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Keywords: cathepsins
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Biochem J (2022) 479 (9): 995–1006.
Published: 12 May 2022
... provides an excellent experimental tool with which to investigate lineage commitment and the mechanisms of programmed cell death that occur in a normal physiological process. Importantly, involution has highlighted a role for lysoptosis, a mechanism of cell death that is mediated by lysosomal cathepsins...
Biochem J (2001) 359 (2): 335–343.
Published: 08 October 2001
... benzyloxycarbonyl-Val-Ala- d l -Asp-fluoromethylketone (‘Z-VAD-FMK’), although they did not by themselves inhibit caspases. We conclude that cathepsin D and one or more cysteine proteases, such as cathepsins B or L, are important mediators of sphingosine-induced apoptosis, working upstream of the caspase cascade...