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Keywords: inflammation
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Biochem J (2023) 480 (23): 1987–2008.
Published: 06 December 2023
..., ERK/P90RSK, LKB1/mTOR and GSK3β/SNAI1 in autocrine and paracrine. This activates a program of mesenchymal transition of epithelial, stromal, and endothelial cells to cause inflammation, fibrosis, and stalled endogenous tissue repair, leading to organ failure. The role of IL11 signalling in cell...
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Biochem J (2022) 479 (24): 2499–2510.
Published: 22 December 2022
...-inflammatory therapeutics. Correspondence: Emily A. Day ( daye1@tcd.ie ) 31 10 2022 6 12 2022 7 12 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 immunometabolism infection inflammation itaconate post-translational...
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Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
... 4.0 (CC BY) . apoptosis cell death immunology inflammation necroptosis RIPK3 Regulated cell death is a biological process with essential functions in organismal development, tissue homeostasis, and immune defense. Regulated cell death comes in many forms [ 1 ], the best-known being...
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Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... roll-out and the emergence of novel variants of concern such as omicron underscore the critical importance of identifying the mechanisms that contribute to this disease. Overt inflammation and cell death have been proposed to be central drivers of severe pathology in COVID-19 patients...
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Biochem J (2020) 477 (14): 2679–2696.
Published: 29 July 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 asthma dysbiosis inflammation microfluidics respiratory diseases Microbiota refers to a concoction of microbial flora present in the body. Microbiota are ecological communities of commensal...
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Biochem J (2020) 477 (12): 2347–2361.
Published: 26 June 2020
... with type 2 diabetes through mechanisms that are not fully understood. Canagliflozin has been shown to increase the activity of the AMP-activated protein kinase (AMPK), a metabolic energy sensor important for increasing fatty acid oxidation and energy expenditure and suppressing lipogenesis and inflammation...
Includes: Supplementary data
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In Collection
Adipose biology
Biochem J (2020) 477 (6): 1089–1107.
Published: 23 March 2020
... the coordination of adipocyte lipogenesis and lipolysis. These defects in adipose tissue metabolism can promote ectopic lipid deposition and inflammation in insulin-sensitive tissues such as skeletal muscle and liver. Sustained caloric excess can expand white adipose tissue to a point of maladaptation exacerbating...
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Biochem J (2020) 477 (3): 691–708.
Published: 11 February 2020
... poorly understood. Here, we showed that hepatic C7ORF41, a critical regulator of innate immune response, was markedly decreased in diet or genetic-induced NAFLD model. We also demonstrated that C7ORF41 overexpression significantly ameliorated hepatic inflammation and lipid accumulation in palmitic acid...
Includes: Supplementary data
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Biochem J (2019) 476 (2): 333–352.
Published: 31 January 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 inflammation interferons mRNA decay The interferon (IFN) cytokine family consists of type I, II and III IFNs. All family members have important antiviral and antimicrobial activities...
Includes: Supplementary data
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Biochem J (2018) 475 (5): 839–852.
Published: 06 March 2018
...Hiroyuki Nakayama; Kinya Otsu Mitochondria play a central role in multiple cellular functions, including energy production, calcium homeostasis, and cell death. Currently, growing evidence indicates the vital roles of mitochondria in triggering and maintaining inflammation. Chronic inflammation...
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Biochem J (2018) 475 (1): 329–340.
Published: 11 January 2018
...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . high-throughput assay inflammation kinase TPL-2 The pro-inflammatory cytokine tumour necrosis...
Includes: Supplementary data
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Biochem J (2017) 474 (4): 521–537.
Published: 03 February 2017
... inflammation macrophage salt-inducible kinase TNF-α Macrophages play diverse roles in the immune response due to their innate ability to adapt their physiology to the changing needs of the host [ 1 – 3 ]. In response to infection or tissue damage, macrophages acquire an inflammatory phenotype...
Includes: Supplementary data
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Biochem J (2016) 473 (18): 2717–2736.
Published: 12 September 2016
... 4 2016 16 5 2016 18 5 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cAMP HCN2 ivabradine inflammation Pain is as old as animals — a low-level sensory system that has warned us of harm from time immemorial...
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Biochem J (2016) 473 (10): 1281–1295.
Published: 11 May 2016
... cell function during atherosclerotic plaque formation. atherosclerosis extracellular matrix inflammation microenvironment shear stress Atherosclerosis is a lipid-driven chronic inflammatory disease of large and medium sized arteries, hinders arterial function and prevents adequate blood...
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Biochem J (2015) 468 (1): 1–15.
Published: 05 May 2015
... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...
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Biochem J (2015) 465 (2): 271–279.
Published: 06 January 2015
...James Ozanne; Alan R. Prescott; Kristopher Clark Macrophages switch to an anti-inflammatory, ‘regulatory’-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential...
Includes: Supplementary data
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Biochem J (2014) 463 (1): e1–e2.
Published: 08 September 2014
... models of IKKβ activation into a single unified model, and suggests that the IKKβ activation loop may integrate distinct ‘upsteam’ signals to activate NF-κB. inflammation inhibitor of NF-κB kinase β (IKKβ) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1...
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Biochem J (2014) 462 (2): 303–314.
Published: 07 August 2014
... proline of the pro-inflammatory cytokine MIF at equimolar concentrations. dopachrome tautomerase epicatechin inflammation macrophage migration inhibitory factor (MIF) myeloperoxidase (MPO) MIF (macrophage migration inhibitory factor) is emerging as an important therapeutic target...
Includes: Supplementary data
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Biochem J (2014) 461 (2): 223–232.
Published: 26 June 2014
... macrosteatosis, inflammation and fibrosis compared with mice containing the C3H/HeN nuclear genome when fed the atherogenic diet. These changes were associated with parallel alterations in inflammation and fibrosis gene expression in wild-type mice, with intermediate responses in MNX mice. Mice with the C57BL/6J...
Includes: Supplementary data
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Biochem J (2014) 459 (3): 479–488.
Published: 11 April 2014
... of inflammation, the function of this protein is not completely understood. In the present study, we examined the regulation of CHI3L1 in primary human skeletal muscle cells. Moreover, we analysed potential autocrine effects of CHI3L1. We show that myotubes express CHI3L1 in a differentiation-dependent manner...
Includes: Supplementary data
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Biochem J (2014) 459 (2): e1–e3.
Published: 28 March 2014
... to avoid side effects associated with LXR agonists, molecular and cellular studies are required to decipher this unexpected action of LXRs. cancer cholesterol inflammation liver X receptor metabolism oxysterol Cholesterol plays an essential role in the stability and architecture...
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Biochem J (2014) 458 (2): 187–193.
Published: 14 February 2014
... pathologies myocardial infarction and atherosclerosis. Mo are innate immune cells derived from the myeloid lineage in the bone marrow [ 23 ]; however, under certain conditions, such as inflammation, extramedullary monocytopoiesis has been reported [ 12 , 24 ]. Consequently, some authors have suggested...
Includes: Multimedia, Supplementary data
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Biochem J (2013) 455 (2): 239–250.
Published: 27 September 2013
... amino acid residues that was identified in its cDNA library. As it induced inflammation and writhing in animals, this protein was named inflamin. It induced two waves of prostanoid production. The first wave peaked at 10 min and 6-oxo PGF 1α (prostaglandin F 1α ) (6-keto PGF 1α ) was the major product...
Includes: Supplementary data
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Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...
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Biochem J (2013) 451 (1): 101–109.
Published: 14 March 2013
...) following the manufacturer's instructions. © The Authors Journal compilation © 2013 Biochemical Society 2013 β-arrestin-2 desensitization inflammation pain phosphorylation transient receptor potential vanilloid 1 (TRPV1) For each experimental condition, cells were treated...
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Biochem J (2013) 450 (2): 253–264.
Published: 15 February 2013
..., inflammation, fibrosis and neurodegenerative diseases. Different animal models, as well as proteomics approaches for the identification of protease substrates, have helped to reveal more precise molecular signalling events mediated by meprin activity, such as activation and release of pro-inflammatory...
Includes: Multimedia, Supplementary data
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Biochem J (2013) 449 (1): 11–23.
Published: 07 December 2012
... regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1...
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Biochem J (2012) 443 (3): 857–867.
Published: 16 April 2012
... correspondence should be addressed (email bart.vanh@qmul.ac.uk ). 22 12 2011 29 2 2012 29 2 2012 29 2 2012 PI3Ks (phosphoinositide 3-kinases) phosphorylate inositol lipids in cellular membranes in response to a variety of stimuli. The involvement of PI3Ks in immunity, inflammation...
Includes: Supplementary data
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Biochem J (2012) 443 (2): e1–e2.
Published: 27 March 2012
...Robert C. Rickert; Guy S. Salvesen; Carl F. Ware In a paper in this issue of the Biochemical Journal that questions the role of c-IAP1 (cellular inhibitor of apoptosis 1) in inflammation, new results from the Duckett laboratory remind us of the importance of truly knowing the mice we depend...
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Biochem J (2011) 440 (1): 13–21.
Published: 27 October 2011
... substrate-binding pocket in our model constituted an active conformation that was suitable for further enzymatic mechanism study and structural-based drug design against mPGES-1. © The Authors Journal compilation © 2011 Biochemical Society 2011 drug design enzyme mechanism inflammation membrane...
Includes: Supplementary data
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Biochem J (2011) 436 (2): 351–362.
Published: 13 May 2011
... and dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation and autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system for siRNA (small interfering RNA) delivery to phagocytes...
Includes: Supplementary data
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Biochem J (2011) 436 (1): 123–132.
Published: 27 April 2011
... 2 2011 28 2 2011 28 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium inflammation oxidative stress peroxiredoxin sepsis thioredoxin Sepsis is a severe infection causing dysregulation of inflammatory responses and may result...
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Biochem J (2011) 434 (1): 11–24.
Published: 27 January 2011
... and structural cells. Chemokines induce the release of leucocyte progenitors from the bone marrow to the peripheral blood and guide their recruitment along a concentration gradient to the site of allergic inflammation and chemokine generation. Key to this recruitment is the dynamic cell-surface expression...
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Biochem J (2010) 432 (3): 535–547.
Published: 25 November 2010
... and sequence, different Gals exert distinct effects on their target cells. We have shown that Gal-1 triggers platelet activation, suggesting a role for Gals in thrombus formation. Since Gal-8 is expressed upon endothelial activation and also contributes to inflammation, to understand further the role...