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Keywords: glycolysis
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Biochem J (2020) 477 (10): 1795–1811.
Published: 21 May 2020
...Tomokazu Ohnishi; Joji Kusuyama; Kenjiro Bandow; Tetsuya Matsuguchi The glycolytic system is selected for ATP synthesis not only in tumor cells but also in differentiated cells. Differentiated osteoblasts also switch the dominant metabolic pathway to aerobic glycolysis. We found that primary...
Includes: Supplementary data
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Biochem J (2020) 477 (9): 1733–1744.
Published: 15 May 2020
.... Interestingly, glycolytic enzymes were more acetylated in the procyclic, which develops in insects and uses oxidative phosphorylation to obtain energy, compared with the bloodstream form, whose main source of energy is glycolysis. Here, we investigated whether acetylation regulates the T. brucei fructose 1,6...
Includes: Supplementary data
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Biochem J (2019) 476 (12): 1713–1724.
Published: 19 June 2019
... glucose utilization and impaired fatty acid use. We demonstrate that glycolysis is uncoupled from glucose oxidation under normoxic conditions in GCN5L1-depleted cells. We show that GCN5L1 directly binds to the Akt-activating mTORC2 component Rictor, and that loss of Rictor acetylation is evident in GCN5L1...
Includes: Supplementary data
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Biochem J (2019) 476 (7): 1053–1082.
Published: 04 April 2019
... © 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . amino acid metabolism comparative proteomics glycolysis maf1 RNA...
Includes: Supplementary data
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Biochem J (2019) 476 (4): 629–643.
Published: 19 February 2019
... a phosphoglycolate group [ 1 ]. These 3′-phosphoglycolate groups can be removed either by releasing phosphoglycolate (via the enzyme APE1, [ 2 – 4 ]) or by releasing glycolate (via the enzyme TDP1, [ 5 – 7 ]) (see Supplementary Figure S1A ). Phosphoglycolate is known to have an effect on two steps in glycolysis...
Includes: Supplementary data
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Biochem J (2018) 475 (16): 2577–2592.
Published: 29 August 2018
... evolution. As a consequence, it was frequently assumed that the topological organisation of the metabolic pathway has formed in a Darwinian process. The situation changed with the discovery of a non-enzymatic glycolysis and pentose phosphate pathway. The suite of metabolism-like reactions is promoted...
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Biochem J (2017) 474 (23): 3935–3950.
Published: 16 November 2017
... of energetic resources such as ATP and NADPH. In this review, we explore these strategies, focusing on key metabolic pathways and processes, such as glycolysis, anaplerosis, the TCA (tricarboxylic acid) cycle, and NADPH production. We show that only a holistic approach for bioengineering — considering...
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Biochem J (2017) 474 (16): 2785–2801.
Published: 07 August 2017
.... In the present study, we used radiometric glycolysis assays, [ 13 C 6 ]-glucose isotope tracing, and extracellular flux analysis to understand how phosphofructokinase (PFK)-mediated changes in glycolysis regulate glucose carbon partitioning into catabolic and anabolic pathways. Expression of kinase-deficient...
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Biochem J (2015) 469 (3): 421–432.
Published: 23 July 2015
...Marco Kloos; Antje Brüser; Jürgen Kirchberger; Torsten Schöneberg; Norbert Sträter Phosphofructokinase-1 (Pfk) acts as the main control point of flux through glycolysis. It is involved in complex allosteric regulation and Pfk mutations have been linked to cancer development. Whereas the 3D...
Includes: Supplementary data
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Biochem J (2015) 467 (2): 303–310.
Published: 02 April 2015
... (phosphatase and tensin homologue deleted on chromosome 10-induced protein kinase-1) gene. Moreover, we demonstrate that, by promoting pink1 expression, DJ1 represses the rate of glycolysis and cell proliferation. 1 These authors equally contributed to this work. 2 To whom correspondence should...
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Biochem J (2015) 465 (1): 49–61.
Published: 12 December 2014
... cells show differences in basal bioenergetics profiles and bioenergetics responses to serum depletion, oestradiol and tamoxifen as measured in real time by extracellular flux analysis in intact cells. breast cancer glycolysis extracellular flux mitochondrial function oxygen consumption rate...
Includes: Supplementary data
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Biochem J (2014) 464 (1): 35–48.
Published: 23 October 2014
... to acetyl-CoA for entry into the Krebs cycle; in the absence of MondoA, pyruvate is diverted towards lactate and alanine, both products of glycolysis. Dynamic testing revealed that MondoA −/− mice excel in sprinting as their skeletal muscles display an enhanced glycolytic capacity. Our studies uncover...
Includes: Supplementary data
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Biochem J (2014) 458 (3): e5–e7.
Published: 28 February 2014
...Juan P. Bolaños TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] protein is known for its ability to inhibit glycolysis, shifting glucose consumption towards the pentose phosphate pathway to promote antioxidant protection of cancer cells. According to sequence homology...
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Biochem J (2013) 454 (2): 227–237.
Published: 09 August 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 fermentation glycolysis hexokinase metabolic regulation trehalose yeast The yeast Saccharomyces cerevisiae is currently the most frequently used organism for the production of bioethanol; however, despite its wide use...
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Biochem J (2013) 452 (3): e7–e9.
Published: 31 May 2013
...Juan P. Bolaños Besides the necessary changes in the expression of cell cycle-related proteins, cancer cells undergo a profound series of metabolic adaptations focused to satisfy their excessive demand for biomass. An essential metabolic transformation of these cells is increased glycolysis, which...
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Biochem J (2013) 452 (3): 531–543.
Published: 31 May 2013
...-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate metabolism. In the present study we analysed the mechanism of regulation of PFKFB3 as an immediate early gene controlled by stress stimuli that activates the p38...
Includes: Supplementary data
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Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
...-cells increase following BCR engagement and are characterized by a metabolic switch to aerobic glycolysis; however, the signalling pathways involved in this metabolic reprogramming are poorly defined. The PKC (protein kinase C) family plays an integral role in B-cell survival and antigenic responses...
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Biochem J (2012) 445 (2): 213–218.
Published: 27 June 2012
...Oscar H. Martínez-Costa; Valentina Sánchez; Antonio Lázaro; Eloy D. Hernández; Keith Tornheim; Juan J. Aragón Eukaryotic PFK (phosphofructokinase), a key regulatory enzyme in glycolysis, has homologous N- and C-terminal domains thought to result from duplication, fusion and divergence...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 537–551.
Published: 29 May 2012
... of 13 C-labelled glucose in both a liver perfusion system and isolated hepatocytes. MS and NMR spectroscopy were deployed to measure isotopic enrichment. The results demonstrate that the stimulation of glycolysis by GKA led to numerous changes in hepatic metabolism: (i) augmented flux through the TCA...
Includes: Supplementary data
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Biochem J (2012) 444 (2): 249–259.
Published: 11 May 2012
... by the activation of AMPK and the silencing of ATF4 (activating transcription factor 4). These findings emphasize the relevance of translational control for normal mitochondrial function and for the progression of cancer. Moreover, they demonstrate that glycolysis and oxidative phosphorylation are controlled...
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Biochem J (2012) 443 (1): 3–11.
Published: 14 March 2012
..., which maintains the antioxidant glutathione in its reduced state, hence exerting neuroprotection. This process is tightly controlled by a key glycolysis-promoting enzyme and is dependent on an appropriate supply of energy substrates from astrocytes. Thus brain bioenergetic and antioxidant defence...
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Biochem J (2012) 442 (2): 345–356.
Published: 13 February 2012
...), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is extensively involved in cell proliferation owing to its key role in carbohydrate metabolism. In the present study we analyse its mechanism of regulation by progestins in breast cancer cells. We report that exposure of T47D cells...
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Biochem J (2009) 424 (1): 99–107.
Published: 23 October 2009
... capacity exist in cardiac myocytes? (ii) Does it modulate the response to stress-associated pathology? The recent availability of technology which allows for the non-invasive measurement of mitochondrial respiration and glycolysis offers the opportunity to address these questions. Therefore we hypothesized...
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Biochem J (2009) 420 (2): 161–168.
Published: 13 May 2009
...Niels Ørtenblad; Will A. Macdonald; Kent Sahlin The control of glycolysis in contracting muscle is not fully understood. The aim of the present study was to examine whether activation of glycolysis is mediated by factors related to the energy state or by a direct effect of Ca 2+ on the regulating...
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Biochem J (2009) 417 (3): 717–726.
Published: 16 January 2009
... cellular ATP production owing to its action on glycolysis and oxidative phosphorylation; however, the specific metabolic steps and mechanisms of 3-BrPA action in human hepatocellular carcinomas, particularly its effects on mitochondrial energetics, are poorly understood. In the present study it was found...
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Biochem J (2006) 400 (1): 143–151.
Published: 27 October 2006
... domain of band 3 erythrocyte cytoskeleton erythrocyte membrane structure glycolysis glycolytic enzyme complex The GEs (glycolytic enzymes) GAPDH (glyceraldehyde-3-phosphate dehydrogenase), aldolase, PFK (phosphofructokinase), LDH (lactate dehydrogenase) and PK (pyruvate kinase) have been...
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Biochem J (2006) 393 (1): 431–439.
Published: 12 December 2005
... with the variable values observed with the 15 controls. Our observations suggest that, when glycolysis and mitochondria generate ATP, and in the absence of appropriate activators of proton transport, UCPs do not transport protons (uncoupling), but rather other ions of physiological relevance that control...
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Biochem J (2005) 392 (3): 675–683.
Published: 06 December 2005
... mutations (F240L and E145Stop), but only the younger one suffers from neurodegeneration. In the present study, we determined the kinetic parameters of key glycolytic enzymes including the mutant TPI for rational modelling of erythrocyte glycolysis. We found that a low TPI activity in the mutant cells (lower...
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Biochem J (2003) 376 (2): 403–411.
Published: 01 December 2003
... premature senescence, reactive oxygen species are considered important intermediates contributing to the phenotype. Moreover, distinct alterations of the cellular carbohydrate metabolism are known to contribute to oncogenic transformation, as is best documented for the phenomenon of aerobic glycolysis...
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Biochem J (2003) 375 (2): 231–246.
Published: 15 October 2003
...@wur.nl ). 20 9 2002 16 5 2003 18 8 2003 18 8 2003 The Biochemical Society, London ©2003 2003 Archaea Embden—Meyerhof pathway Entner—Douderoff pathway glycolysis glycolytic enzyme polysaccharide Abbreviations used: AOR, aldehyde oxidoreductase; ED, Entner...
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Biochem J (2002) 365 (1): 223–228.
Published: 01 July 2002
... 2002 12 4 2002 The Biochemical Society, London ©2002 2002 glycolysis hypoxia insulin maturity-onset diabetes of the young metabolic zonation nuclear receptor Abbreviations used: DIG, digoxigenin; EMSA, electrophoretic mobility-shift assay; EPO, erythropoietin; GK...