...Haifeng Zhang; Shiyu Cui; Zhenghui Jing; Guodan Fu; Rong Liu; Wenbao Zhao; Liting Xu; Lei Yu; Yuhui Bai; Changsheng Lv; Min Wu; Yuan Wei; Liangming Li; Shuang Peng Exosomes are vital mediators for intercellular communications in the tumor microenvironment to accelerate colon cancer progression...

... by Portland Press Limited on behalf of the Biochemical Society 2020 Carbidopa colon cancer glioblastoma L-DOPA pancreatic cancer selective AhR modulator Figure 3. Dopamine and carbidopa as AhR ligands in patient-derived 14-014 and 14-015 glioblastoma cells. Cells were treated with DMSO...

... of metabolic disturbances, we postulated that iron overload in HH disrupts colonic homeostasis and colon–microbiome interaction and exacerbates the development and progression of colonic inflammation and colon cancer. To test this hypothesis, we examined the progression and severity of colitis and colon cancer...

...Mohd O. F. Sikder; Sathish Sivaprakasam; Timothy P. Brown; Muthusamy Thangaraju; Yangzom D. Bhutia; Vadivel Ganapathy SLC6A14 is a Na + /Cl − -coupled transporter for neutral and cationic amino acids. It is expressed at basal levels in the normal colon but is up-regulated in colon cancer. However...

... receptor (TLR) agonists directly activate iNKT cells and the iNKT ligand α-galactosylceramide (α-Galcer) can induce DC maturation, resulting in enhanced protective immune responses. In the present study, we aimed to boost anti-tumour immunity in a murine colon cancer model by synergizing DCs and iNKT cells...

... Tregs or suppress IFN-γ-producing T-cells in response to butyrate. We also provide in vivo evidence for an obligatory role for Slc5a8 in suppression of IFN-γ-producing T-cells. Furthermore, Slc5a8 protects against colitis and colon cancer under conditions of low-fibre intake but not when dietary fibre...

...Heping Yang; Tony W. H. Li; Jian Peng; José M. Mato; Shelly C. Lu We have previously reported that the expression of MAT2A (methionine adenosyltransferase 2A) is increased in human colon cancer and in colon cancer cells treated with IGF-1 (insulin-like growth factor-1), which was required for its...

..., by which alk-SMase may counteract the development of intestinal inflammation and colon cancer. 1 To whom correspondence should be addressed (email rui-dong.duan@med.lu.se ). 12 7 2005 12 10 2005 31 10 2005 31 10 2005 The Biochemical Society, London 2006 alkaline...

... ). 5 9 2001 26 11 2001 8 1 2002 The Biochemical Society, London ©2002 2002 cell death colon cancer Jurkat cell nuclear hormone receptor Abbreviations used: BADGE, bisphenol A diglycidyl ether; PPAR, peroxisome proliferator-activated receptor; TRAIL, tumour necrosis...

...Ashley A. POWELL; Janna M. LaRUE; A. K. BATTA; Jesse D. MARTINEZ Faecal bile acids have long been associated with colon cancer; highly hydrophobic bile acids, which induce apoptosis, have been implicated in the promotion of colon tumours. The moderately hydrophobic chemopreventive agent...

... exist, PGHS-1 and PGHS-2. PGHS-2, normally absent from cells, is rapidly expressed in response to a wide variety of stimuli and has been implicated in the pathogenesis of colon cancer and several inflammatory diseases. The three principal mitogen-activated protein kinase (MAPK) pathways...