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Keywords: gene expression
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Articles
Biochem J (2019) 476 (19): 2927–2938.
Published: 11 October 2019
... genes incorporated into the host genome in a stable cell line or the global gene expression of host genome. This ability is not associated with PKR/RNase L system, as PKR inhibitors does not block MCPIP1-mediated mRNA degradation of exogenously transfected genes. Lastly, expression of MCPIP1 suppressed...
Articles
Biochem J (2018) 475 (9): 1643–1667.
Published: 15 May 2018
...Nicoletta Bianchi; Simone Beninati; Carlo M. Bergamini The type 2 isoenzyme is the most widely expressed transglutaminase in mammals displaying several intra- and extracellular activities depending on its location (protein modification, modulation of gene expression, membrane signalling...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (2): 147–156.
Published: 13 November 2015
... cells and myoblast cells were used to transfect promoter plasmids. To measure gene expression of human skeletal muscle cells, myoblast cells were differentiated into myotubes. To initiate differentiation into myotubes, DMEM/F12 (Invitrogen, Life Technologies) supplemented with 20% (v/v) FBS and 1...
Articles
Biochem J (2015) 467 (3): 453–460.
Published: 17 April 2015
... Igfbp-2 and PPARα expression levels were increased. Wy14643, a selective PPARα agonist, significantly induced Igfbp-2 gene expression in primary cultured hepatocytes. However, Igfbp-2 gene expression in Pparα null mice was not affected by fasting or Wy14643. In addition, through transient...
Articles
Biochem J (2015) 466 (1): 29–36.
Published: 06 February 2015
... assay. Taken together, these results indicate that the gene expression pattern of the main components involved in ECC of human EOM is specific and distinct from that of other striated skeletal muscles. Figure 1 Expression of ECC transcripts and proteins in human EOM biopsies ( A ) Gene...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (3): 383–390.
Published: 10 July 2014
... producing PtdIns5 P not only regulates cell migration in normal fibroblasts, but is also important for cancer cell migration and invasion. Gene expression levels for PIKFYVE and MTMR3 were examined for a large collection of tissue types and samples using the IST Online database ( http...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (2): 169–177.
Published: 27 September 2013
... skeletal muscle cell line and show the potential application of this cell line as a platform for the screaning of drugs to treating defects caused by mutations in genes involved in Ca 2+ regulation. excitation–contraction coupling gene expression immortalized muscle cell ryanodine receptor...
Articles
Biochem J (2013) 455 (1): 67–73.
Published: 13 September 2013
...Michael Aregger; Victoria H. Cowling Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II...
Articles
Biochem J (2013) 454 (2): 283–293.
Published: 09 August 2013
...Jolanta Wiejak; Julia Dunlop; Simon P. Mackay; Stephen J. Yarwood The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) signalling...
Includes: Supplementary data
Articles
Biochem J (2013) 451 (3): 439–451.
Published: 12 April 2013
...Marta Magdalena Gabryelska; Eliza Wyszko; Maciej Szymański; Mariusz Popenda; Jan Barciszewski Hammerhead ribozyme is a versatile tool for down-regulation of gene expression in vivo . Owing to its small size and high activity, it is used as a model for RNA structure–function relationship studies...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (2): 203–212.
Published: 14 August 2012
... ann-harris@northwestern.edu ). 26 4 2012 29 5 2012 6 6 2012 6 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cis- acting regulatory element cystic fibrosis transmembrane conductance regulator ( CFTR ) enhancer gene expression...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (1): 39–49.
Published: 26 April 2012
..., NY 10032, U.S.A. 2 To whom correspondence should be addressed (email Joaquin.Arino@uab.es ). 1 12 2011 9 2 2012 28 2 2012 28 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 gene expression glucose starvation Snf1 stress tolerance...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (2): 167–174.
Published: 14 November 2011
... Biochemical Society 2011 antioxidant-response element (ARE) BTB and CNC homology 1 (BACH1) gene expression gene regulation nuclear factor-erythroid 2-related factor 2 (Nrf2) transcription factor Cells have an inherent ability to sense and respond to environmental stress via a variety...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (1): 73–84.
Published: 27 October 2011
... 2011 19 7 2011 19 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 CpG gene expression methylation nuclear factor Y (NF-Y) sodium–vitamin C co-transporter 2 (SVCT2) upstream stimulating factor (USF) Since most mammalian cells and all human...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (3): 523–533.
Published: 26 August 2011
... in any medium, provided the original work is properly cited. alkaline stress gene expression Msn2 Msn4 protein kinase A (PKA) Saccharomyces cerevisiae transcription factor The regulation of the activity of the cAMP/PKA (protein kinase A) pathway plays a major role in the control...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (3): 477–482.
Published: 13 July 2011
... macrophages, enterocytes and hepatocytes towards plasma. Abnormal levels of hepcidin expression alter plasma iron parameters and lead to iron metabolism disorders. Understanding the mechanisms controlling hepcidin ( HAMP encodes hepcidin) gene expression is therefore an important goal. We identified...
Articles
Biochem J (2011) 435 (2): 313–325.
Published: 29 March 2011
... on the transcriptional regulation of the recently identified NHE8 isoform is also highlighted. Therefore the present review bridges a gap in our knowledge of the transcriptional mechanisms underlying the alterations in the gene expression of intestinal epithelial luminal membrane Na + and Cl − transporters involved...
Articles
Biochem J (2011) 434 (3): 549–558.
Published: 24 February 2011
.... Surprisingly, most tumour suppressor mechanisms co-ordinated by p38α have been reported to occur at the post-translational level. This contrasts with the important role of p38α in the regulation of transcription and the profound changes in gene expression that normally occur during tumorigenesis. We have...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (2): 253–263.
Published: 11 February 2011
... of p65 and IκBβ on gene expression. Since mutation of the NES in p65 shifted both p65 and IκBβ to the nucleus, we compared basal and TNFα-induced expression of p65-dependent genes in cells ectopically expressing IκBβ and p65WT or p65NES mut ( Figure 5 ). Quantitative real-time PCR of the IP-10...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (3): 473–486.
Published: 25 November 2010
... tissue axis. In the present study, we show that PGC-1α [PPARγ (peroxisome-proliferator-activated receptor γ) co-activator 1α] interacts with and co-activates SF-1 to induce LH β (luteinizing hormone β) and α GSU (α-glycoprotein subunit) gene expression, subsequently leading to the increased secretion...
Includes: Supplementary data
Articles
Biochem J (2010) 431 (2): 169–178.
Published: 28 September 2010
.... Moreover, GSH recruitment and sequestration in the nucleus during the G 1 - and S-phases of the cell cycle has a profound impact on cellular redox homoeostasis and on gene expression. For example, the abundance of transcripts encoding stress and defence proteins is decreased when GSH is sequestered...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2010) 429 (3): 603–612.
Published: 14 July 2010
... correspondence should be addressed (email gabriele.gnoni@unisalento.it ). 1 12 2009 26 5 2010 1 6 2010 1 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression internal ribosome entry site (IRES) sterol-regulatory-element-binding protein-1...
Articles
Biochem J (2010) 427 (2): 255–264.
Published: 29 March 2010
...Francesca Aguiló; Nuria Camarero; Joana Relat; Pedro F. Marrero; Diego Haro In the cytosol of lipogenic tissue, ketone bodies are activated by AACS (acetoacetyl-CoA synthetase) and incorporated into cholesterol and fatty acids. AACS gene expression is particularly abundant in white adipose tissue...
Articles
Biochem J (2009) 422 (3): 443–453.
Published: 27 August 2009
... 26 6 2009 26 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Ccr4–Not complex gene expression mRNA deadenylation proteomics transcription regulation The evolutionarily conserved Ccr4–Not complex is important for multiple cellular functions...
Includes: Supplementary data
Articles
Biochem J (2009) 422 (1): 101–109.
Published: 29 July 2009
... protein (EGFP) gene expression polyamines spermine analogues spermidine/spermine N 1 -acetyltransferase (SSAT) The polyamines putrescine, spermidine and spermine are essential in central cellular processes including proliferation and differentiation [ 1 , 2 ]. The intracellular polyamine pools...
Articles
Biochem J (2009) 420 (3): 403–411.
Published: 27 May 2009
... ghrelin expression via binding to a KLF-responsive region in the promoter. gastrointestinal tissue gene expression ghrelin Krüppel-like factor 4 (KLF4) promoter The gastrointestinal tract plays a crucial role in homoeostasis through its effects on the digestion, absorption and assimilation...
Articles
Biochem J (2009) 420 (1): 57–65.
Published: 28 April 2009
... 6 – 7 ]. Arabidopsis gene expression P i starvation mass spectrometry phosphoenolpyruvate carboxylase kinase (PPCK) protein phosphorylation © The Authors Journal compilation © 2009 Biochemical Society 2009 This is an open-access article distributed under the terms...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (2): 561–571.
Published: 23 December 2008
... or overexpression of SREBP-1 on hepatic lipogenic gene expression [ 10 , 11 ]. SREBPs are transcription factors synthesized as precursor proteins that remain bound to the endoplasmic reticulum and to the nuclear envelope in the presence of sufficient sterol concentrations [ 12 , 13 ]. SREBP-1 and SREBP-2...
Articles
Biochem J (2008) 416 (2): 153–159.
Published: 12 November 2008
... correspondence should be addressed (email tommy.martinsson@gu.se ). 11 9 2008 6 10 2008 7 10 2008 7 10 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 anaplastic lymphoma kinase (ALK) gene amplification gene expression mutation neuroblastoma...
Articles
Biochem J (2008) 416 (1): 117–127.
Published: 28 October 2008
... ). 22 2 2008 7 7 2008 11 7 2008 11 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 co-factor gene expression nuclear factor κB (NF-κB) protein stability RelB ubiquitination The transcription factor NF-κB (nuclear factor κB) plays...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (1): e5–e6.
Published: 28 October 2008
... of the mitochondrial genome. 1 To whom correspondence should be addressed (email R.N.Lightowlers@ncl.ac.uk ). 25 9 2008 26 9 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gene expression mitochondrion pentatricopeptide repeat protein post-transcriptional...
Articles
Biochem J (2008) 415 (3): 467–475.
Published: 15 October 2008
... the importance of the TTAATAA core element and pin-point nucleotides that flank this element as crucial for Yap8p binding and in vivo activation of ACR3 expression. A genome-wide search for this element combined with global gene expression analysis indicates that the principal function of Yap8p is to control...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (3): 327–341.
Published: 27 August 2008
... in the mature nervous system to maintain appropriate gene-expression patterns in differentiated cells. Underpinning the function of the nervous system is its plasticity in response to external stimuli, and many transcription factors are involved in regulating gene expression in response to neuronal activity...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 413 (3): 369–387.
Published: 15 July 2008
.... 3 Correspondence can be addressed to either of these authors (email pattwood@cyllene.uwa.edu.au or john.wallace@adelaide.edu.au ). 7 4 2008 7 5 2008 7 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 acetyl-CoA biotin gene expression...
Articles
Biochem J (2008) 413 (1): 151–161.
Published: 12 June 2008
... correspondence should be addressed (email hatfield@mail.nih.gov ). 30 1 2008 13 3 2008 28 3 2008 28 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gene expression liver microarray selenocysteine (Sec) tRNA Trsp knockout xenobiotic...
Articles
Biochem J (2008) 412 (3): 485–493.
Published: 28 May 2008
... be addressed (email christian.velot@igmors.u-psud.fr ). 14 1 2008 19 2 2008 27 2 2008 27 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 acetate Aspergillus nidulans gene expression GPR1/FUN34/YaaH protein family monocarboxylate transport...
Articles
Biochem J (2008) 412 (1): 153–162.
Published: 25 April 2008
... yzhao@medicine.bsd.uchicago.edu ). 7 12 2007 29 1 2008 25 2 2008 25 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 bioactive phospholipid gene expression receptor tyrosine kinase (RTK) signal transduction transcription factor...
Articles
Biochem J (2008) 410 (2): 245–253.
Published: 12 February 2008
... compilation © 2008 Biochemical Society 2008 androgen metabolism farnesoid X receptor (FXR) gene expression glucuronidation prostate UDP-glucuronosyltransferase (UGT) 2B15 (UGT2B15) and UGT2B17 Glucuronidation assays were performed for 1 h at 37 °C by incubating 3 μg of total protein from...
Includes: Supplementary data
Articles
Biochem J (2007) 406 (3): 457–467.
Published: 29 August 2007
... 2007 6 6 2007 6 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cardiac function cardiac metabolism diet-induced obesity futile cycling gene expression triacylglycerol Metabolic adaptation to changes in the physiological environment...
Articles
Biochem J (2007) 405 (1): 191–198.
Published: 13 June 2007
... differentiation [TTG1 (TRANSPARENT TESTA GLABRA1), GL3 (GLABRA3) and EGL3 (ENHANCER OF GL3)] positively regulate PPCK gene expression in response to P i starvation. BHLH32 can physically interact with TTG1 and GL3. We propose that BHLH32 interferes with the function of TTG1-containing complexes and thereby...
Articles
Biochem J (2007) 401 (3): 735–741.
Published: 12 January 2007
... gene expression. Immunoblot analysis using an antibody which recognizes Thr-172-phosphorylated AMPKα1/2 revealed phenobarbital-induced AMPK activation in rat and mouse livers as well. Phenobarbital, however, failed to increase the liver phospho-AMPK level of tumour-bearing rats in which CAR nuclear...
Articles
Biochem J (2007) 401 (1): 57–64.
Published: 11 December 2006
... biochemical evidence that the ubiquitous Oct-1 transcription factor may be involved in hormonally regulated, tissue-specific β-casein gene expression. 1 To whom correspondence should be addressed, at 219 Terrill, 570 Main Street, Burlington, VT 05405, U.S.A. (email fzhao@uvm.edu ). 13 4 2006...
Articles
Biochem J (2006) 398 (2): 257–267.
Published: 15 August 2006
..., London 2006 cell proliferation α-difluoromethylornithine (DFMO) gene expression intestinal epithelium cell (IEC) ornithine decarboxylase (ODC) transcriptional repression The epithelium of the mammalian intestine is a self-renewing tissue serving a number of important physiological...
Articles
Biochem J (2006) 396 (1): 163–172.
Published: 26 April 2006
... that maintain organ architecture. cardiomyocyte collagen extracellular matrix (ECM) gene expression p38 MAPK transcription factor The p38 MAPK (mitogen-activated protein kinase) pathway was originally described as a signalling cascade activated in response to stress conditions and pro...
Includes: Supplementary data
Articles
Biochem J (2006) 394 (1): 115–124.
Published: 27 January 2006
... Sequence Databases under the accession numbers AY943955, AY943956 and AY943954. 15 8 2005 1 11 2005 3 11 2005 3 11 2005 barley gene expression nucleotide sugar plant cell wall UDP- D -glucose 4-epimerase (UGE) UDP-GlcNAc UGE (UDP-Glc 4-epimerase or UDP-Gal 4...
Articles
Biochem J (2005) 391 (3): 613–621.
Published: 25 October 2005
.... These findings may provide insight into control of PiC gene expression in different cell types and under different growth conditions. To our knowledge, this is the first study to analyse the regulation of the PiC gene expression in any cell. 1 To whom correspondence should be addressed (email fpalm...
Articles
Biochem J (2005) 389 (2): 413–421.
Published: 05 July 2005
... 2005 cholesterol and fatty acid synthesis fibrate gene expression peroxisome-proliferator-activated receptor α (PPARα) PPARα-null mice sterol regulatory element binding protein (SREBP) PPARα (peroxisome-proliferator-activated receptor α) is a member of the nuclear hormone receptor...
Articles
Biochem J (2005) 389 (2): 279–287.
Published: 05 July 2005
..., Germany); AMV (avian myeloblastosis virus) reverse transcriptase XL and random nonomers were from TaKaRa Shuzo Co. (Shiga, Japan). CHX (cycloheximide) was obtained from Carbiochem (Darmstadt, Germany); PT (pertussis toxin) was from List Biological Laboratory (Campbell, CA, U.S.A.). gene expression...
Articles
Biochem J (2005) 387 (3): 561–571.
Published: 26 April 2005
...) is a process utilized by eukaryotes to modulate gene expression at pre- and post-transcriptional levels [ 1 ]. In its original form, RNAi may have evolved as a genome immune system that acted to maintain the integrity of eukaryotic genomes. For example, in lower eukaryotes and plants, components of the RNAi...
Articles
Biochem J (2005) 387 (1): 77–84.
Published: 22 March 2005
... The Biochemical Society, London 2005 galactose-1-phosphate uridylyltransferase galactose uptake gene expression metabolic pathway noise transmission Saccharomyces cerevisiae The cellular translation machinery allows the synthesis of large quantities of proteins [ 1 ] from a small number...