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Keywords: doripenem
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Biochem J (2018) 475 (1): 273–288.
Published: 11 January 2018
... the active site. These substitutions cause OXA-239 to hydrolyze late-generation cephalosporins and the monobactam aztreonam with greater efficiency than OXA-23. OXA-239 activity against the carbapenems doripenem and imipenem is reduced ∼3-fold and 20-fold, respectively. Further analysis demonstrated that two...
Includes: Supplementary data