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Keywords: liver
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Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...
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Biochem J (2022) 479 (12): 1361–1374.
Published: 24 June 2022
...Lorenza A. D’Alessandro; Ursula Klingmüller; Marcel Schilling In health and disease, liver cells are continuously exposed to cytokines and growth factors. While individual signal transduction pathways induced by these factors were studied in great detail, the cellular responses induced by repeated...
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Biochem J (2021) 478 (6): 1227–1239.
Published: 19 March 2021
... with serious health consequences, including non-alcoholic fatty liver disease (NAFLD). Considered the hepatic manifestation of metabolic syndrome, NAFLD is characterised by dysregulated lipid metabolism leading to a lipid storage phenotype. Mild to moderate increases in hepatic iron have been observed in ∼30...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (3): 463–486.
Published: 05 February 2021
... in citrate entry into cells via the transporter. These findings raise doubts as to the utility of mouse models to evaluate NaCT biology in humans. NaCT-mediated citrate entry in the liver impacts fatty acid and cholesterol synthesis, fatty acid oxidation, glycolysis, and gluconeogenesis; in neurons...
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Biochem J (2020) 477 (18): 3583–3598.
Published: 28 September 2020
...Hao Hu; Masahiko Negishi Estrogen sulfotransferase (SULT1E1) metabolically inactivates estrogen and SULT1E1 expression is tightly regulated by multiple nuclear receptors. Human fetal, but not adult, livers express appreciable amounts of SULT1E1 protein, which is mimicked in human hepatoma-derived...
Includes: Supplementary data
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Biochem J (2015) 469 (1): 25–32.
Published: 19 June 2015
... with tandem mass tagging to provide precise, extensive coverage of S-glutathionylated targets in mouse liver. Critically, we show significant enrichment of S-glutathionylated mitochondrial and Krebs cycle proteins, identifying that S-glutathionylation is heavily involved in energy metabolism processes in vivo...
Includes: Supplementary data
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Biochem J (2015) 467 (3): 453–460.
Published: 17 April 2015
.... Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present study, we demonstrated the transcriptional regulation of the Igfbp-2 gene by peroxisome-proliferator-activated receptor (PPAR) α in the liver. During fasting, both...
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Biochem J (2014) 461 (2): 223–232.
Published: 26 June 2014
...Angela M. Betancourt; Adrienne L. King; Jessica L. Fetterman; Telisha Millender-Swain; Rachel D. Finley; Claudia R. Oliva; David R. Crowe; Scott W. Ballinger; Shannon M. Bailey NAFLD (non-alcoholic fatty liver disease) involves significant changes in liver metabolism characterized by oxidative...
Includes: Supplementary data
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Biochem J (2013) 453 (1): 71–82.
Published: 13 June 2013
...Kate M. Dudek; Laura Suter; Veerle M. Darras; Emma L. Marczylo; Timothy W. Gant Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic...
Includes: Supplementary data
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Biochem J (2013) 451 (1): 1–12.
Published: 14 March 2013
...Victor A. Zammit The liver regulates both glycaemia and triglyceridaemia. Hyperglycaemia and hypertriglyceridaemia are both characteristic of (pre)diabetes. Recent observations on the specialised role of DGAT2 (diacylglycerol acyltransferase 2) in catalysing the de novo synthesis...
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Biochem J (2013) 449 (2): 479–489.
Published: 14 December 2012
... tissue and soleus muscle, low in EDL (extensor digitorum longus) muscle and detectable in liver only after enrichment. Despite having lower blood glucose levels under both fasted and random-fed conditions, the AS160-knockout mice exhibited insulin resistance in both muscle and liver in a euglycaemic...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 829–839.
Published: 16 April 2012
... 2012 glucose heart hypothermia ketoacidosis liver pyruvate dehydrogenase complex (PDH complex) pyruvate dehydrogenase kinase (PDHK) skeletal muscle The PDH complex (pyruvate dehydrogenase complex) plays a pivotal role in controlling the concentrations of glucose in the fed...
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Biochem J (2012) 443 (1): 165–171.
Published: 14 March 2012
... in liver and its expression induces a metabolic state that mimics long-term fasting. Thus FGF21 is critical for the induction of hepatic fat oxidation, ketogenesis and gluconeogenesis, metabolic processes which are essential for the adaptive metabolic response to starvation. In the present study, we have...
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Biochem J (2012) 443 (1): 103–109.
Published: 14 March 2012
... 2012 Biochemical Society 2012 copper kidney liver resistance to thyroid hormone (RTH) thyroid hormone receptor In the present paper we report that, similar to Se, serum copper (Cu) levels are positively regulated by TH, mainly by directing the production of the Cu-transport protein...
Includes: Supplementary data
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Biochem J (2012) 441 (3): 1007–1016.
Published: 16 January 2012
... the presence of NTCP dimers in rat liver membranes and U2OS cells stably expressing NTCP. Co-immunoprecipitation of tagged NTCP proteins revealed a physical interaction between subunits. The C-terminus of NTCP was not required for subunit interaction, but was essential for exit from the ER (endoplasmic...
Includes: Supplementary data
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Biochem J (2011) 440 (3): 301–308.
Published: 28 November 2011
...), are tissue-dependent. Therefore we have developed insulin analogues with different binding affinities for the two isoforms to test whether tissue-preferential biological effects can be attained. In rats and mice, IR-B is the most prominent isoform in the liver (>95%) and fat (>90%), whereas in muscles...
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Biochem J (2011) 436 (3): 621–629.
Published: 27 May 2011
...Alex Odermatt; Thierry Da Cunha; Carlos A. Penno; Charlie Chandsawangbhuwana; Christian Reichert; Armin Wolf; Min Dong; Michael E. Baker The oxidized bile acid 7-oxoLCA (7-oxolithocholic acid), formed primarily by gut micro-organisms, is reduced in human liver to CDCA (chenodeoxycholic acid...
Includes: Supplementary data
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Biochem J (2011) 436 (1): 91–100.
Published: 27 April 2011
... receptor substrate-1 (IRS-1) liver macrophage paraoxonase paraoxonase 2 (PON2) A portion (4 μg) of crude membrane extracts prepared from isolated peritoneal macrophages was incubated with 10 μM C12 (3-oxo-C 12 -HSL) in a 50 μl volume of 25 mM Tris/HCl (pH 7.4) and 1 mM CaCl 2 at room...
Includes: Supplementary data
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Biochem J (2010) 430 (2): 305–313.
Published: 13 August 2010
... enzyme. To test this proposal we have investigated the uptake and intracellular distribution of rhHyal-1 (recombinant human Hyal-1) by mouse liver, making use of centrifugation methods. Experiments were performed on wild-type mice injected with 125 I-labelled rhHyal-1 and on Hyal-1 −/− mice injected...
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Biochem J (2009) 417 (1): 183–193.
Published: 12 December 2008
...Sudheer K. Mantena; Denty Paul Vaughn, Jr; Kelly K. Andringa; Heather B. Eccleston; Adrienne L. King; Gary A. Abrams; Jeannette E. Doeller; David W. Kraus; Victor M. Darley-Usmar; Shannon M. Bailey NAFLD (non-alcoholic fatty liver disease), associated with obesity and the cardiometabolic syndrome...
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Biochem J (2008) 413 (1): 151–161.
Published: 12 June 2008
... synthesis is dependent on Sec tRNA and the expression of this class of proteins can be modulated by altering Sec tRNA expression. The gene encoding Sec tRNA ( Trsp ) is a single-copy gene and its targeted removal in liver demonstrated that selenoproteins are essential for proper function wherein...
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Biochem J (2008) 411 (2): 261–270.
Published: 27 March 2008
...Nikolas G. Tsatsos; Michael N. Davies; Brennon L. O'callaghan; Howard C. Towle In the liver, induction of genes encoding enzymes involved in de novo lipogenesis occurs in response to increased glucose metabolism. ChREBP (carbohydrate-response-element-binding protein) is a basic helix–loop–helix...
Includes: Supplementary data
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Biochem J (2007) 404 (2): 169–178.
Published: 14 May 2007
... (which means treating diseases with the body's own cells). Potential targets for cellular therapy include diabetes and liver failure. However, in order for stem cells to be clinically useful, we must learn to identify them and to regulate their differentiation. We will use the intestine as a classical...
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Biochem J (2007) 403 (1): 89–95.
Published: 13 March 2007
... then contribute to the permeabilization of the outer mitochondrial membrane; they could also activate effector caspases. The present study aims at testing whether the membrane of liver lysosomes is disrupted during Fas-mediated cell death of hepatocytes in vivo , a process implicated in several liver pathologies...
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Biochem J (2006) 398 (3): 371–380.
Published: 29 August 2006
...Amalia Fernández-Martínez; Belén Mollá; Rafael Mayoral; Lisardo Boscá; Marta Casado; Paloma Martín-Sanz We have investigated the mechanism of COX-2 (cyclo-oxygenase 2)-dependent inhibition of apoptosis in liver, a key pathway underlying proliferative actions of COX-2 in liver cancers, cirrhosis...
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Biochem J (2006) 395 (3): 599–609.
Published: 11 April 2006
... with these enzymes, we hypothesized that the regulation of Mrp2 gene expression is also dependent on Nrf2. Using BHA (butylated hydroxyanisole), which is a classical activator of the ARE–Nrf2 pathway, we observed an increase in the transcriptional activity of Mrp2 , GCLC and Gsta1 / Gsta2 genes in the mouse liver...
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Biochem J (2006) 394 (1): 153–161.
Published: 27 January 2006
...Tanja Prick; Michael Thumm; Karl Köhrer; Dieter Häussinger; Stephan Vom Dahl In mammalian liver, proteolysis is regulated by the cellular hydration state in a microtubule- and p38 MAPK (p38 mitogen-activated protein kinase)-dependent fashion. Osmosensing in liver cells towards proteolysis...
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Biochem J (2005) 391 (3): 465–472.
Published: 25 October 2005
... lipid raft liver Niemann–Pick type C sphingolipidosis Niemann–Pick type C (NPC) disease is an autosomal, recessively inherited lysosomal storage disorder, characterized by endo-lysosomal accumulation of unesterified cholesterol and sphingolipids [ 1 ]. The disease is caused by mutations...
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Biochem J (2005) 389 (1): 57–62.
Published: 21 June 2005
...Silvia SENESI; Paola MARCOLONGO; Tamas KARDON; Giovanna BUCCI; Andrey SUKHODUB; Ann BURCHELL; Angelo BENEDETTI; Rosella FULCERI Glucose 6-phosphate transport has been well characterized in liver microsomes. The transport is required for the functioning of the glucose-6-phosphatase enzyme...
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Biochem J (2005) 386 (3): 575–581.
Published: 08 March 2005
... that circadian expression of mouse PPARα mRNA requires the basic helix–loop–helix PAS (Per-Arnt-Sim) protein CLOCK, a core component of the negative-feedback loop that drives circadian oscillators in mammals. The circadian expression of PPARα mRNA was abolished in the liver of homozygous Clock mutant mice. Using...
Includes: Supplementary data
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Biochem J (2004) 382 (2): 471–479.
Published: 24 August 2004
... for unpaired data. diabetes gluconeogenesis glucose-6-phosphatase insulin liver sepsis G6Pase (glucose-6-phosphatase) catalyses the final step of the metabolic pathways that are central to hepatic glucose production, i.e. gluconeogenesis and glycogen breakdown [ 1 ]. Thus G6Pase has...
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