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Keywords: cytoskeleton
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Articles
Biochem J (2023) 480 (4): 243–257.
Published: 23 February 2023
... realize that physical forces that alter cell shape, deform internal load-bearing structures, and change molecular conformation could indeed influence biochemistry in living cells, and that use of tensegrity architecture in the cytoskeleton might provide some insight into how this works. My entry...
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Biochem J (2022) 479 (22): 2351–2364.
Published: 23 November 2022
...) on the plasma membrane. The actin cytoskeleton and its accessory proteins are known regulators of apoptotic signaling in nucleated cells but their roles in platelet apoptosis are undefined. Filamin A (FLNA) is a ubiquitously expressed actin-crosslinking protein that also serves as an intracellular signaling...
Includes: Supplementary data
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Biochem J (2022) 479 (17): 1825–1842.
Published: 12 September 2022
... for homeostasis and dysfunction in healthy and pathological states. Specifically, the composition and structure of the cell membrane and cytoskeleton are major determinants of cell stiffness, and studies have identified signaling pathways that affect cytoskeletal dynamics both directly and by altered gene...
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Biochem J (2022) 479 (13): 1409–1428.
Published: 04 July 2022
... for this article was enabled by the participation of University of Sheffield in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. actin cytoskeleton myosins single molecule Figure 2. NDP52 association...
Includes: Supplementary data
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Biochem J (2021) 478 (17): 3297–3317.
Published: 14 September 2021
... cut ( Supplementary Figure S1 ). Alzheimer's disease cytoskeleton receptor tyrosine kinases transcription factors type 2 diabetes Epidemiological studies show that type 2 diabetes (T2D) increases the risk of Alzheimer's Disease (AD) by at least 2-fold, although there are only a few...
Includes: Supplementary data
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In Collection
Awards
Biochem J (2019) 476 (4): 705–718.
Published: 28 February 2019
... this, the leukocyte microvilli undergo extension by rapidly separating the cytoskeleton from the plasma membrane [ 38 ]. More recently, α9β1 has also been shown to stabilise neutrophil adhesion to endothelial cells under shear flow [ 39 ], although the molecular mechanism for this has yet to be investigated...
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Biochem J (2018) 475 (19): 3009–3034.
Published: 05 October 2018
... 8 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cytoskeleton molecular chaperones protein conformation Chaperonin proteins are ATPases which assemble into single- and double-ring protein machines in whose central...
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Biochem J (2018) 475 (14): 2329–2353.
Published: 31 July 2018
... of assembly and disassembly that are controlled by complex inter-relationships with the cytoskeleton. Microtubules form the core of the cilium, the axoneme, and are regulated by post-translational modifications, associated proteins, and microtubule dynamics. Although actin and septin cytoskeletons...
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Biochem J (2017) 474 (18): 3189–3205.
Published: 08 September 2017
... of FtsZ. ATPase cell division cytoskeleton Escherichia coli FtsZ MinD Cell division in bacteria is a highly controlled and regulated process. More than a dozen of proteins are associated with the cell division. Among these, FtsZ, a bacterial cytoskeletal protein, forms...
Includes: Multimedia, Supplementary data
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Biochem J (2017) 474 (18): 3137–3165.
Published: 08 September 2017
... cascade, from which several other downstream pathways diverge reflecting the different roles of reelin. Many of these pathways affect the dynamics of the actin and microtubular cytoskeleton, as well as membrane trafficking through the regulation of the activity of small GTPases, including the Rho and Rap...
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Biochem J (2017) 474 (12): 1965–1979.
Published: 25 May 2017
... of many cellular responses to extracellular cues in development, maintenance, repair and disease. The cytoplasmic domains of syndecans, while having no intrinsic kinase activity, can nevertheless signal through binding proteins. All syndecans appear to be connected to the actin cytoskeleton and can...
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Biochem J (2016) 473 (23): 4427–4441.
Published: 25 November 2016
... and used MBP in control experiments. Correspondence: Shoichiro Ono ( sono@emory.edu ) 11 4 2016 22 9 2016 11 10 2016 11 10 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 actin cofilin cytoskeleton...
Includes: Supplementary data
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Biochem J (2013) 454 (1): 13–30.
Published: 26 July 2013
... cytoskeleton focal adhesion germinal centre kinase III subfamily (GCKIII) Golgi MO25 protein phosphatase 2A (PP2A) protein phosphorylation STRAD (sterile 20-related kinase adaptor α) striatin GCKIIIs are the shortest of the mSte20-like kinases [ 1 ], a fact attributable to the limited length...
Includes: Multimedia, Supplementary data
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Biochem J (2012) 446 (3): 427–435.
Published: 28 August 2012
... insights into the complexity and the versatility of the structural and functional interactions between the cytoskeleton and ion exchangers. Figure 1 Alignment of AE1 (band 3) and the NHE1cd juxta-membrane regions and of 4.1R exon 5-encoded wild-type and EED mutant peptides and pull-down assay...
Includes: Supplementary data
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Biochem J (2011) 440 (3): 319–327.
Published: 28 November 2011
... that dimerization occurs dynamically and constantly at the leading edge of migrating cells, but not the trailing edge. We found that polarized dimerization was not due to ECM (extracellular matrix) attachment, but was rather controlled by reorganization of the actin cytoskeleton by the small GTPases, Cdc42 (cell...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 437 (1): 13–24.
Published: 14 June 2011
... reached by Gromley et al. [ 9 ], arguing against homotypic fusion into a cell-plate-like organelle. cholesterol cytokinesis cytoskeleton membrane trafficking phospholipid soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE) Mammalian cells exhibit...
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Biochem J (2011) 434 (3): 513–521.
Published: 24 February 2011
... contractility, whereas the channel has been found to regulate cell adhesion as well as cellular Mg 2+ homoeostasis. In the present study we show that depletion of TRPM7 by RNA interference in fibroblasts alters cell morphology, the cytoskeleton, and the ability of cells to form lamellipodia and to execute...
Includes: Multimedia, Supplementary data
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Biochem J (2010) 426 (3): 243–253.
Published: 24 February 2010
...) establishment of polarity by recognition of the polarization site and signalling to the cytoskeleton to allow its asymmetric organization; and (iii) asymmetric distribution of the cellular components and polarized secretion, leading to polarized cell growth. Rho GTPases are activated specifically...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 424 (2): e5–e6.
Published: 11 November 2009
... in these plasma membrane vesicles and detergent-resistance of cellular lipid rafts. 1 email dah24@cornell.edu 20 10 2009 20 10 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cholesterol cytoskeleton giant unilamellar vesicle (GUV) lipid raft plasma...
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Biochem J (2009) 419 (1): 141–148.
Published: 13 March 2009
...Amber L. Couzens; Vivian Saridakis; Michael P. Scheid ROCK (Rho-associated coiled-coil kinase) 2 is a member of the AGC kinase family that plays an essential role downstream of Rho in actin cytoskeleton assembly and contractility. The process of ROCK2 activation is complex and requires suppression...
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Biochem J (2008) 410 (1): 141–146.
Published: 29 January 2008
... that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine...
Includes: Supplementary data
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Biochem J (2008) 409 (2): 321–331.
Published: 21 December 2007
... sequences shows identical residues in yellow and conserved residues in blue or green. The alignment was performed using VectorNti (Version 6). CLC chloride channel cytoskeleton K + –Cl − cotransporter (KCC) Na + –K + –2Cl − co-transporter (NKCC) with no K (lysine) kinase (WNK...
Includes: Multimedia, Supplementary data
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Biochem J (2006) 396 (1): 1–5.
Published: 26 April 2006
...Ho Lam Tang; Anh-Huy Phan Le; Hong Lok Lung Accumulating evidence indicates the potential role of actin cytoskeleton in facilitating the mitochondrial recruitment of various pro-apoptotic proteins from the cytosol to initiate apoptosis. In the present paper, we report the observation...
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Biochem J (2006) 393 (2): 565–573.
Published: 23 December 2005
... 2005 17 10 2005 27 10 2005 27 10 2005 The Biochemical Society, London 2006 cytoskeleton focal adhesion kinase (FAK) growth factor receptor LD motif and LIM domain paxillin tyrosine phosphorylation Integrins are heterodimeric cell surface receptors for ECM...
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Biochem J (2005) 392 (3): 435–441.
Published: 06 December 2005
... we have investigated the localization and activity of IP3KB and its modulation by proteolysis. We found that the N- and C-termini (either side of residue 262) of IP3KB localized predominantly to the actin cytoskeleton and ER (endoplasmic reticulum) respectively, both in COS-7 cells and in primary...
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Biochem J (2005) 392 (1): 163–172.
Published: 08 November 2005
... Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Carretera de Utrera km. 1, 41013 Sevilla, Spain. 11 7 2005 9 9 2005 9 9 2005 9 9 2005 The Biochemical Society, London 2005 cAMP cytoskeleton 14-3-3 protein phorbol ester phosphodiesterase 3A (PDE3A) protein kinase...
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Biochem J (2004) 384 (3): 489–494.
Published: 07 December 2004
... min [ 14 ]. 1 To whom correspondence should be addressed (email j.t.c.murray@dundee.ac.uk ). 26 6 2004 24 9 2004 4 10 2004 4 10 2004 The Biochemical Society, London 2004 cytoskeleton filamin kinase substrate tracking and elucidation (KESTREL...
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Biochem J (2004) 378 (3): 1067–1072.
Published: 15 March 2004
... 12 12 2003 The Biochemical Society, London ©2004 2004 α-actinin actin bundling cytoskeleton focal adhesion phosphoinositide protein flexibility Abbreviations used: CH, calponin homology; GST, glutathione S-transferase. Biochem. J. (2004) 378, 1067 1072 (Printed in Great...
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Biochem J (2004) 377 (2): 539–544.
Published: 15 January 2004
... myristoylated peptide directed towards Arf-5 were ineffective. Arf proteins modulate the cytoskeleton, and disruption of the cytoskeleton with cytochalasin D or its stabilization with phalloidin impaired the development of the Na + current. Disaggregation of microtubules was without effect. Dialysis with cAMP...
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Biochem J (2003) 374 (3): 697–705.
Published: 15 September 2003
... cytoskeleton Dictyostelium discoideum myosin light chain Abbreviations used: CTER, calmodulin, troponin C, myosin II ELC and RLC; ECL®, enhanced chemiluminescence; ELC, essential light chain; ESI, electrospray ionization; GST, glutathione S-transferase; MICLC, myosin IC light chain; MlcD, myosin...
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Biochem J (2003) 371 (2): 463–471.
Published: 15 April 2003
... kinase signalling and the actin cytoskeleton. We have shown, using purified proteins and cell extracts, that MIM-B is an actin-binding protein, probably via a WASP (Wiskott–Aldrich syndrome protein)-homology 2 domain at its C-terminus. We have also found that MIM-B binds to the cytoplasmic domain...
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Biochem J (2002) 368 (2): 405–413.
Published: 01 December 2002
...- anisms underlying vesicle transport and recruitment is much less understood. In this sense, the cytoskeleton has been shown to play a function in exocytosis in both neurons [5] and neuroendocrine cells [6,7]. More precisely, in chromaffin cells, it has been demonstrated that an F-actin network layer...
Includes: Multimedia, Supplementary data
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Biochem J (2002) 367 (1): 57–65.
Published: 01 October 2002
.... Proteins of the superfamily have been grouped into six different subfamilies, according to their sequences : Ras, Rho, Rab, Arf, Ran and Rad}Gem}Kir (RGK). The principal role of the Ras subfamily is the regulation of cell growth and differentiation [2], Rho proteins are mainly involved in cytoskeleton...
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Biochem J (2002) 365 (3): 817–824.
Published: 01 August 2002
... To whom correspondence should be addressed (e-mail luc.desgroseillers@umontreal.ca ). 12 2 2002 12 4 2002 16 4 2002 The Biochemical Society, London ©2002 2002 cytoskeleton mRNA localization mRNA transport RNA-binding activity RNA-binding protein Abbreviations...
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Biochem J (2002) 365 (2): 337–342.
Published: 15 July 2002
... cytoskeleton of higher-plant cells is composed of highly dynamic and ordered arrays. In both mitotic and differentiated cells, these arrays continuously reorganize in response to internal and external stimuli, in correlation with the acquisition of specific functions [1]. During the cell cycle and differently...
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Biochem J (2002) 365 (1): 147–155.
Published: 01 July 2002
... survival cytoskeleton destrin Abbreviations used: ADF, actin-depolymerizing factor; pyrene-actin, N -(1-pyrene)iodoacetamide-labelled actin; ∊ATP, 1, N 6 -ethenoadenosine 5′-triphosphate. Biochem. J. (2002) 365, 147 155 (Printed in Great Britain) 147 The actin-severing activity of cofilin...
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Biochem J (2002) 364 (3): 841–847.
Published: 15 June 2002
... are crucial in mediating protein 4.2—spectrin interactions. 1 To whom correspondence should be addressed (e-mail joyoti@bosemain.boseinst.ac.in ). 1 2 2002 5 4 2002 The Biochemical Society, London ©2002 2002 cytoskeleton protein interaction red blood cell Abbreviations...