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Keywords: deacetylation
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Biochem J (2014) 464 (1): 157–168.
Published: 23 October 2014
... FOXO3 is deacetylated by SIRT3. The SIRT3-mediated deacetylation of FOXO3 further reduces FOXO3 phosphorylation, ubiquitination and degradation, thereby stabilizing FOXO3 proteins. As a result, the level of FOXO3 protein is increased during hypoxia. Moreover, a set of FOXO3-dependent mitochondrial...
Includes: Supplementary data
Biochem J (2008) 411 (2): e11–e13.
Published: 27 March 2008
.... Recently, a report comparing SIRT3 −/− and SIRT +/+ mice have provided compelling evidence that endogenous SIRT3 is mitochondrial and appears to be responsible for the majority of protein deacetylation in this organelle. In this issue of the Biochemical Journal , Cooper et al. present additional results...