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Keywords: mitogen-activated protein kinase (MAPK)
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Articles
Biochem J (2015) 467 (3): 425–438.
Published: 17 April 2015
... extracellular-signal-regulated kinases 1 and 2 (ERK1/2) in silico design melanoma mitogen-activated protein kinase (MAPK) The mitogen-activated protein kinase (MAPK) family members, which include the extracellular-signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases (JNKs), p38 MAPKs...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (1): 41–52.
Published: 08 September 2014
... be causally related to nigrostriatal tract degeneration. mitogen-activated protein kinase (MAPK) neurotoxicity Parkinson’s disease (PD) primary neuron 5- S -cysteinyldopamine (CysDA) The underlying pathology in PD (Parkinson's disease) is characterized by a significant degeneration...
Articles
Biochem J (2014) 459 (1): 117–126.
Published: 14 March 2014
...-protein-coupled receptor internalization (GPCR internalization) histamine H 2 receptor ligand (H 2 R ligand) mitogen-activated protein kinase (MAPK) pluridimensional efficacy seven-transmembrane receptor (7TMR) 7TMRs (seven-transmembrane receptors) represent the largest family of cell-surface...
Articles
Biochem J (2013) 450 (2): 351–363.
Published: 15 February 2013
... and reproduction in any medium, provided the original work is properly cited. α 1 -adrenergic receptor cardiomyocyte endothelin mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (p90 RSK) transcriptomics The ERK1/2 (extracellular-signal-regulated kinase 1/2) cascade plays a major...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (2): e5–e7.
Published: 14 August 2012
... Society 2012 Arabidopsis mitogen-activated protein kinase (MAPK) MPK6 peptide array phosphorylation motif protein kinase The activity assays revealed that over 40 of the 162 combinatorial peptides surveyed could be phosphorylated in vitro by MPK6, which enabled the authors to define...
Articles
Biochem J (2012) 445 (1): 1–10.
Published: 15 June 2012
... specification cytokine signalling development mitogen-activated protein kinase (MAPK) self-renewal Embryonic development and maintenance of adult tissue homoeostasis are physiological processes where stem cells, which are characterized by their ability to self-renew and perpetuate themselves...
Articles
Biochem J (2012) 443 (1): 95–102.
Published: 14 March 2012
... primers used for this cloning are shown in Supplementary Tables S2 and S3 (at http://www.BiochemJ.org/bj/443/bj4430095add.htm ). © The Authors Journal compilation © 2012 Biochemical Society 2012 chilling stress constitutive activation kinase activity mitogen-activated protein kinase (MAPK...
Includes: Supplementary data
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Biochem J (2012) 441 (2): 553–569.
Published: 21 December 2011
...-binding sequence and PDZ-binding motifs are indicated by orange and mid-brown lines respectively. The conserved phosphorylation sites involved in RSK activation are indicated by black circles. cell signalling mitogen-activated protein kinase (MAPK) phosphorylation proliferation protein kinase...
Articles
Biochem J (2012) 441 (2): 571–578.
Published: 21 December 2011
...-activated protein kinase (MAPK) mitogen-activated protein kinase phosphatase (MKP) Mxi2 phosphatase ERK (extracellular-signal-regulated kinase) 1/2 MAPKs (mitogen-activated protein kinases) are cytoplasmic serine/threonine kinases that participate in the transduction of signals from the surface...
Articles
Biochem J (2012) 441 (1): 347–357.
Published: 14 December 2011
...-8220 were obtained from Calbiochem. cAMP-response-element-binding protein (CREB) mitogen-activated protein kinase (MAPK) mitogen- and stress-activated kinase (MSK) p38 ribosomal S6 kinase (RSK) MAPK (mitogen-activated protein kinase) signalling cascades are important mediators...
Articles
Biochem J (2012) 441 (1): 77–85.
Published: 14 December 2011
... correspondence should be addressed (email jason_haugh@ncsu.edu ). 9 5 2011 7 9 2011 26 9 2011 26 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 computational biology cross-talk growth factor kinetic analysis mitogen-activated protein kinase (MAPK...
Includes: Supplementary data
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Biochem J (2011) 439 (3): 381–392.
Published: 13 October 2011
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. c-Jun N-terminal kinase (JNK) D domain mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase 7 (MKK7...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (1): 1–10.
Published: 27 January 2011
... 11 2010 23 11 2010 25 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cross-talk mitogen-activated protein kinase (MAPK) negative regulator Smad7 transforming growth factor-β (TGF-β) TGF-β (transforming growth factor-β) belongs...
Articles
Biochem J (2011) 433 (1): 11–18.
Published: 15 December 2010
... of adopting different active conformations and that specific ligands can induce and/or stabilize such conformations. adrenergic receptor β-arrestin G-protein-coupled receptor (GPCR) heteromerization mitogen-activated protein kinase (MAPK) signal specificity GPCRs (G-protein-coupled receptors...
Articles
Biochem J (2010) 432 (1): 145–151.
Published: 25 October 2010
... This paper is dedicated to the memory of Damien Lehalle, who lost his life while on a humanitarian mission with Médecins sans Frontières. erythroleukaemia cell erythropoiesis haemoglobin iron mitogen-activated protein kinase (MAPK) mitoferrin 2 To whom correspondence should be addressed...
Articles
Biochem J (2010) 430 (3): 439–451.
Published: 27 August 2010
... mitogen-activated protein kinase (MAPK) p53 reactive oxygen species (ROS) Oxidative stress is considered to be an important pathogenetic factor in several neurodegenerative diseases such as PD (Parkinson's disease) and AD (Alzheimer's disease). Because of its high metabolic rate...
Includes: Supplementary data
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Biochem J (2010) 430 (1): 161–169.
Published: 28 July 2010
..., provided the original work is properly cited. cell signalling hypothiocyanous acid (HOSCN) mitogen-activated protein kinase (MAPK) myeloperoxidase p38 protein tyrosine phosphatase thiol MPO (myeloperoxidase) is a highly basic haem enzyme that is released extracellularly by activated...
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Biochem J (2010) 429 (3): 403–417.
Published: 14 July 2010
... 28 5 2010 2 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell regulation mitogen-activated protein kinase (MAPK) p38 phosphorylation signalling stress response Cells need to be constantly aware of changes in the extracellular milieu...
Articles
Biochem J (2010) 428 (2): 281–291.
Published: 13 May 2010
... in Supplementary Table S3 (at http://www.BiochemJ.org/bj/428/bj4280281add.htm ). brain-derived neurotrophic factor (BDNF) microRNA (miRNA) mitogen-activated protein kinase (MAPK) mitogen- and stress-activated kinase 1 (MSK1) mitogen- and stress-activated kinase 2 (MSK2) neuron where r , B and C...
Includes: Supplementary data
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Biochem J (2010) 428 (1): 103–111.
Published: 28 April 2010
... 2009 3 3 2010 18 3 2010 18 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell cycle extracellular-signal-regulated kinase 3 (ERK3) mitogen-activated protein kinase (MAPK) mitosis protein phosphorylation ERK3 (extracellular-signal...
Includes: Supplementary data
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Biochem J (2010) 427 (3): 435–443.
Published: 14 April 2010
... at Michigan State University. 20 7 2009 21 1 2010 16 2 2010 16 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 c-Jun N-terminal kinase (JNK) epoxomicin mitogen-activated protein kinase (MAPK) mixed lineage kinase 3 (MLK3) proteasome tumour...
Includes: Supplementary data
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Biochem J (2010) 427 (2): 297–304.
Published: 29 March 2010
...-activated protein kinase (MAPK) poly- L -lysine The survival of primary cultured neurons depends on their attachment to the culture matrices. PLL (poly- L -lysine), a synthetic polymer widely used in neuronal cell culture, adsorbs on to plastic or glass surfaces, alters charges from negative...
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Biochem J (2010) 427 (1): 113–124.
Published: 15 March 2010
... granulocyte/macrophage colony-stimulating factor (GM-CSF) inflammation mitogen-activated protein kinase (MAPK) A549 cells were grown to confluence in DMEM (Dulbecco's modified Eagle's medium) (Invitrogen) supplemented with 10% (v/v) FBS (fetal bovine serum) (Invitrogen). IL-1β (R&D Systems...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 705–715.
Published: 16 January 2009
... in the Kv4.2 C-terminal sequence. We found that phosphorylation of Kv4.2 by PKC enhanced ERK phosphorylation of the channel in vitro . These findings suggest the possibility that Kv4.2 is a locus for PKC and ERK cross-talk. cross-talk extracellular-signal-regulated kinase (ERK) mitogen-activated protein...
Articles
Biochem J (2009) 417 (1): 331–342.
Published: 12 December 2008
...-regulated kinase (ERK) c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) p38 phosphorylation yeast MAPKs (mitogen-activated protein kinases) are key components in cell signalling pathways. In mammals, MAPKs are classified into sub-families that include the ERKs...
Includes: Supplementary data
Articles
Biochem J (2008) 413 (3): 429–436.
Published: 15 July 2008
...@vcu.edu ). 14 3 2008 29 4 2008 13 5 2008 13 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Argonaute (Ago) mitogen-activated protein kinase (MAPK) phosphorylation processing body RNA interference (RNAi) Non-coding RNAs of approx. 20...
Includes: Supplementary data
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Biochem J (2008) 413 (2): 217–226.
Published: 26 June 2008
... in cultured cells Plant J 1994 5 111 122 75 Mockaitis K. Howell S. H. Auxin induces mitogenic activated protein kinase (MAPK) activation in roots of Arabidopsis seedlings Plant J. 2000 24 785 796 76 Kovtun Y. Chiu W. L. Zeng W. Sheen J. Suppression...
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Biochem J (2008) 413 (1): 37–49.
Published: 12 June 2008
... will be extremely challenging. Aperts syndrome fibroblast growth factor receptor 2 (FGFR2) fibroblast growth factor receptor substrate 2 (FRS2) fluorescent lifetime imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine...
Articles
Biochem J (2008) 412 (2): e15–e16.
Published: 14 May 2008
... on the molecular mechanism of Bax activation and migration during ischaemia-induced apoptosis in cardiomyocytes. AMP-activated protein kinase (AMPK) apoptosis Bax heart ischaemia mitochondrion mitogen-activated protein kinase (MAPK) protein kinase Programmed cell death, or apoptosis, is an active...
Articles
Biochem J (2008) 412 (2): 287–298.
Published: 14 May 2008
.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. dual-specificity phosphatase 6 (DUSP6) fibroblast growth factor (FGF) mitogen-activated protein kinase (MAPK) mitogen-activated protein...
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Biochem J (2008) 409 (1): 179–185.
Published: 11 December 2007
... be addressed (email olli.silvennoinen@uta.fi ). 10 5 2007 10 9 2007 26 9 2007 26 9 2007 mitogen-activated protein kinase (MAPK) signal transducer and activator of transcription (STAT) protein inhibitor of activated STAT1 (PIAS1) Ser 727 phosphorylation small ubiquitin-related...
Articles
Biochem J (2007) 405 (3): 591–596.
Published: 13 July 2007
...-activated protein kinase (MAPK) protein phosphatase 2C (PP2C) protein serine/threonine phosphatase 5 (PP5) stress-activated protein kinase (SAPK) SAPKs (stress-activated protein kinases), a subfamily of the MAPK (mitogen-activated protein kinase) superfamily, are highly conserved from yeast...
Articles
Biochem J (2007) 405 (3): e5.
Published: 13 July 2007
... damage, and studies on the effect of radio waves on tumour formation in rodents have failed to show any consistent association between exposure to radio waves and tumours [ 1 , 2 ]. extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) mobile phone reactive oxygen...
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Biochem J (2007) 404 (2): 299–308.
Published: 14 May 2007
... of results obtained from three separate experiments on three different donors. aggregation calcium mitogen-activated protein kinase (MAPK) protein kinase C Src family kinase Platelet activation is important for haemostasis and abnormal activation of platelets leading to thrombosis. Upon...
Articles
Biochem J (2007) 404 (1): 141–149.
Published: 26 April 2007
... of total ERK1/2 were present in all samples. © The Authors Journal compilation © 2007 Biochemical Society 2007 allosteric activator L -amino acid calcium-sensing receptor extracellular calcium extracellular-signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK...
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Biochem J (2007) 402 (3): 491–501.
Published: 26 February 2007
..., Dublin, Ireland. 2 To whom correspondence should be addressed (email j.s.c.arthur@dundee.ac.uk ). The Biochemical Society, London 2007 cAMP-response-element-binding protein (CREB) extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) p38 p90 ribosomal S6...
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Biochem J (2007) 402 (2): 271–278.
Published: 12 February 2007
... 10 2006 The Biochemical Society, London 2007 lipopolysaccharide mitochondria mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) signalling uncoupling protein 2 (UCP2) Innate immunity, the host's first line of defense against pathogens, relies on many cells...
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Biochem J (2007) 401 (1): e1.
Published: 11 December 2006
... mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) protein kinase inhibitor small-molecule inhibitor There are four closely related RSK (p90 ribosomal S6 kinase) genes in the human genome (RSK1–4), which belong to the AGC family of protein kinases. RSKs phosphorylate a number...
Articles
Biochem J (2007) 401 (1): 29–38.
Published: 11 December 2006
... domain. BI-D1870 also inhibited RSK3 and RSK4 with similar potency to RSK1 and RSK2 ( Tables 1 and 2 ). The Biochemical Society, London 2007 BI-D1870 kinase-specific inhibitor mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) phosphorylation Members of the AGC...
Includes: Supplementary data
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Biochem J (2006) 396 (3): 517–527.
Published: 29 May 2006
... macrophages mitogen-activated protein kinase (MAPK) oxygen sensing The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor-1) regulates the expression of genes involved in angiogenesis, oxygen transport, glucose metabolism and vascular tone [ 1 ]. HIF-1 consists of an α- and a β...
Articles
Biochem J (2006) 396 (3): 547–556.
Published: 29 May 2006
... promoter-binding factor (E2F) mitogen-activated protein kinase (MAPK) promoter analysis E2F1 ( E2 promoter-binding factor 1) was initially identified as a cellular DNA-binding factor required for the E1A (adenovirus 5 early region 1A product)-mediated activation of the adenoviral E2 gene [ 1...
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Biochem J (2006) 394 (2): 459–464.
Published: 10 February 2006
...-loading buffer and resolved by SDS/PAGE. Myc–RhoA in the lysates and the pull-down assay was detected by Western blot using an anti-Myc antibody. axon guidance HT-22 cell mitogen-activated protein kinase (MAPK) plexin semaphorin Rho GTPase Binding of semaphorin to plexin initiates...
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Biochem J (2006) 394 (1): 299–308.
Published: 27 January 2006
... bowel disease mitogen-activated protein kinase (MAPK) platelet-activating factor phospholipase C PAF (platelet-activating factor; 1- O -alkyl-2-acetyl- sn -glycero-3-phosphocholine), first named by its platelet-aggregating activity, is a type of phospholipid with a phosphocholine head group...
Articles
Biochem J (2006) 394 (1): 365–373.
Published: 27 January 2006
... protein kinase (MAPK) oxidative stress protein phosphatase Many members of the MAPK (mitogen-activated protein kinase) subfamily are components of protein kinase cascades that are activated in response to extracellular signals. Thus ERKs (extracellular-signal-regulated protein kinases) 1, 2...
Articles
Biochem J (2006) 393 (1): 69–77.
Published: 12 December 2005
... and junction adhesion molecule [ 4 – 6 ], the intracellular plaque proteins such as ZO (zonula occludin)-1, ZO-2, ZO-3, cingulin, 7H6 and others [ 4 , 7 – 10 ], and the actin cytoskeleton [ 4 ]. barrier function cell–cell adhesion epithelium ERK occludin mitogen-activated protein kinase (MAPK...
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Biochem J (2005) 392 (2): 249–261.
Published: 22 November 2005
... kinase (ERK) mitogen-activated protein kinase (MAPK) receptor tyrosine kinase signalling network systems biology In molecular biology the MAPK (mitogen-activated protein kinase) pathway is considered to be a paradigm for signal transduction, as it occupies a central role in key cellular...
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Biochem J (2005) 392 (2): 389–397.
Published: 22 November 2005
... 26 4 2005 10 6 2005 10 6 2005 The Biochemical Society, London 2005 differentiation G-protein regulator mitogen-activated protein kinase (MAPK) neuron PC12 cell Purkinje cell protein-2 (Pcp2) Cell lysates were prepared in TB (tissue buffer; 20 mM Tris, pH 7.5, 5 mm...
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Biochem J (2005) 391 (1): 25–32.
Published: 26 September 2005
... with the exception that it has a long C-terminal hydrophilic domain of approx. 400 amino acids [ 8 ]. apoptosis lipid phosphate phosphatase (LPP) lysophosphatidic acid mitogen-activated protein kinase (MAPK) phosphatidic acid sphingosine 1-phosphate (S1P) The Biochemical Society, London 2005...
Includes: Supplementary data
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Biochem J (2005) 390 (1): 359–366.
Published: 09 August 2005
..., London 2005 Gab2 growth-factor-receptor-bound protein 2 (Grb2) mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) proliferation signal transducer and activator of transcription 5 (STAT5) STAT (signal transducer and activator of transcription) transcription factors...
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Biochem J (2005) 389 (3): 723–729.
Published: 26 July 2005
... 2005 1 4 2005 The Biochemical Society, London 2005 Akt articular cartilage chondrocyte insulin-like growth factor-I (IGF-I) mitogen-activated protein kinase (MAPK) proteoglycan synthesis IGF-I (insulin-like growth factor-I) is a protein produced in mammals that is found...