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Keywords: mitochondrion
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Articles
Biochem J (2014) 464 (1): 13–22.
Published: 23 October 2014
... fluorescent genetically encoded Ca 2+ indicators with low affinities. These indicators enable monitoring of mitochondrial and ER Ca 2+ dynamics in combination with a green fluorescent indicator. endoplasmic reticulum (ER) fluorescence Ca 2+ imaging GCaMP mitochondrion multicolour imaging red...
Includes: Supplementary data
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Biochem J (2014) 464 (1): e5–e6.
Published: 23 October 2014
... correspondence should be addressed (email pnp@unife.it ). 22 9 2014 30 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 aequorin Ca 2+ measurement endoplasmic reticulum fluorescent Ca 2+ indicator GCaMP mitochondrion Since the identification...
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Biochem J (2014) 463 (3): e3–e5.
Published: 10 October 2014
... metformin mitochondrion phenformin In 2000, two laboratories published independently in two different journals that metformin inhibited mitochondrial respiratory chain complex I [ 1 , 2 ]. Since then, more than ten different laboratories have reproduced this observation. However, although all...
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Biochem J (2014) 461 (1): 137–146.
Published: 13 June 2014
... of oxidative stress in vitro and in vivo , suggesting that Drp1 might be a useful target to combat necrosis in human disease. dynamin-related protein 1 (Drp1) mitochondrion necrosis oxidative stress p53 ubiquitination 1 To whom correspondence should be addressed (email xxq38...
Includes: Supplementary data
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Biochem J (2014) 460 (1): 91–101.
Published: 25 April 2014
...-tRNA Gln amidotransferase. Misaminoacylated Glu-tRNA Gln is rejected from the ribosomes maintaining the fidelity of the mitochondrial protein synthesis. glutamyl-tRNA Gln amidotransferase CAB (GatCAB) mitochondrial protein synthesis mitochondrion oxidative phosphorylation (OXPHOS) tRNA Gln...
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Biochem J (2014) 459 (1): 127–135.
Published: 14 March 2014
... wavelength (ε=27.7 mM −1 ·cm −1 ) [ 7 ]. aging cytochrome c oxidase (CcO) Drosophila melanogaster lifespan mitochondrion Decline in mitochondrial respiratory capacity, as manifested by attenuations of ADP-stimulated or state 3 respiration and the activities of ETC (electron-transport...
Includes: Supplementary data
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Biochem J (2014) 459 (1): 149–160.
Published: 14 March 2014
... harbouring the MERRF A8344G mutation and overexpression of CA8 desensitizes mutant MERRF cybrids to apoptotic stress. Phosphorylated Akt is involved in the protection of cells by CA8 in MERRF cybrids. apoptosis autophagy carbonic anhydrase-related protein VIII (CA8) mitochondrion mtDNA point...
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Biochem J (2014) 459 (1): 71–81.
Published: 14 March 2014
... with the amino acid change M107I is able to bypass lack of the frataxin by stimulating cysteine desulfurase activity in mitochondria, although a kinetic defect in Fe–S cluster assembly persists. cysteine desulfurase eukaryote frataxin iron–sulfur Isu1 scaffold mitochondrion Frataxin...
Includes: Supplementary data
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Biochem J (2014) 458 (3): e5–e7.
Published: 28 February 2014
... in health and disease. 1 email jbolanos@usal.es 21 1 2014 22 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 2,3-bisphosphoglycerate phosphatase cancer glycolysis haemoglobin hypoxia mitochondrion oxygen sensing TIGAR [TP53 (tumour...
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Biochem J (2014) 458 (1): 33–40.
Published: 20 January 2014
... mitochondrial (MCU) Ca 2+ uptake protein 1 mitochondrial (MICU1) knockdown mitochondrion In recent years, a number of new proteins involved in mitochondrial Ca 2+ transport have been discovered [ 1 ]. MICU1 (Ca 2+ uptake protein 1, mitochondrial) was the first one known to be involved...
Includes: Supplementary data
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Biochem J (2014) 457 (2): 361–368.
Published: 20 December 2013
... of TRPML1 leads to production of reactive oxygen species, and to mitochondrial deterioration. iron lysosomal storage disease mitochondrion reactive oxygen species transient receptor potential (TRP) channel In the present study we aimed to answer whether or not TRPML1 has a role beyond...
Includes: Supplementary data
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Biochem J (2013) 456 (3): 427–439.
Published: 22 November 2013
... fission, which is an essential mediator of ceramide-induced metabolic disruption in skeletal muscle. ceramide dynamin-related protein 1 (Drp1) mitochondrion mitochondrial fission metabolic disruption The current worldwide trends of increasing prevalence of obesity and Type 2 diabetes...
Includes: Supplementary data
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Biochem J (2013) 456 (1): 139–146.
Published: 24 October 2013
.... lipolytica complex I, but N1a was still not reduced by NADH. We conclude that cluster N1a does not affect reactive oxygen species production by the complex I flavin; it is probably required for enzyme assembly or stability. electron transport chain iron–sulfur cluster mitochondrion NADH:quinone...
Includes: Supplementary data
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Biochem J (2013) 455 (1): 27–35.
Published: 13 September 2013
... mitochondrion The mitochondrion is a vitally important organelle that performs essential functions in many biological processes from ATP generation and Fe–S (iron–sulfur) cluster biogenesis to signalling and cell death (apoptosis) [ 1 – 3 ]. Mia40 is an evolutionarily conserved protein located...
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Biochem J (2013) 454 (3): 371–386.
Published: 29 August 2013
...Manuel Gutiérrez-Aguilar; Christopher P. Baines The mitochondrion relies on compartmentalization of certain enzymes, ions and metabolites for the sake of efficient metabolism. In order to fulfil its activities, a myriad of carriers are properly expressed, targeted and folded in the inner...
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Biochem J (2013) 452 (2): 173–181.
Published: 10 May 2013
... and discuss the directions future EF4 research should focus on. 3 12 2012 5 2 2013 6 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 back-translocation elongation factor 4 (EF4) (LepA) GTPase of unknown function 1 (Guf1) mitochondrion...
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Biochem J (2013) 452 (2): 231–239.
Published: 10 May 2013
... for Nox4. complex I electron transport chain mitochondrion Nox4 oxidative stress senescence The solubilized mitochondrial membrane proteins were separated on linear gradient gels at 4°C. Solubilized BHM (bovine heart mitochondria) prepared from tissue and stored at −80°C (3 g...
Includes: Supplementary data
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Biochem J (2013) 450 (2): 345–350.
Published: 15 February 2013
... aminoacyl-tRNA synthetase aspartylation leukoencephalopathy missense mutation mitochondrion LBSL (leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation) is an autosomal recessive white matter disorder [ 1 ]. Patients with LBSL suffer from slowly progressive...
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Biochem J (2012) 448 (3): 297–306.
Published: 21 November 2012
... as described elsewhere [ 32 ]. aminoacyl-tRNA synthetase mitochondrion Neurospora crassa oxidative phosphorylation (OXPHOS) complex respiratory chain The N. crassa WT (wild-type) 74-OR23-1A and 74-OR8-1a strains were grown and handled according to standard procedures [ 25 ]. The strains...
Includes: Supplementary data
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Biochem J (2012) 447 (2): 281–289.
Published: 26 September 2012
... the terms of the Creative Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion...
Includes: Supplementary data
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Biochem J (2012) 445 (3): 333–336.
Published: 13 July 2012
...-independent muscle contraction heart mitochondrion permeabilized myocyte respiration skeletal muscle With great interest, we have read the recent paper in the Biochemical Journal by Christopher Perry et al. [ 1 ] entitled ‘Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial...
Includes: Multimedia, Supplementary data
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Biochem J (2012) 445 (3): 371–376.
Published: 13 July 2012
... consumption). aequorin Ca 2+ Ca 2+ affinity Ca 2+ dynamics mitochondrion Figure 2 shows the increase in [Ca 2+ ] M induced by the addition of different [Ca 2+ ] between 5.5 and 200 μM to permeabilized HeLa cells, and the effect of the level of phosphate in the medium. Phosphate has been...
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Biochem J (2012) 445 (3): 349–359.
Published: 13 July 2012
... were from Sigma–Aldrich. © The Authors Journal compilation © 2012 Biochemical Society 2012 ATP cytokine diabetes insulin-secreting cell mimitin mitochondrion Mimitin is a small 20 kDa mitochondrial protein that is a direct target for c-Myc and is involved in cell proliferation...
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Biochem J (2012) 445 (1): 81–91.
Published: 15 June 2012
... compilation © 2012 Biochemical Society 2012 ABT-263 ABT-737 apoptosis Bcl-2 family protein ceramide analogue ceramide channel 2-methoxyantimicin A 3 mitochondrion The intrinsic pathway of apoptosis, a type of programmed cell death, is regulated at the mitochondrial level by the Bcl-2...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 357–373.
Published: 29 May 2012
... their role in the regulation of transcript stability and metabolism remains to be addressed. mitochondrion ribosome biogenesis RNA degradation RNA polyadenylation RNA turnover Polyadenylation appears to play contrasting roles in the gene expression of different systems. In the eukaryotic...
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Biochem J (2012) 444 (3): 561–571.
Published: 29 May 2012
... proliferation and highlight a novel mechanism of action for MCT inhibitors in cancer. α-cyano-4-hydroxycinnamic acid extracellular flux technology mitochondrion reserve capacity Warburg effect Otto Warburg [ 1 ] first described the increased utilization of anaerobic metabolism...
Includes: Supplementary data
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Biochem J (2012) 444 (2): 249–259.
Published: 11 May 2012
... glycolysis mitochondrion translational control Mitochondria play a central role in the homoeostasis of higher eukaryotic cells. The provision of metabolic energy by oxidative phosphorylation, the execution of cell death and intracellular signalling by Ca 2+ and ROS (reactive oxygen species...
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Biochem J (2012) 444 (1): 1–10.
Published: 26 April 2012
... mitochondrion oxidative stress SIRT3 sirtuin thermogenesis Sirtuins constitute a family of proteins with NAD + -dependent protein deacetylase and/or ADP-ribosyltransferase activities. Seven members of the sirtuin family (SIRT1–SIRT7) have been identified in mammals [ 1 ]. Mammalian sirtuins were...
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Biochem J (2012) 442 (2): 381–389.
Published: 13 February 2012
... M acetic anhydride and 0.3 M triethylamine in anhydrous DMF. 27 7 2011 22 11 2011 5 12 2011 5 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 ergosterol mitochondrion outer membrane signal-anchored protein (SA protein) Proteins...
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Biochem J (2012) 441 (2): 523–540.
Published: 21 December 2011
... of the Creative Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. autophagy mitochondrion neurodegeneration nitrative...
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Biochem J (2012) 441 (1): 275–283.
Published: 14 December 2011
...) mitochondrion pentatricopeptide repeat (PPR) respiratory chain Mutations in nuclear genes are widely associated with defects in respiratory chain construction and assembly. CIV (complex IV) deficiency has been associated with stop mutations and missense mutations in the nuclear subunits and assembly...
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Biochem J (2012) 441 (1): 473–480.
Published: 14 December 2011
... The Authors Journal compilation © 2012 Biochemical Society 2012 frataxin haem iron iron–sulfur cluster (Fe–S cluster) mitochondrion Iron is an essential nutrient for virtually all organisms because many important proteins require iron as a constituent of haem and Fe–S cofactors. Iron...
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Biochem J (2011) 440 (1): 137–146.
Published: 27 October 2011
...). The radiolabelled Fe–S cluster of endogenous aconitase was visualized by native gel electrophoresis and radioautography [ 23 ]. haem iron iron–sulfur mitochondrial carrier protein mitochondrion pyrimidine Iron in cells is used as a cofactor for many essential enzymes [ 1 ]. For example, haem...
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Biochem J (2011) 440 (1): 107–114.
Published: 27 October 2011
... ]. Yeasts were grown at 30°C with shaking (200 rev./min). coenzyme Q mitochondrion phosphorylation respiration yeast Coenzyme Q (CoQ or Q) is an essential isoprenylated benzoquinone component of mitochondria. CoQ resides in the phospholipid bilayer of mitochondrial membranes [ 1 ] where...
Includes: Supplementary data
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Biochem J (2011) 438 (3): e5–e6.
Published: 26 August 2011
... lipopolysaccharide (LPS) metabolism mitochondrion Toll-like receptor 4 (TLR4) References 1 Tannahill G. O'Neill L. A. J. The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3 FEBS Lett. 2011 585 1568 1572 2 Shi L...