.../function. Cardiomyocyte BRAF V600E induced cardiac hypertrophy within 10 d, resulting in increased ejection fraction and fractional shortening over 6 weeks. This was associated with increased cardiomyocyte size without significant fibrosis, consistent with compensated hypertrophy. The experimental Type 1...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cardiac hypertrophy glycolysis heart failure metabolomics mitochondria stable isotope Glycolysis is the central pathway of intermediary carbon metabolism. Not only does catabolism...

... Journal compilation © 2011 Biochemical Society 2011 aldehyde dehydrogenase (ALDH) cardiac hypertrophy extracellular flux glycolysis 4-hydroxynonenal (HNE) mitochondrion Electrophilic aldehydes generated from the oxidation of lipids have been detected in nearly all tissues that have...

... 4 2003 30 4 2003 The Biochemical Society, London ©2003 2003 1 To whom correspondence should be addressed (e-mail c.g.proud@dundee.ac.uk ). cardiac hypertrophy phenylephrine protein kinase C protein synthesis p70 S6 kinase translation initiation Abbreviations...

... membrane. Available data also indicate that FAT/CD36 may have an important role in the aetiology of cardiac disease, especially cardiac hypertrophy and diabetic cardiomyopathy. This review discusses our current knowledge of the three candidate fatty acid transporters, the metabolic consequences...