... blood-derived neutrophils alone, in the presence of the classical chemical NET inducer PMA or in the presence of Staphylococcus aureus . Parallel assays with a random LL-37 fragment library indicated that the NET induction is mediated by the hydrophobic character of the peptide. The trans-localization...

...Josh Duffy; Bhargavi Patham; Kojo Mensa-Wilmot N-terminal signal peptides direct secretory proteins into the ER (endoplasmic reticulum) of eukaryotes or the periplasmic space of prokaryotes. A hydrophobic core (h-region) is important for signal sequence function; however, the mechanism of h-region...

... by determining the secondary/tertiary structure, hydrophobicity and chaperone-like activity of αA- and αB-homopolymers and heteropolymers with different ratios of αA to αB subunits. Although, under physiologically relevant conditions, the αB-homopolymer (37–40 °C) has shown relatively higher activity, the αA...

... inactivation assay. Glycation-induced loss of α-crystallin chaperone activity was associated with decreased hydrophobicity. Furthermore, α-crystallin isolated from glycated TSP (total lens soluble protein) had also increased AGE fluorescence, CML formation and diminished chaperone activity. These results...