... FOXO3 is deacetylated by SIRT3. The SIRT3-mediated deacetylation of FOXO3 further reduces FOXO3 phosphorylation, ubiquitination and degradation, thereby stabilizing FOXO3 proteins. As a result, the level of FOXO3 protein is increased during hypoxia. Moreover, a set of FOXO3-dependent mitochondrial...

.... Recently, a report comparing SIRT3 −/− and SIRT +/+ mice have provided compelling evidence that endogenous SIRT3 is mitochondrial and appears to be responsible for the majority of protein deacetylation in this organelle. In this issue of the Biochemical Journal , Cooper et al. present additional results...

... of which are involved in post-translational modification of histone proteins [ 4 ]. HATs and HDACs have opposing roles in acetylating and deacetylating highly conserved lysine residues on the N-terminal tail of histones, thus altering chromatin assembly and transcriptional activity [ 5 , 6 ]. HDACs...

...Victoria L. STEVENS; Hui ZHANG; Eva Szucs KRISTYANNE The second step in glycosylphosphatidylinositol (GPI) biosynthesis, the deacetylation of GlcNAc-phosphatidylinositol (GlcNAc-PI), has been shown to be stimulated by GTP hydrolysis [Stevens (1993) J. Biol. Chem. 268 , 9718-9724]. We have now...