... for studying the cellular, biochemical and molecular changes associated with oral carcinogenesis. The present study aims to deal with the above need using Acacia nilotica (L.) leaf extract (AN) and ethyl gallate (EG), a phenolic compound present in AN against oral carcinogenesis. Extension of a tumor cell line...

... that miR-17 plays an important role in CRC carcinogenesis by targeting RND3 and may be a therapeutic agent for CRC. 1 Correspondence may be addressed to either of these authors (email wudehua.gd@gmail.com or liliu.gd@gmail.com ). carcinogenesis colorectal neoplasm miR-17 microRNA RND3...

... modulated by limited proteolytic processing. carcinogenesis cathepsin L Disrupted in renal carcinoma 2 (DIRC2) lysosomal membrane major facilitator superfamily proteolysis In order to allow mapping of the proteolysis site, internal HA tags were introduced into DIRC2–3×Myc-pcDNA3.1/Hygro+ after...

...Ayako FURUKAWA; Yusuke HIRAKU; Shinji OIKAWA; Catherine LUXFORD; Michael J. DAVIES; Shosuke KAWANISHI In γ-irradiation, • OH is directly generated from water and causes DNA damage leading to carcinogenesis. Exposure of proteins to γ-irradiation, in the presence of oxygen, gives high yields...

... participate in pancreatic carcinogenesis. Our aim was to investigate in parallel the role of the Ets factor PEA3 in MUC4 and ErbB-2 transcriptional regulation in pancreatic cancer cells. Two MUC4 -expressing WD (well-differentiated) (CAPAN-1 and -2) and one MUC4 -non-expressing poorly differentiated (PANC-1...

...: antioxidant responsive element, cancer chemo- prevention, carcinogenesis, detoxification, glutamate cysteine ligase (also called c-glutamylcysteine synthetase). S-transferase class Alpha 2 (GSTA2) and rat NAD(P)H:quinone oxidoreductase 1 genes [3,4]. Deletion and mutation analyses of the promoter of rat GSTA2...

... is a major connexin expressed in many different cell types, and involves an increase in Cx43 and its cellular re-distribution. Key words: carcinogenesis, keratinocytes, ornithine de- carboxylase. cells show reduced levels of gap junction communication, and those that do retain near normal levels of gap...

... potencies of carcinogens. 1 To whom correspondence should be addressed (e-mail rasnick@mindspring.com). 25 11 1999 6 3 2000 10 4 2000 The Biochemical Society, London © 2000 2000 carcinogenesis dynamics metabolic control analysis Biochem. J. (2000) 348, 497 506...

... loss of chromosomes. Thus the initiation step of carcinogenesis produces aneuploidy below the threshold for cancer, and the promotion step increases the level of aneuploidy above this threshold. We conclude that aneuploidy offers a simple and coherent explanation for all the cancer-specific phenotypes...

... work suggests that these enzymes play a protective role in chemical carcinogenesis [Strassburg, Manns and Tukey (1997) Cancer Res. 57 , 2979–2985]. In this study, UGT1 and UGT2 gene expression was investigated in human oesophageal epithelium and squamous-cell carcinoma in addition...