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Keywords: glibenclamide
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Biochem J (2021) 478 (20): 3757–3774.
Published: 21 October 2021
... overexpressed in PDAC cell lines and PDXs, but is not functional due to its intracellular localization. Using glibenclamide as a pharmacological inhibitor of PEPT1, we demonstrate in cell lines in vitro and mouse xenografts in vivo that inhibition of PEPT1 reduces the proliferation of the cancer cells...
Includes: Supplementary data
Biochem J (2014) 464 (3): 343–354.
Published: 05 December 2014
... regulation. In addition to opening in response to ADP and closing in response to ATP, channel gating can be stimulated by potassium channel opening (KCO) drugs, such as nicorandil and inhibited by the anti-diabetic sulfonylureas, such as glibenclamide. Binding sites for channel openers and antagonists...
Includes: Supplementary data