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Keywords: iron
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Biochem J (2021) 478 (17): 3239–3252.
Published: 07 September 2021
...Amy E. Medlock; Wided Najahi-Missaoui; Mesafint T. Shiferaw; Angela N. Albetel; William N. Lanzilotta; Harry A. Dailey,, Jr Ferrochelatase catalyzes the insertion of ferrous iron into a porphyrin macrocycle to produce the essential cofactor, heme. In humans this enzyme not only catalyzes...
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Biochem J (2020) 477 (16): 3055–3058.
Published: 26 August 2020
...Yong-Sung Park; Suzie Kang; Hyewon Seo; Cheol-Won Yun The answer to the letter ‘Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus ’ has been prepared. We explained our data and showed supplementary information to answer the questions. And we respect the results...
Includes: Supplementary data
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Biochem J (2020) 477 (16): 2967–2970.
Published: 19 August 2020
...Annie Yap; Matthias Misslinger; Hubertus Haas Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper...
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Biochem J (2020) 477 (1): 259–274.
Published: 17 January 2020
...Stéphane Mari; Christophe Bailly; Sébastien Thomine To ensure the success of the new generation in annual species, the mother plant transfers a large proportion of the nutrients it has accumulated during its vegetative life to the next generation through its seeds. Iron (Fe) is required in large...
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Biochem J (2019) 476 (3): 595–611.
Published: 14 February 2019
... derepression of genes involved in the oxidative stress response [ 27 ]. In GAS, these genes include pmtA , which encodes a P 1B-4 -type ATPase that effluxes ferrous iron and likely reduces potentiating the effects of excess Fe on H 2 O 2 and superoxide stress [ 28 , 29 ]. In contrast, Mn-loaded PerR is H 2 O...
Includes: Supplementary data
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Biochem J (2017) 474 (14): 2365–2378.
Published: 03 July 2017
... in A. fumigatus . A. fumigatus copper iron Mac1 MrpA S. cerevisiae In virtually all organisms, copper is an essential cofactor in various enzymatic processes, such as oxidative phosphorylation, nucleotide biosynthesis, and reactive oxidative species detoxification, and harmful effects occur...
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Biochem J (2016) 473 (9): 1203–1213.
Published: 26 April 2016
... are putative virulence factors of A. fumigatus ; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion. When expressed heterologously in Saccharomyces cerevisiae , sit1 and sit2 were localized to the plasma membrane ; sit1 efficiently complemented...
Includes: Supplementary data
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Biochem J (2016) 473 (6): 769–777.
Published: 10 March 2016
..., which requires intracellular iron. In the present study, we assessed ferroptosis following treatment of human fibrosarcoma HT1080 cells with several inhibitors of lysosomal activity and found that they prevented cell death induced by the ferroptosis-inducing compounds erastin and RSL3. Fluorescent...
Includes: Supplementary data
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Biochem J (2015) 466 (2): 401–413.
Published: 20 February 2015
...Kyle Bauckman; Edward Haller; Nicholas Taran; Stephanie Rockfield; Abigail Ruiz-Rivera; Meera Nanjundan The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian...
Includes: Supplementary data
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Biochem J (2014) 457 (2): 361–368.
Published: 20 December 2013
... of TRPML1 leads to production of reactive oxygen species, and to mitochondrial deterioration. iron lysosomal storage disease mitochondrion reactive oxygen species transient receptor potential (TRP) channel In the present study we aimed to answer whether or not TRPML1 has a role beyond...
Includes: Supplementary data
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Biochem J (2013) 449 (3): 683–693.
Published: 09 January 2013
.... The development of antibiotic resistance in S. aureus highlights the need for a preventive vaccine. In the present paper we explore the structure and function of FhuD2 (ferric-hydroxamate uptake D2), a staphylococcal surface lipoprotein mediating iron uptake during invasive infection, recently described...
Includes: Supplementary data
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Biochem J (2013) 449 (1): 275–284.
Published: 07 December 2012
... an unbiased proteomics screen where we identified TfR1 (transferrin receptor 1). TfR1 is required for transferrin binding and internalization and ultimately for iron homoeostasis. TfR1 depletion does not lead to changes in IKK subunit protein levels; however, it does reduce the formation of the IKK complex...
Includes: Supplementary data
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Biochem J (2012) 441 (1): 473–480.
Published: 14 December 2011
...Heeyong Yoon; Ramesh Golla; Emmanuel Lesuisse; Jayashree Pain; Jason E. Donald; Elise R. Lyver; Debkumar Pain; Andrew Dancis Frataxin is a conserved mitochondrial protein deficient in patients with Friedreich's ataxia. Frataxin has been implicated in control of iron homoeostasis and Fe–S cluster...
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Biochem J (2011) 440 (1): 137–146.
Published: 27 October 2011
...Heeyong Yoon; Yan Zhang; Jayashree Pain; Elise R. Lyver; Emmanuel Lesuisse; Debkumar Pain; Andrew Dancis Mitochondria transport and utilize iron for the synthesis of haem and Fe–S clusters. Although many proteins are known to be involved in these processes, additional proteins are likely...
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Biochem J (2011) 434 (1): 105–111.
Published: 27 January 2011
...Areli Cruz-Castañeda; Mavil López-Casamichana; José J. Olivares-Trejo Entamoeba histolytica is a human pathogen which can grow using different sources of iron such as free iron, lactoferrin, transferrin, ferritin or haemoglobin. In the present study, we found that E. histolytica was also capable...
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Biochem J (2010) 432 (1): 57–67.
Published: 25 October 2010
...Husain K. Khambati; Trevor F. Moraes; Jagroop Singh; Stephen R. Shouldice; Rong-hua Yu; Anthony B. Schryvers The periplasmic FbpA (ferric-binding protein A) from Haemophilus influenzae plays a critical role in acquiring iron from host transferrin, shuttling iron from the outer-membrane receptor...
Includes: Supplementary data
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Biochem J (2010) 429 (1): 185–193.
Published: 14 June 2010
...Maya Shvartsman; Eitan Fibach; Z. Ioav Cabantchik In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron]. Using real-time fluorimetry and flow cytometry, in conjunction...
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Biochem J (2010) 427 (2): 289–296.
Published: 29 March 2010
...Chris Tselepis; Samuel J. Ford; Andrew T. McKie; Wolfgang Vogel; Heinz Zoller; Robert J. Simpson; Javier Diaz Castro; Tariq H. Iqbal; Douglas G. Ward Accumulating evidence suggests that hepcidin, a 25-residue peptide hormone, is the master regulator of iron metabolism. Further evidence suggests...
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Biochem J (2009) 417 (1): 323–330.
Published: 12 December 2008
..., kinetics, and UV–visible, EPR, and 1 H-NMR spectroscopies. The purified enzyme was purple and contained substoichiometric amounts of iron and zinc; however, metal-binding studies reveal that GLX2-1 can bind nearly two equivalents of either iron or zinc and that the most stable analogue of GLX2-1...
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Biochem J (2008) 416 (1): 77–84.
Published: 28 October 2008
... Biochemical Society 2008 calcium cholecystokinin ferric ion iron phosphotyrosine sulfotyrosine Modification of tyrosine residues is a critical post-translational modification of many proteins. Tyrosine sulfation occurs in the trans -Golgi network, and is thought to be important in protein...
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Biochem J (2007) 403 (2): 261–266.
Published: 26 March 2007
...Margarita Tenopoulou; Tino Kurz; Paschalis-Thomas Doulias; Dimitrios Galaris; Ulf T. Brunk The calcein-AM (calcein-acetoxymethyl ester) method is a widely used technique that is supposed to assay the intracellular ‘labile iron pool’ (LIP). When cells in culture are exposed to this ester, it passes...
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Biochem J (2004) 381 (3): 629–634.
Published: 27 July 2004
.... 1 To whom correspondence should be addressed (e-mail u.testa@iss.it ). 11 2 2004 31 3 2004 15 4 2004 15 4 2004 The Biochemical Society, London 2004 erythropoiesis haemochromatosis iron liver transferrin transferrin receptor The differentiation stage...
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Biochem J (2004) 380 (2): 465–473.
Published: 01 June 2004
... with cell-cycle progression. Key words: cell cycle, inositol polyphosphate, inositol 1,2,3- trisphosphate, iron, WRK-1 cells. INTRODUCTION Phosphoinositide-based regulatory systems are ubiquitous in eukaryotes. They contribute to many processes, including signal- ling from cell-surface receptors, vesicle...
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Biochem J (2004) 378 (2): 599–607.
Published: 01 March 2004
... or mitochondria to cytoplasm, although many family members do not have assigned substrates. We speculated whether one or more of these transporters will play a role in iron metabolism. Haploid yeast strains each deleted for a single mitochondrial carrier protein were analysed for alterations in iron homoeostasis...
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Biochem J (2003) 375 (3): 793–798.
Published: 01 November 2003
...Liangtao LI; Chris D. VULPE; Jerry KAPLAN Hephaestin is a mammalian gene that encodes a predicted multicopper oxidase required for intestinal iron export. To examine if hephaestin can act as a ferroxidase, we studied yeast strains transformed with plasmids containing both a full-length hephaestin...
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Biochem J (2002) 365 (3): 865–871.
Published: 01 August 2002
... iron was in ferrous state. The positional isomer 9( S )-HPODE caused similar spectral changes. Therefore the catalytic centre of ptLOX appears to accommodate both positional isomers of linoleic acid hydroperoxides in a manner that ensures proper alignment of their hydroperoxy groups with the iron...
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Biochem J (2002) 364 (3): 613–616.
Published: 15 June 2002
...Jonathan S. OAKHILL; Christopher L. JOANNOU; Susan K. BUCHANAN; Andrew R. GORRINGE; Robert W. EVANS Pathogenic bacteria of the genus Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and human transferrin (hTf), a serum protein...
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Biochem J (2001) 359 (3): 575–582.
Published: 25 October 2001
... peptide in the mature subunit. Specific residues for ferroxidase activity and iron nucleation, which are found respectively in H-type or L-type ferritin subunits in animals, are both conserved within each of the four A. thaliana ferritin polypeptides. In addition, the hydrophilic nature of the plant...
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Biochem J (2001) 357 (1): 241–247.
Published: 25 June 2001
...Kouichi ORINO; Lori LEHMAN; Yoshiaki TSUJI; Hitoshi AYAKI; Suzy V. TORTI; Frank M. TORTI Iron is required for normal cell growth and proliferation. However, excess iron is potentially harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton chemistry...
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Biochem J (2001) 356 (2): 549–555.
Published: 24 May 2001
... to H 2 O 2 ; (iii) both events were inhibited by pre-treatment with iron chelators, including desferrioxamine. This compound is known to be taken up by endocytosis only and thus to become localized in the lysosomal compartment. After exposure to oxidative stress, when cells were again in standard...
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