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Keywords: gene expression
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Biochem J (2019) 476 (19): 2927–2938.
Published: 11 October 2019
... genes incorporated into the host genome in a stable cell line or the global gene expression of host genome. This ability is not associated with PKR/RNase L system, as PKR inhibitors does not block MCPIP1-mediated mRNA degradation of exogenously transfected genes. Lastly, expression of MCPIP1 suppressed...
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Biochem J (2018) 475 (9): 1643–1667.
Published: 15 May 2018
...Nicoletta Bianchi; Simone Beninati; Carlo M. Bergamini The type 2 isoenzyme is the most widely expressed transglutaminase in mammals displaying several intra- and extracellular activities depending on its location (protein modification, modulation of gene expression, membrane signalling...
Includes: Supplementary data
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Biochem J (2015) 472 (2): 147–156.
Published: 13 November 2015
... promoter elements to control the transcription and translation of let-7 miRNA genes. gene expression microRNA (micro ribonucleic acid) promoter regulation transcription factor type 2 diabetes 1 To whom correspondence should be addressed (email Anna.Krook@ki.se ). 20 2 2015 1...
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Biochem J (2015) 467 (3): 453–460.
Published: 17 April 2015
... Igfbp-2 and PPARα expression levels were increased. Wy14643, a selective PPARα agonist, significantly induced Igfbp-2 gene expression in primary cultured hepatocytes. However, Igfbp-2 gene expression in Pparα null mice was not affected by fasting or Wy14643. In addition, through transient...
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Biochem J (2015) 466 (1): 29–36.
Published: 06 February 2015
... that the expression level of RyR1 in human extraocular muscles (EOMs) is low and that these muscles express different levels of proteins involved in excitation–contraction coupling (ECC) compared with leg muscles (LMs). calcium homoeostasis excitation–contraction coupling gene expression Extraocular...
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Biochem J (2013) 455 (1): 67–73.
Published: 13 September 2013
...Michael Aregger; Victoria H. Cowling Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II...
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Biochem J (2013) 451 (3): 439–451.
Published: 12 April 2013
...Marta Magdalena Gabryelska; Eliza Wyszko; Maciej Szymański; Mariusz Popenda; Jan Barciszewski Hammerhead ribozyme is a versatile tool for down-regulation of gene expression in vivo . Owing to its small size and high activity, it is used as a model for RNA structure–function relationship studies...
Includes: Supplementary data
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Biochem J (2012) 446 (2): 203–212.
Published: 14 August 2012
... compilation © 2012 Biochemical Society 2012 cis- acting regulatory element cystic fibrosis transmembrane conductance regulator ( CFTR ) enhancer gene expression transcriptional network The recruitment of TFs (transcription factors) and chromatin remodellers to cis- regulatory elements...
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Biochem J (2012) 444 (1): 39–49.
Published: 26 April 2012
..., NY 10032, U.S.A. 2 To whom correspondence should be addressed (email Joaquin.Arino@uab.es ). 1 12 2011 9 2 2012 28 2 2012 28 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 gene expression glucose starvation Snf1 stress tolerance...
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Biochem J (2011) 440 (1): 73–84.
Published: 27 October 2011
...-basic vector for sequencing. CpG gene expression methylation nuclear factor Y (NF-Y) sodium–vitamin C co-transporter 2 (SVCT2) upstream stimulating factor (USF) The antibodies against USF1 (C-20), USF2 (C-20), TFII-I (transcription factor II-I) (H-58) and NF-YA (C-18) were...
Includes: Supplementary data
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Biochem J (2011) 438 (3): 523–533.
Published: 26 August 2011
... to regulation of Msn2 function. alkaline stress gene expression Msn2 Msn4 protein kinase A (PKA) Saccharomyces cerevisiae transcription factor 1 Present address: Department of Genetics & Development and Microbiology & Immunology, Columbia University, New York, NY 10027, U.S.A...
Includes: Supplementary data
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Biochem J (2011) 437 (3): 477–482.
Published: 13 July 2011
... macrophages, enterocytes and hepatocytes towards plasma. Abnormal levels of hepcidin expression alter plasma iron parameters and lead to iron metabolism disorders. Understanding the mechanisms controlling hepcidin ( HAMP encodes hepcidin) gene expression is therefore an important goal. We identified...
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Biochem J (2011) 435 (2): 313–325.
Published: 29 March 2011
... on the transcriptional regulation of the recently identified NHE8 isoform is also highlighted. Therefore the present review bridges a gap in our knowledge of the transcriptional mechanisms underlying the alterations in the gene expression of intestinal epithelial luminal membrane Na + and Cl − transporters involved...
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Biochem J (2011) 434 (3): 549–558.
Published: 24 February 2011
.... Surprisingly, most tumour suppressor mechanisms co-ordinated by p38α have been reported to occur at the post-translational level. This contrasts with the important role of p38α in the regulation of transcription and the profound changes in gene expression that normally occur during tumorigenesis. We have...
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Biochem J (2011) 434 (2): 253–263.
Published: 11 February 2011
... export, thereby providing a negative regulatory feedback mechanism that critically influences the duration of the NF-κB response [ 16 – 18 ]. cellular localization gene expression inhibitory κB β (IκBβ) nuclear factor κB (NF-κB) tumour necrosis factor α (TNFα) The regulatory interplay...
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Biochem J (2010) 432 (3): 473–486.
Published: 25 November 2010
... tissue axis. In the present study, we show that PGC-1α [PPARγ (peroxisome-proliferator-activated receptor γ) co-activator 1α] interacts with and co-activates SF-1 to induce LH β (luteinizing hormone β) and α GSU (α-glycoprotein subunit) gene expression, subsequently leading to the increased secretion...
Includes: Supplementary data
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Biochem J (2010) 431 (2): 169–178.
Published: 28 September 2010
.... Moreover, GSH recruitment and sequestration in the nucleus during the G 1 - and S-phases of the cell cycle has a profound impact on cellular redox homoeostasis and on gene expression. For example, the abundance of transcripts encoding stress and defence proteins is decreased when GSH is sequestered...
Includes: Multimedia, Supplementary data
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Biochem J (2010) 427 (2): 255–264.
Published: 29 March 2010
...Francesca Aguiló; Nuria Camarero; Joana Relat; Pedro F. Marrero; Diego Haro In the cytosol of lipogenic tissue, ketone bodies are activated by AACS (acetoacetyl-CoA synthetase) and incorporated into cholesterol and fatty acids. AACS gene expression is particularly abundant in white adipose tissue...
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Biochem J (2009) 422 (3): 443–453.
Published: 27 August 2009
... 3 2009 15 6 2009 26 6 2009 26 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Ccr4–Not complex gene expression mRNA deadenylation proteomics transcription regulation The evolutionarily conserved Ccr4–Not complex is important...
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Biochem J (2009) 420 (3): 403–411.
Published: 27 May 2009
... and thymus [ 21 ]. KLF4 contains both transcriptional activation and repression domains, and is known to activate and repress gene expression [ 22 ]. Analyses of KLF4 target genes have shown that KLF4 regulates cell growth and differentiation in these tissues by promoting the down-regulation of the ODC...
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Biochem J (2009) 417 (2): 561–571.
Published: 23 December 2008
... citrate carrier gene expression lipogenesis polyunsaturated fatty acids (PUFA) rat liver sterol regulatory element-binding protein-1 (SREBP-1) CiC (citrate carrier), also known as tricarboxylate carrier, is a mitochondrial inner membrane protein that catalyses electroneutral exchange...
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Biochem J (2008) 416 (2): 153–159.
Published: 12 November 2008
... correspondence should be addressed (email tommy.martinsson@gu.se ). 11 9 2008 6 10 2008 7 10 2008 7 10 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 anaplastic lymphoma kinase (ALK) gene amplification gene expression mutation neuroblastoma...
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Biochem J (2008) 415 (3): 467–475.
Published: 15 October 2008
... the importance of the TTAATAA core element and pin-point nucleotides that flank this element as crucial for Yap8p binding and in vivo activation of ACR3 expression. A genome-wide search for this element combined with global gene expression analysis indicates that the principal function of Yap8p is to control...
Includes: Supplementary data
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Biochem J (2008) 414 (3): 327–341.
Published: 27 August 2008
... in the mature nervous system to maintain appropriate gene-expression patterns in differentiated cells. Underpinning the function of the nervous system is its plasticity in response to external stimuli, and many transcription factors are involved in regulating gene expression in response to neuronal activity...
Includes: Multimedia, Supplementary data
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Biochem J (2008) 413 (3): 369–387.
Published: 15 July 2008
... Journal compilation © 2008 Biochemical Society 2008 acetyl-CoA biotin gene expression kinetics metabolism pyruvate carboxylase structure PC (pyruvate carboxylase; EC 6.4.1.1) was discovered by Utter and Keech [ 1 ] in the course of studies on the intracellular distribution of enzymes...
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Biochem J (2008) 413 (1): 151–161.
Published: 12 June 2008
... correspondence should be addressed (email hatfield@mail.nih.gov ). 30 1 2008 13 3 2008 28 3 2008 28 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gene expression liver microarray selenocysteine (Sec) tRNA Trsp knockout xenobiotic...
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Biochem J (2007) 405 (1): 191–198.
Published: 13 June 2007
... differentiation [TTG1 (TRANSPARENT TESTA GLABRA1), GL3 (GLABRA3) and EGL3 (ENHANCER OF GL3)] positively regulate PPCK gene expression in response to P i starvation. BHLH32 can physically interact with TTG1 and GL3. We propose that BHLH32 interferes with the function of TTG1-containing complexes and thereby...
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Biochem J (2006) 396 (1): 163–172.
Published: 26 April 2006
... These authors contributed equally to this work. cardiomyocyte collagen extracellular matrix (ECM) gene expression p38 MAPK transcription factor The p38 MAPK (mitogen-activated protein kinase) pathway was originally described as a signalling cascade activated in response to stress conditions...
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Biochem J (2005) 389 (2): 413–421.
Published: 05 July 2005
... should be addressed (email brian.knight@csc.mrc.ac.uk ). 15 11 2004 18 2 2005 18 3 2005 18 3 2005 The Biochemical Society, London 2005 cholesterol and fatty acid synthesis fibrate gene expression peroxisome-proliferator-activated receptor α (PPARα) PPARα-null mice...
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Biochem J (2005) 389 (2): 279–287.
Published: 05 July 2005
... be related to the appearance of the intrinsic function of PMNs in the inflammatory site. gene expression growth-regulated oncogene inflammation peroxide tone phospholipid hydroperoxide glutathione peroxidase polymorphonuclear leucocyte Casein-induced PMNs and macrophages were collected...
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Biochem J (2005) 387 (3): 561–571.
Published: 26 April 2005
... of these two classes of proteins in gene-silencing pathways, as well as explore the evidence for novel roles of PPD and Dicer proteins. Dicer gene expression gene silencing PAZ Piwi domain protein (PPD protein) RNA-induced silencing complex (RISC) RNA interference (RNAi) 1 These authors...
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Biochem J (2005) 387 (1): 77–84.
Published: 22 March 2005
... of such a small number of transcripts is that stochastic variations in this number can potentially translate into large oscillations in protein concentrations. Is this compatible with cellular homoeostasis? It has been suggested that noise in gene expression is a biologically important variable, is generally...