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Keywords: macrophage
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Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
... various chronic diseases. Recently, examining the effects of bioactive compounds on autophagy activity in atherogenesis has drawn considerable attention. The current review discusses the role of macrophage autophagy in the development and progression of atherosclerosis. We also summarize our current...
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Biochem J (2017) 474 (4): 521–537.
Published: 03 February 2017
...Nicola J. Darling; Rachel Toth; J. Simon C. Arthur; Kristopher Clark The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti...
Includes: Supplementary data
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Biochem J (2014) 463 (1): 75–82.
Published: 08 September 2014
... study, we show that cAMP-induced modulation of the RAGE isoform in macrophages can control the inflammatory state in both in vitro and in vivo experimental conditions. The RAGE ligand S100B stimulated MCP-1 (monocyte chemoattractant protein-1) secretion from peritoneal macrophages, but cAMP elevation...
Includes: Supplementary data
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Biochem J (2014) 461 (2): 177–188.
Published: 26 June 2014
... such as macrophages and T-cells and the impact this can have on systemic inflammation and insulin resistance. We also dissect the mechanisms by which SOCS (1–7) regulate insulin signalling in different tissues including their impact on the insulin receptor and insulin receptor substrates. Lastly, we discuss...
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Biochem J (2014) 458 (2): 187–193.
Published: 14 February 2014
... mobilize from the bone marrow to wounded tissues where they differentiate into macrophages or dendritic cells and trigger an immune response. In the healthy heart a limited, but near-constant, number of resident macrophages have been detected; however, this number significantly increases during cardiac...
Includes: Multimedia, Supplementary data
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Biochem J (2013) 454 (3): 543–549.
Published: 29 August 2013
... enterica sv. Typhimurium could act as antioxidants and protect from the oxidative stress encountered after macrophage invasion. Our results show that the ability to produce siderophores enhanced the survival of Salmonella in the macrophage mainly at the early stages of infection, coincident...
Includes: Supplementary data
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Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
... by the infiltration of immune cells into the adipose tissue and the vascular walls respectively. The monocyte/macrophage populations that are recruited in these seemingly different settings also display a high similarity by exhibiting similar phenotypes in both conditions. In the insulin resistant as well...
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Biochem J (2013) 449 (1): 69–78.
Published: 07 December 2012
.... In the present study, we characterize the cellular and systemic factors influencing Fpn expression in Hmox1 −/− bone marrow-derived macrophages and in the liver and kidney of Hmox1 −/− mice. In Hmox1 −/− macrophages, Fpn protein was relatively highly expressed under high levels of hepcidin in culture medium...
Includes: Supplementary data
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Biochem J (2012) 445 (2): 229–236.
Published: 27 June 2012
...Shubha Murthy; Alan J. Ryan; A. Brent Carter Rac1, a small GTPase, regulates macrophage MMP (matrix metalloproteinase)-9 in an ERK (extracellular-signal-regulated kinase)- and SP (specificity protein)-1-dependent manner. SP-1 contains a PEST (Pro-Glu-Ser-Thr) domain that may modulate protein...
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Biochem J (2012) 444 (1): 51–57.
Published: 26 April 2012
...Maud E. S. Achard; Sian L. Stafford; Nilesh J. Bokil; Jy Chartres; Paul V. Bernhardt; Mark A. Schembri; Matthew J. Sweet; Alastair G. McEwan The movement of key transition metal ions is recognized to be of critical importance in the interaction between macrophages and intracellular pathogens...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 436 (2): 351–362.
Published: 13 May 2011
...Gregory J. Tesz; Myriam Aouadi; Matthieu Prot; Sarah M. Nicoloro; Emilie Boutet; Shinya U. Amano; Anca Goller; Mengxi Wang; Chang-An Guo; William E. Salomon; Joseph V. Virbasius; Rebecca A. Baum; Mark J. O'Connor, Jr; Ernesto Soto; Gary R. Ostroff; Michael P. Czech Phagocytic macrophages...
Includes: Supplementary data
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Biochem J (2010) 430 (2): 237–244.
Published: 13 August 2010
... in the present study that MEF2A and MEF2D, two other MEF2 family members, are expressed in human primary monocytes and in higher amounts in monocyte-derived macrophages. High levels of MEF2A–MEF2D heterodimers are found in macrophage-differentiated HL60 cells. Chromatin immunoprecipitations demonstrate...
Includes: Supplementary data
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Biochem J (2010) 425 (3): 595–602.
Published: 15 January 2010
... that in macrophages the TLR (Toll-like receptor)-mediated induction of IL-1ra from both its proximal and distal promoters involves the p38 and ERK1/2 (extracellular-signal-regulated kinase 1/2) MAPK (mitogen-activated protein kinase) cascades. In addition, we show that MSK1 and 2 (mitogen- and stress-activated kinase...
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Biochem J (2010) 425 (1): 169–180.
Published: 14 December 2009
... particularly in macrophages has been implicated in many diseases. We demonstrate in the present study that GRK2 and GRK5 (G-protein-coupled-receptor kinases 2 and 5) regulate TNFα-induced NF-κB signalling in Raw 264.7 macrophages. RNAi (RNA interference) knockdown of GRK2 or GRK5 in macrophages significantly...
Includes: Supplementary data
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Biochem J (2009) 423 (1): e5–e8.
Published: 14 September 2009
... N. Hazeki K. Okazaki N. Kametani Y. Murakami H. Takaba Y. Ishikawa Y. Nigorikawa K. Hazeki O. Specific role of phosphoinositide 3-kinase p110α in the regulation of phagocytosis and pinocytosis in macrophages Biochem. J. 2009 423 99 108 9...
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Biochem J (2009) 422 (2): 373–382.
Published: 13 August 2009
... by macrophage-like RAW264.7 cells. The insert region of Rac2 is also dispensable for gp91 phox /Nox2 activation at the cellular level. Although Rac2, as well as Rac1, is capable of enhancing superoxide production by Nox1 and Nox3, the enhancements by the two GTPases are both independent of the insert region. We...
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Biochem J (2007) 402 (2): 387–395.
Published: 12 February 2007
... (lipopolysaccharide). In the present study, we showed that LPS increased levels of resistin mRNA and promoter activity in murine RAW264.7 macrophages. Investigation of cis -regulatory elements in the mouse resistin promoter required for LPS-mediated induction showed that an Octamer (ATTTGCAT) element, located at −914...
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Biochem J (2005) 391 (1): 51–57.
Published: 26 September 2005
... that have revealed an important role for it in lymphocyte activation. In contrast, the physiological role of ADA2 is unknown. ADA2 is found in negligible quantities in serum and may be produced by monocytes/macrophages. ADA2 activity in the serum is increased in various diseases in which monocyte/macrophage...
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Biochem J (2005) 389 (3): 877–884.
Published: 26 July 2005
... macrophage oxidative stress In attempts to explain the cytotoxic effects of radiation damage, HO · has been repeatedly invoked as an important intermediate, because HO · forms by radiolysis of water. It is generally assumed that HO · -mediated DNA damage, particularly in S-phase cells, which...
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Biochem J (2005) 387 (2): 355–365.
Published: 05 April 2005
... predisposition to or outcome of Gram-negative sepsis. In the present work, we studied the expression and regulation of the Tlr4 gene of mouse. In vivo , TLR4 levels were higher in macrophages compared with B, T or natural killer cells. High basal TLR4 promoter activity was observed in RAW 264.7, J774 and P388D1...
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Biochem J (2004) 379 (1): 11–22.
Published: 01 April 2004
.... It is also apparent from work with HSL null mice that more than one enzyme species may be classified as a hormone-sensitive lipase. The possible presence of HSL in macrophages remains controversial, and the role of the protein in pancreatic β-cells has yet to be fully elucidated. Altered expression of HSL...
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Biochem J (2003) 376 (3): 545–552.
Published: 15 December 2003
... signalling pathways play a significant role in many aspects of immune responses, from development, differentiation, activation and survival of lymphocytes to macrophage activation. The importance of PKCs in cellular immune responses suggests that improved understanding of the molecular events that govern...
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Biochem J (2003) 374 (1): 97–107.
Published: 15 August 2003
... in situ hybridization. The results from both immunohistochemistry and in situ hybridization indicate that EOS is associated with macrophages. We corroborated this observation by double immunofluorescence using the anti-EOS antibody and an anti-CD68 antibody, a macrophage specific marker. Furthermore, we...
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Biochem J (2003) 369 (3): 447–452.
Published: 01 February 2003
...Sanjay GHOSH; Srikanta GOSWAMI; Samit ADHYA Intracellular parasitic protozoans of the genus Leishmania depend for their survival on the elaboration of enzymic and other mechanisms for evading toxic free-radical damage inflicted by their phagocytic macrophage host. One such mechanism may involve...
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Biochem J (2002) 366 (3): 689–704.
Published: 15 September 2002
... of the particles into a plasma membrane-derived vacuole known as the phagosome. Such nascent phagosomes, however, lack the ability to kill pathogens or to degrade the ingested targets. These properties are acquired during the course of phagosomal maturation, a complex sequence INTRODUCTION Macrophages...
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Biochem J (2002) 364 (2): 329–341.
Published: 01 June 2002
... and the relation of skeletal and non-skeletal structures. Removal of mineralized matrix involves apoptosis of matrix cells and differentiation of acid-secreting cells (osteoclasts) from macrophage precursors. Key regulators of matrix removal are signals in the tumour-necrosis-factor family. Osteoclasts dissolve...
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Biochem J (2001) 357 (2): 521–527.
Published: 09 July 2001
...Román GALETTO; Marta ALBAJAR; José I. POLANCO; Mario M. ZAKIN; José C. RODRÍGUEZ-REY Apolipoprotein E (apoE) is a protein involved in reverse cholesterol transport. Among other tissues, apoE is expressed in macrophages where its expression increases when macrophages develop into foam cells. It has...
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Biochem J (2001) 356 (1): 53–60.
Published: 08 May 2001
... 2001 The Biochemical Society, London ©2001 2001 cellular localization lysosome macrophage molecular cloning subcellular localization Abbreviations used: PHT, peptide/histidine transporter; r, rat; PepT, peptide transporter; PEPT, oligopeptide transporter; LAMP1, lysosome...
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Biochem J (1999) 342 (3): 503–507.
Published: 05 September 1999
...Li-Chun CHEN; Diane KEPKA-LENHART; Timothy M. WRIGHT; Sidney M. MORRIS, JR. Salicylate enhanced the interferon-γ-dependent activation of two transcription factors in a murine macrophage cell line: signal transducer and activator of transcription (STAT)1 and interferon-γ-responsive factor 1...