..., chemical biology has a great deal to contribute. This review will describe the importance of science at the chemistry/biology interface to both understand and combat the SARS-CoV-2 pandemic. Correspondence: George M. Burslem ( George.Burslem@Pennmedicine.upenn.edu ) 10 11 2020 16 12 2020...

... the Creative Commons Attribution License 4.0 (CC BY) . autophagy chemical biology high-throughput screening kinases Macroautophagy (referred to as autophagy here for simplicity) is a lysosome-dependent degradative pathway that recycles intracellular components such as proteins and/or whole...

... of molecules that promote protein degradation as chemical tools, the preclinical and clinical examples disclosed to date, and the future prospects for this exciting area of chemical biology. Correspondence: Raj Chopra; raj.chopra@icr.ac.uk 30 11 2016 4 1 2017 16 1 2017 © 2017...

... The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . biochemical techniques and resources cellular targeting chemical biology protein dynamics...

.... atypical chemical biology chemoenzymatic isopeptide ligation post-translational modification semisynthesis ubiquitin ubiquitination ubiquitylation Modification of substrate proteins with ubiquitin (Ub) and polyubiquitin (polyUb) chains of diverse topology is now firmly established...

.... adenosine 5′-triphosphate (ATP) chemical biology kinase pseudokinase Tribbles Tribbles 2 (TRB2/TRIB2) thermo-stability assay (TSA) Protein pseudokinases are key components of all vertebrate kinomes and are defined as lacking at least one of the conserved motifs that are required for efficient...

... Systems. bosutinib chemical biology dasatinib inflammation interleukin-10 salt-inducible kinase Drug development for the treatment of chronic inflammatory diseases has mainly focused on interfering with the pro-inflammatory pathways driving the acute inflammatory response...

...Peter R. Shepherd © The Authors Journal compilation © 2014 Biochemical Society 2014 Asia Asian Chemical Biology Initiative chemical biology metabolism Science in Asia has been developing rapidly in recent years in both quality and quality. The Biochemical Journal spotted...

.../jbc.M112.429316 23382387 22 Schenone M. Dančík V. Wagner B. K. Clemons P. A. Target identification and mechanism of action in chemical biology and drug discovery Nat. Chem. Biol. 2013 9 232 240 10.1038/nchembio.1199 23508189 23 Ziegler S. Pries V. Hedberg C...

... emerged as important regulators of disease and developmental processes. To gain insight into the mechanistic actions of the PRDM family, we have performed comprehensive characterization of a prototype member protein, the histone methyltransferase PRDM9, using biochemical, biophysical and chemical biology...

... incubated in 5 μM ice-cold FM4-64 in MS medium for 5 min and promptly visualized by confocal microscopy. chemical biology endocytosis gravitropism PIN-FORMED protein (PIN protein) trafficking and endocytosis inhibitor 1/TENin1 (TE1) trans -Golgi network (TGN) After transplant...

... of mitotic networks J. Biol. Chem. 2009 284 15880 15893 1 email p.cohen@dundee.ac.uk 14 9 2009 27 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell regulation chemical biology chemical inhibitor protein kinase signal transduction...