... ]; for intrinsic oncogenic role of PI3Kβ: [ 19–21 ]; for PI3K role in PTEN loss of function consequences: [ 15 , 16 , 38 , 45 , 46 , 84 ]. Studies where both PI3Kα and PI3Kβ were involved were excluded. genetically engineered mouse models lipid signalling pharmacological inhibitors PI3K...

...) as a crucial effector of PRDX6-dependent proliferation and inducer of Src family kinase activation. These results support further the biological importance of the emerging field of lipid signalling in melanoma and highlight the particular functional relevance of PRDX6-dependent phospholipase activity. 1...

.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cancer kinase isoform lipid signalling phosphoinositide 3-kinase (PI3K) phosphatase and tensin homologue deleted on chromosome 10 (PTEN...

.... Key words: lipid signalling, phosphatase, phosphoinositide. INTRODUCTION PTEN (phosphatase and tensin homologue deleted on chromo- some 10) is a tumour suppressor and lipid phosphatase that ant- agonizes phosphoinositide 3-kinase-dependent signalling through metabolism of the membrane-localized lipid...

... enriched in mono- and di-unsaturated species that we propose to function as the intracellular messenger forms of this lipid. Key words: lipid signalling, mass spectrometry, PAE cells, phosphatidylbutanol, phosphatidylcholine. activity [6]. Additionally we, and others, have shown that PtdOH is involved...