... component of this compute function is the dynamic regulation of RAS activation and downstream signaling that allows RAS to produce a rich and nuanced spectrum of biological outputs. We discuss recent findings how the dynamics of RAS and its downstream signaling is regulated. Starting from the structural...

.... Depending on the quality of the data, the error can be as small as 0.1 nm. Beyond mere mean distances, PELDOR yields distance distributions, which provide access to conformational distributions and dynamics. It can also be used to count the number of monomers in a complex and allows determination...

... 24 10 2005 24 10 2005 The Biochemical Society, London 2006 dihydrofolate reductase dynamics hydrogen transfer kinetics protein motions tunnelling It has long been accepted that electrons can be transferred in chemical reactions by quantum mechanical tunnelling...

... of human TFIIB NTD, which characterize the structure and dynamics of the TFIIB Zn 2+ -binding domain in both Zn 2+ -bound and -free states. The NMR data show that, whereas the backbone fold of NTD is pre-formed in the apo state, Zn 2+ binding reduces backbone mobility in the β-turn (Arg 28 –Gly 30...

... potencies of carcinogens. 1 To whom correspondence should be addressed (e-mail rasnick@mindspring.com). 25 11 1999 6 3 2000 10 4 2000 The Biochemical Society, London © 2000 2000 carcinogenesis dynamics metabolic control analysis Biochem. J. (2000) 348, 497 506...