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Keywords: endocytosis
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Articles
Biochem J (2022) 479 (20): 2261–2278.
Published: 28 October 2022
... of the Biochemical Society 2022 endocytosis Kaposi's sarcoma-associated herpesvirus molecular interactions transmembrane proteins ubiquitin ligases Ubiquitination is a post-translational protein modification that is highly conserved in eukaryotic cells. This modification controls various...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (16): 3099–3123.
Published: 26 August 2021
...Katherine M. Wood; Corinne J. Smith Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes...
Articles
Biochem J (2020) 477 (24): 4769–4783.
Published: 24 December 2020
... of the Biochemical Society 2020 appl1 appl2 crystallography curvature endocytosis heterodimer APPL1 APPL2 curvature endocytosis heterodimerization structure x-ray crystallography In response to extracellular stimuli, signaling transduction usually elicits endocytosis and intracellular...
Includes: Supplementary data
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Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
...Alessandra Casamento; Emmanuel Boucrot Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional Clathrin-independent endocytic (CIE) routes, including Fast Endophilin...
Articles
Biochem J (2019) 476 (14): 2093–2109.
Published: 31 July 2019
... be endocytosed from the cell surface. The phosphatidylinositol binding clathrin assembly protein (PICALM) is involved in clathrin-mediated endocytosis and polymorphisms in and near the gene locus were identified as genetic risk factors for AD. PICALM overexpression enhances APP internalization and Aβ production...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (9): 1669–1685.
Published: 15 May 2018
...: Gustavo A. Chiabrando ( gustavo.chiabrando@unc.edu.ar ) 23 11 2017 16 4 2018 17 4 2018 18 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 endocytosis GTPases intracellular signaling membranes trafficking...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (13): 2133–2144.
Published: 13 June 2017
...-mediated, cholesterol-dependent P2X7R–Panx1 clustering and endocytosis. These findings have important implications for understanding the role of Panx1 in the nervous system and provide important new insights into Panx1–P2X7R cross-talk. Correspondence: Leigh Anne Swayne ( lswayne@uvic.ca ) 5 4...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (24): 4507–4525.
Published: 09 December 2016
...Aidan P. McCann; Christopher J. Scott; Sandra Van Schaeybroeck; James F. Burrows In recent times, our knowledge of the roles ubiquitin plays in multiple cellular processes has expanded exponentially, with one example being the role of ubiquitin in receptor endocytosis and trafficking. This has...
Articles
Biochem J (2016) 473 (15): 2251–2271.
Published: 28 July 2016
...@einstein.yu.edu ). 29 2 2016 25 3 2016 30 3 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 autophagy Class III phosphoinositide 3-kinase endocytosis phosphoinositide 3-kinase phosphorylation/dephosphorylation Vps34...
Articles
Biochem J (2016) 473 (12): 1703–1718.
Published: 10 June 2016
..., septins protect ErbB2 from ubiquitylation, endocytosis and lysosomal degradation. The FCF-induced degradation pathway is distinct from and additive with the degradation induced by inhibiting ErbB2 chaperone Hsp90. These results identify septins as novel regulators of ErbB2 expression that contribute...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
.... [(2015) Biochem. J. 470 , 319330] now demonstrates that ATP not only permeates pannexin 1 channels but stimulates the removal of pannexin 1 from the cell surface, providing negative feedback that limits pannexin 1 function. ATP endocytosis P2X7 pannexin 1 purine receptors trafficking...
Articles
Biochem J (2015) 472 (2): 183–193.
Published: 13 November 2015
... such soybean extracts were identified that were specifically able to decrease mZip4 endocytosis in response to zinc. These soybean extracts also effectively increased the abundance of apically localized mZip4 in transfected polarized Caco2 and Madin–Darby canine kidney cells and, moreover, two apically...
Includes: Supplementary data
Articles
Biochem J (2015) 471 (1): 79–88.
Published: 21 September 2015
... ligase that promotes Lys 63 -linked polyubiquitination of MHC class I, providing the signal for clathrin-mediated endocytosis. Endocytosis is followed by sorting into the intralumenal vesicles (ILVs) of multivesicular bodies (MVBs) and eventual delivery to lysosomes. The sorting of MHC class I into MVBs...
Articles
Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
... with regards to Panx1 surface stability in diverse scenarios in which ATP can be rapidly elevated in the extracellular space. adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1 pannexin1 trafficking Six individual pannexin 1 (Panx1) proteins come together to form channels...
Includes: Multimedia, Supplementary data
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Biochem J (2014) 461 (2): 159–175.
Published: 26 June 2014
... endocytosis human disease inositol phosphatase membrane traffic phosphoinositide secretory pathway Phosphoinositides are a family of lipid molecules that play critical roles in the cell [ 1 , 2 ]. Derived from phosphorylation of phosphatidylinositol (PtdIns), phosphoinositides consist of two...
Articles
Biochem J (2014) 460 (2): 177–185.
Published: 13 May 2014
...) and are essential for the gravitropic response in plants. The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. Short-term TE1 treatment causes accumulation of PM...
Includes: Supplementary data
Articles
Biochem J (2014) 458 (2): 195–201.
Published: 14 February 2014
... through clathrin- and raftlin-dependent endocytosis and delivered to endosomal TLR3. The dsRNA uptake machinery, in addition to TLR3, is critical for extracellular viral RNA-induced immune responses. A wide spectrum of TLR3 ligand structures beyond dsRNA and their delivery systems provide new insights...
Articles
Biochem J (2013) 453 (2): 291–301.
Published: 28 June 2013
... by the endocytosis of the receptor via βTrCP (β-transducin repeat-containing protein). In the present study, we show that βTrCP interacts directly via its WD40 domain with the UbE (ubiquitin-dependent endocytosis) motif in GHR, promoting GHR ubiquitination in vitro . NMR experiments demonstrated that the UbE motif...
Articles
Biochem J (2013) 452 (3): 411–421.
Published: 31 May 2013
... ). 21 6 2012 7 3 2013 26 3 2013 26 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 AGAP2 β-arrestin2 Arf GTPase-activating protein endocytosis G-protein-coupled receptor recycling endosome β 2 ARs (β 2 -adrenergic receptors) are members...
Articles
Biochem J (2013) 450 (1): 115–125.
Published: 24 January 2013
... correspondence should be addressed (email mayr@uke.uni-hamburg.de ). 3 10 2012 15 11 2012 28 11 2012 28 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 endocytosis Ins(1,2,3,4,5,6) P 6 (InsP 6 ) micro nutrients myo -inositol phytase phytate...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 383–394.
Published: 29 May 2012
.... There are four EHD proteins in mammalian cells, EHD1–EHD4, each with diverse roles in the recycling pathway of endocytosis. EHD2 is a plasma-membrane-associated member of the EHD family that regulates internalization. Since several endocytic proteins have been shown to undergo nucleocytoplasmic shuttling...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 633–643.
Published: 21 December 2011
...Lianwu Fu; Andras Rab; Li Ping Tang; Steven M. Rowe; Zsuzsa Bebok; James F. Collawn CFTR (cystic fibrosis transmembrane conductance regulator) is expressed in the apical membrane of epithelial cells. Cell-surface CFTR levels are regulated by endocytosis and recycling. A number of adaptor proteins...
Articles
Biochem J (2011) 439 (3): 433–445.
Published: 13 October 2011
...Sigi Benjamin; Hilla Weidberg; Debora Rapaport; Olga Pekar; Marina Nudelman; Daniel Segal; Koret Hirschberg; Shulamit Katzav; Marcelo Ehrlich; Mia Horowitz EHDs [EH (Eps15 homology)-domain-containing proteins] participate in different stages of endocytosis. EHD2 is a plasma-membrane-associated EHD...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (2): 255–267.
Published: 28 June 2011
... receptor substrate 15. 1 To whom correspondence should be addressed (email hgirao@ibili.uc.pt ). 16 12 2010 21 4 2011 9 5 2011 9 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 connexin43 (Cx43) endocytosis epidermal growth factor...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 436 (1): 45–52.
Published: 27 April 2011
... with clathrin plaques, although its homologues IRSp53 and IRTKS (insulin receptor tyrosine kinase substrate) associate with other punctate structures. The results from the present study suggest that I-BAR-containing proteins help generate the mem-brane curvature required for endocytosis and implies...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (3): 559–569.
Published: 24 February 2011
...Kosuke Miyauchi; Mariana Marin; Gregory B. Melikyan Diverse enveloped viruses enter cells by endocytosis and fusion with intracellular compartments. Recent evidence suggests that HIV also infects permissive cell lines by fusing with endosomes in a pH-independent manner. This finding highlights...
Includes: Supplementary data
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Biochem J (2011) 434 (2): 343–351.
Published: 11 February 2011
... 2011 endocytosis deubiquitinating enzyme (DUB) granulocyte colony-stimulating factor 3 (CSF3) receptor signal transducer and activator of transcription (STAT) 5 suppressor of cytokine signalling (SOCS) 3 To control the duration of signalling, many activated growth-factor receptors...
Articles
Biochem J (2011) 433 (2): 253–262.
Published: 22 December 2010
... in spermatogenic defects. Other studies have shown that MTMR2 functions in endocytosis and membrane trafficking. In the testis, MTMR2 interacts and co-localizes with c-Src/phospho-Src-(Tyr 416 ), a non-receptor protein tyrosine kinase that regulates the phosphorylation state of proteins at the apical ES...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (1): 75–83.
Published: 15 December 2010
...Bastian Dislich; Manuel E. Than; Stefan F. Lichtenthaler SNX33 (sorting nexin 33) is a homologue of the endocytic prote-in SNX9 and has been implicated in actin polymerization and the endocytosis of the amyloid precursor protein. SNX33 belongs to the large family of BAR (Bin/amphiphysin/Rvs) domain...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (2): 305–313.
Published: 13 August 2010
...Marie-Christine Gasingirwa; Jacqueline Thirion; Jeannine Mertens-Strijthagen; Simone Wattiaux-De Coninck; Bruno Flamion; Robert Wattiaux; Michel Jadot It has been suggested that intracellular Hyal-1 (hyaluronidase-1), which is considered a lysosomal enzyme, originates via endocytosis of the serum...
Articles
Biochem J (2010) 429 (1): 185–193.
Published: 14 June 2010
...Maya Shvartsman; Eitan Fibach; Z. Ioav Cabantchik In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron]. Using real-time fluorimetry and flow cytometry, in conjunction...
Articles
Biochem J (2010) 428 (1): 33–45.
Published: 28 April 2010
..., suggesting its involvement in endocytosis. Uptake experiments using standard molecules for the study of endocytosis revealed that gAP2 specifically participated in the endocytosis of LDL (low-density lipoprotein). Targeted down-regulation of the gene encoding gμ2 in growing and encysting trophozoites...
Includes: Supplementary data
Articles
Biochem J (2009) 424 (1): 89–97.
Published: 23 October 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 endocytosis endosomal sorting complex required for transport (ESCRT) multivesicular body Rim101 pathway Snf7/chromatin modifying protein 4 (CHMP4) vacuolar protein sorting During endocytosis, cell surface proteins...
Articles
Biochem J (2009) 421 (3): 377–385.
Published: 15 July 2009
...Andrew Young; Martina Gentzsch; Cynthia Y. Abban; Ying Jia; Patricio I. Meneses; Robert J. Bridges; Neil A. Bradbury Dynasore, a small molecule inhibitor of dynamin, was used to probe the role of dynamin in the endocytosis of wild-type and mutant CFTR (cystic fibrosis transmembrane conductance...
Articles
Biochem J (2009) 420 (2): 179–191.
Published: 13 May 2009
... (CPP) cholesterol endocytosis fluorescence microscopy methyl-β-cyclodextrin (MβCD) octa-arginine CPPs (cell-penetrating peptides) or protein-transduction domains have now been described for two decades [ 1 , 2 ]. During this period, several different CPP classes have been described...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 420 (2): 169–180.
Published: 13 May 2009
... are defective in endocytosis. Furthermore, towards the end of cytokinesis, constriction of the actomyosin ring and dissociation of type II myosin and septum materials are substantially delayed in the absence of functional Sip1. These results indicate that the conserved Sip1 protein comprises a novel non-SCF F...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 419 (2): 289–300.
Published: 27 March 2009
...@biologia.unipi.it ). 8 7 2008 3 11 2008 13 1 2009 13 1 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 actin/tubulin remodelling channel-interacting PDZ protein (CIPP) Cypin endocytosis insulin receptor tyrosine kinase substrate protein p53 (IRSp53...
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Biochem J (2009) 418 (3): 701–715.
Published: 25 February 2009
... phosphoprotein and a monomeric adaptor for clathrin-mediated endocytosis. In the present study, we employed GFP (green fluorescent protein) fusion constructs of different isoforms and mutants of rat Dab2 and characterized their effect on the size, distribution and dynamics of clathrin assemblies. Enhanced levels...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 417 (3): 737–746.
Published: 16 January 2009
...). In addition to their role in phosphorylation of receptor tyrosine residues and downstream signalling substrates, JAKs have recently been implicated in controlling expression of cytokine receptors, predominantly by masking critical motifs involved in endocytosis and lysosomal targeting. In the present study...
Articles
Biochem J (2009) 417 (3): 685–694.
Published: 16 January 2009
... the virulence of a pleomorphic strain of the parasite, for reasons that are not clear. In the present paper, we report that GPI-PLC stimulates endocytosis of transferrin by 300–500%. Surprisingly, GPI-PLC is not detected at endosomes, suggesting that the enzyme does not interact directly with the endosomal...
Articles
Biochem J (2008) 415 (3): e1–e3.
Published: 15 October 2008
... in plants. A study in this issue of the Biochemical Journal by König et al. reports for the first time in this kingdom the association of PtdIns(4,5) P 2 with an endomembrane fraction enriched for clathrin. This work is discussed in the context of current evidence for constitutive and evoked endocytosis...
Articles
Biochem J (2008) 413 (3): e11–e12.
Published: 15 July 2008
.... report another aspect on endocytosis in response to CD95 ligation in type II cells, namely a caspase-independent endocytosis with vesicle translocation to the mitochondrial compartment, suggestive of an interplay between both organelles in the sense of an ‘organelle scrambling’. Thus early effects...
Articles
Biochem J (2008) 413 (3): 467–478.
Published: 15 July 2008
... encompasses a series of subcellular changes that are mandatory for, or even bolster, the apoptotic cascade. In the present study, we analysed the role of endocytosis in the propagation of cell death signalling after CD95/Fas engagement in type II cells (CEM cells). We show that this receptor–ligand...
Articles
Biochem J (2008) 413 (2): 251–259.
Published: 26 June 2008
... plasma membrane. 1 To whom correspondence should be addressed (e-mail vogel@imbg.ku.dk ). 31 10 2007 7 4 2008 10 4 2008 10 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 endocytosis hepatocyte growth factor activator inhibitor-1 (HAI-1...
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Biochem J (2008) 412 (3): 415–423.
Published: 28 May 2008
...Joshua Z. Rappoport Investigations into the mechanisms which regulate entry of integral membrane proteins, and associated ligands, into the cell through vesicular carriers (endocytosis) have greatly benefited from the application of live-cell imaging. Several excellent recent reviews have detailed...
Articles
Biochem J (2008) 411 (2): 271–278.
Published: 27 March 2008
... to a LfR of ∼105 kDa. Apo-Lf treatment significantly increased LfR abundance at the plasma membrane and internalization probably occurs via clathrin-mediated endocytosis through early and recycling endosomes, as LfR was co-localized with EEA1 (early endosome antigen 1) and TfR (transferrin receptor) using...
Articles
Biochem J (2008) 410 (3): 555–564.
Published: 27 February 2008
... show that rΔF508 CFTR endocytosis is 6-fold more rapid (∼30% per 2.5 min) than WT (wild-type, ∼5% per 2.5 min) CFTR at 37 °C in polarized airway epithelial cells (CFBE41o − ). We also investigated rΔF508 CFTR endocytosis under two further conditions: in culture at the permissive temperature (27 °C...
Articles
Biochem J (2008) 409 (2): 471–479.
Published: 21 December 2007
... the molecular mechanism of DGKδ-mediated regulation of clathrin-dependent endocytosis that controls the internalization, recycling and degradation of receptors. Involvement of DGKδ in the regulation of clathrin-dependent endocytosis was previously proposed following genome-wide RNAi (RNA interference) screening...
Articles
Biochem J (2008) 409 (1): 107–116.
Published: 11 December 2007
... internalization of the P2Y 11 receptor. This is remarkable because the P2Y 11 receptor by itself is not able to undergo endocytosis. Co-internalization of these receptors was also seen in 1321N1 astrocytoma cells co-expressing both P2Y 11 and P2Y 1 receptors, upon stimulation with ATP or the P2Y 1 receptor...
Includes: Supplementary data
Articles
Biochem J (2007) 405 (1): 147–155.
Published: 13 June 2007
... for their internalization by clathrin-mediated endocytosis and subsequent trafficking, our results support a model whereby ubiquitin and clathrin adaptor binding sites act in concert to remove ENaC from the cell surface. 1 Present address: Department of Physiology II, Institute of Physiology, University...