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Keywords: cisplatin
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Biochem J (2022) 479 (13): 1429–1439.
Published: 04 July 2022
... to intracellular ligands, notably thiols such as cysteine and glutathione, where the Ru(II) reaches high intracellular concentrations. Here, we show that the Ru(II) ion also binds to DNA, at exposed guanosine N7 positions. It therefore has a similar cellular target to the anticancer drug cisplatin...
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Biochem J (2020) 477 (5): 937–951.
Published: 06 March 2020
...Hala Ouzon-Shubeita; Caroline K. Vilas; Seongmin Lee The cisplatin-1,2-d(GpG) (Pt-GG) intrastrand cross-link is the predominant DNA lesion generated by cisplatin. Cisplatin has been shown to predominantly induce G to T mutations and Pt-GG permits significant misincorporation of dATP by human DNA...
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Biochem J (2019) 476 (24): 3705–3719.
Published: 17 December 2019
...Avani Vyas; Umamaheswar Duvvuri; Kirill Kiselyov Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented...
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Biochem J (2017) 474 (7): 1195–1203.
Published: 20 March 2017
...Yasemin Sunucu Karafakıoğlu; Mehmet Fatih Bozkurt; Ömer Hazman; A. Fatih Fıdan The aim of the present study was to investigate the effects of safranal on cisplatin-induced nephrotoxicity and oxidative stress in rats. Adult male Sprague–Dawley rats were randomly divided into five groups. The control...
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Biochem J (2014) 463 (2): 167–176.
Published: 22 September 2014
.... Furthermore, in the presence of copper, the NMBD allows interaction with protein kinase D, yielding phosphorylation of serine residues, ATP7B trafficking and protection from proteasome degradation. A specific feature of ATP7A is glycosylation and stabilization on plasma membranes. Cisplatin, a platinum...
Includes: Supplementary data
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Biochem J (2009) 419 (1): 51–59.
Published: 13 March 2009
...Nataliya V. Dolgova; Doug Olson; Svetlana Lutsenko; Oleg Y. Dmitriev Wilson disease ATPase (ATP7B) has been implicated in the resistance of cancer cells to cisplatin. Using a simple in vivo assay in bacterial culture, in the present study we demonstrate that ATP7B can confer resistance to cisplatin...
Includes: Supplementary data
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Biochem J (2002) 364 (2): 441–447.
Published: 01 June 2002
..., and increased further up to 16h of treatment. Modulation of MLH1 and p73 gene expression improves cellular susceptibility to apoptosis triggered by the DNA-damaging agent cisplatin. Indeed, in ascorbate-supplemented cells, increased cisplatin-induced apoptosis was seen, involving activation of the MLH1/c-Abl...
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Biochem J (1999) 343 (3): 697–703.
Published: 25 October 1999
... possesses two different chaperone sites, both in the N- and C-domains, and that the chaperone activity of HSP90 is blocked by binding of geldanamycin (GA) to the N-domain, the same as the ATP-binding site. Here we show that Cisplatin [ cis -diamminedichloroplatinum (II), CDDP], an antineoplastic agent...
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