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Keywords: mitogen-activated protein kinaseClose
Ji Xiao, Jing Tang, Quan Chen, Dan Tang, Meimei Liu, Min Luo, Yan Wang, Jiazheng Wang, Zhenyu Zhao, Chaoke Tang, Deming Wang, Zhongcheng Mo
Biochem J (2015) 471 (2): 281–291.
Published: 02 October 2015
...Ji Xiao; Jing Tang; Quan Chen; Dan Tang; Meimei Liu; Min Luo; Yan Wang; Jiazheng Wang; Zhenyu Zhao; Chaoke Tang; Deming Wang; Zhongcheng Mo p38 MAPK (mitogen-activated protein kinase) is a critical regulator in lung inflammation. It can be inactivated by DUSP1 (dual-specificity phosphatase 1) which...
Includes: Supplementary data
Kennedy MAKONDO, Kazuhiro KIMURA, Naoki KITAMURA, Takanori KITAMURA, Daisuke YAMAJI, Bae Dong JUNG, Masayuki SAITO
Biochem J (2003) 374 (1): 63–69.
Published: 15 August 2003
...@vetmed.hokudai.ac.jp ). 27 2 2003 19 5 2003 21 5 2003 21 5 2003 The Biochemical Society, London ©2003 2003 hepatocyte growth factor (HGF) mitogen-activated protein kinase nitric oxide nitric oxide synthase wortmannin Abbreviations used: BAEC, bovine aortic endothelial...
Biochem J (2003) 372 (3): 787–797.
Published: 15 June 2003
... of P3-dependent PTHrP expression in MCF-7 cells. Mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK) kinase 1 (MEK-1)/ERK1/2 inhibitor PD98059 interfered with this activity. Promoter studies revealed that the PMA effect depended on the Ets and stimulating protein-1 (Sp1...
Jun MAYAMA, Takayuki KUMANO, Makoto HAYAKARI, Takehiko YAMAZAKI, Shu AIZAWA, Toshihiro KUDO, Shigeki TSUCHIDA
Biochem J (2003) 372 (2): 611–616.
Published: 01 June 2003
... inactivation due to CCl 4 . 1 To whom correspondence should be addressed (e-mail firstname.lastname@example.org ). 18 11 2002 24 2 2003 27 2 2003 3 3 2003 The Biochemical Society, London ©2003 2003 glutathiolation glyoxalase I mitogen-activated protein kinase oxidative...
Charles S.T. HII, Maurizio COSTABILE, George C. MAYNE, Channing J. DER, Andrew W. MURRAY, Antonio FERRANTE
Biochem J (2003) 370 (2): 497–503.
Published: 01 March 2003
... (Printed in Great Britain) 497 Selective deficiency in protein kinase C isoenzyme expression and inadequacy in mitogen-activated protein kinase activation in cord blood T cells Charles S. T. HII*1, Maurizio COSTABILE George C. MAYNE*, Channing J. DER, Andrew W. MURRAY and Antonio FERRANTE*s *Department...
Biochem J (2003) 370 (2): 459–467.
Published: 01 March 2003
... protein synthesis in LPS-stimulated BV-2 cells involved activation of the extracellular-signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) pathway and was sensitive to the protein kinase C (PKC) inhibitors staurosporine and chelerythrine, and the MAP kinase/ERK kinase 1/2...
Biochem J (2003) 369 (2): 351–356.
Published: 15 January 2003
...Sam A. JOHNSON; Richard M. DENTON In isolated rat adipocytes, the insulin stimulation of pyruvate dehydrogenase can be partially inhibited by inhibitors of PI3K (phosphoinositide 3-kinase) and MEK1/2 (mitogen-activated protein kinase/extracellular signal-regulated kinase kinase). In combination...
Angela CLERK, Timothy J. KEMP, Joanne G. HARRISON, Anthony J. MULLEN, Paul J.R. BARTON, Peter H. SUGDEN
Biochem J (2002) 368 (1): 101–110.
Published: 15 November 2002
... to up-regulate its own transcription and, since the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein kinases (MAPKs) phosphorylate c-Jun(Ser-63/73) to increase its transactivating activity, JNKs are thought to be the principal factors involved in c- jun up-regulation. Hypertrophy...
Béatrice THOMAS, Sylvie THIRION, Lydie HUMBERT, Lujian TAN, Mary B. GOLDRING, Gilbert BÉRÉZIAT, Francis BERENBAUM
Biochem J (2002) 362 (2): 367–373.
Published: 22 February 2002
... monolayer cultures (alg-) after stimulation with IL-1β. Moreover, IL-1β induced COX-2 expression at 0.01ng/ml in (alg+) cells, whereas a 100-fold higher dose of cytokine was necessary for stimulation in (alg-) cells. SB203580, a selective p38 mitogen-activated protein kinase (MAPK) inhibitor, completely...
Frédéric BOST, Leslie CARON, Irène MARCHETTI, Christian DANI, Yannick LE MARCHAND-BRUSTEL, Bernard BINÉTRUY
Biochem J (2002) 361 (3): 621–627.
Published: 25 January 2002
..., but not the c-Jun N-terminal kinase, p38 mitogen-activated protein kinase or phosphoinositide 3-kinase pathways. To investigate the role of ERK activation, co-treatment of RA with PD98059, a specific inhibitor of the ERK signalling pathway, prevented both adipocyte formation and expression of the adipogenic...
Biochem J (2001) 360 (3): 639–644.
Published: 10 December 2001
... for the response to high osmolarity in the S. cerevisiae heterologous system. The unusual multidomain structure of HstK suggests that a two-component system could be directly coupled to Ser/Thr kinases in the same signal transduction pathway. Anabaena mitogen-activated protein kinase protein kinase signal...
Biochem J (2001) 359 (2): 375–380.
Published: 08 October 2001
... of the GATA-4 band also occurred on SDS/PAGE as monitored by immunoblotting. The in vitro treatment of nuclear extracts with λ-protein phosphatase abolished the upward shift, indicating that GATA-4 was phosphorylated. ET-1 activated the p44/42 mitogen-activated protein kinase (MAPK) and the MAPK kinase (MEK...
Biochem J (2001) 358 (2): 489–495.
Published: 24 August 2001
... to constitutively active Ras or Raf, but attenuated reporter gene activation induced by a constitutively active mutant of mitogen-activated protein kinase kinase kinase 1 (MEKK1), an upstream kinase that preferentially activates JNKs, by 50%. Overexpression of JIP-1 also significantly reduced the increase in cell...
Stephan VOM DAHL, Frank DOMBROWSKI, Marcus SCHMITT, Freimut SCHLIESS, Ulrich PFEIFER, Dieter HÄUSSINGER
Biochem J (2001) 354 (1): 31–36.
Published: 08 February 2001
... volume, colchicine, mitogen-activated protein kinase, protein degradation, SB 203580. MATERIALS AND METHODS Liver perfusion Livers, from male Wistar rats (160 230 g) fed on a standard chow, were perfused in an open non-recirculating manner as described previously . The perfusion medium was bicarbon...
Biochem J (2000) 351 (2): 327–334.
Published: 10 October 2000
... of PC12 cells with the specific p38 mitogen-activated protein kinase inhibitor SB203580 induced eIF4E dephosphorylation but did not cause any effect on protein synthesis rate. Rapamycin, the inhibitor of mammalian target of rapamycin (‘mTOR’), but not PD98059, the inhibitor of extracellular signal...
Biochem J (2000) 351 (1): 257–264.
Published: 26 September 2000
... recently, however, has it been shown that these signalling pathways Abbreviations used: BK, bradykinin ; VSMC, vascular smooth-muscle cell ; B2R, B2 receptor ; MAPK, mitogen-activated protein kinase ; JAK, Janus- activated kinase ; STAT, signal transducers and activators of transcription ; Ang II...
Pauliina LAINE, Niina REUNANEN, Laura RAVANTI, Marco FOSCHI, Manoranjan SANTRA, V. Renato IOZZO, Veli-Matti KÄHÄRI
Biochem J (2000) 349 (1): 19–25.
Published: 26 June 2000
... proteoglycan mitogen-activated protein kinase Biochem. J. (2000) 349, 19 25 (Printed in Great Britain) 19 Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts Pauliina LAINE Niina REUNANEN Laura RAVANTI Marco FOSCHI, Manoranjan...
Biochem J (2000) 346 (1): 169–175.
Published: 08 February 2000
...Benjamin TURGEON; Marc K. SABA-EL-LEIL; Sylvain MELOCHE MAP (mitogen-activated protein) kinases are a family of serine/threonine kinases that have a pivotal role in signal transduction. Here we report the cloning and characterization of a mouse homologue of extracellular-signal-regulated protein...
Paulus C. J. VAN DER HOEVEN, José C. M. VAN DER WAL, Paula RUURS, Marc C. M. VAN DIJK, Wim J. VAN BLITTERSWIJK
Biochem J (2000) 345 (2): 297–306.
Published: 10 January 2000
... binds both PKC-f (at phospho-Ser-186) and Raf-1 in INTRODUCTION Activation of the mitogen-activated protein kinase (MAPK or extracellular-signal-regulated protein kinase, ERK) pathway is a central event in the response of cells to mitogenic stimuli. In this pathway, Raf-1 is recruited to the plasma...
Biochem J (1999) 343 (1): 21–27.
Published: 24 September 1999
... the stabilization of α1(I) collagen mRNA, and required new protein synthesis. In addition, TGFβ 1 - and BMP-2-induced increases in α1(I) collagen mRNA levels were both dependent on protein kinase C and protein tyrosine kinase activities. Furthermore, the mitogen-activated protein kinase (MAPK) [MAPK/extracellular...
Biochem J (1999) 342 (2): 301–308.
Published: 24 August 1999
... activated mitogen-activated protein kinase and increased cytosolic free calcium concentrations, confirming the reconstitution of TrkA-mediated signalling pathways. The expression of ChAT and VAChT mRNA, as well as ACh content, were coordinately up-regulated by NGF in SN56- trkA transfectants. None...
Renata JASINSKA, Qiu-Xia ZHANG, Carlos PILQUIL, Indrapal SINGH, James XU, Jay DEWALD, Deirdre A. DILLON, Luc G. BERTHIAUME, George M. CARMAN, David W. WAGGONER, David N. BRINDLEY
Biochem J (1999) 340 (3): 677–686.
Published: 08 June 1999
..., Seattle, WA 98119, U.S 1 To whom correspondence should be addressed (e-mail email@example.com). 15 1 1999 8 3 1999 1 4 1999 The Biochemical Society, London © 1999 1999 ceramide 1-phosphate DNA synthesis lysophosphatidate mitogen-activated protein kinase...
Biochem J (1999) 338 (3): 619–628.
Published: 08 March 1999
... correspondence should be addressed (e-mail firstname.lastname@example.org ). 1 10 1998 2 12 1998 5 1 1999 The Biochemical Society, London © 1999 1999 calcium G-protein-coupled receptor mitogen-activated protein kinase protein kinase C stress-activated protein kinase Biochem. J. (1999) 338...
Biochem J (1999) 338 (2): 387–392.
Published: 22 February 1999
...@cxwms.ac.uk ). 30 6 1998 1 12 1998 17 12 1998 The Biochemical Society, London © 1999 1999 lethal toxin mitogen-activated protein kinase Ras Rho GTPases toxin B Biochem. J. (1999) 338, 387 392 (Printed in Great Britain) 387 Synergistic activation of JNK/SAPK by interleukin-1...
Koichi GONDA, Hiroyuki OKAMOTO, Noriko TAKUWA, Yutaka YATOMI, Hiroshi OKAZAKI, Takeshi SAKURAI, Sadao KIMURA, Rannar SILLARD, Kiyonori HARII, Yoh TAKUWA
Biochem J (1999) 337 (1): 67–75.
Published: 17 December 1998
... mitogen-activated protein kinase (MAPK) in a PTX-sensitive and Ras-dependent manner. S1P also induced the activation of two stress-activated MAPKs, c-Jun N-terminal kinase and p38, in a manner that was totally insensitive to PTX. In CHO-AGR16 cells, S1P induced stress-fibre formation, with an increase...