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Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf

Ramin Samadani, Jun Zhang, Amanda Brophy, Taiji Oashi, U. Deva Priyakumar, E. Prabhu Raman, Franz J. St John, Kwan-Young Jung, Steven Fletcher, Edwin Pozharski, Alexander D. MacKerell, Jr, Paul Shapiro

Biochem J (2015) 467 (3): 425–438.

https://doi.org/10.1042/BJ20131571

Published: 17 April 2015

... extracellular-signal-regulated kinases 1 and 2 (ERK1/2) in silico design melanoma mitogen-activated protein kinase (MAPK) The mitogen-activated protein kinase (MAPK) family members, which include the extracellular-signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases (JNKs), p38 MAPKs...

View article titled, Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf

Includes: Supplementary data

Articles

The neurotoxicity of 5- S -cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling

David Vauzour, John T. Pinto, Arthur J. L. Cooper, Jeremy P. E. Spencer

Biochem J (2014) 463 (1): 41–52.

https://doi.org/10.1042/BJ20131519

Published: 08 September 2014

... laser-scanning confocal microscope (excitation, 488 nm; emission, 530 nm). mitogen-activated protein kinase (MAPK) neurotoxicity Parkinson’s disease (PD) primary neuron 5- S -cysteinyldopamine (CysDA) The underlying pathology in PD (Parkinson's disease) is characterized...

View article titled, The neurotoxicity of 5- S -cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling

Articles

Signal transduction mechanism of biased ligands at histamine H 2 receptors

Natalia Alonso, Federico Monczor, Emiliana Echeverría, Carlos Davio, Carina Shayo, Natalia Fernández

Biochem J (2014) 459 (1): 117–126.

https://doi.org/10.1042/BJ20131226

Published: 14 March 2014

... that histamine receptor ligands show functional selectivity respect to distinct receptor behaviours. biased agonism G-protein-coupled receptor internalization (GPCR internalization) histamine H 2 receptor ligand (H 2 R ligand) mitogen-activated protein kinase (MAPK) pluridimensional efficacy seven...

View article titled, Signal transduction mechanism of biased ligands at histamine H 2 receptors

Articles

p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G q -protein-coupled receptor stimuli, endothelin-1 and α 1 -adrenergic receptor agonists

Emre Amirak, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Biochem J (2013) 450 (2): 351–363.

https://doi.org/10.1042/BJ20121371

Published: 15 February 2013

... use, distribution and reproduction in any medium, provided the original work is properly cited. α 1 -adrenergic receptor cardiomyocyte endothelin mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (p90 RSK) transcriptomics The ERK1/2 (extracellular-signal-regulated...

View article titled, p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G q -protein-coupled receptor stimuli, endothelin-1 and α 1 -adrenergic receptor agonists

Includes: Supplementary data

Articles

Postal code for a plant MAPK

Brian E. Ellis

Biochem J (2012) 446 (2): e5–e7.

https://doi.org/10.1042/BJ20121003

Published: 14 August 2012

.... describe in this issue of the Biochemical Journal how arrayed combinatorial peptide scanning offers an efficient route to discovery of new potential kinase substrates. Arabidopsis mitogen-activated protein kinase (MAPK) MPK6 peptide array phosphorylation motif protein kinase 20 6 2012...

View article titled, Postal code for a plant MAPK

Articles

The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation

Feride Oeztuerk-Winder, Juan-Jose Ventura

Biochem J (2012) 445 (1): 1–10.

https://doi.org/10.1042/BJ20120401

Published: 15 June 2012

... signalling development mitogen-activated protein kinase (MAPK) self-renewal 1 To whom correspondence should be addressed (email jv282@cscr.cam.ac.uk ). 6 3 2012 16 4 2012 18 4 2012 The use of conditional floxed alleles and specific small chemical inhibitors has allowed...

View article titled, The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation

Articles

Biochemical identification of the OsMKK6–OsMPK3 signalling pathway for chilling stress tolerance in rice

Guosheng Xie, Hideki Kato, Ryozo Imai

Biochem J (2012) 443 (1): 95–102.

https://doi.org/10.1042/BJ20111792

Published: 14 March 2012

... 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 chilling stress constitutive activation kinase activity mitogen-activated protein kinase (MAPK) Oryza sativa L Low temperature is one of the major environmental factors that limits the productivity...

View article titled, Biochemical identification of the OsMKK6–OsMPK3 signalling pathway for chilling stress tolerance in rice

Includes: Supplementary data

Articles

Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases

Berta Casar, Javier Rodríguez, Gilad Gibor, Rony Seger, Piero Crespo

Biochem J (2012) 441 (2): 571–578.

https://doi.org/10.1042/BJ20110870

Published: 21 December 2011

... of GFP–ERK1c and HA–Mxi2. The results shown are representative of three independent experiments. extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase phosphatase (MKP) Mxi2 phosphatase ERK (extracellular-signal-regulated...

View article titled, Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases

Articles

Regulation and function of the RSK family of protein kinases

Yves Romeo, Xiaocui Zhang, Philippe P. Roux

Biochem J (2012) 441 (2): 553–569.

https://doi.org/10.1042/BJ20110289

Published: 21 December 2011

... Society 2012 cell signalling mitogen-activated protein kinase (MAPK) phosphorylation proliferation protein kinase 90 kDa ribosomal S6 kinase (RSK) At the subcellular level, RSK1–3 are usually present in the cytoplasm of quiescent cells, but upon stimulation, a significant proportion...

View article titled, Regulation and function of the RSK family of protein kinases

Articles

Characterization of the cellular action of the MSK inhibitor SB-747651A

Shaista Naqvi, Andrew Macdonald, Claire E. McCoy, Joanne Darragh, Alastair D. Reith, J. Simon C. Arthur

Biochem J (2012) 441 (1): 347–357.

https://doi.org/10.1042/BJ20110970

Published: 14 December 2011

... 2011 3 10 2011 5 10 2011 5 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cAMP-response-element-binding protein (CREB) mitogen-activated protein kinase (MAPK) mitogen- and stress-activated kinase (MSK) p38 ribosomal S6 kinase (RSK) MAPK...

View article titled, Characterization of the cellular action of the MSK inhibitor SB-747651A

Articles

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation

Murat Cirit, Jason M. Haugh

Biochem J (2012) 441 (1): 77–85.

https://doi.org/10.1042/BJ20110833

Published: 14 December 2011

... correspondence should be addressed (email jason_haugh@ncsu.edu ). 9 5 2011 7 9 2011 26 9 2011 26 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 computational biology cross-talk growth factor kinetic analysis mitogen-activated protein kinase (MAPK...

View article titled, Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation

Includes: Supplementary data

Articles

Docking interactions of the JNK scaffold protein WDR62

Ksenya Cohen-Katsenelson, Tanya Wasserman, Samer Khateb, Alan J. Whitmarsh, Ami Aronheim

Biochem J (2011) 439 (3): 381–392.

https://doi.org/10.1042/BJ20110284

Published: 13 October 2011

...) D domain mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase 7 (MKK7) scaffold WD repeat domain 62 (WDR62) MAPKs (mitogen-activated protein kinases) regulate a variety of cellular processes in response to extracellular signals. MAPKs are activated through a protein...

View article titled, Docking interactions of the JNK scaffold protein WDR62

Includes: Supplementary data

Articles

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

Xiaohua Yan, Ye-Guang Chen

Biochem J (2011) 434 (1): 1–10.

https://doi.org/10.1042/BJ20101827

Published: 27 January 2011

.... 1 To whom correspondence should be addressed (email ygchen@tsinghua.edu.cn ). 9 11 2010 23 11 2010 25 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cross-talk mitogen-activated protein kinase (MAPK) negative regulator Smad7 transforming...

View article titled, Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

Articles

Exploring a role for heteromerization in GPCR signalling specificity

Raphael Rozenfeld, Lakshmi A. Devi

Biochem J (2011) 433 (1): 11–18.

https://doi.org/10.1042/BJ20100458

Published: 15 December 2010

... Biochemical Society 2011 adrenergic receptor β-arrestin G-protein-coupled receptor (GPCR) heteromerization mitogen-activated protein kinase (MAPK) signal specificity GPCRs (G-protein-coupled receptors), also called seven-transmembrane receptors or heptahelical receptors, are a large family...

View article titled, Exploring a role for heteromerization in GPCR signalling specificity

Articles

Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake 1

Louay Mardini, Jadwiga Gasiorek, Anna Derjuga, Lucie Carrière, Matthias Schranzhofer, Barry H. Paw, Prem Ponka, Volker Blank

Biochem J (2010) 432 (1): 145–151.

https://doi.org/10.1042/BJ20100541

Published: 25 October 2010

... Journal compilation © 2010 Biochemical Society 2010 erythroleukaemia cell erythropoiesis haemoglobin iron mitogen-activated protein kinase (MAPK) mitoferrin The mechanisms governing haemoglobin synthesis and the maturation of erythroid cells have been studied in great detail and serve...

View article titled, Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake 1

Articles

p38 MAPK /p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

Simone Cardaci, Giuseppe Filomeni, Giuseppe Rotilio, Maria R. Ciriolo

Biochem J (2010) 430 (3): 439–451.

https://doi.org/10.1042/BJ20100503

Published: 27 August 2010

...@bio.uniroma2.it ). 6 4 2010 17 6 2010 30 6 2010 30 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 apoptosis glucose glutathione mitogen-activated protein kinase (MAPK) p53 reactive oxygen species (ROS) Oxidative stress is considered...

View article titled, p38 MAPK /p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

Includes: Supplementary data

Articles

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

Amanda E. Lane, Joanne T. M. Tan, Clare L. Hawkins, Alison K. Heather, Michael J. Davies

Biochem J (2010) 430 (1): 161–169.

https://doi.org/10.1042/BJ20100082

Published: 28 July 2010

... the original work is properly cited. cell signalling hypothiocyanous acid (HOSCN) mitogen-activated protein kinase (MAPK) myeloperoxidase p38 protein tyrosine phosphatase thiol HOCl and HOBr are powerful oxidants and important components of the human immune response against invading...

View article titled, The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

Articles

Mechanisms and functions of p38 MAPK signalling

Ana Cuadrado, Angel R. Nebreda

Biochem J (2010) 429 (3): 403–417.

https://doi.org/10.1042/BJ20100323

Published: 14 July 2010

... regulation mitogen-activated protein kinase (MAPK) p38 phosphorylation signalling stress response Cells need to be constantly aware of changes in the extracellular milieu to respond accordingly, so they have developed sophisticated mechanisms to receive signals, transmit the information...

View article titled, Mechanisms and functions of p38 MAPK signalling

Articles

Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

Judit Remenyi, Christopher J. Hunter, Christian Cole, Hideaki Ando, Soren Impey, Claire E. Monk, Kirsty J. Martin, Geoffrey J. Barton, Gyorgy Hutvagner, J. Simon C. Arthur

Biochem J (2010) 428 (2): 281–291.

https://doi.org/10.1042/BJ20100024

Published: 13 May 2010

...) mitogen-activated protein kinase (MAPK) mitogen- and stress-activated kinase 1 (MSK1) mitogen- and stress-activated kinase 2 (MSK2) neuron Neurotrophins comprise a family of growth factors that are important for both neuronal development and survival as well as synapse formation and plasticity...

View article titled, Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

Includes: Supplementary data

Articles

C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis

Pierre-Luc Tanguay, Geneviève Rodier, Sylvain Meloche

Biochem J (2010) 428 (1): 103–111.

https://doi.org/10.1042/BJ20091604

Published: 28 April 2010

... 2010 cell cycle extracellular-signal-regulated kinase 3 (ERK3) mitogen-activated protein kinase (MAPK) mitosis protein phosphorylation ERK3 (extracellular-signal-regulated kinase 3) is an atypical member of the MAPK (mitogen-activated protein kinase) family of serine/threonine protein...

View article titled, C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis

Includes: Supplementary data

Articles

Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling

Geou-Yarh Liou, Hua Zhang, Eva M. Miller, Steve A. Seibold, Weiqin Chen, Kathleen A. Gallo

Biochem J (2010) 427 (3): 435–443.

https://doi.org/10.1042/BJ20091077

Published: 14 April 2010

... © The Authors Journal compilation © 2010 Biochemical Society 2010 c-Jun N-terminal kinase (JNK) epoxomicin mitogen-activated protein kinase (MAPK) mixed lineage kinase 3 (MLK3) proteasome tumour necrosis factor α (TNFα) In addition to its kinase domain, MLK3 contains several...

View article titled, Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling

Includes: Supplementary data

Articles

Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons

Mitsunobu Hoshino, Tetsuhiro Tsujimoto, Sayumi Yamazoe, Motonari Uesugi, Sumio Terada

Biochem J (2010) 427 (2): 297–304.

https://doi.org/10.1042/BJ20100071

Published: 29 March 2010

... should be addressed (email terada.nana@tmd.ac.jp ). 11 1 2010 10 2 2010 11 2 2010 11 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell culture focal adhesion kinase (FAK) heparan sulfate hippocampal neuron mitogen-activated protein kinase...

View article titled, Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons

Articles

Glucocorticoids inhibit IL-1β-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1

Robert Newton, Elizabeth M. King, Wei Gong, Christopher F. Rider, Karl J. Staples, Neil S. Holden, Martin W. Bergmann

Biochem J (2010) 427 (1): 113–124.

https://doi.org/10.1042/BJ20091038

Published: 15 March 2010

... granulocyte/macrophage colony-stimulating factor (GM-CSF) inflammation mitogen-activated protein kinase (MAPK) In primary HBE cells, GM-CSF release was readily detectible at 6 and 18 h following IL-1β treatment ( Figure 1 C). At 18 h, IL-1β-treated cells ( n =7) released 571±93 pg/ml...

View article titled, Glucocorticoids inhibit IL-1β-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1

Includes: Supplementary data

Articles

Kv4.2 is a locus for PKC and ERK/MAPK cross-talk

Laura A. Schrader, Yajun Ren, Feng Cheng, Dui Bui, J. David Sweatt, Anne E. Anderson

Biochem J (2009) 417 (3): 705–715.

https://doi.org/10.1042/BJ20081213

Published: 16 January 2009

... in the Kv4.2 C-terminal sequence. We found that phosphorylation of Kv4.2 by PKC enhanced ERK phosphorylation of the channel in vitro . These findings suggest the possibility that Kv4.2 is a locus for PKC and ERK cross-talk. cross-talk extracellular-signal-regulated kinase (ERK) mitogen-activated protein...

View article titled, Kv4.2 is a locus for PKC and ERK/MAPK cross-talk

Articles

When expressed in yeast, mammalian mitogen-activated protein kinases lose proper regulation and become spontaneously phosphorylated

Vered Levin-Salomon, Inbal Maayan, Liat Avrahami-Moyal, Irit Marbach, Oded Livnah, David Engelberg

Biochem J (2009) 417 (1): 331–342.

https://doi.org/10.1042/BJ20081335

Published: 12 December 2008

...-activated protein kinase (MAPK) p38 phosphorylation yeast MAPKs (mitogen-activated protein kinases) are key components in cell signalling pathways. In mammals, MAPKs are classified into sub-families that include the ERKs (extracellular-signal-regulated kinases), the JNKs (c-Jun N-terminal kinases...

View article titled, When expressed in yeast, mammalian mitogen-activated protein kinases lose proper regulation and become spontaneously phosphorylated

Includes: Supplementary data

Articles

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

Yan Zeng, Heidi Sankala, Xiaoxiao Zhang, Paul R. Graves

Biochem J (2008) 413 (3): 429–436.

https://doi.org/10.1042/BJ20080599

Published: 15 July 2008

...@vcu.edu ). 14 3 2008 29 4 2008 13 5 2008 13 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Argonaute (Ago) mitogen-activated protein kinase (MAPK) phosphorylation processing body RNA interference (RNAi) Non-coding RNAs of approx. 20...

View article titled, Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

Includes: Supplementary data

Articles

Arabidopsis MAPKs: a complex signalling network involved in multiple biological processes

Jean Colcombet, Heribert Hirt

Biochem J (2008) 413 (2): 217–226.

https://doi.org/10.1042/BJ20080625

Published: 26 June 2008

... that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells Plant J 1994 5 111 122 75 Mockaitis K. Howell S. H. Auxin induces mitogenic activated protein kinase (MAPK) activation in roots...

View article titled, Arabidopsis MAPKs: a complex signalling network involved in multiple biological processes

Articles

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Zamal Ahmed, Annika C. Schüller, Klaus Suhling, Carolyn Tregidgo, John E. Ladbury

Biochem J (2008) 413 (1): 37–49.

https://doi.org/10.1042/BJ20071594

Published: 12 June 2008

... Society 2008 Aperts syndrome fibroblast growth factor receptor 2 (FGFR2) fibroblast growth factor receptor substrate 2 (FRS2) fluorescent lifetime imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine kinase...

View article titled, Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Articles

AMPK, MAPK and Bax in the heart: some questions answered

Vilmante Borutaite

Biochem J (2008) 412 (2): e15–e16.

https://doi.org/10.1042/BJ20080712

Published: 14 May 2008

.... Experimental myocardial ischemia characteristics of isolated mitochondria subpopulations J. Mol. Cell. Cardiol. 1978 10 109 123 AMP-activated protein kinase (AMPK) apoptosis Bax heart ischaemia mitochondrion mitogen-activated protein kinase (MAPK) protein kinase Programmed cell death...

View article titled, AMPK, MAPK and Bax in the heart: some questions answered

Articles

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6 / MKP - 3 gene promoter

Maria Ekerot, Marios P. Stavridis, Laurent Delavaine, Michael P. Mitchell, Christopher Staples, David M. Owens, Iain D. Keenan, Robin J. Dickinson, Kate G. Storey, Stephen M. Keyse

Biochem J (2008) 412 (2): 287–298.

https://doi.org/10.1042/BJ20071512

Published: 14 May 2008

... use, distribution and reproduction in any medium, provided the original work is properly cited. dual-specificity phosphatase 6 (DUSP6) fibroblast growth factor (FGF) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase phosphatase-3 (MKP-3) phosphatase transcription...

View article titled, Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6 / MKP - 3 gene promoter

Articles

MAPK-induced Ser 727 phosphorylation promotes SUMOylation of STAT1

Sari Vanhatupa, Daniela Ungureanu, Maija Paakkunainen, Olli Silvennoinen

Biochem J (2008) 409 (1): 179–185.

https://doi.org/10.1042/BJ20070620

Published: 11 December 2007

... 26 9 2007 26 9 2007 mitogen-activated protein kinase (MAPK) signal transducer and activator of transcription (STAT) protein inhibitor of activated STAT1 (PIAS1) Ser 727 phosphorylation small ubiquitin-related modifier (SUMO) transcription factor IFN-γ (interferon-γ) has...

View article titled, MAPK-induced Ser 727 phosphorylation promotes SUMOylation of STAT1

Articles

MAPK activation by radio waves

J. Simon C. Arthur

Biochem J (2007) 405 (3): e5.

https://doi.org/10.1042/BJ20070762

Published: 13 July 2007

...) mitogen-activated protein kinase (MAPK) mobile phone reactive oxygen species ultra-high frequency radio wave (UHF radio wave) Over the last 10 to 15 years, there has been a large increase in the use of mobile phones, and more recently in wireless computer networks. These networks transmit...

View article titled, MAPK activation by radio waves

Articles

Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cϵ

Jun-ichi Saito, Shinnosuke Toriumi, Kenjiro Awano, Hidenori Ichijo, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura

Biochem J (2007) 405 (3): 591–596.

https://doi.org/10.1042/BJ20070231

Published: 13 July 2007

...-activated protein kinase (MAPK) protein phosphatase 2C (PP2C) protein serine/threonine phosphatase 5 (PP5) stress-activated protein kinase (SAPK) SAPKs (stress-activated protein kinases), a subfamily of the MAPK (mitogen-activated protein kinase) superfamily, are highly conserved from yeast...

View article titled, Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cϵ

Articles

Regulation and functional consequences of ADP receptor-mediated ERK2 activation in platelets

Analia Garcia, Haripriya Shankar, Swaminathan Murugappan, Soochong Kim, Satya P. Kunapuli

Biochem J (2007) 404 (2): 299–308.

https://doi.org/10.1042/BJ20061584

Published: 14 May 2007

... mitogen-activated protein kinase (MAPK) protein kinase C Src family kinase Platelet activation is important for haemostasis and abnormal activation of platelets leading to thrombosis. Upon vascular injury circulating platelets adhere to the collagen-rich sub-endothelium and become activated...

View article titled, Regulation and functional consequences of ADP receptor-mediated ERK2 activation in platelets

Articles

Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation

Heather J. Lee, Hee-Chang Mun, Narelle C. Lewis, Michael F. Crouch, Emma L. Culverston, Rebecca S. Mason, Arthur D. Conigrave

Biochem J (2007) 404 (1): 141–149.

https://doi.org/10.1042/BJ20061826

Published: 26 April 2007

... extracellular-signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) The calcium-sensing receptor (CaR) is a multi-metabolic sensor belonging to Class 3 (Family C) of the G-protein-coupled receptor superfamily (for reviews, see [ 1 – 3 ]). Metabolic modalities that are detected...

View article titled, Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation

Articles

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS

Claire E. Mccoy, Andrew Macdonald, Nick A. Morrice, David G. Campbell, Maria Deak, Rachel Toth, Joanne Mcilrath, J. Simon C. Arthur

Biochem J (2007) 402 (3): 491–501.

https://doi.org/10.1042/BJ20061183

Published: 26 February 2007

...) extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) p38 p90 ribosomal S6 kinase (RSK) precursor ion scanning MS 1 Present address: Department of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. 2 To whom correspondence should...

View article titled, Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS

Articles

Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages

Yalin Emre, Corinne Hurtaud, Tobias Nübel, François Criscuolo, Daniel Ricquier, Anne-Marie Cassard-Doulcier

Biochem J (2007) 402 (2): 271–278.

https://doi.org/10.1042/BJ20061430

Published: 12 February 2007

... 10 2006 The Biochemical Society, London 2007 lipopolysaccharide mitochondria mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) signalling uncoupling protein 2 (UCP2) UCP2 (uncoupling protein 2) is a carrier protein located in the inner mitochondrial...

View article titled, Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages

Articles

A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor

Christopher G. Proud

Biochem J (2007) 401 (1): e1.

https://doi.org/10.1042/BJ20061691

Published: 11 December 2006

... mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) protein kinase inhibitor small-molecule inhibitor There are four closely related RSK (p90 ribosomal S6 kinase) genes in the human genome (RSK1–4), which belong to the AGC family of protein kinases. RSKs phosphorylate a number...

View article titled, A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor

Articles

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Gopal P. Sapkota, Lorna Cummings, Felicity S. Newell, Christopher Armstrong, Jennifer Bain, Morten Frodin, Matthias Grauert, Matthias Hoffmann, Gisela Schnapp, Martin Steegmaier, Philip Cohen, Dario R. Alessi

Biochem J (2007) 401 (1): 29–38.

https://doi.org/10.1042/BJ20061088

Published: 11 December 2006

... evidence indicating that MSK, and not RSK, isoforms mediate the mitogen-induced phosphorylation of this transcription factor. BI-D1870 kinase-specific inhibitor mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) phosphorylation 1 To whom correspondence should...

View article titled, BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Includes: Supplementary data

Articles

Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB

Stilla Frede, Christian Stockmann, Patricia Freitag, Joachim Fandrey

Biochem J (2006) 396 (3): 517–527.

https://doi.org/10.1042/BJ20051839

Published: 29 May 2006

...-Rad kit. adrenomedullin (ADM) hypoxia-inducible factor-1 (HIF-1) inflammation macrophages mitogen-activated protein kinase (MAPK) oxygen sensing The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor-1) regulates the expression of genes involved in angiogenesis...

View article titled, Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB

Articles

ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene

Zoulika Kherrouche, Alexandre Blais, Elisabeth Ferreira, Yvan De Launoit, Didier Monté

Biochem J (2006) 396 (3): 547–556.

https://doi.org/10.1042/BJ20051981

Published: 29 May 2006

... (ASK-1) cell cycle E2 promoter-binding factor (E2F) mitogen-activated protein kinase (MAPK) promoter analysis E2F1 ( E2 promoter-binding factor 1) was initially identified as a cellular DNA-binding factor required for the E1A (adenovirus 5 early region 1A product)-mediated activation...

View article titled, ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene

Articles

Semaphorin 4D activates the MAPK pathway downstream of plexin-B1

Jennifer Aurandt, Weiquan Li, Kun-Liang Guan

Biochem J (2006) 394 (2): 459–464.

https://doi.org/10.1042/BJ20051123

Published: 10 February 2006

..., London 2006 axon guidance HT-22 cell mitogen-activated protein kinase (MAPK) plexin semaphorin Rho GTPase Semaphorins are a family of soluble and membrane-associated proteins that were originally characterized in the nervous system and play a critical role in axon guidance. Outside...

View article titled, Semaphorin 4D activates the MAPK pathway downstream of plexin-B1

Articles

Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity

Jun Wu, Åke Nilsson, Bo A. G. Jönsson, Hanna Stenstad, William Agace, Yajun Cheng, Rui-Dong Duan

Biochem J (2006) 394 (1): 299–308.

https://doi.org/10.1042/BJ20051121

Published: 27 January 2006

... sphingomyelinase colon cancer inflammatory bowel disease mitogen-activated protein kinase (MAPK) platelet-activating factor phospholipase C PAF (platelet-activating factor; 1- O -alkyl-2-acetyl- sn -glycero-3-phosphocholine), first named by its platelet-aggregating activity, is a type of phospholipid...

View article titled, Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity

Articles

Characterization of the reversible phosphorylation and activation of ERK8

Iva V. Klevernic, Margaret J. Stafford, Nicholas Morrice, Mark Peggie, Simon Morton, Philip Cohen

Biochem J (2006) 394 (1): 365–373.

https://doi.org/10.1042/BJ20051288

Published: 27 January 2006

... 30 11 2005 9 12 2005 9 12 2005 The Biochemical Society, London 2006 extracellular-signal-regulated kinase 8 (ERK8) mass spectrometry mitogen-activated protein kinase (MAPK) oxidative stress protein phosphatase Many members of the MAPK (mitogen-activated protein...

View article titled, Characterization of the reversible phosphorylation and activation of ERK8

Articles

MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide

Shyamali Basuroy, Ankur Seth, Bertha Elias, Anjaparavanda P. Naren, Radhakrishna Rao

Biochem J (2006) 393 (1): 69–77.

https://doi.org/10.1042/BJ20050959

Published: 12 December 2005

... The Biochemical Society, London 2006 barrier function cell–cell adhesion epithelium ERK occludin mitogen-activated protein kinase (MAPK) zonula occludins-1 (ZO-1) The TJ (tight junction), located at the apical end of the lateral membrane of epithelial cells, forms a barrier to the diffusion...

View article titled, MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide

Articles

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

Richard J. Orton, Oliver E. Sturm, Vladislav Vyshemirsky, Muffy Calder, David R. Gilbert, Walter Kolch

Biochem J (2005) 392 (2): 249–261.

https://doi.org/10.1042/BJ20050908

Published: 22 November 2005

... (ERK) mitogen-activated protein kinase (MAPK) receptor tyrosine kinase signalling network systems biology Most activators of the MAPK pathway initiate signalling by activating receptors in the cell membrane, which assemble into receptor signalling complexes and activate a MAPKKK typically...

View article titled, Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

Articles

Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gβγ-mediated activation of Ras and p38 MAPK

Jiazhen Guan, Yuan Luo, Bradley M. Denker

Biochem J (2005) 392 (2): 389–397.

https://doi.org/10.1042/BJ20042102

Published: 22 November 2005

... 26 4 2005 10 6 2005 10 6 2005 The Biochemical Society, London 2005 differentiation G-protein regulator mitogen-activated protein kinase (MAPK) neuron PC12 cell Purkinje cell protein-2 (Pcp2) Purkinje cell protein-2 (Pcp2; also known as L7) is an abundant...

View article titled, Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gβγ-mediated activation of Ras and p38 MAPK

Articles

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

Jaclyn Long, Peter Darroch, Kah Fei Wan, Kok Choi Kong, Nicholas Ktistakis, Nigel J. Pyne, Susan Pyne

Biochem J (2005) 391 (1): 25–32.

https://doi.org/10.1042/BJ20050342

Published: 26 September 2005

... mitogen-activated protein kinase (MAPK) phosphatidic acid sphingosine 1-phosphate (S1P) LPPs (lipid phosphate phosphatases) are integral membrane proteins that display broad substrate specificity in vitro catalysing the dephosphorylation of lipid phosphates [e.g. S1P (sphingosine 1-phosphate...

View article titled, Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

Includes: Supplementary data

Articles

Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter

Rémy Nyga, Christian Pecquet, Noria Harir, Haihua Gu, Isabelle Dhennin-Duthille, Aline Régnier, Valérie Gouilleux-Gruart, Kaïss Lassoued, Fabrice Gouilleux

Biochem J (2005) 390 (1): 359–366.

https://doi.org/10.1042/BJ20041523

Published: 09 August 2005

..., London 2005 Gab2 growth-factor-receptor-bound protein 2 (Grb2) mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) proliferation signal transducer and activator of transcription 5 (STAT5) NP40 (Nonidet P40) cell lysates were separated by SDS/PAGE and blotted...

View article titled, Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter

Articles

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK

Bela G. Starkman, John D. Cravero, Marcello Delcarlo, Jr, Richard F. Loeser

Biochem J (2005) 389 (3): 723–729.

https://doi.org/10.1042/BJ20041636

Published: 26 July 2005

...) by cartilage [ 11 ]. Surprisingly, the cell signalling mechanism by which IGF-I stimulates proteoglycan synthesis has not been reported. Akt articular cartilage chondrocyte insulin-like growth factor-I (IGF-I) mitogen-activated protein kinase (MAPK) proteoglycan synthesis Elucidation...

View article titled, IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK

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