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Keywords: glucagon
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Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
... are critically discussed. The effects of several anti-diabetic drugs, particularly metformin, on hepatic gluconeogenesis are also considered. We conclude that the main effect of AMPK activation pertinent to the control of hepatic gluconeogenesis is to antagonize glucagon signalling in the short-term...
Biochem J (2012) 443 (1): 193–203.
Published: 14 March 2012
...-aminoimidazole-4-carboxamide-1-β- D -ribofuranoside) or A769662 led to persistent GYS inactivation and Ser 7 phosphorylation, whereas inactivation by glucagon treatment was transient. In hepatocytes from mice harbouring a liver-specific deletion of the AMPK catalytic α1/α2 subunits, GYS2 inactivation by AICA...
Includes: Supplementary data
Biochem J (2010) 431 (3): 411–421.
Published: 11 October 2010
... of cytosol and cyclic nucleotide also delayed MPT onset, and incubation with purified outer membranes led to phosphorylation of a major 31 kDa band. After ischaemia, administration at reperfusion of membrane-permeant cAMPs and cAMP-mobilizing glucagon prevented reperfusion injury to hepatocytes...
Biochem J (2007) 407 (3): 373–381.
Published: 12 October 2007
...Susumu Kodama; Rick Moore; Yukio Yamamoto; Masahiko Negishi The nuclear PXR (pregnane X receptor) was originally characterized as a key transcription factor that activated hepatic genes encoding drug-metabolizing enzymes. We have now demonstrated that PXR also represses glucagon-activated...
Biochem J (2005) 388 (2): 419–425.
Published: 24 May 2005
... to address this question and to determine the flux through the ADC reaction in isolated mitochondria obtained from rat liver. In addition, liver perfusion system was used to examine a possible action of insulin, glucagon or cAMP on a flux through the ADC reaction. In mitochondria and liver perfusion, 15 N...
Biochem J (1999) 344 (1): 15–21.
Published: 08 November 1999
..., the repeated administration of cysteine failed to cause the complete disappearance of this mRNA in 24 h. In hepatocytes in primary culture, cysteine plus methionine and glucagon had, independently, an approx. 4-fold inhibitory effect on the abundance of the 3-PGDH mRNA and caused its almost complete...