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Keywords: coagulation
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Articles
Biochem J (2022) 479 (6): 731–750.
Published: 28 March 2022
...Tristram A. J. Ryan; Roger J. S. Preston; Luke A. J. O'Neill The interplay between innate immunity and coagulation after infection or injury, termed immunothrombosis, is the primary cause of disseminated intravascular coagulation (DIC), a condition that occurs in sepsis. Thrombosis associated...
Articles
Biochem J (2019) 476 (19): 2909–2926.
Published: 11 October 2019
...Tina M. Misenheimer; Kraig T. Kumfer; Barbara E. Bates; Emily R. Nettesheim; Bradford S. Schwartz The mechanism of generation of factor VIIa, considered the initiating protease in the tissue factor-initiated extrinsic limb of blood coagulation, is obscure. Decreased levels of plasma VIIa...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (24): 4629–4650.
Published: 09 December 2016
... Society 2016 antiphospholipid syndrome β2-glycoprotein I coagulation molecular interactions thrombin β2-Glycoprotein I (β2GpI) is a heavily glycosylated plasma protein (45 kDa), which is synthesized in the liver [ 1 ] and represents the major autoantigen in the antiphospholipid syndrome...
Includes: Supplementary data
Articles
Biochem J (2015) 467 (1): 37–46.
Published: 20 March 2015
... membranes can regulate blood coagulation. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (email uncbrl@med.unc.edu ). 18 9 2014 3 12 2014 8 1 2015 8 1 2015 © The Authors Journal compilation © 2015 Biochemical...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (3): 455–460.
Published: 13 July 2011
...Hai Po Helena Liang; Teresa M. Brophy; Philip J. Hogg TF (tissue factor) is a transmembrane cofactor that initiates blood coagulation in mammals by binding Factor VIIa to activate Factors X and IX. The cofactor can reside in a cryptic configuration on primary cells and de-encryption may involve...
Articles
Biochem J (2009) 422 (2): 257–264.
Published: 13 August 2009
...Jina Song; Kimberley Talbot; Jeffrey Hewitt; Ross T. A. MacGillivray; Edward L. G. Pryzdial Blood coagulation FV (Factor V) is activated by thrombin-mediated excision of the B domain, resulting in a non-covalent heterodimer, FVa (activated FV). Previous studies implicated Glu 96 , Asp 102 and Asp...
Articles
Biochem J (2008) 412 (3): 545–551.
Published: 28 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 coagulation fibrinolysis haemostatic peptide ideal amphipathic peptide (IAP) prothrombinase tenase Blood coagulation is the result of an intricate and self-regulated course of enzymatic reactions mediated by serine proteases...
Articles
Biochem J (2007) 405 (3): 429–438.
Published: 13 July 2007
...Katrine S. Larsen; Henrik Østergaard; Jais R. Bjelke; Ole H. Olsen; Hanne B. Rasmussen; Leif Christensen; Birthe B. Kragelund; Henning R. Stennicke The remarkably high specificity of the coagulation proteases towards macromolecular substrates is provided by numerous interactions involving...
Articles
Biochem J (2006) 393 (2): 529–535.
Published: 23 December 2005
...Joel R. Livingston; Michael R. Sutherland; Harvey M. Friedman; Edward L. G. Pryzdial The HSV1 (herpes simplex virus type 1) surface has been shown recently to initiate blood coagulation by FVIIa (activated Factor VII)-dependent proteolytic activation of FX (Factor X). At least two types of direct...
Articles
Biochem J (2005) 390 (2): 485–492.
Published: 23 August 2005
... -phenylalanine)], thrombin (Calbiochem) was first incubated for 1 h with the inhibitor and then the reaction was started by addition of FPR. The Biochemical Society, London 2005 allostery coagulation hirudin limited proteolysis Na + thrombin Thrombin plays a key role at the interface...
Includes: Supplementary data
Articles
Biochem J (2003) 369 (1): 129–139.
Published: 01 January 2003
... of berythractivase has been deposited in the GenBank ® , EMBL, DDBJ and GSDB Nucleotide Sequence Databases under the accession number AF450503. 22 3 2002 26 7 2002 11 9 2002 11 9 2002 The Biochemical Society, London ©2003 2003 berythractivase coagulation haemostasis...
Articles
Biochem J (2001) 360 (2): 499–506.
Published: 26 November 2001
... reproducing TSR (TSR-peptide) was also synthesized in an attempt to obtain direct evidence of the domain involvement in PS anticoagulant activity. In a coagulation assay, both rTSR-less and factor Xa-cleaved PS were devoid of activated protein C cofactor activity. The TSR-peptide did not inhibit rHPS activity...