1-50 of 194
Keywords: mitochondria
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Articles
Biochem J (2024) 481 (4): 295–312.
Published: 19 February 2024
... agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. blood ketones colonic ketogenesis 3-hydroxy-3-methylglutaryl-CoA synthase-2 inflammatory bowel disease inflammatory cytokines microbiome mitochondria Ketone bodies (acetoacetate, β...
Includes: Supplementary data
Articles
Biochem J (2024) 481 (3): 161–175.
Published: 29 January 2024
... in Supplementary Table S1 ). Figure 3. Morphology of mitochondria isolated from C. elegans and S. cerevisiae . ( A ) Tomographic segmentations of C. elegans and S. cerevisiae mitochondria are displayed (green, outer mitochondrial membrane; blue, inner mitochondrial membrane; multi-colour, crista...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2024) 481 (3): 119–139.
Published: 29 January 2024
... to humans and it regulates several aspects of mitochondrial physiology and, hence, cellular functions. In neurons, mitochondria are emerging as platforms for RNA transport and local protein translation. In this review, we discuss how RNA localization to mitochondria helps to sustain mitochondrial function...
Articles
In Collection
Awards
Biochem J (2023) 480 (21): 1767–1789.
Published: 15 November 2023
... and the Biochemical Society under a transformative agreement with JISC. function metabolism mitochondria mitochondrial dysfunction structure Volume wise, skeletal muscle tissue is mostly composed of long, cylindrical, multi-nucleated, and contractile cells, known as muscle fibres, which...
Articles
Articles
In Collection
Awards
Biochem J (2023) 480 (11): 773–789.
Published: 07 June 2023
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . diabetes glucose homeostasis hormone secretion insulin mitochondria pancreatic beta cell Type 2 diabetes (T2D) affects almost 1 in 10 adults worldwide...
Articles
Articles
Biochem J (2021) 478 (24): 4153–4167.
Published: 16 December 2021
... for this article was enabled by the participation of University of Liverpool in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. aging mitochondria molecular chaperones Saccharomyces cerevisiae Dietary...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (21): 3809–3826.
Published: 09 November 2021
... source of ROS production. Classic studies have suggested that reductions in skeletal muscle mitochondrial content and/or function contribute to lipid-induced insulin resistance; however, in recent years the role of mitochondria in the pathophysiology of insulin resistance has been gradually re-evaluated...
Articles
Biochem J (2021) 478 (16): 3125–3143.
Published: 26 August 2021
...Fabian den Brave; Jeannine Engelke; Thomas Becker Mitochondria import about 1000 proteins that are produced as precursors on cytosolic ribosomes. Defects in mitochondrial protein import result in the accumulation of non-imported precursor proteins and proteotoxic stress. The cell is equipped...
Articles
Biochem J (2021) 478 (13): 2539–2553.
Published: 09 July 2021
... of intracellular lipids. insulin resistance mitochondria muscle metabolism obesity skeletal muscle Skeletal muscle plays a fundamental role in the maintenance of glucose homeostasis, and as a result, a reduction in skeletal muscle insulin responsiveness is implicated in the development of type 2...
Articles
Biochem J (2021) 478 (10): 1977–1984.
Published: 28 May 2021
... compartments. We point out the role of mitochondria as an environmental and developmental sensor organelle that regulates ROS homeostasis and downstream events and we propose future directions of research that should help better understanding the roles of ROS in germination and seedling emergence...
Articles
Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell death cocaine metabolism mitochondria oxidative stress The prevalence of cocaine abuse is increasing, with the U.K. having some of the highest rates for powder cocaine usage and the highest level of crack...
Articles
Biochem J (2020) 477 (21): 4085–4132.
Published: 05 November 2020
...Daniella H. Hock; David R. L. Robinson; David A. Stroud Mitochondria produce the bulk of the energy used by almost all eukaryotic cells through oxidative phosphorylation (OXPHOS) which occurs on the four complexes of the respiratory chain and the F 1 –F 0 ATPase. Mitochondrial diseases...
Articles
Biochem J (2020) 477 (18): 3613–3623.
Published: 28 September 2020
... is not involved in this paradoxical effect of amino acid shortage. We correlate the autophagy failure with mitochondria aggregation and we show that amino acid starvation-induced autophagy is restored in lipid droplet-deficient yeast by increasing mitochondrial biomass physiologically (respiration) or genetically...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (17): 3417–3431.
Published: 17 September 2020
... a role in elevated respiration in mitochondria, it remains unclear whether thermogenic plants possess molecular mechanisms for the mitochondrial degradation of AOX. To better understand the mechanism of AOX turnover in mitochondria, we performed a series of in organello AOX degradation assays using...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (8): 1515–1524.
Published: 29 April 2020
... ). Moreover, PolyP can stimulate F 0 F 1 -ATPase activity in the presence of ATP and, importantly, can be hydrolyzed in this enzyme instead of ATP. Furthermore, PolyP can be produced in mitochondria in the presence of substrates for respiration and phosphate by the F 0 F 1 -ATPsynthase. Thus, polyP...
Articles
In Collection
Adipose biology
Biochem J (2020) 477 (3): 709–725.
Published: 14 February 2020
... of the Biochemical Society 2020 brown adipose tissue mitochondria obesity thermogenesis The significance of brown adipose tissue (BAT) in body weight regulation is under intense investigation. The study of thermogenic mechanisms in mammals may lay the foundation to exploit these biochemical pathways...
Articles
Articles
Articles
Biochem J (2019) 476 (15): 2235–2237.
Published: 15 August 2019
...Henver S. Brunetta; Graham P. Holloway Branched-chain keto acids (BCKA) metabolism involves several well-regulated steps within mitochondria, requires cofactors, and is modulated according to the metabolic status of the cells. This regulation has made it challenging to utilize in vitro approaches...
Articles
Biochem J (2019) 476 (12): 1805–1815.
Published: 28 June 2019
...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 mitochondria molybdenum cofactor nitric oxide nitrite reduction sulfite oxidase In mammals, two biochemical pathways are known for the de novo generation of nitric oxide (NO): an oxidative pathway catalyzed...
Articles
Articles
Biochem J (2019) 476 (1): 25–37.
Published: 07 January 2019
...David P. Scanlon; Michael W. Salter The mitochondrial proteome is estimated to contain ∼1100 proteins, the vast majority of which are nuclear-encoded, with only 13 proteins encoded by the mitochondrial genome. The import of these nuclear-encoded proteins into mitochondria was widely believed...
Articles
Biochem J (2018) 475 (22): 3535–3560.
Published: 20 November 2018
... signaling, mitochondria and relevant pathways for the nutritional support of spermatogenesis. Correspondence: Marco G. Alves ( alvesmarc@gmail.com ) 9 8 2018 28 9 2018 19 10 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018...
Articles
Biochem J (2018) 475 (21): 3471–3492.
Published: 15 November 2018
...) on the MOM. BH3 profiling and examination of Bcl-2 and BH3-only protein concentrations revealed that cells with high Sab concentrations were primed for apoptosis, as determined by the decrease in pro-survival Bcl-2 proteins and an increase in pro-apoptotic BH3-only proteins on mitochondria. Furthermore...
Includes: Supplementary data
Articles
Articles
Biochem J (2018) 475 (13): 2191–2208.
Published: 16 July 2018
... of the Biochemical Society 2018 cellular targeting mitochondria protein import The intermembrane space proteome is the smallest subcompartment of mitochondria and only consists of tens to hundreds of proteins (37 in yeast and 127 in human mitochondria) [ 56 , 57 ], yet a distinct import pathway has...
Articles
Biochem J (2018) 475 (9): 1611–1634.
Published: 09 May 2018
... to identify and selectively eradicate CSCs, together with the possibility to ‘force’ CSCs within certain metabolic dependences, in order to effectively target such metabolic biochemical inflexibilities. Finally, we focus on targeting mitochondria to halt CSC dissemination and effectively eradicate cancer...
Articles
Biochem J (2018) 475 (2): 495–509.
Published: 31 January 2018
...Inga Kruse; Andrew E. Maclean; Lionel Hill; Janneke Balk Mitochondria play a key role in the biosynthesis of two metal cofactors, iron–sulfur (FeS) clusters and molybdenum cofactor (Moco). The two pathways intersect at several points, but a scarcity of mutants has hindered studies to better...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (23): 4019–4034.
Published: 24 November 2017
... quantification. We propose novel experiments to verify the hypotheses made here to further develop our understanding of the threshold effect and connect with rational choices for mtDNA disease therapies. MELAS mitochondria mitochondrial dysfunction mtDNA threshold effect Mitochondria are organelles...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (16): 2785–2801.
Published: 07 August 2017
... and phospholipids, respectively. Pyrimidines, UDP- N -acetylhexosamine, and the fatty acyl chains of phosphatidylinositol and triglycerides showed lower 13 C incorporation under conditions of high PFK activity; the isotopologue 13 C enrichment pattern of each metabolite indicated limitations in mitochondria...
Articles
Biochem J (2017) 474 (15): 2533–2545.
Published: 12 July 2017
...Lisa MacPherson; Kostas Tokatlidis Mitochondria fulfill a diverse range of functions in cells including oxygen metabolism, homeostasis of inorganic ions and execution of apoptosis. Biogenesis of mitochondria relies on protein import pathways that are ensured by dedicated multiprotein translocase...
Articles
Biochem J (2017) 474 (12): 2067–2094.
Published: 09 June 2017
...Charles Owen Smith; Keith Nehrke; Paul S. Brookes Mitochondria play an important role in tissue ischemia and reperfusion (IR) injury, with energetic failure and the opening of the mitochondrial permeability transition pore being the major causes of IR-induced cell death. Thus, mitochondria...
Articles
Articles
Biochem J (2016) 473 (23): 4443–4456.
Published: 25 November 2016
... and pathophysiologic states. Current methods do not provide the sensitivity, specificity and spatiotemporal resolution needed for such experiments on intact cells. We developed the use of HyPer, a genetic indicator for H 2 O 2 that can be expressed in the cytosol (cyto-HyPer) or the mitochondria (mito-HyPer) of live...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (23): 4457–4471.
Published: 25 November 2016
... of 280 ± 2 pS in a symmetrical 150 mM KCl solution. The mitoBK Ca channel was activated by the Ca 2+ and by potassium channel opener NS1619. The channel activity was irreversibly inhibited by paxilline, a selective inhibitor of the BK Ca channels. In isolated fibroblast mitochondria NS1619 depolarized...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (22): 4103–4127.
Published: 10 November 2016
...Dave Speijer Reactive oxygen species (ROS) formation by mitochondria is an incompletely understood eukaryotic process. I proposed a kinetic model [BioEssays (2011) 33 , 88–94] in which the ratio between electrons entering the respiratory chain via FADH 2 or NADH (the F/N ratio) is a crucial...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (21): 3903–3921.
Published: 27 October 2016
...Guoqiang Wang; Elisabeth Mémin; Ishwarya Murali; Lawrence D. Gaspers The damage to liver mitochondria is universally observed in both humans and animal models after excessive alcohol consumption. Acute alcohol treatment has been shown to stimulate calcium (Ca 2+ ) release from internal stores...
Articles
Biochem J (2016) 473 (21): 3755–3758.
Published: 27 October 2016
.... Correspondence: Ján A. Miernyk ( miernykj@missouri.edu ) or ( jan.miernyk@ars.usda.gov ) 11 7 2016 19 8 2016 22 8 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 biogenesis bioinformatics mitochondria secondary structure...
Articles
Biochem J (2016) 473 (18): 2813–2829.
Published: 12 September 2016
...). To attain such high levels, GDH depends on very efficient mitochondrial targeting that, for human isoenzymes hGDH1 and hGDH2, is mediated by an unusually long cleavable presequence (N53). Here, we studied the mitochondrial transport of these proteins using isolated yeast mitochondria and human cell lines...
Includes: Supplementary data
Articles
Articles
Biochem J (2016) 473 (12): 1693–1702.
Published: 10 June 2016
... cuniculus (rabbit) 93% 3/150 No Rattus norvegicus (rat) 90% 6/150 No alternative splicing glycobiology mitochondria O-GlcNAc transferase (OGT) O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification (PTM) O-linked N -acetylglucosamine modification (O...
Articles
Articles
Biochem J (2016) 473 (9): 1191–1202.
Published: 26 April 2016
... myocardium after acute ischaemia/reperfusion. The aim of the present study was to identify harmful FA intermediates and their detrimental mechanisms of action in mitochondria and the ischaemic myocardium. In the present study, we found that the long-chain acyl-CoA and acylcarnitine content is increased...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (6): 797–804.
Published: 10 March 2016
... in a discontinuous sucrose density gradient (1–1.5 M) by ultracentrifugation (85000  g ) essentially as described in [ 12 ]. Optimal cell disruption was monitored using microscopy and nuclear contamination was monitored by Western blotting. To prepare submitochondrial fractions, mitochondria at a protein...
Articles
Articles
Biochem J (2015) 471 (2): 231–241.
Published: 02 October 2015
...Anjaneyulu Murari; Venkata Ramana Thiriveedi; Fareed Mohammad; Viswamithra Vengaldas; Madhavi Gorla; Prasad Tammineni; Thanuja Krishnamoorthy; Naresh Babu V. Sepuri Mitochondria play an essential role in synthesis and export of iron–sulfur (Fe–S) clusters to other sections of a cell. Although...
Includes: Supplementary data
Articles
Biochem J (2015) 469 (3): 357–366.
Published: 23 July 2015
...Vincenzo Abbate; Olivier Reelfs; Robert C. Hider; Charareh Pourzand Mitochondrial labile iron (LI) plays a crucial role in oxidative injuries and pathologies. At present, there is no organelle-specific sensitive iron sensor which can reside exclusively in the mitochondria and reliably monitor...
Includes: Supplementary data