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Keywords: kinases
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Articles
Biochem J (2023) 480 (20): 1693–1717.
Published: 30 October 2023
... calmodulin in the sensing unit [ 17 ]. Biosensors for reporting kinase activity typically feature a sensing unit designed to act as a surrogate substrate for the kinase of interest through the inclusion of a kinase-specific phosphorylation sequence and a phospho-amino acid binding domain (PAABD) [ 18...
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Biochem J (2023) 480 (11): 815–833.
Published: 12 June 2023
...Eliza Störmer; Jui-Hung Weng; Jian Wu; Daniela Bertinetti; Pallavi Kaila Sharma; Wen Ma; Friedrich W. Herberg; Susan S. Taylor LRR-kinase 2 (LRRK2) is a multi-domain protein with three catalytically inert N-terminal domains (NtDs) and four C-terminal domains, including a kinase and a GTPase domain...
Includes: Supplementary data
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Biochem J (2022) 479 (7): 825–838.
Published: 11 April 2022
... pluripotency as observed in the prototypical Protein Kinase A (PKA) as well as in other signaling systems, from typical multidomain signaling proteins to bacterial enzymes. We identify key drivers of pluripotent allostery and illustrate how hypothesizing allosteric pluripotency may solve apparent discrepancies...
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Biochem J (2021) 478 (17): 3179–3184.
Published: 07 September 2021
... proteolysis and kinase-mediated phosphorylation, enabling integration of signals from multiple pathways into the decision to commit to apoptosis. A new study from Maluch et al. examines how phosphorylation within caspase cleavage sites impacts the efficiency of substrate cleavage. The results demonstrate...
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Biochem J (2020) 477 (8): 1525–1539.
Published: 29 April 2020
...Matthew J. Byrne; Nazia Nasir; Christine Basmadjian; Chitra Bhatia; Rory F. Cunnison; Katherine H. Carr; Corine Mas-Droux; Sharon Yeoh; Céline Cano; Richard Bayliss Nek7 is a serine/threonine-protein kinase required for proper spindle formation and cytokinesis. Elevated Nek7 levels have been...
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Biochem J (2018) 475 (5): 905–921.
Published: 09 March 2018
...Alexander S. Moffett; Diwakar Shukla Eukaryotic protein kinases (PKs) are a large family of proteins critical for cellular response to external signals, acting as molecular switches. PKs propagate biochemical signals by catalyzing phosphorylation of other proteins, including other PKs, which can...
Articles
Biochem J (2018) 475 (1): 117–135.
Published: 02 January 2018
...Nazma Malik; Thomas Macartney; Annika Hornberger; Karen E. Anderson; Hannah Tovell; Alan R. Prescott; Dario R. Alessi Derailment of the PI3K-AGC protein kinase signalling network contributes to many human diseases including cancer. Recent work has revealed that the poorly studied AGC kinase family...
Includes: Supplementary data
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Biochem J (1999) 343 (3): 637–644.
Published: 25 October 1999
...Hongwei QIAN; Luisa PIPOLO; Walter G. THOMAS Protein kinase C (PKC) phosphorylates the C-terminus of the type 1 angiotensin II receptor (AT 1 ), although the exact site(s) of phosphorylation are unidentified. In the present study, we examined the phosphorylation of epitope-tagged wild-type AT 1A...
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Biochem J (1999) 339 (2): 435–442.
Published: 08 April 1999
...Yang FENG; David R. HODGE; Giuseppe PALMIERI; Dan L. CHASE; Dan L. LONGO; Douglas K. FERRIS The polo-like kinase (Plk) family has been shown to have an important role in the regulation of the cell-division cycle, especially in organization of the spindle structure, in species from fungi to humans...