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Articles

Mechanisms of TNF-independent RIPK3-mediated cell death

Bart Tummers, Douglas R. Green

Biochem J (2022) 479 (19): 2049–2062.

DOI: https://doi.org/10.1042/BCJ20210724

Published: 14 October 2022

...Bart Tummers; Douglas R. Green Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also...

View article titled, Mechanisms of TNF-independent RIPK3-mediated cell death

Articles

Cell death in skin function, inflammation, and disease

In Collection

Cell death and survival

Holly Anderton, Suhaib Alqudah

Biochem J (2022) 479 (15): 1621–1651.

DOI: https://doi.org/10.1042/BCJ20210606

Published: 05 August 2022

...Holly Anderton; Suhaib Alqudah Cell death is an essential process that plays a vital role in restoring and maintaining skin homeostasis. It supports recovery from acute injury and infection and regulates barrier function and immunity. Cell death can also provoke inflammatory responses. Loss of cell...

View article titled, Cell death in skin function, inflammation, and disease

Articles

Alveolar cells in the mammary gland: lineage commitment and cell death

In Collection

Cell death and survival

Christine J. Watson

Biochem J (2022) 479 (9): 995–1006.

DOI: https://doi.org/10.1042/BCJ20210734

Published: 12 May 2022

...Christine J. Watson The mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of lactation. The milk-producing cells arise primarily during...

View article titled, Alveolar cells in the mammary gland: lineage commitment and cell death

Articles

Ferroptosis in plants: regulation of lipid peroxidation and redox status

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Cell death and survival

Ayelén Mariana Distéfano, Gabriel Alejandro López, Victoria Bauer, Eduardo Zabaleta, Gabriela Carolina Pagnussat

Biochem J (2022) 479 (7): 857–866.

DOI: https://doi.org/10.1042/BCJ20210682

Published: 19 April 2022

...Ayelén Mariana Distéfano; Gabriel Alejandro López; Victoria Bauer; Eduardo Zabaleta; Gabriela Carolina Pagnussat Regulated cell death (RCD) is an essential process that plays key roles along the plant life cycle. Unlike accidental cell death, which is an uncontrolled biological process, RCD...

View article titled, Ferroptosis in plants: regulation of lipid peroxidation and redox status

Articles

The concept of intrinsic versus extrinsic apoptosis

In Collection

Cell death and survival

Laura Lossi

Biochem J (2022) 479 (3): 357–384.

DOI: https://doi.org/10.1042/BCJ20210854

Published: 11 February 2022

...Laura Lossi Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better-known forms of regulated cell death, is activated when cell-surface death receptors like Fas...

View article titled, The concept of intrinsic versus extrinsic apoptosis

Articles

TAT–RHIM: a more complex issue than expected

In Collection

Cell death and survival

Benedikt Kolbrink, Theresa Riebeling, Nikolas K. Teiwes, Claudia Steinem, Hubert Kalbacher, Ulrich Kunzendorf, Stefan Krautwald

Biochem J (2022) 479 (3): 259–272.

DOI: https://doi.org/10.1042/BCJ20210677

Published: 04 February 2022

...-containing adaptor-inducing interferon-β. Remarkably, all four aforementioned mammalian proteins harbouring such a RHIM domain are key components of inflammatory signalling and regulated cell death (RCD) processes. Immunogenic cell death by regulated necrosis causes extensive tissue damage in a wide range...

View article titled, TAT–RHIM: a more complex issue than expected

Articles

The role of mitochondria in cocaine addiction

Claire Thornton, Etty Grad, Rami Yaka

Biochem J (2021) 478 (4): 749–764.

DOI: https://doi.org/10.1042/BCJ20200615

Published: 24 February 2021

... Limited on behalf of the Biochemical Society 2021 cell death cocaine metabolism mitochondria oxidative stress Figure 3. Increased oxidative stress is a hallmark of exposure to cocaine. Superoxide production increases following mitochondrial dysfunction and pathological glutamate...

View article titled, The role of mitochondria in cocaine addiction

Articles

High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2

Kristina K. Durham, Kevin M. Chathely, Bernardo L. Trigatti

Biochem J (2018) 475 (7): 1253–1265.

DOI: https://doi.org/10.1042/BCJ20170703

Published: 05 April 2018

... ischemia (oxygen and glucose deprivation, OGD) to assess the mechanistic involvement of SR-B1, PI3K (phosphatidylinositol-3-kinase), and AKT in HDL-mediated protection of cardiomyocytes from cell death. Neonatal mouse cardiomyocytes and immortalized human ventricular cardiomyocytes, subjected to OGD for 4...

View article titled, High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2

Articles

Cardiomyocyte diffusible redox mediators control Trypanosoma cruzi infection: role of parasite mitochondrial iron superoxide dismutase

Damián Estrada, Gabriela Specker, Alejandra Martínez, Patricia Pereira Dias, Barbara Hissa, Luciana O. Andrade, Rafael Radi, Lucía Piacenza

Biochem J (2018) 475 (7): 1235–1251.

DOI: https://doi.org/10.1042/BCJ20170698

Published: 05 April 2018

... mediators may control parasite proliferation through the induction of intracellular amastigote programmed cell death (PCD). In this work, we show that T. cruzi (CL-Brener strain) infection in primary cardiomyocytes produced an early (24 h post infection) mitochondrial dysfunction with H 2 O 2 generation...

View article titled, Cardiomyocyte diffusible redox mediators control Trypanosoma cruzi infection: role of parasite mitochondrial iron superoxide dismutase

Includes: Supplementary data

Articles

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

Maria C. Tanzer, Anne Tripaydonis, Andrew I. Webb, Samuel N. Young, Leila N. Varghese, Cathrine Hall, Warren S. Alexander, Joanne M. Hildebrand, John Silke, James M. Murphy

Biochem J (2015) 471 (2): 255–265.

DOI: https://doi.org/10.1042/BJ20150678

Published: 02 October 2015

... of a phosphomimetic S345D MLKL activation loop mutant-induced stimulus-independent cell death in all knockout cells, demonstrating that RIPK3 phosphorylation of the activation loop of MLKL is sufficient to induce cell death. Cell death was also induced by S228A, S228E and S158A MLKL mutants in the absence of death...

View article titled, Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

Includes: Supplementary data

Articles

GSDM family genes meet autophagy

Masaru Tamura, Toshihiko Shiroishi

Biochem J (2015) 469 (2): e5–e7.

DOI: https://doi.org/10.1042/BJ20150558

Published: 06 July 2015

... the N-terminal and C-terminal domains interact with each other. The hyper-activation of autophagy by mutations in the C-terminal domain of Gsdma3 induced cell death to the alopecia phenotype observed in Gsdma3 mutant mice. They showed that the expression of phosphatidylethanolamine conjugate (LC3-II...

View article titled, GSDM family genes meet autophagy

Articles

The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps

Ariane Neumann, Evelien T. M. Berends, Andreas Nerlich, E. Margo Molhoek, Richard L. Gallo, Timo Meerloo, Victor Nizet, Hassan Y. Naim, Maren von Köckritz-Blickwede

Biochem J (2014) 464 (1): 3–11.

DOI: https://doi.org/10.1042/BJ20140778

Published: 23 October 2014

... membrane of neutrophils. cathelicidin cell death hydrophobicity nuclear membrane NETosis neutrophil extracellular trap The cell death mechanism ‘NETosis’ is a novel fundamental innate immune defence based on the specialized cell death of activated neutrophils, which release extracellular...

View article titled, The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps

Articles

Metformin and respiratory chain complex I: the last piece of the puzzle?

Eric Fontaine

Biochem J (2014) 463 (3): e3–e5.

DOI: https://doi.org/10.1042/BJ20141020

Published: 10 October 2014

...Eric Fontaine Metformin is the most widely prescribed drug used to treat patients affected by Type 2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed...

View article titled, Metformin and respiratory chain complex I: the last piece of the puzzle?

Articles

Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution

Teresa Arnandis, Ivan Ferrer-Vicens, Luis Torres, Concha García, Elena R. Garcia-Trevijano, Rosa Zaragoza, Juan R. Viña

Biochem J (2014) 459 (2): 355–368.

DOI: https://doi.org/10.1042/BJ20130847

Published: 28 March 2014

... for calpain-1 in the weaned gland after the pregnancy/lactation cycle, controlling programmed cell death and participating in the epigenetic programme during adipocyte differentiation. adipocyte differentiation calpain cell death histone H3 cleavage nucleoporin nuclear permeability The weaning...

View article titled, Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution

Includes: Supplementary data

Articles

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

Masato Ogura, Junko Yamaki, Miwako K. Homma, Yoshimi Homma

Biochem J (2012) 447 (2): 281–289.

DOI: https://doi.org/10.1042/BJ20120509

Published: 26 September 2012

... the terms of the Creative Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion...

View article titled, Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

Includes: Supplementary data

Articles

Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death

Allison M. McGee, Christopher P. Baines

Biochem J (2011) 433 (1): 119–125.

DOI: https://doi.org/10.1042/BJ20101431

Published: 15 December 2010

...Allison M. McGee; Christopher P. Baines Opening of the MPT (mitochondrial permeability transition) pore is a critical event in mitochondrial-mediated cell death. However, with the exception of CypD (cyclophilin D), the exact molecular composition of the MPT pore remains uncertain. C1qbp (complement...

View article titled, Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death

Articles

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

Feng-Ming Wang, Yi-Jiun Chen, Hong-Jiao Ouyang

Biochem J (2011) 433 (1): 245–252.

DOI: https://doi.org/10.1042/BJ20101293

Published: 15 December 2010

... target gene expression under ER (endoplasmic reticulum) stress in MEFs (mouse embryonic fibroblasts). Consistent with XBP1s favouring cell survival under ER stress, Sirt1 −/− MEFs display a greater resistance to ER-stress-induced apoptotic cell death compared with Sirt1 +/+ MEFs. Taken together...

View article titled, Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

Articles

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

Aurélie Rossin, Mathieu Derouet, Fadi Abdel-Sater, Anne-Odile Hueber

Biochem J (2009) 419 (1): 185–194.

DOI: https://doi.org/10.1042/BJ20081212

Published: 13 March 2009

... of M2 for different time periods. HEK-293 cell death was measured by morphological observation of Trypan Blue-stained cells. Each sample was counted four independent times per experiment in at least three different experiments. AR230 cells and MDA-MB-231 cells were fixed in ice-cold 70% ethanol...

View article titled, Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

Includes: Supplementary data

Articles

Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus

Natalia Tkachuk, Julia Kiyan, Sergey Tkachuk, Roman Kiyan, Nelli Shushakova, Hermann Haller, Inna Dumler

Biochem J (2008) 415 (2): 265–273.

DOI: https://doi.org/10.1042/BJ20071652

Published: 25 September 2008

...Natalia Tkachuk; Julia Kiyan; Sergey Tkachuk; Roman Kiyan; Nelli Shushakova; Hermann Haller; Inna Dumler Deregulated apoptosis of MCs (mesangial cells) is associated with a number of kidney diseases including end-stage diabetic nephropathy. Cell death by apoptosis is a tightly orchestrated event...

View article titled, Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus

Articles

Fortilin binds Ca 2+ and blocks Ca 2+ -dependent apoptosis in vivo

Potchanapond Graidist, Michio Yazawa, Moltira Tonganunt, Akiko Nakatomi, Curtis Chun-Jen Lin, Jui-Yoa Chang, Amornrat Phongdara, Ken Fujise

Biochem J (2007) 408 (2): 181–191.

DOI: https://doi.org/10.1042/BJ20070679

Published: 14 November 2007

... a potent anti-apoptotic function: its overexpression protects HeLa [ 3 ] and U2OS [ 7 ] cells against apoptosis. In addition, the depletion of fortilin from cells induces spontaneous cell death in MCF-7 [ 3 ] and U937 cells [ 6 ]. Although fortilin is likely to make cells cancerous and cancerous cells more...

View article titled, Fortilin binds Ca 2+ and blocks Ca 2+ -dependent apoptosis in vivo

Articles

Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I

Virginie de Hemptinne, Dieter Rondas, Joël Vandekerckhove, Katia Vancompernolle

Biochem J (2007) 407 (1): 121–128.

DOI: https://doi.org/10.1042/BJ20070379

Published: 12 September 2007

...Virginie de Hemptinne; Dieter Rondas; Joël Vandekerckhove; Katia Vancompernolle We have previously shown that TNF (tumour necrosis factor) induces phosphorylation of GLO1 (glyoxalase I), which is required for cell death in L929 cells. In the present paper, we show that the TNF-induced...

View article titled, Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I

Articles

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

Bruno GUIGAS, Dominique DETAILLE, Christiane CHAUVIN, Cécile BATANDIER, Frédéric De OLIVEIRA, Eric FONTAINE, Xavier LEVERVE

Biochem J (2004) 382 (3): 877–884.

DOI: https://doi.org/10.1042/BJ20040885

Published: 07 September 2004

.... In the present study, the effects of metformin on respiration, complex 1 activity, mitochondrial permeability transition, cytochrome c release and cell death were investigated in cultured cells from a human carcinoma-derived cell line (KB cells). Metformin significantly decreased respiration both in intact cells...

View article titled, Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

Articles

Structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentous fungi and their induction of cell death of cultured rice cells

Kazuhiro AOKI, Ryosuke UCHIYAMA, Saki ITONORI, Mutsumi SUGITA, Fang-Sik CHE, Akira ISOGAI, Noriyasu HADA, Junko HADA, Tadahiro TAKEDA, Hidehiko KUMAGAI, Kenji YAMAMOTO

Biochem J (2004) 378 (2): 461–472.

DOI: https://doi.org/10.1042/bj20031307

Published: 01 March 2004

... (phytosphingosine) as the sole sphingoid base and 2-hydroxytetracosanoic acid (>90%) as the major fatty acid. ZGLs were found to cause cell death in suspensions of cultured rice cells. The cell death-inducing activity of ZGLs is probably due to the characteristic glycan moiety of Man(α1-6)GlcN, and PC-containing...

View article titled, Structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentous fungi and their induction of cell death of cultured rice cells

Articles

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

Gerd HEIMLICH, Alastair D. McKINNON, Katussevani BERNARDO, Dieter BRDICZKA, John C. REED, Renate KAIN, Martin KRÖNKE, Juliane M. JÜRGENSMEIER

Biochem J (2004) 378 (1): 247–255.

DOI: https://doi.org/10.1042/bj20031152

Published: 15 February 2004

..., Macclesfield, Cheshire SK10 4TG, U.K. (e-mail Juliane.Jurgensmeier@astrazeneca.com ). 30 7 2003 31 10 2003 13 11 2003 13 11 2003 The Biochemical Society, London ©2004 2004 apoptosis Bax Bcl-2 cell death cytochrome c mitochondria Abbreviations used: Bax-ΔC, Bax...

View article titled, Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

Articles

The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells

Miguel PIGNATELLI, Rosario LUNA-MEDINA, Arturo PÉREZ-RENDÓN, Angel SANTOS, Ana PEREZ-CASTILLO

Biochem J (2003) 373 (3): 739–746.

DOI: https://doi.org/10.1042/bj20021918

Published: 01 August 2003

... Neuro2A cells. In accordance with this role of EGR-1 in cell death, antisense oligonucleotides increase cell viability in cells cultured in the absence of serum. This apoptotic activity of the EGR-1 appears to be mediated by p73, a member of the p53 family of proteins, since an increase in the amount...

View article titled, The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells

Articles

Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein

Hwain SHIN, Kazuya OKADA, John C. WILKINSON, Katherine M. SOLOMON, Colin S. DUCKETT, John C. REED, Guy S. SALVESEN

Biochem J (2003) 373 (3): 965–971.

DOI: https://doi.org/10.1042/bj20030583

Published: 01 August 2003

.... WILKINSON , Katherine M. SOLOMON , Colin S. DUCKETT , John C. REED* and Guy S. SALVESEN*1 *The Program in Apoptosis and Cell Death Research, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, U.S.A., and Departments of Pathology and Internal Medicine, University of Michigan, Ann Arbor...

View article titled, Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein

Articles

Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family

Liang LIANG, Mujun ZHAO, Zhenhua XU, Kazunari K. YOKOYAMA, Tsaiping LI

Biochem J (2003) 370 (1): 195–203.

DOI: https://doi.org/10.1042/bj20020656

Published: 15 February 2003

... a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Among CIDEs, two from human (CIDE-A and CIDE-B) and three from mouse (CIDE-A, CIDE-B and FSP27) have been reported. In this study human CIDE-3, a novel member of CIDEs, was identified upon sequence analysis...

View article titled, Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family

Articles

Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

Gavin P. McSTAY, Samantha J. CLARKE, Andrew P. HALESTRAP

Biochem J (2002) 367 (2): 541–548.

DOI: https://doi.org/10.1042/bj20011672

Published: 15 October 2002

... To whom correspondence should be addressed (e-mail A.Halestrap@Bristol.ac.uk ). 14 11 2001 23 7 2002 30 7 2002 30 7 2002 The Biochemical Society, London ©2002 2002 apoptosis cell death cyclophilin D diamide oxidative stress phenylarsine oxide Abbreviations...

View article titled, Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

Articles

Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia

Zheng DONG, Junichiro NISHIYAMA, Xiaolan YI, Manjeri A. VENKATACHALAM, Michael DENTON, Sumin GU, Senlin LI, Mei QIANG

Biochem J (2002) 364 (2): 413–421.

DOI: https://doi.org/10.1042/bj20011431

Published: 01 June 2002

...Zheng DONG; Junichiro NISHIYAMA; Xiaolan YI; Manjeri A. VENKATACHALAM; Michael DENTON; Sumin GU; Senlin LI; Mei QIANG Inhibitors of apoptosis (IAPs) antagonize cell death and regulate the cell cycle. One mechanism controlling IAP expression is translation initiation through the internal ribosome...

View article titled, Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia

Articles

Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage

M. Valeria CATANI, Antonio COSTANZO, Isabella SAVINI, Massimo LEVRERO, Vincenzo DE LAURENZI, Jean Y.J. WANG, Gerry MELINO, Luciana AVIGLIANO

Biochem J (2002) 364 (2): 441–447.

DOI: https://doi.org/10.1042/bj20011713

Published: 01 June 2002

...@uniroma2.it ). 22 11 2001 30 1 2002 22 3 2002 The Biochemical Society, London ©2002 2002 c-Abl cell death cisplatin vitamin C Abbreviations used: AA-2P, magnesium l -ascorbate 2-phosphate; CTD, C-terminal repeat domain of RNA polymerase II; GAPDH, glyceraldehyde-3...

View article titled, Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage

Articles

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

Maria RUZZENE, Daniele PENZO, Lorenzo A. PINNA

Biochem J (2002) 364 (1): 41–47.

DOI: https://doi.org/10.1042/bj3640041

Published: 08 May 2002

... to caspase cleavage. casein kinase 2 cell death protein phosphorylation proteolysis Abbreviations used: HS1, haematopoietic lineage cell-specific protein 1; MTT, 3-(4,5-dimethylthiazol-2-yl)-3,5-diphenyltetrazolium bromide; PARP, poly(ADP-ribose) polymerase; TBB, 4,5,6,7...

View article titled, Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

Articles

Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-γ, in caspase-dependent and -independent manners

Sebastian FEHLBERG, Stefan TRAUTWEIN, Alexandra GÖKE, Rüdiger GÖKE

Biochem J (2002) 362 (3): 573–578.

DOI: https://doi.org/10.1042/bj3620573

Published: 08 March 2002

...Sebastian FEHLBERG; Stefan TRAUTWEIN; Alexandra GÖKE; Rüdiger GÖKE Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors which are involved in many biological processes, such as regulation of cell differentiation, lipid metabolism, inflammation and cell death. PPARs...

View article titled, Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-γ, in caspase-dependent and -independent manners

Articles

The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells

Thierry COPPOLA, Véronique PERRET-MENOUD, Sonia GATTESCO, Sarah MAGNIN, Isabel POMBO, Ulrich BLANK, Romano REGAZZI

Biochem J (2002) 362 (2): 273–279.

DOI: https://doi.org/10.1042/bj3620273

Published: 22 February 2002

... 13 12 2001 The Biochemical Society, London ©2002 2002 cell death exocytosis insulin Abbreviations used: ΔC1, Rab3-GEP mutant lacking 127 amino acids at the C-terminus; ΔC2, Rab3-GEP mutant lacking 229 amino acids at the C-terminus; ΔDD, Rab3-GEP mutant lacking the death...

View article titled, The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells

Articles

Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells

Andrea GUIDARELLI, Roberta de SANCTIS, Barbara CELLINI, Mara FIORANI, Marina DACHÀ, Orazio CANTONI

Biochem J (2001) 356 (2): 509–513.

DOI: https://doi.org/10.1042/bj3560509

Published: 24 May 2001

... of the mitochondrial electron transport chain [4], promotes lipid peroxidation [5] and DNA damage [6] and finally leads to mitochondrial permeability transition and cell death [7]. Thus many defence mechanisms have evolved to limit the levels and}or deleterious effects of ONOO in biological systems [8 11...

View article titled, Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells

Articles

Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation

Patrice Xavier PETIT, Marie-Claude GENDRON, Nicolas SCHRANTZ, Didier MÉTIVIER, Guido KROEMER, Zofia MACIOROWSKA, Franck SUREAU, Steven KOESTER

Biochem J (2001) 353 (2): 357–367.

DOI: https://doi.org/10.1042/bj3530357

Published: 08 January 2001

..., London © 2001 2001 Bcl-2 cell death mitochondrial transmembrane potential permeability transition redox status Biochem. J. (2001) 353, 357 367 (Printed in Great Britain) 357 Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells : correlation...

View article titled, Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation

Articles

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

Bruno ANTONSSON, Sylvie MONTESSUIT, Sandra LAUPER, Robert ESKES, Jean-Claude MARTINOU

Biochem J (2000) 345 (2): 271–278.

DOI: https://doi.org/10.1042/bj3450271

Published: 10 January 2000

... 10 1999 29 10 1999 The Biochemical Society, London © 2000 2000 apoptosis Bcl-2 protein cell death Biochem. J. (2000) 345, 271 278 (Printed in Great Britain) 271 Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from...

View article titled, Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

Articles

Changes in polyamine catabolism in HL-60 human promyelogenous leukaemic cells in response to etoposide-induced apoptosis

Gayle S. LINDSAY, Heather M. WALLACE

Biochem J (1999) 337 (1): 83–87.

DOI: https://doi.org/10.1042/bj3370083

Published: 17 December 1998

... of the acetyltransferase and overall loss of intracellular polyamines may be involved in the final, possibly necrotic, stages of cell death. 1 To whom correspondence should be addressed (e-mail h.m.wallace@abdn.ac.uk ). 23 7 1998 1 9 1998 21 10 1998 The Biochemical Society, London © 1999...

View article titled, Changes in polyamine catabolism in HL-60 human promyelogenous leukaemic cells in response to etoposide-induced apoptosis

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