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AMPK inhibits liver gluconeogenesis: fact or fiction?

In Collection

Cell signaling in the 21st century

Manuel Johanns, Louis Hue, Mark H. Rider

Biochem J (2023) 480 (1): 105–125.

DOI: https://doi.org/10.1042/BCJ20220582

Published: 13 January 2023

...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...

View article titled, AMPK inhibits liver gluconeogenesis: fact or fiction?

Articles

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider

Biochem J (2022) 479 (12): 1317–1336.

DOI: https://doi.org/10.1042/BCJ20220170

Published: 22 June 2022

... properties. The main aim was to investigate the effects of 991 and other direct AMPK activators on HGP and determine whether the observed effects were AMPK-dependent. In incubated hepatocytes, 991 substantially decreased gluconeogenesis from lactate, pyruvate and glycerol, but not from other substrates...

View article titled, Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Includes: Supplementary data

Articles

Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2

Lina He, Yang Li, Ni Zeng, Bangyan L. Stiles

Biochem J (2020) 477 (5): 1021–1031.

DOI: https://doi.org/10.1042/BCJ20190570

Published: 13 March 2020

...Lina He; Yang Li; Ni Zeng; Bangyan L. Stiles Hepatic glucose metabolism signaling downstream of insulin can diverge to multiple pathways including AKT. Genetic studies suggest that AKT is necessary for insulin to suppress gluconeogenesis. To specifically address the role of AKT2, the dominant liver...

View article titled, Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2

Articles

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

Yang Qiu, Rachel J. Perry, João-Paulo G. Camporez, Xian-Man Zhang, Mario Kahn, Gary W. Cline, Gerald I. Shulman, Daniel F. Vatner

Biochem J (2018) 475 (6): 1063–1074.

DOI: https://doi.org/10.1042/BCJ20180063

Published: 20 March 2018

... and death; however, the molecular mechanisms by which MCPA and MCPG cause hypoglycemia have not been established in vivo . To determine the in vivo mechanisms of action of these toxins, we infused them into conscious rodents and assessed rates of hepatic gluconeogenesis and ketogenesis, hepatic acyl-CoA...

View article titled, In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

Includes: Supplementary data

Articles

A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1,6-bisphosphatase

Cristian A. Droppelmann, Doris E. Sáez, Joel L. Asenjo, Alejandro J. Yáñez, Mar García-Rocha, Ilona I. Concha, Manuel Grez, Joan J. Guinovart, Juan C. Slebe

Biochem J (2015) 472 (2): 225–237.

DOI: https://doi.org/10.1042/BJ20150269

Published: 13 November 2015

... relationship to related pathologies, such as diabetes. In order to gain insight into the regulation of glucose metabolism, we studied the liver-expressed isoforms aldolase B and fructose-1,6-bisphosphatase-1 (FBPase-1), key enzymes in gluconeogenesis, analysing their cellular localization in hepatocytes under...

View article titled, A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1,6-bisphosphatase

Includes: Supplementary data

Articles

TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Kenneth K. Y. Cheng, Karen S. L. Lam, Yu Wang, Donghai Wu, Mingliang Zhang, Baile Wang, Xiaomu Li, Ruby L. C. Hoo, Zhe Huang, Gary Sweeney, Aimin Xu

Biochem J (2013) 455 (2): 207–216.

DOI: https://doi.org/10.1042/BJ20130760

Published: 27 September 2013

... in Type 2 diabetes. APPL1 [adaptor protein, phosphotyrosine interaction, PH (pleckstrin homology) domain and leucine zipper containing 1] sensitizes hepatic insulin action on suppression of gluconeogenesis by binding to Akt. However, the mechanisms underlying the insulin-sensitizing actions of APPL1...

View article titled, TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Includes: Supplementary data

Articles

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13 C-isotopomer-based metabolomics

Itzhak Nissim, Oksana Horyn, Ilana Nissim, Yevgeny Daikhin, Suzanne L. Wehrli, Marc Yudkoff, Franz M. Matschinsky

Biochem J (2012) 444 (3): 537–551.

DOI: https://doi.org/10.1042/BJ20120163

Published: 29 May 2012

... and outflow of lactate. The present study provides a deeper insight into the hepatic actions of GKAs and uncovers the potential benefits and risks of GKA for treatment of diabetes. GKA improved hepatic bioenergetics, ureagenesis and glycogenesis, but decreased gluconeogenesis with a potential risk of lactic...

View article titled, Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13 C-isotopomer-based metabolomics

Includes: Supplementary data

Articles

Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation

Yong-Soo Lee, Don-Kyu Kim, Yong Deuk Kim, Ki Cheol Park, Minho Shong, Hyun-A Seong, Hyun Jung Ha, Hueng-Sik Choi

Biochem J (2008) 413 (3): 559–569.

DOI: https://doi.org/10.1042/BJ20071637

Published: 15 July 2008

... of gluconeogenesis. 1 To whom correspondence should be addressed (email hsc@chonnam.ac.kr ). The atypical orphan NR (nuclear receptor) SHP (small heterodimer partner) appears to be a versatile protein that functions in many cellular events. It has an atypical structure, consisting of a putative LBD...

View article titled, Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation

Includes: Supplementary data

Articles

Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene

Susumu Kodama, Rick Moore, Yukio Yamamoto, Masahiko Negishi

Biochem J (2007) 407 (3): 373–381.

DOI: https://doi.org/10.1042/BJ20070481

Published: 12 October 2007

... immunoprecipitation) assays were performed to show a decreased CREB binding to the G6Pase promoter in fasting wild-type mice after PCN treatment. Thus drug activation of PXR can repress the transcriptional activity of CREB, down-regulating gluconeogenesis. 9 4 2007 9 7 2007 17 7 2007 17 7 2007...

View article titled, Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene

Articles

Glutamine gluconeogenesis in the small intestine of 72 h-fasted adult rats is undetectable

Guy Martin, Bernard Ferrier, Agnès Conjard, Mireille Martin, Rémi Nazaret, Michelle Boghossian, Fadi Saadé, Claire Mancuso, Daniel Durozard, Gabriel Baverel

Biochem J (2007) 401 (2): 465–473.

DOI: https://doi.org/10.1042/BJ20061148

Published: 21 December 2006

...Guy Martin; Bernard Ferrier; Agnès Conjard; Mireille Martin; Rémi Nazaret; Michelle Boghossian; Fadi Saadé; Claire Mancuso; Daniel Durozard; Gabriel Baverel Recent reports have indicated that 48–72 h of fasting, Type 1 diabetes and high-protein feeding induce gluconeogenesis in the small intestine...

View article titled, Glutamine gluconeogenesis in the small intestine of 72 h-fasted adult rats is undetectable

Articles

Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2 H and 13 C NMR

Natasha Hausler, Jeffrey Browning, Matthew Merritt, Charles Storey, Angela Milde, F. Mark H. Jeffrey, A. Dean Sherry, Craig R. Malloy, Shawn C. Burgess

Biochem J (2006) 394 (2): 465–473.

DOI: https://doi.org/10.1042/BJ20051174

Published: 10 February 2006

... output unchanged. When lactate and pyruvate were eliminated from the perfusion medium, both gluconeogenesis and tricarboxylic-acid-cycle flux were dramatically lower. Insulin lowered glucose production by inhibiting glycogenolysis at both low and high doses, but only at high levels of insulin did...

View article titled, Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2 H and 13 C NMR

Articles

Characteristics of glutamine metabolism in human precision-cut kidney slices: a 13 C-NMR study

Anne VITTORELLI, Catherine GAUTHIER, Christian MICHOUDET, Guy MARTIN, Gabriel BAVEREL

Biochem J (2005) 387 (3): 825–834.

DOI: https://doi.org/10.1042/BJ20041309

Published: 26 April 2005

... 2004 17 11 2004 3 12 2004 3 12 2004 The Biochemical Society, London 2005 ammoniagenesis 13 C NMR gluconeogenesis glutamine metabolism human kidney valproate It is well established that the human kidney takes up glutamine from the circulating blood under various...

View article titled, Characteristics of glutamine metabolism in human precision-cut kidney slices: a 13 C-NMR study

Articles

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Alfonso MORA, Christopher LIPINA, François TRONCHE, Calum SUTHERLAND, Dario R. ALESSI

Biochem J (2005) 385 (3): 639–648.

DOI: https://doi.org/10.1042/BJ20041782

Published: 24 January 2005

... protein 1), which regulate gluconeogenesis, are no longer controlled by feeding. Furthermore, three other insulin-controlled genes, namely IGFBP1 (insulin-like-growth-factor-binding protein-1), IRS2 (insulin receptor substrate 2) and glucokinase, were regulated abnormally by feeding in the liver of PDK1...

View article titled, Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Articles

Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Rolf GREMPLER, Anne KIENITZ, Torsten WERNER, Marion MEYER, Andreas BARTHEL, Fabienne AILETT, Calum SUTHERLAND, Reinhard WALTHER, Dieter SCHMOLL

Biochem J (2004) 382 (2): 471–479.

DOI: https://doi.org/10.1042/BJ20040160

Published: 24 August 2004

... for unpaired data. diabetes gluconeogenesis glucose-6-phosphatase insulin liver sepsis G6Pase (glucose-6-phosphatase) catalyses the final step of the metabolic pathways that are central to hepatic glucose production, i.e. gluconeogenesis and glycogen breakdown [ 1 ]. Thus G6Pase has...

View article titled, Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Articles

Complexity of glutamine metabolism in kidney tubules from fed and fasted rats

Barbara VERCOUTÈRE, Daniel DUROZARD, Gabriel BAVEREL, Guy MARTIN

Biochem J (2004) 378 (2): 485–495.

DOI: https://doi.org/10.1042/bj20031088

Published: 01 March 2004

... glutamate degradation only by decreasing flux through glutamate dehydrogenase in the reductive amination direction, but surprisingly did not significantly alter complete oxidation of the glutamine carbon skeleton. Finally, gluconeogenesis from glutamine involved not only substantial recycling through...

View article titled, Complexity of glutamine metabolism in kidney tubules from fed and fasted rats

Articles

Molecular and structural characterization of NADPH-dependent d-glycerate dehydrogenase from the enteric parasitic protist Entamoeba histolytica

Vahab ALI, Yasuo SHIGETA, Tomoyoshi NOZAKI

Biochem J (2003) 375 (3): 729–736.

DOI: https://doi.org/10.1042/bj20030630

Published: 01 November 2003

... of serine, and, thus, also in controlling cysteine biosyn- thesis located downstream of serine metabolic pathways in this protist. Key words: anaerobic protist, cysteine biosynthesis, Entamoeba histolytica, gluconeogenesis, glycerate dehydrogenase, serine biosynthesis. INTRODUCTION D-Glycerate dehydrogenase...

View article titled, Molecular and structural characterization of NADPH-dependent d-glycerate dehydrogenase from the enteric parasitic protist Entamoeba histolytica

Articles

Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose

Toshihiro YAGI, Edurne BAROJA-FERNÁNDEZ, Ryuji YAMAMOTO, Francisco José MUÑOZ, Takashi AKAZAWA, Kyoung Su HONG, Javier POZUETA-ROMERO

Biochem J (2003) 370 (2): 409–415.

DOI: https://doi.org/10.1042/bj20021140

Published: 01 March 2003

... number AB087802. 19 7 2002 8 11 2002 12 11 2002 12 11 2002 gluconeogenesis glycogen nucleotide-sugar Abbreviations used: G1P, glucose 1-phosphate; UDPG, UDP-glucose; UGPase, UDPG pyrophosphorylase; UGPPase, UDPG pyrophosphatase. The Biochemical Society...

View article titled, Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose

Articles

Hepatocyte nuclear factor-4alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

Jared N. BOUSTEAD, Beth T. STADELMAIER, Angela M. EEDS, Peter O. WIEBE, Christina A. SVITEK, James K. OESER, Richard M. O'BRIEN

Biochem J (2003) 369 (1): 17–22.

DOI: https://doi.org/10.1042/bj20021382

Published: 01 January 2003

..., respiration and therm- ogenesis (reviewed in [6 as well as hepatic gluconeogenesis [7,8]. Recently, two PGC-1a homologues have been identified, PGC-1b [9] and PGC-1-related co-activator ( PRC ) [10]. In liver, expression of both PGC-1a and PGC-1b are markedly induced by fasting [9], and adenoviral-mediated...

View article titled, Hepatocyte nuclear factor-4alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

Articles

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

Fabienne FOUFELLE, Pascal FERRÉ

Biochem J (2002) 366 (2): 377–391.

DOI: https://doi.org/10.1042/bj20020430

Published: 01 September 2002

...Fabienne FOUFELLE; Pascal FERRÉ The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels...

View article titled, New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

Articles

d-Lactate transport and metabolism in rat liver mitochondria

Lidia de BARI, Anna ATLANTE, Nicoletta GUARAGNELLA, Giovanni PRINCIPATO, Salvatore PASSARELLA

Biochem J (2002) 365 (2): 391–403.

DOI: https://doi.org/10.1042/bj20020139

Published: 15 July 2002

... from cytosol, as well as for d -lactate-dependent gluconeogenesis. 1 To whom correspondence should be addressed (e-mail passarel@unimol.it ). 23 1 2002 3 4 2002 9 4 2002 The Biochemical Society, London ©2002 2002 antiporter dehydrogenase flavoprotein...

View article titled, d-Lactate transport and metabolism in rat liver mitochondria

Articles

The glucose-6-phosphatase system

Emile van SCHAFTINGEN, Isabelle GERIN

Biochem J (2002) 362 (3): 513–532.

DOI: https://doi.org/10.1042/bj3620513

Published: 08 March 2002

... be addressed (e-mail vanschaftingen@bchm.ucl.ac.be ). 2 Present address: Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. The Biochemical Society, London ©2002 2002 gluconeogenesis glucose 6-phosphate glycogen glycogen storage disease transporter...

View article titled, The glucose-6-phosphatase system

Articles

Lactate supply as a determinant of the distribution of intracellular pH within the hepatic lobule

Shamus P. BURNS, Helena C. MURPHY, Richard A. ILES, Robert D. COHEN

Biochem J (2001) 358 (3): 569–571.

DOI: https://doi.org/10.1042/bj3580569

Published: 10 September 2001

... more alkaline than perivenous cells. In the present studies, the perivenous 21% of the lobular volume was destroyed by retrograde digitonin perfusion, and antegrade perfusion restored. pH i was determined by 31 P-NMR. The remaining periportal cells, the site of gluconeogenesis from lactate, had...

View article titled, Lactate supply as a determinant of the distribution of intracellular pH within the hepatic lobule

Articles

Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression

Dieter SCHMOLL, Rolf GREMPLER, Andreas BARTHEL, Hans-Georg JOOST, Reinhard WALTHER

Biochem J (2001) 357 (3): 867–873.

DOI: https://doi.org/10.1042/bj3570867

Published: 25 July 2001

... of glucose 6-phosphate to glucose, which is the terminal step of both hepatic gluconeogenesis and glycogen breakdown [1]. G6Pase gene expression is induced by cAMP and gluco- corticoids and is reduced by insulin. In Type II diabetes G6Pase gene expression is increased,which contributes to elevated hepatic...

View article titled, Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression

Articles

Regulation by glucagon (cAMP) and insulin of the promoter of the human phosphoenolpyruvate carboxykinase gene (cytosolic) in cultured rat hepatocytes and in human hepatoblastoma cells

Anne K. RUCKTÄSCHEL, Daryl K. GRANNER, Bruno CHRIST

Biochem J (2000) 352 (1): 211–217.

DOI: https://doi.org/10.1042/bj3520211

Published: 07 November 2000

... action of insulin was exerted through the PI 3- kinase pathway in cultured rat hepatocytes. Key words: gluconeogenesis, HepG2 cells, liver, phospho- inositide 3-kinase. required for its stimulation by cAMP [18], are highly conserved in the human promoter. An insulin-responsive region, which has been...

View article titled, Regulation by glucagon (cAMP) and insulin of the promoter of the human phosphoenolpyruvate carboxykinase gene (cytosolic) in cultured rat hepatocytes and in human hepatoblastoma cells

Articles

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. OWEN, Elena DORAN, Andrew P. HALESTRAP

Biochem J (2000) 348 (3): 607–614.

DOI: https://doi.org/10.1042/bj3480607

Published: 07 June 2000

... of gluconeogenesis from L -lactate in isolated rat hepatocytes was also time- and concentration-dependent, and accompanied by changes in metabolite levels similar to those induced by other inhibitors of gluconeogenesis acting on complex 1. Freeze-clamped livers from metformin-treated rats exhibited similar changes...

View article titled, Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Articles

N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Irwin J. KURLAND, Brett CHAPMAN, M. Raafat EL-MAGHRABI

Biochem J (2000) 347 (2): 459–467.

DOI: https://doi.org/10.1042/bj3470459

Published: 10 April 2000

... activities to work in the physiological range of pH and substrate concen- trations found in each particular tissue. Key words: enzyme kinetics, gluconeogenesis, glycolysis, hepatic glucose metabolism, structure}function. ditional level of control [1]. Recently, the X-ray crystallographic analysis...

View article titled, N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Articles

Structure, function and regulation of pyruvate carboxylase

Sarawut JITRAPAKDEE, John C. WALLACE

Biochem J (1999) 340 (1): 1–16.

DOI: https://doi.org/10.1042/bj3400001

Published: 10 May 1999

... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...

View article titled, Structure, function and regulation of pyruvate carboxylase

Articles

Identification of an oxygen-responsive element in the 5′-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation

Jutta BRATKE, Thomas KIETZMANN, Kurt JUNGERMANN

Biochem J (1999) 339 (3): 563–569.

DOI: https://doi.org/10.1042/bj3390563

Published: 26 April 1999

... modulated by the pO # . These findings corroborated that sequences of the putative CRE2 site were responsible for themodulation byoxygen of theCRE1-dependent induction by glucagon of PCK1 gene transcription. Key words: cAMP-response element, gluconeogenesis, hypoxia, metabolic zonation, PCK. perivenous area...

View article titled, Identification of an oxygen-responsive element in the 5′-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation

Articles

Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells

Dieter SCHMOLL, Christina WASNER, Carolyn J. HINDS, Bernard B. ALLAN, Reinhard WALTHER, Ann BURCHELL

Biochem J (1999) 338 (2): 457–463.

DOI: https://doi.org/10.1042/bj3380457

Published: 22 February 1999

...-mail schmoll@rz.uni-greifswald.de ). The sequence data reported in this article have been deposited with the GenBank database under accession number AF051355. 9 10 1998 18 12 1998 The Biochemical Society, London © 1999 1999 gluconeogenesis insulin liver phosphoenolpyruvate...

View article titled, Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells

NARROW

AMPK inhibits liver gluconeogenesis: fact or fiction?

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1,6-bisphosphatase

TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13 C-isotopomer-based metabolomics

Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation

Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene

Glutamine gluconeogenesis in the small intestine of 72 h-fasted adult rats is undetectable

Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2 H and 13 C NMR

Characteristics of glutamine metabolism in human precision-cut kidney slices: a 13 C-NMR study

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Complexity of glutamine metabolism in kidney tubules from fed and fasted rats

Molecular and structural characterization of NADPH-dependent d-glycerate dehydrogenase from the enteric parasitic protist Entamoeba histolytica

Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose

Hepatocyte nuclear factor-4alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

d-Lactate transport and metabolism in rat liver mitochondria

The glucose-6-phosphatase system

Lactate supply as a determinant of the distribution of intracellular pH within the hepatic lobule

Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression

Regulation by glucagon (cAMP) and insulin of the promoter of the human phosphoenolpyruvate carboxykinase gene (cytosolic) in cultured rat hepatocytes and in human hepatoblastoma cells

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Structure, function and regulation of pyruvate carboxylase

Identification of an oxygen-responsive element in the 5′-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation

Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells

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