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Keywords: leucine-rich repeat kinase
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Biochem J (2022) 479 (17): 1759–1783.
Published: 06 September 2022
...Alexia F. Kalogeropulou; Elena Purlyte; Francesca Tonelli; Sven M. Lange; Melanie Wightman; Alan R. Prescott; Shalini Padmanabhan; Esther Sammler; Dario R. Alessi Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce...
Includes: Supplementary data
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Biochem J (2020) 477 (7): 1203–1218.
Published: 02 April 2020
...Margaux Leemans; Christian Galicia; Egon Deyaert; Elise Daems; Linda Krause; Jone Paesmans; Els Pardon; Jan Steyaert; Arjan Kortholt; Frank Sobott; Dagmar Klostermeier; Wim Versées Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead...
Includes: Supplementary data
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Biochem J (2019) 476 (1): 51–66.
Published: 07 January 2019
... disease-associated protein LRRK2 (leucine-rich repeat kinase 2). We previously demonstrated that the Roco protein from Chlorobium tepidum (CtRoco) undergoes a dimer–monomer cycle during the GTPase reaction, with the protein being mainly dimeric in the nucleotide-free and GDP (guanosine-5′-diphosphate...
Includes: Supplementary data
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