1-50 of 63
Keywords: hypoxia
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Articles
Biochem J (2022) 479 (6): 767–786.
Published: 28 March 2022
...Michael Batie; Julianty Frost; Dilem Shakir; Sonia Rocha Reduced oxygen availability (hypoxia) can act as a signalling cue in physiological processes such as development, but also in pathological conditions such as cancer or ischaemic disease. As such, understanding how cells and organisms respond...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (3): 245–257.
Published: 04 February 2022
...Michael Batie; Niall S. Kenneth; Sonia Rocha Hypoxia is a common denominator in the pathophysiology of a variety of human disease states. Insight into how cells detect, and respond to low oxygen is crucial to understanding the role of hypoxia in disease. Central to the hypoxic response is rapid...
Articles
Articles
Biochem J (2019) 476 (12): 1713–1724.
Published: 19 June 2019
.... In this study, we sought to determine the mechanism by which GCN5L1 impacts energy substrate utilization and mitochondrial health. We find that hypoxia and reoxygenation (H/R) leads to a reduction in cell viability and Akt phosphorylation in GCN5L1 knockdown AC16 cardiomyocytes, in parallel with elevated...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (12): 2073–2090.
Published: 29 June 2018
..., SINHCAF (SIN3A and HDAC-associated factor)/FAM60A (family of homology 60A), links the SIN3A–HDAC co-repressor complex function to the hypoxia response. We show that SINHCAF specifically represses HIF-2α mRNA and protein expression, via its interaction with the transcription factor SP1 (specificity protein...
Includes: Supplementary data
Articles
Articles
Articles
Biochem J (2016) 473 (17): 2561–2572.
Published: 30 August 2016
... activity [ 41 ], when upon exposure to hypoxia and/or hypercapnia they release a variety of neurotransmitters which elicit increases in afferent fibre discharge along the carotid sinus nerve and thereby govern cardiorespiratory reflexes that elicit corrective changes in ventilation [ 42 – 45 ]. Recent...
Articles
Biochem J (2016) 473 (16): 2507–2518.
Published: 11 August 2016
..., is poorly understood. To elucidate the function of SPCA2, we studied human colon cancer HCT116 cells, grown under ambient and decreased O 2 levels. We found that in contrast with other Ca 2+ -ATPase isoforms the expression of SPCA2 was up-regulated under hypoxia (3% O 2 ), in both adherent (2D) and spheroid...
Includes: Supplementary data
Articles
Articles
Articles
Biochem J (2014) 462 (3): 385–395.
Published: 22 August 2014
... that gene expression is co-ordinated by changes in transcription and translation in hypoxia, much less is known about how chromatin changes allow for transcription to take place. The missing link between co-ordinating chromatin structure and the hypoxia-induced transcriptional programme could be in the form...
Articles
Biochem J (2014) 462 (1): 103–112.
Published: 24 July 2014
... of the enzymes metabolizing ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) and increased levels of miR-21 are linked to disease pathology, but the mechanisms are not understood. In the present study we assessed the potential role of miR-21 in the regulation of hypoxia-induced changes in ADMA...
Articles
Biochem J (2014) 461 (3): 391–402.
Published: 10 July 2014
...Daochun Luo; Isabella Caniggia; Martin Post BOK (BCL-2-related ovarian killer) is a member of the pro-apoptotic BCL-2 family that is highly expressed in the human placenta. BOK excess causes increased trophoblast autophagy and apoptosis in pre-eclampsia, a pathological condition of hypoxia...
Includes: Supplementary data
Articles
Biochem J (2014) 458 (3): e5–e7.
Published: 28 February 2014
... in health and disease. 1 email jbolanos@usal.es 21 1 2014 22 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 2,3-bisphosphoglycerate phosphatase cancer glycolysis haemoglobin hypoxia mitochondrion oxygen sensing TIGAR [TP53 (tumour...
Articles
Articles
Biochem J (2013) 455 (2): 217–227.
Published: 27 September 2013
... different forms of stress in neurons. heat-shock protein hypoxia interaction neuron Nogo oxidative stress Nogo-A is possibly the best characterized of a variety of neurite outgrowth inhibitors present in CNS (central nervous system) myelin. Neutralizing its activity with function-blocking...
Includes: Supplementary data
Articles
Articles
Biochem J (2013) 452 (1): 79–86.
Published: 25 April 2013
...Jiechuang Su; Christopher P. Guise; William R. Wilson One-electron reductases that reduce nitro compounds in hypoxic human tumour cells are poorly characterized, but are important for targeting hypoxia with nitroaromatic prodrugs. Fluorogenic probes with defined reductase profiles are needed...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 389–400.
Published: 14 December 2012
...Luke R. G. Pike; Dean C. Singleton; Francesca Buffa; Olga Abramczyk; Kanchan Phadwal; Ji-Liang Li; Anna Katharina Simon; James T. Murray; Adrian L. Harris Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 811–820.
Published: 16 April 2012
... of apoptosis in hypoxic tumours. We have shown that, in cancer cells, hypoxia disrupts the p53–RPA70 complex, thereby enhancing RPA70-mediated NER (nucleotide excision repair)/NHEJ (non-homologous end-joining) repair. In normal cells, RPA70 binds to the p53-NTD (N-terminal domain), whereas this binding...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (1): 153–164.
Published: 14 March 2012
... of hypoxia. In the present study, we located the core proximal promoter of the mouse Ngb gene to a 554 bp segment, which harbours putative conserved NF-κB (nuclear factor κB)- and Egr1 (early growth-response factor 1) -binding sites. Overexpression and knockdown of transcription factors p65, p50, Egr1 or Sp1...
Articles
Articles
Articles
Biochem J (2010) 431 (3): 345–352.
Published: 11 October 2010
..., whereas Fe-S dependent activities in the chloroplast and mitochondria were unaffected. In addition, the HYD3 -knockdown lines grew poorly on hypoxanthine, indicating impaired function of xanthine dehydrogenase, another cytosolic Fe-S enzyme. The expression levels of selected genes in response to hypoxia...
Includes: Supplementary data
Articles
Articles
Articles
Articles
Articles
Biochem J (2009) 421 (2): 163–169.
Published: 26 June 2009
... to be activated under conditions that deplete cellular ATP and elevate AMP levels, such as glucose deprivation, hypoxia, ischaemia and heat shock [ 2 – 4 ]. Previous work, however, indicates that other mechanisms, independent of bioenergetic changes, might be involved in AMPK activation; these include CaMKKII (Ca...
Includes: Supplementary data
Articles
Articles
Biochem J (2009) 418 (3): 673–682.
Published: 25 February 2009
...Ivan Mikula; Suzanne Durocher; Pavel Martasek; Bulent Mutus; Anny Slama-Schwok Nitrite (NO 2 − ) recycling to nitric oxide (NO) is catalysed by a number of enzymes and induces a protective vasodilation effect under hypoxia/ischaemia. In the present work, we tested the in vitro ability of the three...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (1): 183–193.
Published: 12 December 2008
... respectively, for 8 or 16 weeks and liver hypoxia, mitochondrial bioenergetics, NO (nitric oxide)-dependent control of respiration, and 3-NT (3-nitrotyrosine), a marker of protein modification by RNS, were examined. Feeding a HFD for 16 weeks induced NASH-like pathology accompanied by elevated triacylglycerols...
Articles
Biochem J (2008) 416 (3): 387–394.
Published: 26 November 2008
...Patrick J. Pollard; Christoph Loenarz; David R. Mole; Michael A. McDonough; Jonathan M. Gleadle; Christopher J. Schofield; Peter J. Ratcliffe The transcription factor HIF (hypoxia-inducible factor) mediates a highly pleiotrophic response to hypoxia. Many recent studies have focused on defining...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (1): 19–29.
Published: 29 July 2008
...Niall Steven Kenneth; Sonia Rocha Hypoxia induces profound changes in the cellular gene expression profile. The discovery of a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and the factors that contribute to HIF regulation have greatly enhanced our...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 413 (1): 125–134.
Published: 12 June 2008
... that the cathepsin L 5′-UTR contained a functional IRES (internal ribosome entry site). This complete IRES was present only in one of the three splice variants, which differed in their 5′-UTR. Then, we analysed cathepsin L expression in this human melanoma cell line grown under hypoxia. We demonstrated that under...
Articles
Biochem J (2008) 412 (3): 477–484.
Published: 28 May 2008
...Patrick van Uden; Niall S. Kenneth; Sonia Rocha HIF (hypoxia-inducible factor) is the main transcription factor activated by low oxygen tensions. HIF-1α (and other α subunits) is tightly controlled mostly at the protein level, through the concerted action of a class of enzymes called PHDs (prolyl...
Includes: Supplementary data
Articles
Biochem J (2008) 409 (1): 65–75.
Published: 11 December 2007
...Katia Monastyrskaya; Fabian Tschumi; Eduard B. Babiychuk; Deborah Stroka; Annette Draeger The pH i (intracellular pH) is an important physiological parameter which is altered during hypoxia and ischaemia, pathological conditions accompanied by a dramatic decrease in pH i . Sensors of pH i include...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 409 (1): 19–26.
Published: 11 December 2007
... levels to the point where oxygen demand exceeds supply (termed hypoxia) leads rapidly to metabolic crisis and represents a severe threat to ongoing physiological function and ultimately, viability. Because of the central role of oxygen in metabolism, it is perhaps not surprising that we have evolved...
Articles
Articles
Articles
Biochem J (2007) 408 (2): e5–e6.
Published: 14 November 2007
...Eric Metzen The transcriptional activator HIF (hypoxia-inducible factor) is a focal point of biomedical research because many situations in physiology and in pathology coincide with hypoxia. The effects of HIF activation may be a facet of normal growth, as in embryonic development, they may...
Articles
Articles
Biochem J (2006) 393 (2): 471–480.
Published: 23 December 2005
...Nathalie Arquier; Paul Vigne; Eric Duplan; Tien Hsu; Pascal P. Therond; Christian Frelin; Gisela D'Angelo The mechanism by which hypoxia induces gene transcription involves the inhibition of HIF-1α (hypoxia-inducible factor-1 α subunit) PHD (prolyl hydroxylase) activity, which prevents the VHL (von...
Articles
Biochem J (2005) 390 (2): 427–436.
Published: 23 August 2005
...). These results indicate that the JAK/STAT pathway may play a pivotal role during tumour-associated or retinal angiogenesis in which endothelial cell survival during tissue hypoxia is critical for maintaining either the growth of neoplasms or the inappropriate retinal neovascularization common in diabetic...
Articles
Articles
Articles
Articles
Biochem J (2004) 380 (2): 419–424.
Published: 01 June 2004
... factors HIFs (hypoxia-inducible factors). Enzymes that link changes in oxygen tensions with the stability and transcriptional activity of HIFs are considered as oxygen sensors. These enzymes are oxygen-, iron- and 2-oxoglutarate-dependent dioxygenases that hydroxylate key proline and asparagine residues...