...Jing Wu; Jun Yang; Xiaofang Wang; Lin Wei; Kai Mi; Yan Shen; Tong Liu; Hailong Yang; Lixian Mu Although cathelicidins in mammals have been well characterized, little is known about the function of cathelicidin in amphibians. In the present study, a novel 24-residue peptide (cathelicidin-NV...

...Yan Chen; Shasha Cai; Xue Qiao; Mali Wu; Zhilai Guo; Renping Wang; Yi-Qun Kuang; Haining Yu; Yipeng Wang Crocodilians are regarded as possessing a powerful immune system. However, the composition and action of the crocodilian immune system have remained unclear until now. Cathelicidins...

...Myung-Chul Chung; Scott N. Dean; Monique L. van Hoek In addition to membrane disruption, the cathelicidin antimicrobial peptide (AMP) LL-37 translocates through the bacterial inner membrane to target intracellular molecules. The present study aims to identify an alternate mechanism...

..., the nuclear membrane is disrupted by an as-yet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence microscopy revealed that 5 μM LL-37 significantly facilitated NET formation by primary human...

...-assembly in the multifunctional innate immune peptide LL-37, to determine how this evolved trait affects its interaction with biological membranes and how it influences its biological activities. cathelicidin covalent dimer cross-linking LL-37 oligomerization RL-37 LL-37, the only human...

...Ziv OREN; Jeffrey C. LERMAN; Gudmundur H. GUDMUNDSSON; Birgitta AGERBERTH; Yechiel SHAI The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic α-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence...