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Keywords: insulin
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Biochem J (2024) 481 (1): 33–44.
Published: 04 January 2024
... to generate unmodified as well as AGE-modified protease substrates. Activity of proteases towards these substrates was quantified. Second, we tested the effect of AGE-modified proinsulin on the processing to insulin. Proteases showed the expected activity towards the unmodified peptide substrates containing...
Includes: Supplementary data
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Biochem J (2023) 480 (11): 773–789.
Published: 07 June 2023
...Guy A. Rutter; Vaibhav Sidarala; Brett A. Kaufman; Scott A. Soleimanpour Glucose-regulated insulin secretion becomes defective in all forms of diabetes. The signaling mechanisms through which the sugar acts on the ensemble of beta cells within the islet remain a vigorous area of research after more...
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Biochem J (2022) 479 (3): 445–462.
Published: 11 February 2022
...Daniel J. Fazakerley; Francoise Koumanov; Geoffrey D. Holman Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells. Signals from the occupied insulin receptor are translated into downstream signalling changes in serine/threonine kinases within timescales...
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Biochem J (2021) 478 (21): 3827–3846.
Published: 09 November 2021
...Erik A. Richter; Lykke Sylow; Mark Hargreaves The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regulatory forces under varying conditions. While insulin is secreted after food intake and is the primary hormone increasing...
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Biochem J (2021) 478 (3): 633–646.
Published: 12 February 2021
... of the allosteric AMPK activators A-769662 and 991 on glucose uptake in adipocytes. For this purpose, primary rat or human adipocytes, and cultured 3T3-L1 adipocytes, were treated with either of the allosteric activators, or AICAR, and basal and insulin-stimulated glucose uptake was assessed. Additionally...
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Biochem J (2017) 474 (1): 47–50.
Published: 22 December 2016
... © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 CRISPR incretin insulin Recent years have witnessed a surge of interest in gut hormones, following the dramatic successes of many new medicines that target the intestinal endocrine...
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Biochem J (2015) 471 (3): 381–389.
Published: 16 October 2015
...Chun-Yan Lim; Wanjin Hong; Weiping Han Adiponectin, a hormone secreted from adipocytes and released at a high rate into the circulation, plays a pivotal role in maintaining insulin sensitivity at the whole-body level. Despite the importance of this adipokine in metabolic homoeostasis, the mechanism...
Includes: Multimedia, Supplementary data
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Biochem J (2015) 470 (2): 207–221.
Published: 20 August 2015
... ). 1 4 2015 8 7 2015 9 7 2015 9 7 2015 amino acid autophagy growth insulin L-type (leucine) amino acid transporter 1 (LAT1) leucine p70S6K1 proliferation transcription factor EB (TFEB) sodium-coupled neutral amino acid transporter 2 (SNAT2) uncoordinated-51-like kinase...
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Biochem J (2015) 469 (3): 445–454.
Published: 23 July 2015
...Nobuyuki Takenaka; Yukio Sumi; Keiko Matsuda; Junko Fujita; Tetsuya Hosooka; Tetsuya Noguchi; Atsu Aiba; Takaya Satoh Insulin-stimulated glucose uptake in skeletal muscle is mediated by the translocation of the glucose transporter GLUT4 from intracellular storage sites to the plasma membrane...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 467–473.
Published: 06 March 2015
...Xiao Luo; Ting Li; Yue Zhu; Yunbin Dai; Jianwei Zhao; Zhan-Yun Guo; Ming-Wei Wang Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein-coupled receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), but its precise biological functions...
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Biochem J (2015) 466 (2): 203–218.
Published: 20 February 2015
...Guy A. Rutter; Timothy J. Pullen; David J. Hodson; Aida Martinez-Sanchez Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion underlies all forms of diabetes mellitus, a disease currently reaching...
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Biochem J (2014) 458 (3): 491–498.
Published: 28 February 2014
... leptin storage and secretion regulation in 3T3-L1 and primary adipocytes. Leptin is stored in membrane-bound vesicles that are localized predominantly in the ER (endoplasmic reticulum) and close to the plasma membrane of both 3T3-L1 and primary adipocytes. Insulin increases leptin secretion as early...
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Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
...Ying Feng; Barnabas G. Williams; Françoise Koumanov; Adrian J. Wolstenholme; Geoffrey D. Holman Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 (abnormal dauer formation 2) receptor for insulin...
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Biochem J (2013) 455 (2): e1–e3.
Published: 27 September 2013
...James S. V. Lally; Gregory R. Steinberg Skeletal muscle is critical for whole-body glucose homoeostasis. Insulin and muscle contractions induced by exercise can increase glucose uptake through distinct intracellular signalling pathways involving PKB (protein kinase B)/Akt and AMPK (AMP-activated...
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Biochem J (2013) 450 (2): 365–373.
Published: 15 February 2013
...Tetsuya Kitaguchi; Manami Oya; Yoshiko Wada; Takashi Tsuboi; Atsushi Miyawaki Intracellular cAMP and Ca 2+ are important second messengers that regulate insulin secretion in pancreatic β-cells; however, the molecular mechanism underlying their mutual interaction for exocytosis is not fully...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 503–514.
Published: 29 May 2012
... in adipocytes in response to cellular stimuli with relevance for adipocyte function and/or AMPK signalling. None of the treatments, including insulin, cAMP inducers or AICAR (5-amino-4-imidazolecarboxamide riboside), affected SIK2 activity towards peptide or protein substrates in vitro . However, stimulation...
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Biochem J (2012) 443 (1): 57–64.
Published: 14 March 2012
... underlying these diseases, with the scope to identify common cellular targets for therapy. In the present study we have examined the insulin-like signalling properties of an experimental AD 8-hydroxyquinoline drug known as CQ (clioquinol). The IIS [insulin/IGF-1 (insulin-like growth factor-1) signalling...
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Biochem J (2012) 442 (3): 539–550.
Published: 24 February 2012
...). When introduced into AR42j-B13 cells, Ad-PNM caused a rapid change to a flattened morphology and a cessation of cell division. The expression of exocrine markers is suppressed. Both insulin genes are up-regulated as well as a number of transcription factors normally characteristic of beta cells...
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Biochem J (2012) 442 (2): 303–310.
Published: 13 February 2012
...), the first and rate-limiting enzyme of the haem pathway. Acute porphyria attacks are usually treated by the administration of glucose; its effect is apparently related to its ability to inhibit ALAS1 by modulating insulin plasma levels. It has been shown that insulin blunts hepatocyte ALAS1 induction...
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Biochem J (2012) 442 (1): 161–169.
Published: 27 January 2012
... and appetite. However, in these models the PI3K activity is chronically reduced. Therefore we analysed the effects of acutely inhibiting PI3K isoforms alone, or PI3K and mTOR, on glucose metabolism and food intake. In the present study impairments in glucose tolerance, insulin tolerance and increased hepatic...
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Biochem J (2011) 440 (3): 397–403.
Published: 28 November 2011
...Louise Knudsen; Pierre De Meyts; Vladislav V. Kiselyov More than 20 years after the description of the two IR (insulin receptor) isoforms, designated IR-A (lacking exon 11) and IR-B (with exon 11), nearly every functional aspect of the alternative splicing both in vitro and in vivo remains...
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Biochem J (2011) 435 (2): 539–544.
Published: 29 March 2011
... for processes including glucose metabolism. Therefore a potential complication of such anticancer drugs is insulin resistance and/or diabetes. In the process of characterizing the metabolic effects of early-phase Akt inhibitors, we discovered an off-target inhibitory effect on mammalian facilitative glucose...
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Biochem J (2010) 432 (3): 515–525.
Published: 25 November 2010
... in the activation process. We have determined the distribution of NHE1 by means of immunofluorescence microscopy and cell-surface biotinylation. We have discovered changes in the distribution of NHE1 that occur when cardiomyocytes are stimulated with insulin that are PI3K (phosphoinositide 3-kinase)-dependent...
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Biochem J (2010) 432 (1): 191–198.
Published: 25 October 2010
..., Akt also plays an essential role in other physiological processes, such as the insulin-regulated transport of glucose into muscle and fat cells. This process, which is essential for whole-body glucose homoeostasis in mammals, is thought to be mediated via Akt-dependent movement of GLUT4 glucose...
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Biochem J (2010) 431 (3): 381–390.
Published: 11 October 2010
...Javier Pizarro-Delgado; Matthias Braun; Inés Hernández-Fisac; Rafael Martín-Del-Río; Jorge Tamarit-Rodriguez We have demonstrated recently that branched-chain α-keto acid stimulation of insulin secretion is dependent on islet GABA (γ-aminobutyric acid) metabolism: GABA transamination to succinic...
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Biochem J (2010) 425 (1): 41–52.
Published: 14 December 2009
... distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 419 (3): 645–653.
Published: 14 April 2009
... expression. Lipophilic molecules were extracted from rat livers, saponified and re-constituted as an LE (lipophilic extract). LE synergized with insulin to induce primary hepatocyte, but not β-cell, Gck expression in an SREBP-1c (sterol-regulatory-element-binding protein-1c)-independent manner. The dramatic...
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Biochem J (2009) 419 (2): 475–484.
Published: 27 March 2009
...Hilal Zaid; Ilana Talior-Volodarsky; Costin Antonescu; Zhi Liu; Amira Klip Dietary glucose is taken up by skeletal muscle through GLUT4 (glucose transporter 4). We recently identified by MS proteins displaying insulin-dependent co-precipitation with Myc-tagged GLUT4 from L6 myotubes, including...
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Biochem J (2009) 417 (1): 235–246.
Published: 12 December 2008
...) of HIF-1 α mRNA. Overexpression of CPEB1 and CPEB2 affected HIF-1α protein levels mediated by the 3′-UTR of HIF-1 α mRNA. Stimulation of neuroblastoma SK-N-MC cells with insulin and thus activation of endogenous CPEBs increased the expression of a luciferase reporter gene fused to the 3′-UTR of HIF-1 α...