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Keywords: inflammation
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Articles
Biochem J (2022) 479 (24): 2499–2510.
Published: 22 December 2022
...-inflammatory therapeutics. Correspondence: Emily A. Day ( daye1@tcd.ie ) 31 10 2022 6 12 2022 7 12 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 immunometabolism infection inflammation itaconate post...
Articles
Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
... Attribution License 4.0 (CC BY) . apoptosis cell death immunology inflammation necroptosis RIPK3 Regulated cell death is a biological process with essential functions in organismal development, tissue homeostasis, and immune defense. Regulated cell death comes in many forms [ 1 ], the best...
Articles
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... roll-out and the emergence of novel variants of concern such as omicron underscore the critical importance of identifying the mechanisms that contribute to this disease. Overt inflammation and cell death have been proposed to be central drivers of severe pathology in COVID-19 patients...
Articles
Biochem J (2021) 478 (22): 4027–4043.
Published: 26 November 2021
...Dipanjan Chattopadhyay; Snehasis Das; Suktara Guria; Soumyadeep Basu; Sutapa Mukherjee In the context of obesity-induced adipose tissue (AT) inflammation, migration of macrophages and their polarization from predominantly anti-inflammatory to proinflammatory subtype is considered a pivotal event...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (14): 2679–2696.
Published: 29 July 2020
... where the metabolism of dietary fiber in the gut of mice led to the alleviation of inflammation in the lungs [ 27 ]. There have been many hypotheses regarding the translocation of gut microbiota into lungs which are a cause for many immune responses and hence respiratory diseases. Even though...
Articles
Biochem J (2020) 477 (12): 2347–2361.
Published: 26 June 2020
... with type 2 diabetes through mechanisms that are not fully understood. Canagliflozin has been shown to increase the activity of the AMP-activated protein kinase (AMPK), a metabolic energy sensor important for increasing fatty acid oxidation and energy expenditure and suppressing lipogenesis and inflammation...
Includes: Supplementary data
Articles
In Collection
Adipose biology
Biochem J (2020) 477 (6): 1089–1107.
Published: 23 March 2020
... the coordination of adipocyte lipogenesis and lipolysis. These defects in adipose tissue metabolism can promote ectopic lipid deposition and inflammation in insulin-sensitive tissues such as skeletal muscle and liver. Sustained caloric excess can expand white adipose tissue to a point of maladaptation exacerbating...
Articles
Biochem J (2020) 477 (3): 691–708.
Published: 11 February 2020
... poorly understood. Here, we showed that hepatic C7ORF41, a critical regulator of innate immune response, was markedly decreased in diet or genetic-induced NAFLD model. We also demonstrated that C7ORF41 overexpression significantly ameliorated hepatic inflammation and lipid accumulation in palmitic acid...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (22): 3533–3548.
Published: 27 November 2019
... as CXCR5 knockdown by specific siRNA effectively inhibited DFO-induced inflammation. The phosphorylation of Akt2, a protective factor of adipose inflammation, was significantly inhibited by CXCL13 treatment during adipogenic differentiation. Mechanistically, CXCL13 induces the expression of PHLPP1, an Akt2...
Articles
Biochem J (2019) 476 (2): 333–352.
Published: 31 January 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 inflammation interferons mRNA decay The interferon (IFN) cytokine family consists of type I, II and III IFNs. All family members have important antiviral and antimicrobial activities...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (5): 839–852.
Published: 06 March 2018
...Hiroyuki Nakayama; Kinya Otsu Mitochondria play a central role in multiple cellular functions, including energy production, calcium homeostasis, and cell death. Currently, growing evidence indicates the vital roles of mitochondria in triggering and maintaining inflammation. Chronic inflammation...
Articles
Biochem J (2018) 475 (4): 775–786.
Published: 23 February 2018
... ) 9 11 2017 16 1 2018 18 1 2018 22 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cytokine gC1qR (gC1qBP) inflammation MCP-1 (CCL2) periodontal ligament cells (PDL cells) protein–protein interactions...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (1): 329–340.
Published: 11 January 2018
...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . high-throughput assay inflammation kinase TPL-2 The pro-inflammatory cytokine tumour necrosis...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (17): 2993–3010.
Published: 17 August 2017
... 2017 17 7 2017 19 7 2017 24 7 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 arthritis Barbasco Cambará nociception pain inflammation Arthritis is a chronic inflammatory systemic autoimmune disease...
Articles
Biochem J (2017) 474 (16): 2733–2747.
Published: 02 August 2017
...Chunyang Du; Tao Zhang; Xia Xiao; Yonghong Shi; Huijun Duan; Yunzhuo Ren Protease-activated receptor-2 (PAR2), which belongs to a specific class of the G-protein-coupled receptors, is central to several inflammation processes. However, the precise molecular mechanism involved remains undefined...
Articles
Biochem J (2017) 474 (4): 521–537.
Published: 03 February 2017
... inflammation macrophage salt-inducible kinase TNF-α Macrophages play diverse roles in the immune response due to their innate ability to adapt their physiology to the changing needs of the host [ 1 – 3 ]. In response to infection or tissue damage, macrophages acquire an inflammatory phenotype...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (1): 65–78.
Published: 22 December 2016
... the binding of ATF2 to the TNF-responsive element. Altogether, these data suggest that ATF2 could be a potential target to prevent inflammation-induced P. aeruginosa binding in the lung of patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis. Correspondence: Sophie Groux...
Articles
Biochem J (2016) 473 (18): 2717–2736.
Published: 12 September 2016
... of the h yperpolarisation-activated c yclic n ucleotide-gated (HCN) ion channel family, and HCN2 in particular, may provide the key to this distressing and poorly understood syndrome. cAMP HCN2 ivabradine inflammation Nociception: The detection of harmful or potentially harmful...
Articles
Biochem J (2016) 473 (14): 2061–2071.
Published: 12 July 2016
..., vascular-targeted therapies constitute promising strategies for the treatment of inflammatory pathologies. In the present study, we evaluated the effect of 8,9-dehydrohispanolone-15,16-lactol diterpene (DT) on lung endothelium during inflammation. Lung endothelial cells pre-treated with DT and activated...
Articles
Biochem J (2016) 473 (10): 1281–1295.
Published: 11 May 2016
... multiple aspects of vascular and inflammatory cell phenotype, determining the location, composition and clinical consequences of atherosclerotic plaque formation. atherosclerosis extracellular matrix inflammation microenvironment shear stress Atherosclerosis is a lipid-driven chronic...
Articles
Biochem J (2016) 473 (7): 887–898.
Published: 29 March 2016
...-terminal domains were modified in order to display altered glycan recognition, allowed the discrimination of distinctive effects exerted by Gal-8 on CD4 + T-cell responses. galectin glycan affinity inflammation T-cell proliferation T-cell receptor co-stimulation Galectins (Gals...
Includes: Supplementary data
Articles
Biochem J (2015) 468 (1): 1–15.
Published: 05 May 2015
... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...
Articles
Biochem J (2015) 465 (3): 503–515.
Published: 22 January 2015
... disruption and barrier dysfunction. 2 To whom correspondence should be addressed (email rrao2@uthsc.edu ). apoptosis signal-regulated kinase 1 (Ask1) calcium c-Jun N-terminal kinase (JNK) intestine inflammation MKK7 Src tight junction 7 4 2014 13 10 2014 7 11 2014 7...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (2): 271–279.
Published: 06 January 2015
...James Ozanne; Alan R. Prescott; Kristopher Clark Macrophages switch to an anti-inflammatory, ‘regulatory’-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (1): e1–e2.
Published: 08 September 2014
... Journal compilation © 2014 Biochemical Society 2014 inflammation inhibitor of NF-κB kinase β (IKKβ) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1) phosphorylation ubiquitination The NF-κB (nuclear factor κB) transcription factor family controls...
Articles
Biochem J (2014) 462 (2): 303–314.
Published: 07 August 2014
... proline of the pro-inflammatory cytokine MIF at equimolar concentrations. dopachrome tautomerase epicatechin inflammation macrophage migration inhibitory factor (MIF) myeloperoxidase (MPO) MIF (macrophage migration inhibitory factor) is emerging as an important therapeutic target...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (2): 223–232.
Published: 26 June 2014
... macrosteatosis, inflammation and fibrosis compared with mice containing the C3H/HeN nuclear genome when fed the atherogenic diet. These changes were associated with parallel alterations in inflammation and fibrosis gene expression in wild-type mice, with intermediate responses in MNX mice. Mice with the C57BL/6J...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (3): 479–488.
Published: 11 April 2014
... of inflammation, the function of this protein is not completely understood. In the present study, we examined the regulation of CHI3L1 in primary human skeletal muscle cells. Moreover, we analysed potential autocrine effects of CHI3L1. We show that myotubes express CHI3L1 in a differentiation-dependent manner...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (2): e1–e3.
Published: 28 March 2014
... 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer cholesterol inflammation liver X receptor metabolism oxysterol Cholesterol plays an essential role in the stability and architecture of the plasma membrane, and as a precursor for bile acid...
Articles
Biochem J (2014) 458 (2): 187–193.
Published: 14 February 2014
... Biochemical Society 2014 cardiovascular disease fibrosis inflammation monocyte macrophage CVDs (cardiovascular diseases) are the leading cause of death in the developed world. Despite marked progress in the understanding of CVD, the underlying mechanisms involved in many of these pathologies...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 455 (2): 239–250.
Published: 27 September 2013
... amino acid residues that was identified in its cDNA library. As it induced inflammation and writhing in animals, this protein was named inflamin. It induced two waves of prostanoid production. The first wave peaked at 10 min and 6-oxo PGF 1α (prostaglandin F 1α ) (6-keto PGF 1α ) was the major product...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...
Articles
Biochem J (2013) 451 (1): 101–109.
Published: 14 March 2013
...) was then resuspended in 400 μl of homogenization buffer containing 1% Triton X-100. β-arrestin-2 desensitization inflammation pain phosphorylation transient receptor potential vanilloid 1 (TRPV1) Post-translational modifications in the TRPV1 (transient receptor potential vanilloid 1) channel...
Articles
Biochem J (2013) 451 (1): 55–60.
Published: 14 March 2013
...Ling Liu; Zhou Zhou; Shengping Huang; Yanhong Guo; Yanbo Fan; Ji Zhang; Jifeng Zhang; Mingui Fu; Y. Eugene Chen Endothelial activation characterized by the expression of multiple chemokines and adhesive molecules is a critical initial step of vascular inflammation, which results in recruitment...
Articles
Biochem J (2013) 450 (2): 253–264.
Published: 15 February 2013
..., inflammation, fibrosis and neurodegenerative diseases. Different animal models, as well as proteomics approaches for the identification of protease substrates, have helped to reveal more precise molecular signalling events mediated by meprin activity, such as activation and release of pro-inflammatory...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 449 (1): 11–23.
Published: 07 December 2012
... regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1...
Articles
Biochem J (2012) 447 (2): 193–204.
Published: 26 September 2012
... The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cytoprotection endothelium inflammation protein kinase C (PKC) The vascular endothelium lies at a critical tissue interface and is capable of mounting specific responses to a variety of soluble and physical factors...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (3): 499–508.
Published: 28 August 2012
... to RBCs (red blood cells). It has been suggested that these changes have potential negative clinical effects characterized by inflammation and microcirculatory dysfunction which add to other transfusion-related toxicities. However, the mechanisms linking RBC storage and toxicity remain unclear...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 857–867.
Published: 16 April 2012
... lipids in cellular membranes in response to a variety of stimuli. The involvement of PI3Ks in immunity, inflammation and cancer has made these enzymes important new targets for drug development [ 1 – 3 ]. This also applies to p110δ, a PI3K isoform mainly expressed in leucocytes [ 4 , 5 ], and Phase I/II...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): e1–e2.
Published: 27 March 2012
...Robert C. Rickert; Guy S. Salvesen; Carl F. Ware In a paper in this issue of the Biochemical Journal that questions the role of c-IAP1 (cellular inhibitor of apoptosis 1) in inflammation, new results from the Duckett laboratory remind us of the importance of truly knowing the mice we depend...
Articles
Biochem J (2012) 443 (2): 451–461.
Published: 27 March 2012
... ). 14 6 2011 19 12 2011 23 1 2012 23 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cyclo-oxygenase-2 (COX-2) E-prostanoid (EP) receptor gene regulation inflammation lipid mediator microsomal prostaglandin E synthase 1 (mPGES-1) PGs...
Articles
Biochem J (2012) 442 (1): 127–137.
Published: 27 January 2012
...Justin S. Bickford; Kimberly J. Newsom; John-David Herlihy; Christian Mueller; Benjamin Keeler; Xiaolei Qiu; Jewell N. Walters; Nan Su; Shannon M. Wallet; Terence R. Flotte; Harry S. Nick Airway inflammation in allergen-induced asthma is associated with eicosanoid release. These bioactive lipids...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (1): 13–21.
Published: 27 October 2011
... 29 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 drug design enzyme mechanism inflammation membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) microsomal prostaglandin E synthase-1 (mPGES-1) one-third-of-the-sites reactivity...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (2): 351–362.
Published: 13 May 2011
... and dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation and autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system for siRNA (small interfering RNA) delivery to phagocytes...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (1): 123–132.
Published: 27 April 2011
... correspondence should be addressed (email: h.f.galley@abdn.ac.uk ). 21 12 2010 24 2 2011 28 2 2011 28 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium inflammation oxidative stress peroxiredoxin sepsis thioredoxin Sepsis...
Includes: Supplementary data
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Biochem J (2011) 435 (2): 431–439.
Published: 29 March 2011
... by previously unknown mechanisms. ER stress plays a critical role in inflammatory induction and COX2 (cyclo-oxygenase 2) is an important mediator of this inflammation. In the present study, we demonstrate the molecular mechanisms of HBx on induction of ER stress and COX2 expression. In addition, HBx reduced...
Articles
Biochem J (2011) 434 (1): 11–24.
Published: 27 January 2011
... 2011 allergy asthma chemokine G-protein-coupled receptor (GPCR) inflammation leucocyte Allergic diseases such as asthma, allergic rhinitis and atopic dermatitis are typified by an undesirable reaction to antigens (allergens) and are characterized by an influx of eosinophils...
Articles
Biochem J (2010) 432 (3): 535–547.
Published: 25 November 2010
... and sequence, different Gals exert distinct effects on their target cells. We have shown that Gal-1 triggers platelet activation, suggesting a role for Gals in thrombus formation. Since Gal-8 is expressed upon endothelial activation and also contributes to inflammation, to understand further the role...
Articles
Biochem J (2010) 430 (2): e1–e4.
Published: 13 August 2010
...Marie-Soleil Gauthier; Neil B. Ruderman In recent years, it has become widely accepted that obesity is characterized by a chronic low-grade inflammation of adipose tissue that predisposes affected individuals to insulin resistance, Type 2 diabetes and other disorders associated with the metabolic...
Articles
Biochem J (2010) 430 (1): 141–149.
Published: 28 July 2010
... activation between IR-MO and NIR-MO individuals. Our results support the concept that NIR-MO individuals lack the inflammatory response that characterizes the IR-MO patient and that IL-6, IL-1β, ERK and NF-κB are important effectors that mediate the inflammation effects promoting insulin resistance. 1...