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Keywords: malaria
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Biochem J (2022) 479 (24): 2529–2546.
Published: 22 December 2022
...Melanie H. Dietrich; Mikha Gabriela; Kitsanapong Reaksudsan; Matthew W. A. Dixon; Li-Jin Chan; Amy Adair; Stephanie Trickey; Matthew T. O'Neill; Li Lynn Tan; Sash Lopaticki; Julie Healer; Sravya Keremane; Alan F. Cowman; Wai-Hong Tham Transmission blocking interventions can stop malaria parasite...
Includes: Supplementary data
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Biochem J (2022) 479 (3): 337–356.
Published: 04 February 2022
...Samuel Pazicky; Arne Alder; Haydyn Mertens; Dmitri Svergun; Tim Gilberger; Christian Löw As the decline of malaria cases stalled over the last five years, novel targets in Plasmodium falciparum are necessary for the development of new drugs. Glycogen Synthase Kinase (PfGSK3) has been identified...
Includes: Supplementary data
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Biochem J (2021) 478 (3): 579–595.
Published: 10 February 2021
... in the absence of other nanobodies. Percentage competition was calculated by dividing the max response of the premixed Pf12p D1D2 and nanobody solution binding by the max response of Pf12p binding alone, multiplied by 100. Plasmodium falciparum is the most lethal of human malaria species...
Includes: Supplementary data
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Biochem J (2020) 477 (7): 1323–1344.
Published: 17 April 2020
... Society 2020 Plasmodium falciparum metacaspase-2 apoptosis-like cell death malaria mitochondrial potential oxidative stress SS-5 Z-FA-FMK analog Apoptosis is a highly regulated phenomenon important for the maintenance of homeostasis in tissues and during embryonic development [ 1...
Includes: Supplementary data
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Biochem J (2016) 473 (19): 3189–3204.
Published: 27 September 2016
...Nyssa Drinkwater; Komagal Kannan Sivaraman; Rebecca S. Bamert; Wioletta Rut; Khadija Mohamed; Natalie B. Vinh; Peter J. Scammells; Marcin Drag; Sheena McGowan Malaria is one of the world's most prevalent parasitic diseases, with over 200 million cases annually. Alarmingly, the spread of drug...
Includes: Supplementary data
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Biochem J (2014) 461 (3): 349–369.
Published: 10 July 2014
...Nyssa Drinkwater; Sheena McGowan Despite a century of control and eradication campaigns, malaria remains one of the world's most devastating diseases. Our once-powerful therapeutic weapons are losing the war against the Plasmodium parasite, whose ability to rapidly develop and spread drug...
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Biochem J (2014) 461 (2): 189–203.
Published: 26 June 2014
...Neha Singhal; Atul; Babu S. Mastan; Kota Arun Kumar; Puran Singh Sijwali Malaria parasites must respond to stresses and environmental signals to perpetuate efficiently during their multistage development in diverse environments. To gain insights into the parasite's stress response mechanisms, we...
Includes: Supplementary data
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Biochem J (2013) 452 (3): 457–466.
Published: 31 May 2013
...Klemens Engelberg; Aditya S. Paul; Boris Prinz; Maya Kono; Wilhelm Ching; Dorothee Heincke; Thomas Dobner; Tobias Spielmann; Manoj T. Duraisingh; Tim-Wolf Gilberger Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high...
Includes: Supplementary data
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Biochem J (2012) 443 (2): 397–405.
Published: 27 March 2012
...Julia Knöckel; Ingrid B. Müller; Sabine Butzloff; Bärbel Bergmann; Rolf D. Walter; Carsten Wrenger The malaria parasite Plasmodium falciparum is able to synthesize de novo PLP (pyridoxal 5′-phosphate), the active form of vitamin B 6 . In the present study, we have shown that the de novo synthesized...
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Biochem J (2011) 438 (2): 229–244.
Published: 12 August 2011
...Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I. Louw; Lo Persson; Olle Heby New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 436 (3): 641–650.
Published: 27 May 2011
...Esther Jortzik; Boniface M. Mailu; Janina Preuss; Marina Fischer; Lars Bode; Stefan Rahlfs; Katja Becker The survival of malaria parasites in human RBCs (red blood cells) depends on the pentose phosphate pathway, both in Plasmodium falciparum and its human host. G6PD (glucose-6-phosphate...
Includes: Supplementary data
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Biochem J (2008) 415 (2): 309–316.
Published: 25 September 2008
...Cecilia Giulivi; Catherine Ross-Inta; Ashley A. Horton; Shirley Luckhart No studies have been performed on the mitochondria of malaria vector mosquitoes. This information would be valuable in understanding mosquito aging and detoxification of insecticides, two parameters that have a significant...
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Biochem J (2007) 402 (1): 197–204.
Published: 25 January 2007
...John M. Pisciotta; Isabelle Coppens; Abhai K. Tripathi; Peter F. Scholl; Joel Shuman; Sunil Bajad; Vladimir Shulaev; David J. Sullivan, Jr The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin...
Includes: Supplementary data
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Biochem J (2004) 383 (3): 401–412.
Published: 26 October 2004
...Avadhesha SUROLIA; T. N. C. RAMYA; V. RAMYA; Namita SUROLIA Malaria, a tropical disease caused by Plasmodium sp., has been haunting mankind for ages. Unsuccessful attempts to develop a vaccine, the emergence of resistance against the existing drugs and the increasing mortality rate all call...
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Biochem J (2004) 381 (3): 905–909.
Published: 27 July 2004
...Thierry JOËT; Kesinee CHOTIVANICH; Kamolrat SILAMUT; Asha P. PATEL; Christophe MORIN; Sanjeev KRISHNA Plasmodium vivax is the second most common species of malaria parasite and causes up to 80 million episodes of infection each year. New drug targets are urgently needed because of emerging...
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Biochem J (2004) 381 (3): 593–597.
Published: 27 July 2004
... demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs. 1 To whom...
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Biochem J (2002) 363 (3): 833–838.
Published: 24 April 2002
..., in which γ-glutamylcysteine synthetase (γ-GCS) catalyses the ligation of glutamate and cysteine and subsequently glutathione synthetase (GS) adds glycine to the dipeptide. Recently it was shown that the synthesis of γ-glutamylcysteine is crucial for the survival of the erythrocytic stages of the malaria...
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Biochem J (2001) 360 (2): 481–489.
Published: 26 November 2001
...Puran S. SIJWALI; Bhaskar R. SHENAI; Jiri GUT; Ajay SINGH; Philip J. ROSENTHAL In the malaria parasite Plasmodium falciparum , erythrocytic trophozoites hydrolyse haemoglobin to provide amino acids for parasite protein synthesis. Cysteine protease inhibitors block parasite haemoglobin hydrolysis...
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Biochem J (2001) 355 (2): 333–338.
Published: 06 April 2001
...Amit V. PANDEY; Himani BISHT; Vinod K. BABBARWAL; Jaya SRIVASTAVA; Kailash C. PANDEY; Virander S. CHAUHAN The haem detoxification pathway of the malaria parasite Plasmodium falciparum is a potential biochemical target for drug development. Free haem, released after haemoglobin degradation...
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Biochem J (1999) 339 (2): 363–370.
Published: 08 April 1999
...Paul LORIA; Susanne MILLER; Michael FOLEY; Leann TILLEY The malaria parasite feeds by degrading haemoglobin in an acidic food vacuole, producing free haem moieties as a by-product. The haem in oxyhaemoglobin is oxidized from the Fe(II) state to the Fe(III) state with the consequent production...