... culture. ABC transport proteins ABCG2 asymmetry binding site molecular docking multidrug resistance As their name implies, multidrug resistance (MDR) pumps are able to transport a large range of chemically diverse substrates out of cells. While presumably this was driven...

..., to treat HIV-1 infections? antiviral drugs drug development HIV host–pathogen interactions multidrug resistance © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 14 12 2016 28 2 2017 3 3 2017 Correspondence: Giovanni...

... Lowry method was applied [ 11 ]. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (email sarkadi@biomembrane.hu ). ABCG2 bile acid cholesterol multidrug resistance © The Authors Journal compilation © 2013 Biochemical...

...Ajeet Mandal; Antresh Kumar; Ashutosh Singh; Andrew M. Lynn; Khyati Kapoor; Rajendra Prasad A major multidrug transporter, MDR1 (multidrug resistance 1), a member of the MFS (major facilitator superfamily), invariably contributes to an increased efflux of commonly used azoles and thus corroborates...

...Tânia R. Cabrito; Miguel C. Teixeira; Ashutosh Singh; Rajendra Prasad; Isabel Sá-Correia The action of multidrug efflux pumps in MDR (multidrug resistance) acquisition has been proposed to partially depend on the transport of physiological substrates which may indirectly affect drug partition...

...Alexander Welch; Chidiebere U. Awah; Shiheng Jing; Hendrik W. van Veen; Henrietta Venter The MexAB–OprM drug efflux pump is central to multidrug resistance of Pseudomonas aeruginosa . The ability of the tripartite protein to confer drug resistance on the pathogen is crucially dependent...

... was followed by the loss of the mitochondrial membrane potential and apoptosis execution. This cell remodelling was absent in receptor-independent cell death, such as that induced by the mitochondriotropic drug staurosporine, and in a CEM cell line selected for its multidrug resistance (CEM VBL100...

...Yasuhisa Kimura; Noriyuki Kioka; Hiroaki Kato; Michinori Matsuo; Kazumitsu Ueda MDR1 (multidrug resistance 1)/P-glycoprotein is an ATP-driven transporter which excretes a wide variety of structurally unrelated hydrophobic compounds from cells. It is suggested that drugs bind to MDR1 directly from...

... 2006 The Biochemical Society, London 2006 ATP-binding cassette superfamily (ABC superfamily) fluorescence quenching multidrug resistance nucleotide-binding domain P-glycoprotein (Pgp) transition state The ABC (ATP-binding cassette) transporter superfamily is one...

...Frederic Buyse; Yue-xian Hou; Catherine Vigano; Qing Zhao; Jean-Marie Ruysschaert; Xiu-bao Chang MRP1 (multidrug resistance protein 1) couples ATP binding/hydrolysis at its two non-equivalent NBDs (nucleotide-binding domains) with solute transport. Some of the NBD1 mutants, such as W653C, decreased...

...Stéphane BARAKAT; Landry GAYET; Guila DAYAN; Stéphane LABIALLE; Adina LAZAR; Vladimir OLEINIKOV; Anthony W. COLEMAN; Loris G. BAGGETTO Considerable interest exists about the localization of P-gp (P-glycoprotein) in DRMs (detergent-resistant membranes) of multidrug resistant cancer cells...

...Omar ALQAWI; Susan BATES; Elias GEORGES ABCG2 [also known as BCRP (breast cancer resistance protein) or MXR] is an ABC (ATP-binding cassette) protein shown to confer multidrug resistance. ABCG2 was initially identified in resistant breast carcinoma cells (MCF-7/AdrVp1000) selected with doxorubicin...

...Monique MALLÉA; Abdallah MAHAMOUD; Jacqueline CHEVALIER; Sandrine ALIBERT-FRANCO; Pierre BROUANT; Jacques BARBE; Jean-Marie PAGÈS Over the last decade, MDR (multidrug resistance) has increased worldwide in microbial pathogens by efflux mechanisms, leading to treatment failures in human infections...

...Hideyuki MITOMO; Ryo KATO; Akiko ITO; Shiho KASAMATSU; Yoji IKEGAMI; Isao KII; Akira KUDO; Eiry KOBATAKE; Yasuhiro SUMINO; Toshihisa ISHIKAWA Overexpression of the A TP- b inding c assette transporter ABCG2 reportedly causes multidrug resistance, whereas altered drug-resistance profiles...

... depletion glucosphingolipid-induced proliferation multidrug resistance poly-drug chemotherapy reactive oxygen species sphingolipid Abbreviations used: Cer, ceramide; C 2 -Cer, N -acetylsphingosine; COX-2, cyclo-oxygenase-2; CPZ, chlorpromazine; DAG, diacylglycerol; GlcCer, glucosylceramide...

...Zahia OUAR; Marcelle BENS; Caroline VIGNES; Marc PAULAIS; Claudine PRINGEL; Jocelyne FLEURY; Françoise CLUZEAUD; Roger LACAVE; Alain VANDEWALLE It has been suggested that the inappropriate sequestration of weak-base chemotherapeutic drugs in acidic vesicles by multidrug-resistance (MDR) cells...

...Sung H. LEE; Guillermo A. ALTENBERG Overexpression of multidrug resistance protein 1 (MRP1), an ATP-binding cassette protein, causes multidrug resistance. We developed a functional cysteine-less version of MRP1 that provides a framework for detailed biochemical and biophysical studies. The 18 Cys...

...Rangan MAITRA; Patricia A. HALPIN; Katherine H. KARLSON; Rodney L. PAGE; Daniel Y. PAIK; Matthew O. LEAVITT; Bryan D. MOYER; Bruce A. STANTON; Joshua W. HAMILTON Previous studies have demonstrated that mitomycin C (MMC) and other DNA cross-linking agents can suppress MDR1 (multidrug resistance 1...

... cells). Similarly, MDCKII cells expressing the human multidrug resistance protein 1 showed a 4-fold increase in GSH excretion across the basolateral membrane. In several independent cMOAT-transfectants, the level of GSH excretion correlated with the expression level of the protein. Furthermore, we have...

... (multidrug resistance gene product; MDR1). These proteins contain two multispanning transmembrane domains, each followed by one nucleotide-binding domain (NBD) and a linker region distal to the first NBD. ATP hydrolysis by the NBDs is critical for ABC protein function; the linker region seems to have...