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Keywords: molecular modelling
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Biochem J (2016) 473 (23): 4473–4491.
Published: 25 November 2016
... dual polarisation interferometry molecular modelling small angle X-ray scattering ultracentrifugation To measure the physical parameters of a layer deposited on the surface of a sensor chip, the Ana Light® Bio200 dual-polarization interferometer (Farfield Sensor Ltd, Salford, U.K.) was used...
Includes: Supplementary data
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Biochem J (2015) 466 (1): 177–188.
Published: 06 February 2015
... transmembrane helices (TMs) 7–10. In the present paper, we generate a molecular model of MCT4 based on our previous models of MCT1 and identify residues in the intracellular substrate-binding cavity that differ significantly between MCT4 and MCT1/MCT2 and so might account for differences in inhibitor binding...
Includes: Supplementary data
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Biochem J (2011) 433 (1): 75–83.
Published: 15 December 2010
.... Additionally, the BAR domain prevented the heterodimerization between SNX9 and SNX33, as determined by domain swap experiments. Molecular modelling of the SNX33 BAR domain structure revealed that key amino acids located at the BAR domain dimer interface of the SNX9 homodimer are not conserved in SNX33...
Includes: Supplementary data
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Biochem J (2007) 402 (3): 503–513.
Published: 26 February 2007
... fibrin clots, has been studied at 37 °C. Catalytic parameters, although showing a somewhat lower catalytic efficiency with respect to thrombin and plasmin, indeed display values indicating a pathophysiological significance of this process. A parallel molecular modelling study predicts preferential...
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Biochem J (2006) 396 (2): 255–263.
Published: 15 May 2006
...-2,2-bis(p-chlorophenyl)ethane (DDT) docking knockdown resistance (kdr) molecular modelling pyrethroids sodium channel The selective conductance of sodium ions across the plasma membrane by the voltage-gated sodium channel underlies the propagation of action potentials in neuronal cells...
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Biochem J (2005) 388 (2): 585–591.
Published: 24 May 2005
... on dilution. Molecular modelling suggests that there would be no barriers to the dimerization of the whole enzyme through the PEF domains. This orientation would place the catalytic centres at opposite ends of the dimer. Intrinsic tryptophan fluorescence measurements were performed using a PerkinElmer...
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Biochem J (2003) 375 (1): 23–32.
Published: 01 October 2003
... by the mutations, and the preferential use by the mutein of another unknown transducing receptor chain. 25 3 2003 15 5 2003 23 6 2003 14 8 2003 The Biochemical Society, London ©2003 2003 cytokine interleukin-11 (IL-11) interleukin-11 agonist ligand binding molecular modelling...
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Biochem J (2003) 373 (2): 345–355.
Published: 15 July 2003
... Center, INF280, 69120 Heidelberg, Germany, and Drug Design, Development and Molecular Modelling Divisions, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Calcutta 700 032, India As an acute-phase protein, human C-reactive protein (CRP) is clinically important. CRPs were purified from...
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Biochem J (2002) 366 (1): 343–351.
Published: 15 August 2002
... by interaction in the decapeptide region) could be a rate-limiting step in fibril formation. A theoretical framework that explains the results is presented in parallel with the data. Key words: Alzheimer s disease, b-sheet, electron microscopy, molecular modelling, pair correlation. detergents, and analysed...
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Biochem J (2001) 355 (3): 569–576.
Published: 24 April 2001
...Marcus C. DURRANT Qualitative molecular modelling has been used to identify possible routes for transfer of protons from the surface of the nitrogenase protein to the iron–molybdenum cofactor (FeMoco) and to substrates during catalysis. Three proton-transfer routes have been identified; a water...
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Biochem J (2000) 347 (2): 553–559.
Published: 10 April 2000
... investigated. Kinetic studies on the oxidation of β- D -glucose combined with molecular modelling showed the side chain of Arg-516, which forms two hydrogen bonds with the 3-OH group of β- D -glucose, to be absolutely essential for the efficient binding of β- D -glucose. The R516K variant, whose side chain...
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Biochem J (1999) 344 (1): 159–166.
Published: 08 November 1999
...). 1 6 1999 28 7 1999 10 9 1999 The Biochemical Society, London © 1999 1999 chemical modification kinetics molecular modelling site-directed mutagenesis Biochem. J. (1999) 344, 159 166 (Printed in Great Britain) 159 Identification of residues essential for a two-step...