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Keywords: melanoma
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Biochem J (2023) 480 (23): 1951–1968.
Published: 01 December 2023
... pathways or inhibit ATP-consuming anabolic pathways, helping to restore cellular energy balance. Analysis of human cancer genome studies reveals that the PRKAA2 gene (encoding the α2 isoform of the catalytic subunit) is often subject to mis-sense mutations in cancer, particularly in melanoma and non...
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Biochem J (2023) 480 (23): 1929–1949.
Published: 01 December 2023
... transformation of healthy cells into melanoma, basal cell carcinoma or squamous cell carcinoma tumours. One such family of channel proteins critical for cellular communication is pannexins (PANX1, PANX2, PANX3), all of which are present in the skin. These heptameric single-membrane channels act as conduits...
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Biochem J (2015) 471 (2): 267–279.
Published: 02 October 2015
..., we found in a previous study that protein levels of several peroxiredoxins, including PRDX6 (peroxiredoxin 6), are highly elevated in experimentally induced melanomas. In the present study, we investigated the functional role of PRDX6 in human melanoma cells. PRDX6 is a bifunctional enzyme, which...
Includes: Supplementary data
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Biochem J (2011) 437 (1): 97–107.
Published: 14 June 2011
...Alice Barbarin; Raymond Frade The switch of human melanoma cell phenotype from non to highly tumorigenic and metastatic is triggered by the increase of procathepsin L secretion, which modifies the tumour microenvironment. The aim of the present study was to identify components involved...
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