... © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme cofactor lipoic acid lipoyl synthase radical S -adenosylmethionine (SAM) sulfur insertion As mentioned above, the auxiliary cluster contains a serine ligand in addition to the expected three cysteine...

...Jenny E. Harmer; Martyn J. Hiscox; Pedro C. Dinis; Stephen J. Fox; Andreas Iliopoulos; James E. Hussey; James Sandy; Florian T. Van Beek; Jonathan W. Essex; Peter L. Roach Lipoyl cofactors are essential for living organisms and are produced by the insertion of two sulfur atoms into the relatively...

... endothelial cells by regulating VCAM (vascular cell-adhesion molecule)-1 activation of endothelial cell PKCα (protein kinase Cα). However, it is not known whether tocopherols directly regulate cofactor-dependent or oxidative activation of PKCα. We report in the present paper that cofactor-dependent activation...

... and is being pursued as an attractive cancer target. Multiple small molecules targeting AurB have entered the clinic for the treatment of cancer. A protein cofactor, INCENP (inner centromere protein), regulates the cellular localization and activation of AurB. In the present study, we examined the effect...

... is facilitated by negatively charged polyanions such as heparin, dextransulfate or extracellular ribonucleic acids. Since auto-activation is essential for the anti-proliferative function of FSAP, the influence of nucleic acids as cofactors for the FSAP-mediated inhibition of PDGF-BB was investigated. Natural...

...Anja HARST; Hongying LIN; Wolfgang M. J. OBERMANN The ATP-dependent molecular chaperone Hsp90 (heat-shock protein 90) is essential for the maturation of hormone receptors and protein kinases. During the process of client protein activation, Hsp90 co-operates with cofactors/co-chaperones of unique...

.... In the present study, we found that this transcriptional repression by MZF-1 required FHL3 (four and a half LIM domain protein 3) as a cofactor. Yeast two-hybrid and immunoprecipitation assays demonstrated that FHL3 bound MZF-1 in vitro and in vivo . Overexpression of FHL3 in KU812 cells suppressed the β-chain...

... of the biopterin cofactor is now becoming clearer, with emerging data implicating one-electron redox cycling as well as the multiple allosteric effects on enzyme activity. Regulation of the NOSs has been described at all levels from gene transcription to covalent modification and allosteric regulation...