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Keywords: inflammasome
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Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
...Ashley Weir; James E. Vince For over 15 years the lytic cell death termed pyroptosis was defined by its dependency on the inflammatory caspase, caspase-1, which, upon pathogen sensing, is activated by innate immune cytoplasmic protein complexes known as inflammasomes. However, this definition...
Biochem J (2020) 477 (20): 3923–3934.
Published: 23 October 2020
... by LPS plus Nigericin treatment. Consistently, other HSP90 inhibitors, including Radicicol, 17-DMAG and 17-AAG, all ameliorated pyroptosis in THP-1 cells by suppressing the inflammasome/Caspase-1/GSDMD signal pathway in pyroptosis. HSP90 inhibition compromised the protein stability of NLRP3, a critical...
Biochem J (2020) 477 (6): 1089–1107.
Published: 23 March 2020
.... metaflammation). Metabolic stress and endogenous danger signals can engage pathogen recognition receptors (PRRs) of the innate immune system thereby activating pro-inflammatory and stress pathways in adipose tissue. The Nod-like receptor protein 3 (NLRP3) inflammasome can act as a metabolic danger sensor...
Biochem J (2018) 475 (12): 1995–2008.
Published: 21 June 2018
...Ying Liu; Xin Gao; Yi Miao; Yuanyuan Wang; Huan Wang; Zhe Cheng; Xi Wang; Xiaogang Jing; Liuqun Jia; Lingling Dai; Meng Liu; Lin An Activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome received substantial attention recently in inflammatory diseases...
Includes: Supplementary data
Biochem J (2013) 449 (3): 613–621.
Published: 09 January 2013
...), ASC functions downstream of NLRs (nucleotide-binding domain, leucine-rich repeat-containing receptors) and AIM2 (absent in melanoma 2) through the formation of supramolecular structures termed inflammasomes. However, the mechanism underlying ASC signalling and its dependency on oligomeric arrangements...
Includes: Supplementary data