Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Date
Availability
1-29 of 29
Keywords: metastasis
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (11): 1149–1164.
Published: 08 June 2022
..., providing protection against natural killer (NK) cell killing activity. We utilized small interfering RNA (siRNA) to down-regulate UCKL-1 in vitro and in vivo to determine the effect of UCKL-1 on tumor growth and metastasis. The down-regulation of UCKL-1 in YAC-1 lymphoma cells in vitro resulted...
Articles
Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Journal:
Biochemical Journal
Biochem J (2022) 479 (5): 719–730.
Published: 16 March 2022
.... In fact, some of the AATs are actually down-regulated in response to Slc6a14 deletion, most likely related to altered mTORC1 signaling. Taken together, these results underscore the positive role SLC6A14 plays in PDAC growth and metastasis. Therefore, SLC6A14 is a viable drug target for the treatment...
Articles
Ravichandran Vignesh, Anita Sjölander, Ganesh Venkatraman, Suresh Kumar Rayala, Gopala Krishna Aradhyam
Journal:
Biochemical Journal
Biochem J (2021) 478 (12): 2265–2283.
Published: 18 June 2021
... supernatants from tumor cells have significantly higher amounts of secreted calnuc compared to non-tumor cells, selectively packaged into exosomes. Exosomal calnuc is causal for epithelial–mesenchymal transition and atypical migration in non-tumor cells, which are key events in tumorigenesis and metastasis...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (9): 1809–1825.
Published: 14 May 2021
... that have been co-opted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 597–617.
Published: 12 February 2021
... and systemically. Recently, a new concept has emerged to better describe this process by defining four attributes that metastatic cells should undergo. Every individual hallmark represents a unique trait of a metastatic cell that impacts directly in the outcome of the metastasis process. These critical features...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
...Min Du; Guozheng Wang; Igor L. Barsukov; Stephane R. Gross; Richard Smith; Philip S. Rudland Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes. S100P can differentially interact with nonmuscle...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (16): 2321–2346.
Published: 28 August 2019
..., gene mutations that lead to increased expression of Golgi-targeted PI4P-binding proteins or PI 4-kinases can be associated with a distended Golgi morphology [ 37 ] and the anterograde trafficking of proteins [ 38 – 41 ] that drive angiogenesis [ 42 , 43 ], tumour invasion [ 44 – 47 ] and metastasis...
Articles
Christopher J. Clarke, Stephane R. Gross, Thamir M. Ismail, Philip S. Rudland, Morteta Al-Medhtiy, Michael Santangeli, Roger Barraclough
Journal:
Biochemical Journal
Biochem J (2017) 474 (19): 3227–3240.
Published: 12 September 2017
...Christopher J. Clarke; Stephane R. Gross; Thamir M. Ismail; Philip S. Rudland; Morteta Al-Medhtiy; Michael Santangeli; Roger Barraclough S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype...
Includes: Supplementary data
Articles
Shashi K. Gopal, David W. Greening, Alin Rai, Maoshan Chen, Rong Xu, Adnan Shafiq, Rommel A. Mathias, Hong-Jian Zhu, Richard J. Simpson
Journal:
Biochemical Journal
Biochem J (2017) 474 (1): 21–45.
Published: 22 December 2016
... of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial–mesenchymal transition, EMT), which is associated with increased...
Articles
Lopamudra Das, Shrikant Babanrao Kokate, Suvasmita Rath, Niranjan Rout, Shivaram Prasad Singh, Sheila Eileen Crowe, Asish K. Mukhopadhyay, Asima Bhattacharyya
Journal:
Biochemical Journal
Biochem J (2016) 473 (11): 1629–1640.
Published: 27 May 2016
...) is an E3 ubiquitin ligase which has been implicated in various cancers but its role in H. pylori -mediated gastric carcinogenesis has not been established. We investigated the involvement of Siah2 in gastric cancer metastasis which was assessed by invasiveness and migration of H. pylori -infected gastric...
Includes: Supplementary data
Articles
Mariana F. Rodrigues, Emilie Obre, Fabiana H.M. de Melo, Gilson C. Santos, Jr, Antonio Galina, Miriam G. Jasiulionis, Rodrigue Rossignol, Franklin D. Rumjanek, Nivea D. Amoêdo
Journal:
Biochemical Journal
Biochem J (2016) 473 (6): 703–715.
Published: 10 March 2016
... environments, particularly with regard to oxygen and nutrient availability. Our results indicate that progression to metastasis requires mitochondrial function. Our research, centered on cell lines that display increasing degrees of malignancy, focused on metabolic events, especially those involving...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (4): 449–461.
Published: 09 February 2016
... regulation of FABP5 gene expression plays an important role during human prostate carcinogenesis, along with up-regulation of c-Myc and Sp1. DNA methylation epigenetics fatty-acid-binding proteins (FABPs) FABP5 metastasis prostate cancer Genomic DNA was extracted from each cell line...
Includes: Supplementary data
Articles
Beáta Biri, Bence Kiss, Róbert Király, Gitta Schlosser, Orsolya Láng, László Kőhidai, László Fésüs, László Nyitray
Journal:
Biochemical Journal
Biochem J (2016) 473 (1): 31–42.
Published: 09 December 2015
... and include matrix remodelling, adhesion and migration. S100A4 belongs to the Ca 2+ -binding EF-hand S100 protein family and acts both intra- and extra-cellularly through binding to various partners. It regulates cell migration and its overexpression is strongly associated with metastasis and poor survival...
Articles
Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity
Journal:
Biochemical Journal
Biochem J (2015) 465 (1): 89–101.
Published: 12 December 2014
...Fauzia Chaudhary; Robert Lucito; Nicholas K. Tonks MIM (Missing-in-Metastasis), also known as MTSS1 (metastasis suppressor 1), is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared with non-metastatic counterparts. MIM regulates cytoskeletal dynamics...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (1): 157–165.
Published: 08 September 2014
... the proliferation of various breast and ovarian cancer cell lines in association with activation of MAPK signalling. Since that time, studies have revealed the ATX–LPA signalling axis to be capable of influencing growth, invasion, metastasis and even the therapeutic response of breast cancer. autotaxin...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 426 (3): 327–335.
Published: 24 February 2010
...Isao Matsuura; Chen-Yu Lai; Keng-Nan Chiang TGF-β (transforming growth factor-β) induces a cytostatic response in most normal cell types. In cancer cells, however, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we show that S100A4...
Articles
Daisuke Kamei, Makoto Murakami, Yuka Sasaki, Yoshihito Nakatani, Masataka Majima, Yukio Ishikawa, Toshiharu Ishii, Satoshi Uematsu, Shizuo Akira, Shuntaro Hara, Ichiro Kudo
Journal:
Biochemical Journal
Biochem J (2010) 425 (2): 361–371.
Published: 23 December 2009
... vascular endothelial growth factor, and the activity of matrix metalloproteinase-2. Lung metastasis of intravenously injected LLC cells was also significantly less obvious in mPGES-1-null mice than in wild-type mice. Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 447–457.
Published: 28 May 2008
... kinetics: (2) cancer metastasis peptide phage display serine protease urokinase-type plasminogen activator (uPA) Serine proteases of the trypsin family (clan SA) have many physiological and pathophysiological functions. There is therefore extensive interest in generating specific...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (3): 635–649.
Published: 15 January 2008
.... There is now overwhelming evidence that chemokines are also involved in the progression of cancer, where they function in several capacities. First, specific chemokine–receptor pairs are involved in tumour metastasis. This is not surprising, in view of their role as chemoattractants in cell migration. Secondly...
Includes: Multimedia, Supplementary data
Articles
Sabine Middelhaufe, Livia Garzia, Uta-Maria Ohndorf, Barbara Kachholz, Massimo Zollo, Clemens Steegborn
Journal:
Biochemical Journal
Biochem J (2007) 407 (2): 199–205.
Published: 25 September 2007
...Sabine Middelhaufe; Livia Garzia; Uta-Maria Ohndorf; Barbara Kachholz; Massimo Zollo; Clemens Steegborn The human orthologue of the Drosophila prune protein (h-Prune) is an interaction partner and regulator of the metastasis suppressor protein NM23-H1 (non-metastatic protein 23). Studies...
Articles
Susan WILSON, Brett GREER, John HOOPER, Andries ZIJLSTRA, Brian WALKER, James QUIGLEY, Susan HAWTHORNE
Journal:
Biochemical Journal
Biochem J (2005) 388 (3): 967–972.
Published: 07 June 2005
... and malignant cell types. Previous in vitro studies on prostate cancer cells suggest a role for PAR-2 in prostate cancer metastasis. A polyclonal anti-human TMPRSS2 antibody was generated against the TMPRSS2 serine protease domain. The antibody showed specific reactivity with recombinant expressed TMPRSS2...
Articles
Hironori YAMAGUCHI, Joji KITAYAMA, Noriko TAKUWA, Kayo ARIKAWA, Isao INOKI, Kazuhiko TAKEHARA, Hirokazu NAGAWA, Yoh TAKUWA
Journal:
Biochemical Journal
Biochem J (2003) 374 (3): 715–722.
Published: 15 September 2003
... to stimulation of cell migration, particularly at the lower S1P concentrations. Treatment of B16F10 cells with S1P inhibited lung metastasis 3 weeks after injection into mouse tail veins. Intriguingly, overexpression of S1P 2 greatly potentiated the inhibition of metastasis by S1P, whereas that of S1P 1 resulted...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 371 (2): 463–471.
Published: 15 April 2003
...Jacquelyn A. WOODINGS; Stewart J. SHARP; Laura M. MACHESKY We have found that MIM-B, a putative metastasis suppressor protein, is implicated in actin cytoskeletal control and interaction with a protein tyrosine phosphatase (PTP). MIM was originally described as a protein whose mRNA was M issing i n...
Articles
Albert M. WU, June H. WU, Ming-Sung TSAI, Jia-Hau LIU, Sabine ANDRÉ, Kojiro WASANO, Herbert KALTNER, Hans-Joachim GABIUS
Journal:
Biochemical Journal
Biochem J (2002) 367 (3): 653–664.
Published: 01 November 2002
... correspondence should be addressed (e-mail amwu@mail.cgu.edu.tw ). 16 4 2002 9 7 2002 22 7 2002 22 7 2002 The Biochemical Society, London ©2002 2002 enterocyte lacto- N -tetraose lectin-combining sites metastasis raft Abbreviations used: CRD, carbohydrate...
Articles
David M. SHAW, Andrew M. WOODS, Kevin A. MYERS, Caroline WESTWATER, Veena RAHI-SAUND, Michael J. DAVIES, David V. RENOUF, Elizabeth F. HOUNSELL, Peter L. STERN
Journal:
Biochemical Journal
Biochem J (2002) 363 (1): 137–145.
Published: 22 March 2002
..., London ©2002 2002 leucine-rich repeat protein metastasis oncotrophoblast antigen oligosaccharide tumour-associated antigen Abbreviations used: 2-AB, 2-aminobenzamide; ECL ® (Amersham Biosciences), enhanced chemiluminescence; GU, glucose units; HPAEC—PAD, high-pH anion-exchange...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 349 (1): 189–193.
Published: 26 June 2000
... not affect the level of MMP-2 secretion, and after zymography the level of enzyme activity was 78% of control values after 18 h incubation. The secretion of MMPs is linked to increased cellular invasion and, in tumours, to increased capacity for metastasis. The ability of CaCo-2 cells to invade in a chamber...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 346 (3): 623–630.
Published: 07 March 2000
...Paul D. WAGNER; Ngoc-Diep VU nm23 genes have been implicated in the suppression of tumour metastasis and cell motility; however, the biochemical mechanisms for these suppressions are not known. We have previously described the transfer of phosphate from the catalytic histidine residues of nm23...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 343 (1): 71–75.
Published: 24 September 1999
... cell lines, which has been observed by others. 1 To whom correspondence should be addressed (e-mail prehm@uni-muenster.de ). 7 4 1999 1 6 1999 16 7 1999 The Biochemical Society, London © 1999 1999 CD44 cell-surface receptors metastasis Biochem. J. (1999) 343...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 342 (2): 361–368.
Published: 24 August 1999
... specificities, peptide sequences and immunoreactivities, we propose that heparanase activities present in human platelets, rat liver and in rat and human tumour cells are, in fact, mediated by a similar enzyme. Key words: cancer, ECM degradation, heparan sulphate, hep- arin, metastasis. both heparin and HS...
