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Keywords: crystallography
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Biochem J (2024) 481 (6): 437–460.
Published: 13 March 2024
... ]. Crystallography atomic co-ordinates and structure were deposited in the Protein Data Bank (PDB) with accession codes 8FYY , 8FYZ , 8FZ1 and 8G0H . The HXMS data in this study have been deposited in the Pride database under accession code PXD047072. All other source data is included in the paper and any...
Includes: Supplementary data
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Biochem J (2023) 480 (18): 1479–1483.
Published: 25 September 2023
... triphosphate (dITP) across dC and dT in a DNA template. They found that dITP can be incorporated across C or T, with the ratio of 13.7. X ray crystallography studies revealed that the mutagenic incorporation of dITP by human polη was affected by several factors including base pair geometry in the active site...
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Biochem J (2022) 479 (24): 2529–2546.
Published: 22 December 2022
... 6-cys domains of Pfs230 enabled the identification of high affinity nanobodies against Pfs230 ( K D ranging from 0.14 nM and 14.05 nM). Using X-ray crystallography and BLI, we show that nanobodies F5 and F10 bind to distinct epitopes on Pfs230 D1. These nanobodies fused to an Fc domain showing...
Includes: Supplementary data
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Biochem J (2022) 479 (12): 1303–1315.
Published: 22 June 2022
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell polarity crystallography isothermal titration calorimetry PDZ domain virology Cell polarity is the fundamental process...
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Biochem J (2021) 478 (23): 4137–4149.
Published: 06 December 2021
... signals. Inserts display close-up spectra of the APA (NL: 3.01E5) and PLP (NL: 9.51E4) signals. crystallography ornithine decarboxylase polyamines ODC is a PLP-dependent enzyme that catalyzes the decarboxylation of ornithine to putrescine, the rate-limiting step in the biosynthesis...
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Biochem J (2021) 478 (7): 1321–1332.
Published: 06 April 2021
... crystallography PDZ domain protein–protein interactions Scribble Vangl2 The establishment of cell polarity, defined as the asymmetric distribution of proteins, carbohydrates and lipids within the cell, is a crucial process for the organization and development of all animal tissues [ 1 ]. In multicellular...
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Biochem J (2021) 478 (4): 943–959.
Published: 26 February 2021
... Society 2021 crystallography enzyme–substrate interactions glycoside hydrolase molecular mechanisms NAD-dependent The glycoside hydrolases (GHs) constitute a large group of enzymes of 167 GH families classified currently in the carbohydrate active enzyme database (CAZy) [ 1 , 2...
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Biochem J (2020) 477 (24): 4769–4783.
Published: 24 December 2020
... ]. APPL1 APPL2 curvature endocytosis heterodimerization structure x-ray crystallography appl1 appl2 crystallography curvature endocytosis heterodimer First, we investigated how APPL BAR-PH subunits interact in homodimer. As shown in size exclusion chromatography ( Figure 1A ), either...
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Biochem J (2020) 477 (24): 4785–4796.
Published: 24 December 2020
... 2020 arabidopsis thaliana crystallography protein structure tetrapyrroles Heme is an essential pigment for plants and participates in various key biological processes [ 1 ]. It carries electrons for the respiratory and photosynthetic electron transfer chains within mitochondria...
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Biochem J (2020) 477 (24): 4711–4728.
Published: 18 December 2020
... and processing statistics for the crystals are presented in ( Tables 1 and 2 ). The quality of data sets was assessed using SFCHECK [ 20 ] which suggested no twinning in the data. crystallography domain swapping peptide substrate sortase transpeptidase Streptococcus pneumoniae (S...
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Biochem J (2020) 477 (23): 4527–4541.
Published: 03 December 2020
... crystallography orf virus poxvirus virology Apoptosis is a form of programmed cell death utilized by multicellular organisms as a defence mechanism against invading pathogens [ 1 ] and viruses have evolved multiple strategies to antagonize this process [ 2 ]. One such strategy utilized to subvert host...
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Biochem J (2020) 477 (17): 3271–3286.
Published: 10 September 2020
... 14 8 2020 14 8 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 antifreeze protein β-structure crystallography ice recombinant proteins surface waters The mechanism by which antifreeze proteins (AFPs) recognize...
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Biochem J (2020) 477 (17): 3287–3297.
Published: 10 September 2020
... crystallography References 1 Zmasek , C.M. and Godzik , A. ( 2013 ) Evolution of the animal apoptosis network . Cold Spring Harb. Perspect. Biol. 5 , a008649 10.1101/cshperspect.a008649 2 Youle , R.J. and Strasser , A. ( 2008 ) The BCL-2 protein family...
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Biochem J (2020) 477 (13): 2439–2449.
Published: 02 July 2020
... Society 2020 Introduction allosteric regulation crystallography enzyme activation Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) catalyzes the first step of branch-chain amino acid biosynthesis, playing a crucial role in the life cycle of plants and bacteria [ 1 , 2 ]. Due to its absence...
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Biochem J (2020) 477 (12): 2263–2279.
Published: 24 June 2020
... encouraging results against hematologic malignancies [ 5–9 ]. BRD2 cell-based assay crystallography glioblastoma NCI diversity pyrano 1 3 oxazine derivative © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 29 4 2020 27 5 2020...
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Biochem J (2020) 477 (4): 787–800.
Published: 27 February 2020
... with two prominent enzymes PRMT1 and CARM1 (PRMT4) by isothermal titration calorimetry (ITC), activity assays and crystallography are reported. Key findings are that 2-aminopyridine is a viable replacement for guanidine, providing an inhibitor that binds more strongly to CARM1 than PRMT1. Moreover...
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Biochem J (2020) 477 (1): 161–172.
Published: 10 January 2020
... of a polyCU sequence in 3′UTR of p73 mRNA led to a loss of RBM38 binding ability, suggesting that the polyCU sequence was involved in RBM38 binding [ 9 ]. Thus, the sequence specificity and recognition mechanism of RBM38's RNA binding remains unclear. crystallography RBM38 RNA RNA-binding proteins...
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Biochem J (2019) 476 (23): 3649–3660.
Published: 10 December 2019
... the Creative Commons Attribution License 4.0 (CC BY) . ABC transport proteins crystallography molecular dynamics thermodynamics Bacteria are capable of thriving under both nutrient rich and limiting conditions. This extraordinary adaption is due to their ability of acquiring their essential...
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Biochem J (2019) 476 (21): 3333–3353.
Published: 15 November 2019
... crystallography phosphodiesterase second messenger site-directed mutagenesis Cyclic dinucleotides (CDNs) have been implicated in modulating varieties of cellular activities in bacteria that include motility [ 1 ], virulence [ 2 ], biofilm formation and dispersal [ 3 , 4 ] and exopolysaccharide...
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Biochem J (2019) 476 (13): 1957–1973.
Published: 15 July 2019
... ( chaohe@ahu.edu.cn ) or Fudong Li ( lifudong@ustc.edu.cn ) * Both authors contributed equally to this work. 14 2 2019 21 6 2019 28 6 2019 28 6 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 crystallography...
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Biochem J (2019) 476 (2): 211–223.
Published: 18 January 2019
... substrates. * These authors contributed equally to this work. 24 9 2018 27 11 2018 5 12 2018 6 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 catalytic mechanism crystallography histone desuccinylation...
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Biochem J (2019) 476 (1): 51–66.
Published: 07 January 2019
... 9JT, U.K. 8 10 2018 7 12 2018 11 12 2018 11 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 crystallography GTPases hydrogen–deuterium exchange mass spectrometry leucine-rich repeat kinase protein...
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Biochem J (2018) 475 (23): 3875–3886.
Published: 12 December 2018
... crystallography cytochrome p450 O -demethylase Microbial polysaccharide utilization is a key component of the global carbon cycle. Complex carbohydrate degradation requires cognate suites of enzymes to enable utilization by bacteria. Modifications of carbohydrate structures found in nature can...
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Biochem J (2018) 475 (19): 3057–3071.
Published: 10 October 2018
...: Dinakar M. Salunke ( dinakar.salunke55@gmail.com ) 10 7 2018 25 8 2018 31 8 2018 4 9 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 crystallography metalloprotein oxidative stress salicylic acid superoxide...
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Biochem J (2018) 475 (7): 1353–1370.
Published: 16 April 2018
... electron-transferring subunit that contains at least one Fe–S cluster [ 2 ]. crystallography electrochemistry hydrogen metabolism iron–sulfur clusters metalloenzymes NiFe hydrogenase © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018...
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Biochem J (2018) 475 (4): 787–802.
Published: 23 February 2018
... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 crystallography enzyme–substrate interactions polyamines small-angle scattering The polypeptide chain of Mt TSPS contains 328 amino acids, and its calculated molecular mass is 37 kDa...
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Biochem J (2018) 475 (4): 705–722.
Published: 16 February 2018
...) [ 17 ]. crystallography cytochrome P450 monooxygenases Mycobacterium © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 13 12 2017 10 1 2018 16 1 2018 17 1 2018 All organic substrates, derivatisation agents...
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Biochem J (2018) 475 (3): 571–585.
Published: 09 February 2018
... on behalf of the Biochemical Society 2018 DNA polymerase crystallography minor groove interaction replication fidelity metal cofactor Published reversion-frequency studies with Asn279Ala and wild-type polβ have shown that the mutation increases the replication fidelity approximately five-fold...
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Biochem J (2018) 475 (1): 261–272.
Published: 11 January 2018
...: Andrew D. Hanson ( adha@ufl.edu ) * These authors contributed equally to this work. 20 10 2017 2 12 2017 7 12 2017 11 12 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADP-sugars crystallography flavins...
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Biochem J (2018) 475 (1): 225–245.
Published: 05 January 2018
... Merrill ( rmerrill@uoguelph.ca ) 23 10 2017 30 11 2017 4 12 2017 5 12 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 bacterial toxins crystallography DNA modification enzyme kinetics Pathogenic bacteria...
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Biochem J (2017) 474 (23): 3871–3886.
Published: 10 November 2017
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cerulenin crystallography fatty acid OleA thiolase The transition from reliance on fossil fuels to developing renewable hydrocarbons for biofuels and commodity chemicals has been a major focus...
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Biochem J (2017) 474 (22): 3747–3761.
Published: 01 November 2017
... the KCTD family BTB domain to be a highly versatile scaffold compatible with a range of oligomeric assemblies and geometries. This observed interface plasticity may support functional changes in regulation of this unusual E3 ligase family. BTB crystallography Cul3 Cullin-RING ligase protein–protein...
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Biochem J (2017) 474 (19): 3307–3319.
Published: 20 September 2017
...@u-bordeaux.fr ) † Deceased; this article is dedicated to the memory of Bernard Gallois. 4 5 2017 26 7 2017 31 7 2017 31 7 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 crystallography NMR...
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Biochem J (2017) 474 (11): 1803–1806.
Published: 10 May 2017
... 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 crystallography Factor H immune evasion SdrE Staphylococcus aureus The human immune system consists of a powerful array of both adaptive and innate responses to detect and eliminate...
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Biochem J (2017) 474 (7): 1273–1287.
Published: 23 March 2017
... 2 2017 15 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 crystallography Parkinson's disease protein–protein interactions Correspondence: Christian Ottmann ( c.ottmann@tue.nl ) Parkinson's disease (PD...
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Biochem J (2017) 474 (6): 907–921.
Published: 07 March 2017
... 2017 crystallography FabG Mycobacterium short-chain dehydrogenase/reductase β-ketoacyl reductase FabG proteins are ubiquitous enzymes also known as β-ketoacyl-acyl carrier protein (ACP) reductases. They act in type II fatty acid synthase systems [ 1 ] (FAS-II) by catalyzing...
Includes: Supplementary data