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Keywords: insulin resistance
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Biochem J (2021) 478 (20): 3723–3739.
Published: 21 October 2021
... ) 25 6 2021 28 9 2021 30 9 2021 endoplasmic reticulum stress hepatic physiology insulin resistance insulin signalling lipogenesis sterol regulatory element-binding proteins In 2002, we wrote a review in the Biochemical Journal on the importance of the transcription...
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Biochem J (2021) 478 (13): 2539–2553.
Published: 09 July 2021
...Henver S. Brunetta; Heather L. Petrick; Bayley Vachon; Everson A. Nunes; Graham P. Holloway Reductions in mitochondrial function have been proposed to cause insulin resistance, however the possibility that impairments in insulin signaling negatively affects mitochondrial bioenergetics has received...
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Adipose biology
Biochem J (2020) 477 (13): 2509–2541.
Published: 10 July 2020
...Yasuhiro Onogi; Ahmed Elagamy Mohamed Mahmoud Khalil; Siegfried Ussar Adipose tissue is a central regulator of metabolism and an important pharmacological target to treat the metabolic consequences of obesity, such as insulin resistance and dyslipidemia. Among the various cellular compartments...
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Biochem J (2013) 455 (2): 207–216.
Published: 27 September 2013
... with arginine abolishes insulin-dependent ubiquitination and membrane localization of APPL1, and also diminishes membrane recruitment and activation of Akt, thereby abrogating the effects of APPL1 on alleviation of hepatic insulin resistance and glucose intolerance in obese mice. Further analysis identified...
Includes: Supplementary data
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Biochem J (2012) 448 (1): 43–53.
Published: 18 October 2012
... sarcolemmal presence of the long-chain fatty acid transporter CD36 are associated with and contribute to impaired cardiac insulin sensitivity and function. In the present study we aimed at preventing the development of insulin resistance and contractile dysfunction in cardiomyocytes by blocking CD36-mediated...
Includes: Supplementary data
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Biochem J (2012) 442 (2): 253–262.
Published: 13 February 2012
... pathologies, including insulin resistance, fatty liver, atherosclerosis and dyslipidaemia. The present review summarizes what is known about the contributions of macrophages to metabolic diseases and the signalling pathways that are involved in metabolic stress-induced macrophage activation. Understanding...
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Biochem J (2011) 435 (3): 723–732.
Published: 13 April 2011
... of intracellular NEFAs (non-esterified fatty acids) compared with the control cells when adipocytes were challenged with fatty acids. The changes were accompanied by an increase in fatty acid uptake and a decrease in fatty acid release. Interestingly, CPT1A protected against fatty acid-induced insulin resistance...
Includes: Supplementary data
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Biochem J (2010) 432 (2): 333–341.
Published: 12 November 2010
... the hyperinsulinaemia/hyperglycaemia-induced epigenetic changes and alteration of Fbn1 (fibrillin 1) and Col3A1 (collagen type III α1) gene expression. Insulin resistance and Type 2 diabetes in male Sprague–Dawley rats was developed by feeding rats an HFD (high-fat diet) and administering a low dose of STZ...
Includes: Supplementary data
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Biochem J (2010) 431 (2): e1–e3.
Published: 28 September 2010
... in the treatment of diseases such as cancer where S6K1 is overexpressed, but most importantly in metabolic disease such as insulin resistance and obesity. Work in the laboratory of B. V. is supported by the Medical Research Council [grant number G0700755] and Cancer Research UK [grant number C23338/A10200...
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Biochem J (2010) 430 (1): 141–149.
Published: 28 July 2010
... be considered ‘inappropriately’ healthy for their degree of obesity. We think that studying these obese but metabolically healthy individuals and comparing them with equally obese but insulin-resistant individuals could provide important insights into the mechanistic link between adipose tissue expansion...
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Biochem J (2004) 378 (1): 105–116.
Published: 15 February 2004
...Michael W. GREENE; Nick MORRICE; Robert S. GAROFALO; Richard A. ROTH Non-esterified fatty acid (free fatty acid)-induced activation of the novel PKC (protein kinase C) isoenzymes PKCδ and PKCθ correlates with insulin resistance, including decreased insulin-stimulated IRS-1 (insulin receptor...
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Biochem J (2002) 367 (3): 677–685.
Published: 01 November 2002
... and maturation, and thus exerted a dual (pre- and post-translational) negative effect on ApN secretion by cultured mouse adipose explants. ApN inhibition by β-agonists was reproduced in mouse in vivo and in humans in vitro . ApN down-regulation may have an important role in fuel homoeostasis, insulin resistance...
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Biochem J (2001) 355 (3): 757–763.
Published: 24 April 2001
...-sensitive step specifically leading to insulin resistance. 1 To whom correspondence should be addressed, at the Department of Clinical Biochemistry (e-mail nava@bgumail.bgu.ac.il ). 29 12 2000 25 1 2001 15 2 2001 The Biochemical Society, London © 2001 2001 diabetes...
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Biochem J (2000) 349 (3): 657–665.
Published: 25 July 2000
...Mark J. HOLNESS; Maria L. LANGDOWN; Mary C. SUGDEN There is increasing epidemiological evidence in humans which associates low birthweight with later metabolic disorders, including insulin resistance and glucose intolerance. There is evidence that nutritional and hormonal factors (e.g. maternal...
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Biochem J (2000) 349 (2): 579–586.
Published: 10 July 2000
... role in the development of impaired insulin action on adipose tissue and skeletal muscle. In this study we undertook to investigate the potential of GSH depletion to induce insulin resistance, by utilizing the GSH synthesis inhibitor, L -buthionine-[ S , R ]-sulfoximine (BSO). GSH depletion (20-80...
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