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Keywords: hydrophobic motif
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Biochem J (2012) 448 (2): 285–295.
Published: 07 November 2012
...-dependent kinase-1) and its C-terminal hydrophobic motif (Ser 473 ) by mTORC2 [mTOR (mammalian target of rapamycin) complex 2]. Potent PDK1 inhibitors such as GSK2334470 have recently been elaborated as potential anti-cancer agents. However, these compounds were surprisingly ineffective at suppressing Akt...
Includes: Supplementary data