosis can be induced under a variety of conditions, including nutrient deprivation and plays a major role in ischaemia...
Includes: Supplementary data
Biochem J (2014) 457 (3): 369–377.
Published: 10 January 2014
... checkpoint in the programmed necrosis or ‘necroptosis’ cell death pathway. In the present study, we report the crystal structure of the human MLKL pseudokinase domain at 1.7 Å (1 Å=0.1 nm) resolution and probe its nucleotide-binding mechanism by performing structure-based mutagenesis. By comparing...
Includes: Supplementary data
Biochem J (2013) 456 (3): 409–415.
Published: 22 November 2013
...Thomas McQuade; YoungSik Cho; Francis Ka-Ming Chan Programmed necrosis or necroptosis is controlled by the action of two serine/threonine kinases, RIP1 (receptor-interacting serine/threonine protein kinase 1; also known as RIPK1) and RIP3. The phosphorylation of RIP1 and RIP3 is critical...