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Keywords: migration
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Articles
Biochem J (2015) 472 (3): 393–403.
Published: 27 November 2015
... in the carcinogenesis of many human solid tumours. In the present study, we show that HOXB5 mRNA was significantly overexpressed in gastric cancer tissues compared with adjacent normal tissues. HOXB5 -up-regulated cancer cells showed increased invasion and migration activity, but no change in proliferation activity...
Includes: Supplementary data
Articles
Biochem J (2014) 460 (2): 295–307.
Published: 13 May 2014
... caveolar protein, and this interaction was dependent on Cav-1 expression. Knockdown of Cav-1 and Annx2 markedly decreased cell surface expression of ENO-1. ENO-1 overexpression increased cell migration and invasion in a Cav-1-dependent manner. Thus the differential association of ENO-1 with caveolar...
Includes: Supplementary data
Articles
Biochem J (2014) 460 (1): 117–129.
Published: 25 April 2014
... CRC migration and invasion, which are vital steps in CRC liver metastasis. miR-30b was significantly down-regulated in primary CRC specimens compared with normal tissues. Furthermore, miR-30b was much lower in liver metastasis tissues than in CRCs. We validated SIX1 (SIX homeobox 1), a member...
Includes: Supplementary data
Articles
Biochem J (2012) 448 (1): 35–42.
Published: 18 October 2012
... assay, suggesting that lamellipodial persistence as seen in two-dimensions is not crucial in three-dimensional environments. actin dynamics breast cancer cell invasion lamellipodium migration Scar/WAVE complex The mammalian Scar (suppressor of cAMP receptor)/WAVE [WASP (Wiskott...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2012) 443 (2): 491–503.
Published: 27 March 2012
... Tkachuk uPA (urokinase-type plasminogen activator) stimulates cell migration through multiple pathways, including formation of plasmin and extracellular metalloproteinases, and binding to the uPAR (uPA receptor; also known as CD87), integrins and LRP1 (low-density lipoprotein receptor-related protein 1...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (1): 13–25.
Published: 27 January 2012
... to its abundance in controlling cellular functions, ubiquitylation is also of key relevance to human pathologies, including cancer and inflammation. In the present review, we focus on its role in the control of cell adhesion, polarity and directional migration. It will become clear that protein...
Articles
Biochem J (2012) 441 (3): 979–987.
Published: 16 January 2012
... found that USP4 deubiquitinates both TRAF2 and TRAF6 in vivo and in vitro in a deubiquitinase activity-dependent manner. Importantly, the results of the present study showed that USP4 is a negative regulator of TNFα- and IL-1β-induced cancer cell migration. Taken together, the present study provides...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 665–674.
Published: 21 December 2011
... of these authors (email duanma@shmu.edu.cn or zhmao@shum.edu.cn ). 23 3 2011 19 9 2011 26 9 2011 26 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 invasion Kunitz-type domain migration prosaposin protein–protein interaction tissue factor pathway...
Articles
Biochem J (2011) 439 (3): 469–477.
Published: 13 October 2011
...Kathye Verreman; Jean-Luc Baert; Alexis Verger; Hervé Drobecq; Elisabeth Ferreira; Yvan de Launoit; Didier Monte The PEA3 (polyoma enhancer activator 3) group members [ERM (ETS-related molecule), ER81 (ETS-related 81) and PEA3] of the Ets transcription factor family are involved in migration...
Articles
Biochem J (2010) 427 (1): 29–40.
Published: 15 March 2010
... growth factor) receptors], thereby regulating cell signalling, migration, proliferation and network assembly. Neuropilin-1 co-immunoprecipitated and co-localized with phosphorylated PDGFRs in the presence of growth factors. Neuropilin-1 knockdown blocked PDGF-AA-induced PDGFRα phosphorylation...
Includes: Supplementary data
Articles
Biochem J (2009) 418 (1): 13–27.
Published: 28 January 2009
... diseases, as well as to prevent transplant rejection. However, there is substantial evidence for PI3K-independent mechanisms that facilitate T-lymphocyte migration. In this regard, several other signalling-pathway components, including small GTPases, PLC (phospholipase C) and PKC (protein kinase C...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2005) 389 (2): 333–341.
Published: 05 July 2005
...Eva M. JiméNez-Mateos; Francisco Wandosell; Orly Reiner; Jesús Avila; Christian González-Billault For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding...
Articles
Biochem J (2004) 377 (2): 449–457.
Published: 15 January 2004
... cell migration. To examine the nischarin–α5 interaction in detail, and to find the minimal region required for the interaction, several mutants of nischarin and α5 were created. The results obtained for the yeast two-hybrid system indicate that a 99-aminoacid region of nischarin (from residues 464...
Articles
Biochem J (2003) 371 (2): 233–241.
Published: 15 April 2003
... 2003 The Biochemical Society, London ©2003 2003 actin endocytosis migration phagocytosis pinocytosis Abbreviations used: ACK, activated Cdc42-associated tyrosine kinase; Arp2/3 complex, Arp2–Arp3 complex; EGF, epidermal growth factor; GPI, glycosyl-phosphatidylinositol; Hrs...
Articles
Biochem J (2001) 357 (1): 39–47.
Published: 25 June 2001
...Guillermo LÓPEZ-LLUCH; Margaret M. BIRD; Benito CANAS; Jasminka GODOVAC-ZIMMERMAN; Anne RIDLEY; Anthony W. SEGAL; Lodewijk V. DEKKER Neutrophils play a key role in host-defence mechanisms against invading pathogens, using their capacity to migrate, engulf micro-organisms and produce toxic radicals...
Articles
Biochem J (2000) 352 (2): 399–407.
Published: 24 November 2000
... prevented desensitization, as determined by intracellular calcium mobilization by sequential stimulation with ligand. In chemotaxis assays, the N297A mutation resulted in cell migration towards gradients of up to 100nM N -formyl-methionyl-leucyl-phenylalanine (fMLF), whereas cells expressing the wild-type...