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Keywords: degradation
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Biochem J (2023) 480 (21): 1719–1731.
Published: 02 November 2023
...Radoslav Petkov; Amy H. Camp; Rivka L. Isaacson; James H. Torpey The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which...
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Biochem J (2015) 467 (2): 321–331.
Published: 02 April 2015
...Xuemin Wang; Jianling Xie; Sergio Regufe da Mota; Claire E. Moore; Christopher G. Proud Eukaryotic elongation factor 2 kinase (eEF2K) is activated under diverse stress conditions, where it aids cell survival but also undergoes degradation. We show that degradation of eEF2K requires...
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Biochem J (2014) 459 (2): 301–312.
Published: 28 March 2014
... of ubiquitinated ASBT after RSV treatment. Phosphorylation at Ser 335 and Thr 339 was shown previously to play a role in proteosomal degradation of rat ASBT. However, mutation at corresponding residues in rat ASBT revealed that phosphorylation does not contribute to RSV-mediated degradation of ASBT. Combined, our...
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Biochem J (2013) 449 (3): 783–794.
Published: 09 January 2013
... and Research, Mohali, S.A.S. Nagar, Punjab 140306, India (email anand@iisermohali.ac.in ). 2 2 2012 29 10 2012 5 11 2012 5 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 degradation γ-glutamylcysteine synthetase (γ-GCS) glutathione redox...
Includes: Supplementary data
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Biochem J (2012) 446 (2): 213–223.
Published: 14 August 2012
...André Struglics; Maria Hansson Although it has been shown that aggrecanases are involved in aggrecan degradation, the role of MMP (matrix metalloproteinase) aggrecanolysis is less well studied. To investigate MMP proteolysis of human aggrecan, in the present study we used neoepitope antibodies...
Includes: Supplementary data
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Biochem J (2012) 444 (2): 279–289.
Published: 11 May 2012
... how AMOT is regulated. In the present study, we report that AMOT undergoes proteasomal degradation. We identify three members of Nedd4 (neural-precursor-cell-expressed developmentally down-regulated)-like ubiquitin E3 ligases, Nedd4, Nedd4-2 and Itch, as the ubiquitin E3 ligases for the long isoform...
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Biochem J (2011) 436 (1): 113–121.
Published: 27 April 2011
... filamentous sarcomeric material. The causes and mechanisms of protein aggregation in myotilinopathies and other forms of MFM remain unknown, although impaired degradation may explain, in part, the abnormal protein accumulation. In the present paper we have studied the mechanisms regulating myotilin turnover...
Includes: Supplementary data
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Biochem J (2008) 410 (2): 401–407.
Published: 12 February 2008
...Junko Takeuchi; Hui Chen; Martin A. Hoyt; Philip Coffino Mouse ODC (ornithine decarboxylase) is quickly degraded by the 26S proteasome in mammalian and fungal cells. Its degradation is independent of ubiquitin but requires a degradation signal composed of residues 425–461 at the ODC C-terminus...
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Biochem J (2006) 397 (1): 31–38.
Published: 14 June 2006
... (Janus kinase 1) respectively. Ligand-induced down-regulation of the type I IFNR is a major mechanism of negative regulation of cellular signalling and involves the internalization and lysosomal degradation of IFNAR1. IFNα promotes the phosphorylation of IFNAR1 on Ser 535 , followed by recruitment...
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Biochem J (2003) 375 (1): 183–189.
Published: 01 October 2003
...Peter J. ROUGHLEY; James BARNETT; Fengrong ZUO; John S. MORT Proteoglycan aggregates and purified aggrecan from adult and fetal bovine cartilage and adult and neonatal human cartilage were subjected to in vitro degradation by recombinant aggrecanase-1 and aggrecanase-2. The ability...
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Biochem J (2003) 370 (1): 29–34.
Published: 15 February 2003
...Philippe SOUBEYRAN; Ana BARAC; Iwona SZYMKIEWICZ; Ivan DIKIC The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl...
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Biochem J (2000) 352 (1): 1–17.
Published: 07 November 2000
... repair, cell-cycle arrest, engagement of apoptosis, angiogenesis, redox regulation, metastasis, nitric oxide production, and protein degradation [2,3]. These general biological and cellular properties of p53 have been discussed extensively, and we would suggest the reader refers to a collection...
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Biochem J (2000) 351 (1): 161–166.
Published: 26 September 2000
...John D. SANDY; Vivian THOMPSON; Kurt DOEGE; Christie VERSCHAREN We have examined the abundance and structure of intermediates in the chondrocyte-mediated degradation of aggrecan by aggrecanase(s). Degradation products were identified by Western-blot analysis with antibodies to cleavage-site...
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Biochem J (1999) 339 (2): 453–461.
Published: 08 April 1999
... receptors (those that are not type-I-receptor-associated) can be resistant to ubiquitination and degradation. In total these data indicate that the ubiquitin/proteasome pathway mediates Ins(1,4,5) P 3 -receptor down-regulation and suggest that ubiquitination is stimulated by the binding of Ins(1,4,5) P 3...
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