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Keywords: diabetes
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Biochem J (2024) 481 (1): 33–44.
Published: 04 January 2024
...Sebastian Brings; Walter Mier; Barbro Beijer; Elisabeth Kliemank; Stephan Herzig; Julia Szendroedi; Peter P. Nawroth; Thomas Fleming Advanced glycation end products (AGEs) are non-enzymatic post-translational modifications of amino acids and are associated with diabetic complications. One proposed...
Includes: Supplementary data
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Awards
Biochem J (2023) 480 (11): 773–789.
Published: 07 June 2023
...Guy A. Rutter; Vaibhav Sidarala; Brett A. Kaufman; Scott A. Soleimanpour Glucose-regulated insulin secretion becomes defective in all forms of diabetes. The signaling mechanisms through which the sugar acts on the ensemble of beta cells within the islet remain a vigorous area of research after more...
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Biochem J (2022) 479 (5): 583–607.
Published: 04 March 2022
... the Creative Commons Attribution License 4.0 (CC BY) . cancer metabolism diabetes immunometabolism Currently, the Centers for Disease Control have identified thirteen tumor types of which overweight and obesity increase risk [ 1–27 ] ( Table 1 ). In most of these, excess weight also worsens...
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Biochem J (2021) 478 (21): 3809–3826.
Published: 09 November 2021
...Sara M. Frangos; David J. Bishop; Graham P. Holloway While the etiology of type 2 diabetes is multifaceted, the induction of insulin resistance in skeletal muscle is a key phenomenon, and impairments in insulin signaling in this tissue directly contribute to hyperglycemia. Despite the lack...
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Adipose biology
Biochem J (2020) 477 (5): 985–1008.
Published: 13 March 2020
... and that lipolysis can mediate homeostatic metabolic signals at both the cellular and whole-body level to promote inter-organ communication. Finally, adipocyte lipolysis is involved in various diseases such as cancer, type 2 diabetes and fatty liver disease, and targeting adipocyte lipolysis is of therapeutic...
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Biochem J (2018) 475 (18): 2985–2996.
Published: 25 September 2018
... administered to diabetic mice. The present study was designed to clarify why two human proteins with distinct physiological functions both lower BG in db/db mice and if the mouse orthologue FGF15 has similar effect to FGF19 and FGF21. Recombinant human FGF19, -21 and a mouse FGF15 variant (C110S) were...
Includes: Supplementary data
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Biochem J (2017) 474 (8): 1321–1332.
Published: 24 March 2017
...Michael J. Berridge Vitamin D deficiency has been linked to the onset of diabetes. This review summarizes the role of Vitamin D in maintaining the normal release of insulin by the pancreatic beta cells (β-cells). Diabetes is initiated by the onset of insulin resistance. The β-cells can overcome...
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Biochem J (2015) 467 (1): 115–126.
Published: 20 March 2015
...Sujith Dassanayaka; Ryan D. Readnower; Joshua K. Salabei; Bethany W. Long; Allison L. Aird; Yu-Ting Zheng; Senthilkumar Muthusamy; Heberty T. Facundo; Bradford G. Hill; Steven P. Jones Previous reports indicate that hyperglycaemia/diabetes enhances flux through accessory pathways, such as protein O...
Includes: Supplementary data
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Biochem J (2015) 466 (2): 203–218.
Published: 20 February 2015
...Guy A. Rutter; Timothy J. Pullen; David J. Hodson; Aida Martinez-Sanchez Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion underlies all forms of diabetes mellitus, a disease currently reaching...
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Biochem J (2014) 463 (2): 287–296.
Published: 22 September 2014
...Antonio Fernández-Pérez; Mario Vallejo Alterations in transcription factors expressed in insulin-producing islet β-cells generate pancreatic dysfunction leading to diabetes. The homeodomain transcription factor Alx3 ( aristaless -like homeobox 3) expressed in pancreatic islets participates...
Includes: Supplementary data
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Biochem J (2014) 459 (3): 551–564.
Published: 11 April 2014
... way the co-operative interaction between two allosterically regulated proteins (GK and GKRP), which operate as a critical drug-sensitive molecular switch in hepatic carbohydrate metabolism. allosteric regulation co-operativity diabetes fructose phosphate ester glucokinase glucokinase...
Includes: Supplementary data
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Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...
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Biochem J (2012) 445 (3): 349–359.
Published: 13 July 2012
...Katarzyna Hanzelka; Lukasz Skalniak; Jolanta Jura; Sigurd Lenzen; Ewa Gurgul-Convey Mimitin, a novel mitochondrial protein, has been shown to act as a molecular chaperone for the mitochondrial complex I and to regulate ATP synthesis. During Type 1 diabetes development, pro-inflammatory cytokines...
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Biochem J (2012) 444 (2): 239–247.
Published: 11 May 2012
... the serine/threonine PP2A (protein phosphatase 2A) holoenzyme containing the B55α regulatory subunit, with nuclear import of FOXO1 in pancreatic islet β-cells under oxidative stress, a condition associated with cellular dysfunction in Type 2 diabetes. The mechanism of FOXO1 dephosphorylation and nuclear...
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Biochem J (2012) 442 (3): 539–550.
Published: 24 February 2012
... diabetes in streptozotocin-treated NOD-SCID (non-obese diabetic severe combined immunodeficiency) mice. However the transformation is not complete. The cells lack expression of several genes important for beta cell function and they do not show glucose-sensitive insulin secretion. We conclude...
Includes: Supplementary data
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Biochem J (2012) 442 (3): 723–732.
Published: 24 February 2012
... of these authors (email graeme.lancaster@bakeridi.edu.au or mark.febbraio@bakeridi.edu.au ). 18 11 2011 9 12 2011 14 12 2011 14 12 2011 adipocyte diabetes inhibitor of nuclear factor κB kinase β (IKKβ) insulin phosphoinositide 3-kinase (PI3K) protein kinase B (PKB...
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Biochem J (2010) 428 (3): 305–324.
Published: 27 May 2010
... cause human obesity, or protect against it, the melanocortin system is by far the most significant. The present review is a discussion of the current understanding of the roles and mechanism of action of POMC, melanocortin receptors and AgRP (agouti-related peptide) in obesity and Type 2 diabetes...
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Biochem J (2010) 427 (1): 1–17.
Published: 15 March 2010
... diabetes metabolic syndrome metabolism obesity Wnt signalling The name Wnt is derived from a combination of two homologous genes; W g (the Drosophila wingless gene) and I nt [the murine homologue MMTV (mouse mammary tumour virus) integration site 1 gene]. Wnts represent a large morphogenic...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 422 (1): 11–22.
Published: 29 July 2009
... the Sec insertion sequence (SECIS), was discovered following the cloning of the selenoprotein DIO (iodothyronine deiodinase) 1 [ 7 ]. All eukaryotic selenoproteins require a form of the SECIS element for recoding UGA to the Sec codon [ 8 ]. cancer diabetes Keshan disease multiminicore disease...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 421 (2): 181–191.
Published: 26 June 2009
... that express the ABCG2 + transporter and have the capacity to transdifferentiate into insulin-producing cells. Although the potential therapeutic application remains to be tested, PaSCs could represent a future option for insulin replacement in diabetes research. 18 7 2008 17 3 2009 20 4 2009...
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Biochem J (2009) 419 (1): 29–49.
Published: 13 March 2009
... Sac-1 domain to potentially degrade PtdIns4 P to PtdIns at specific subcellular sites. Many reviews have delineated the molecular characterization of 5-ptases [ 1 , 27 – 35 ], so this review focuses on evidence for the role that specific 5-ptases may play in diabetes, cancer, inflammation...
Includes: Multimedia, Supplementary data
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Biochem J (2008) 415 (1): 1–10.
Published: 12 September 2008
... from various species suggest that all three regulatory elements (A3, E1 and C1), important for glucose regulation of insulin gene expression, are conserved between species with the A-box (A3) to which Pdx-1 binds being the most highly conserved one [ 24 ]. diabetes glucose insulin NeuroD1...
Includes: Multimedia, Supplementary data
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Biochem J (2008) 409 (1): 1–18.
Published: 11 December 2007
... emerges as a key player in the regulation of cell responses, offering new possibilities of therapeutic intervention in human pathologies, including cancer, heart disease, diabetes, brain afflictions and immune dysfunctions. 1 To whom correspondence should be addressed (email imerida@cnb.uam.es...
Includes: Multimedia, Supplementary data
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Biochem J (2005) 392 (3): 633–639.
Published: 06 December 2005
...Christopher Lipina; Xu Huang; David Finlay; Edward J McManus; Dario R. Alessi; Calum Sutherland GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes leads to normalization...
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Biochem J (2005) 392 (2): e1.
Published: 22 November 2005
... by fructose. 1 email vmm3@cwru.edu 5 10 2005 10 10 2005 The Biochemical Society, London 2005 advanced glycation end-product (AGE) diabetes fructoselysine glucoselysine glycation Maillard reaction Glycation is the process by which reducing sugars react non...
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Biochem J (2004) 378 (2): 693–697.
Published: 01 March 2004
... The Biochemical Society, London ©2004 2004 diabetes glucokinase regulatory protein hexokinase IV human glucokinase liver Abbreviations used: GKRP, glucokinase regulatory protein; fructose 1- P , fructose 1-phosphate; fructose 6- P , fructose 6-phosphate; sorbitol 6- P , sorbitol 6-phosphate...
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Biochem J (2004) 377 (3): 709–716.
Published: 01 February 2004
...Emma T. A. S. JAIKARAN; Melanie R. NILSSON; Anne CLARK Islet amyloid polypeptide (IAPP), or ‘amylin’, is co-stored with insulin in secretory granules of pancreatic islet β-cells. In Type 2 diabetes, IAPP converts into a β-sheet conformation and oligomerizes to form amyloid fibrils and islet...
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Biochem J (2003) 375 (3): 581–592.
Published: 01 November 2003
.... Advanced glycation endproduct residues were increased in blood plasma and at sites of vascular complications development in experimental diabetes; renal glomeruli, retina and peripheral nerve. In clinical uraemia, the concentrations of plasma protein advanced glycation endproduct residues increased 1–7...
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Biochem J (2003) 371 (3): 831–841.
Published: 01 May 2003
... bodies that produce insulin in response to glucose stimulation. This is the first report of a differentiation event induced by the ectopic expression of a transcription factor in embryonic pluri- potent stem cells. Key words: diabetes, insulin, pancreatic differentiation, tran- scription factor...
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Biochem J (2002) 366 (2): 633–641.
Published: 01 September 2002
... The Biochemical Society, London ©2002 2002 diabetes enteroendocrine intestine islet pancreas Abbreviations used: EMSA, electrophoretic mobility-shift assay; Foxa, Forkhead box a; GLI, glucagon-like immunoreactivity; GLP, glucagon-like peptide; HNF, hepatocyte nuclear factor; RT-PCR, reverse...
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Biochem J (2002) 361 (3): 629–633.
Published: 25 January 2002
... The Biochemical Society, London ©2002 2002 diabetes obesity signalling factor subtraction method transcription factor Abbreviations used: C/EBP, CCAAT/enhancer-binding protein; Dex, dexamethasone; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; IBMX, 3-isobutyl-1...
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Biochem J (2001) 360 (2): 313–320.
Published: 26 November 2001
.... Preincubation with 1mM Fe 2+ and 2mM cysteine was essential for the enzyme's activity. d -c hiro -Inositol, a myo -inositol isomer, is a substrate for the recombinant MIOX with an estimated K m of 33.5mM. Both myo -inositol and d - chiro -inositol have been implicated in the pathogenesis of diabetes. Thus...
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