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Keywords: cofactor
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Biochem J (2014) 464 (1): e1–e3.
Published: 23 October 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme cofactor lipoic acid lipoyl synthase radical S -adenosylmethionine (SAM) sulfur insertion Lipoic acid [( R )-5-(1,2-dithiolan-3-yl)pentanoic acid] is a sulfur-containing covalently bound coenzyme found...
Biochem J (2012) 441 (1): 189–198.
Published: 14 December 2011
... endothelial cells by regulating VCAM (vascular cell-adhesion molecule)-1 activation of endothelial cell PKCα (protein kinase Cα). However, it is not known whether tocopherols directly regulate cofactor-dependent or oxidative activation of PKCα. We report in the present paper that cofactor-dependent activation...
Biochem J (2009) 417 (1): 355–360.
Published: 12 December 2008
... and is being pursued as an attractive cancer target. Multiple small molecules targeting AurB have entered the clinic for the treatment of cancer. A protein cofactor, INCENP (inner centromere protein), regulates the cellular localization and activation of AurB. In the present study, we examined the effect...
Biochem J (2005) 386 (1): 191–200.
Published: 08 February 2005
.... In the present study, we found that this transcriptional repression by MZF-1 required FHL3 (four and a half LIM domain protein 3) as a cofactor. Yeast two-hybrid and immunoprecipitation assays demonstrated that FHL3 bound MZF-1 in vitro and in vivo . Overexpression of FHL3 in KU812 cells suppressed the β-chain...
Biochem J (2001) 357 (3): 593–615.
Published: 25 July 2001
... of the biopterin cofactor is now becoming clearer, with emerging data implicating one-electron redox cycling as well as the multiple allosteric effects on enzyme activity. Regulation of the NOSs has been described at all levels from gene transcription to covalent modification and allosteric regulation...